LOCUS       NM_006386               4761 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens DEAD-box helicase 17 (DDX17), transcript variant 1,
            mRNA.
ACCESSION   NM_006386
VERSION     NM_006386.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4761)
  AUTHORS   Chapus,F., Giraud,G., Huchon,P., Roda,M., Grand,X., Charre,C.,
            Goldsmith,C., Roca Suarez,A.A., Martinez,M.G., Fresquet,J.,
            Diederichs,A., Locatelli,M., Polveche,H., Scholtes,C., Chemin,I.,
            Hernandez Vargas,H., Rivoire,M., Bourgeois,C.F., Zoulim,F. and
            Testoni,B.
  TITLE     Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription
            termination in infected human hepatocytes
  JOURNAL   J Hepatol 81 (4), 609-620 (2024)
   PUBMED   38782119
  REMARK    GeneRIF: Helicases DDX5 and DDX17 promote heterogeneity in HBV
            transcription termination in infected human hepatocytes.
REFERENCE   2  (bases 1 to 4761)
  AUTHORS   Ding,C.Z., Wang,G.L., Jiang,G.Q., Wang,H.T., Liu,Y.Y., Zhang,H.L.,
            Sun,F. and Wei,L.
  TITLE     [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation
            and apoptosis of non-small cell lung cancer cells]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 46 (3), 239-248 (2024)
   PUBMED   38494770
  REMARK    GeneRIF: [circDDX17 targets miR-223-3p / RIP3 to regulate the
            proliferation and apoptosis of non-small cell lung cancer cells].
REFERENCE   3  (bases 1 to 4761)
  AUTHORS   Yao,C., Zeng,L., Liu,Q., Qiu,X. and Chen,C.
  TITLE     LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell
            Invasion and Migration via Modulating Transcription Factor DDX17
  JOURNAL   Breast J 2023, 3970444 (2023)
   PUBMED   37720188
  REMARK    GeneRIF: LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer
            Cell Invasion and Migration via Modulating Transcription Factor
            DDX17.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4761)
  AUTHORS   Zhao,G., Wang,Q., Zhang,Y., Gu,R., Liu,M., Li,Q., Zhang,J.,
            Yuan,H., Feng,T., Ou,D., Li,S., Li,S., Li,K., Mo,C. and Lin,P.
  TITLE     DDX17 induces epithelial-mesenchymal transition and metastasis
            through the miR-149-3p/CYBRD1 pathway in colorectal cancer
  JOURNAL   Cell Death Dis 14 (1), 1 (2023)
   PUBMED   36593242
  REMARK    GeneRIF: DDX17 induces epithelial-mesenchymal transition and
            metastasis through the miR-149-3p/CYBRD1 pathway in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4761)
  AUTHORS   Boleslavska,B., Oravetzova,A., Shukla,K., Nascakova,Z., Ibini,O.N.,
            Hasanova,Z., Andrs,M., Kanagaraj,R., Dobrovolna,J. and Janscak,P.
  TITLE     DDX17 helicase promotes resolution of R-loop-mediated
            transcription-replication conflicts in human cells
  JOURNAL   Nucleic Acids Res 50 (21), 12274-12290 (2022)
   PUBMED   36453994
  REMARK    GeneRIF: DDX17 helicase promotes resolution of R-loop-mediated
            transcription-replication conflicts in human cells.
REFERENCE   6  (bases 1 to 4761)
  AUTHORS   Lee,C.G.
  TITLE     RH70, a bidirectional RNA helicase, co-purifies with U1snRNP
  JOURNAL   J Biol Chem 277 (42), 39679-39683 (2002)
   PUBMED   12193588
  REMARK    GeneRIF: has a role in pre-mRNA splicing, in particular, at the
            early stages of the splicing reaction involving U1snRNP
REFERENCE   7  (bases 1 to 4761)
  AUTHORS   Honig,A., Auboeuf,D., Parker,M.M., O'Malley,B.W. and Berget,S.M.
  TITLE     Regulation of alternative splicing by the ATP-dependent DEAD-box
            RNA helicase p72
  JOURNAL   Mol Cell Biol 22 (16), 5698-5707 (2002)
   PUBMED   12138182
  REMARK    GeneRIF: Results show that the abundant DEAD-box RNA helicase p72,
            but not its close relative p68, affects the splicing of alternative
            exons containing AC-rich exon enhancer elements.
REFERENCE   8  (bases 1 to 4761)
  AUTHORS   Uhlmann-Schiffler,H., Rossler,O.G. and Stahl,H.
  TITLE     The mRNA of DEAD box protein p72 is alternatively translated into
            an 82-kDa RNA helicase
  JOURNAL   J Biol Chem 277 (2), 1066-1075 (2002)
   PUBMED   11675387
  REMARK    GeneRIF: Alternate protein isoforms arise through the use of a
            non-AUG (CUG) and a downstream in-frame AUG translation initiation
            codons.
REFERENCE   9  (bases 1 to 4761)
  AUTHORS   Luking,A., Stahl,U. and Schmidt,U.
  TITLE     The protein family of RNA helicases
  JOURNAL   Crit Rev Biochem Mol Biol 33 (4), 259-296 (1998)
   PUBMED   9747670
  REMARK    Review article
REFERENCE   10 (bases 1 to 4761)
  AUTHORS   Lamm,G.M., Nicol,S.M., Fuller-Pace,F.V. and Lamond,A.I.
  TITLE     p72: a human nuclear DEAD box protein highly related to p68
  JOURNAL   Nucleic Acids Res 24 (19), 3739-3747 (1996)
   PUBMED   8871553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP353248.1, AK024985.1,
            CB215934.1, Z97056.1 and AL080113.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006386.4.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure, such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and splicesosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            which is an ATPase activated by a variety of RNA species, but not
            by dsDNA. This protein, and that encoded by DDX5 gene, are more
            closely related to each other than to any other member of the DEAD
            box family. This gene can encode multiple isoforms due to both
            alternative splicing and the use of alternative translation
            initiation codons, including a non-AUG (CUG) start codon. [provided
            by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1 (also known
            as p82) through the use of a non-AUG (CUG) translation initiation
            codon. Alternate translation from an in-frame, downstream AUG
            results in a shorter isoform (known as p72).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.25535.1, AK024985.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000403230.3/ ENSP00000385536.2
            non-AUG initiation codon :: PMID: 11675387
            RefSeq Select criteria   :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BP353248.1         30-32
            4-2381              AK024985.1         1-2378
            2382-2504           AK024985.1         2381-2503
            2505-2749           CB215934.1         247-491
            2750-4760           Z97056.1           94622-96632         c
            4761-4761           AL080113.1         1667-1667
FEATURES             Location/Qualifiers
     source          1..4761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..4761
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /note="DEAD-box helicase 17"
                     /db_xref="GeneID:10521"
                     /db_xref="HGNC:HGNC:2740"
                     /db_xref="MIM:608469"
     exon            1..361
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2264
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; non-AUG (CUG) translation initiation codon;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD);
                     DEAD (Asp-Glu-Ala-Asp) box polypeptide 17; probable
                     ATP-dependent RNA helicase DDX17; DEAD box protein p72;
                     RNA-dependent helicase p72; DEAD (Asp-Glu-Ala-Asp) box
                     helicase 17; DEAD box protein p82; p72 RNA helicase"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX17
                     isoform 1 precursor"
                     /protein_id="NP_006377.2"
                     /db_xref="CCDS:CCDS33646.1"
                     /db_xref="GeneID:10521"
                     /db_xref="HGNC:HGNC:2740"
                     /db_xref="MIM:608469"
                     /translation="MPTGFVAPILCVLLPSPTREAATVASATGDSASERESAAPAAAP
                     TAEAPPPSVVTRPEPQALPSPAIRAPLPDLYPFGTMRGGGFGDRDRDRDRGGFGARGG
                     GGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITV
                     RGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTG
                     SGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKST
                     CIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMG
                     FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQ
                     IVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHG
                     DKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGR
                     TARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGGRSR
                     YRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNS
                     AFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSSQSSSQQFSGI
                     GRSGQQPQPLMSQQFAQPPGATNMIGYMGQTAYQYPPPPPPPPPSRK"
     exon            362..512
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            513..612
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            613..746
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            747..812
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            813..954
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1115
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1288
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1399
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1461
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1521
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1758
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..4761
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /note="hexamer: AATAAA"
     polyA_site      4761
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /note="major polyA site"
ORIGIN      
        1 gccattttgt gcagtcgctg ggaaggaagg agacgcctaa accgcggcac tgcccggttt
       61 gagcgtagcc aaacctgccc accggctttg tagccccgat tctctgtgtt ttgctcccgt
      121 ctccgacgag agaggcggcg acggtggcgt ctgcgacggg agacagcgcg tcggagcgag
      181 agagcgctgc gcctgccgcc gccccaacag cggaggcgcc gccgccatcg gtcgtcacca
      241 gaccggagcc gcaggccctc ccgagcccgg ccatccgtgc cccgctccca gatctctatc
      301 cttttgggac catgcgcgga ggaggctttg gggaccggga ccgggatcgt gaccgtggag
      361 gatttggagc aagaggtggt ggtggccttc ccccgaagaa atttggtaat cctggggagc
      421 gtttgcgtaa aaaaaagtgg gatttgagtg agctccccaa gtttgagaaa aatttttatg
      481 tggaacatcc ggaagtagca aggctgacac catatgaggt tgatgagcta cgccgaaaga
      541 aggagattac agtgaggggg ggagatgttt gtcctaaacc cgtgtttgcc ttccatcatg
      601 ctaacttccc acaatatgta atggatgtgt tgatggatca gcactttaca gaaccaactc
      661 caattcagtg ccagggattt ccgttggctc ttagtggccg ggatatggtg ggcattgctc
      721 agactggctc tgggaagacg ttggcgtatc tcctgcctgc aattgttcat attaaccacc
      781 agccatactt ggaaagggga gatggcccaa tctgtctagt tctggctcct accagagagc
      841 ttgcccagca agtacagcag gtggccgatg actatggcaa atgttctaga ttgaagagta
      901 cttgtattta tggaggtgct cctaaaggtc cccagattcg agacttggaa agaggtgttg
      961 agatctgcat agccactcct ggacgtctga tagatttcct ggagtcagga aagacaaatc
     1021 ttcgccgatg tacttacctt gtattggacg aagctgacag aatgcttgat atggggtttg
     1081 aaccccagat ccgtaaaatt gttgaccaaa tcaggcctga taggcagaca ctgatgtgga
     1141 gtgcaacctg gccaaaagaa gtaagacagc ttgcagagga tttccttcgt gattacaccc
     1201 agatcaacgt aggcaatctg gagttgagtg ccaaccacaa catcctccag atagtggatg
     1261 tctgcatgga aagtgaaaaa gaccacaagt tgatccaact aatggaagaa ataatggctg
     1321 aaaaggaaaa caaaacaata atatttgtgg agacaaagag acgctgtgat gatctgactc
     1381 gaaggatgcg cagagatggt tggccagcta tgtgtatcca tggagacaag agtcaaccag
     1441 aaagagattg ggtacttaat gagttccgtt ctggaaaggc acccatcctt attgctacag
     1501 atgtagcctc ccgtgggcta gatgtggaag atgtcaagtt tgtgatcaac tatgactatc
     1561 caaacagctc agaggattat gtgcaccgta ttggccgaac agcccgtagc accaacaagg
     1621 gtaccgccta taccttcttc accccaggga acctaaaaca ggccagagag cttatcaaag
     1681 tgctggaaga ggccaatcag gctatcaatc caaaactgat gcagcttgtg gaccacagag
     1741 gaggcggcgg aggcgggggt ggtcgttctc gttaccggac cacttcttca gccaacaatc
     1801 ccaatctgat gtatcaggat gagtgtgacc gaaggcttcg aggagtcaag gatggtggcc
     1861 ggagagactc tgcaagctat cgggatcgta gtgaaaccga tagagctggt tatgctaatg
     1921 gcagtggcta tggaagtcca aattctgcct ttggagcaca agcaggccaa tacacctatg
     1981 gtcaaggcac ctatggggca gctgcttatg gcaccagtag ctatacagct caagaatatg
     2041 gtgctggcac ttatggagct agtagcacca cctcaactgg gagaagttca cagagctcta
     2101 gccagcagtt tagtgggata ggccggtctg ggcagcagcc acagccactg atgtcacaac
     2161 agtttgcaca gcctccggga gctaccaata tgataggtta catggggcag actgcctacc
     2221 aataccctcc tcctcctccc cctcctcctc cttcacgtaa atgaaaccac tcaagtggta
     2281 gtgactccag cagacttaat tacattttaa ggaacactgt ctttcctttt tttttcctct
     2341 tcgccttttc tttttttttc cttttttctt tttttttttt taatttttcc ccccaaccat
     2401 cgtgatttgt cttttcatgc agattagtta gaattcactg ccaggtttct tctgcccacc
     2461 aaaatgatcc agtctggaat aacattttgt aaaaaaaaaa aaaatatata tatatatata
     2521 tagctgactg gaagagatta atttcttccc ccaacttctt gcatgttgaa gatatttgag
     2581 ctatttttca tctaaaagag taaggtatta ggcccttttg tgggagcccc atgttttgtt
     2641 tttctgagtt ggtggggagg gagggagggg gagggctgaa ttgttttgca gaggaagatg
     2701 gcatctgtgc tttaaatttc tcattactgg gttagaaaac aaagagggat tgccctgcac
     2761 attttctttt gtgcttttaa atgtttctta agttggaaca ggtttcctcg ggcctgtttt
     2821 gactgattgc tggagtgcat ttgatagtta aaaattacta attggtttta tttcccttca
     2881 cactctgcct ccccacttct ccccccgtta ctgaaaaata accattttag tgtcaggcta
     2941 gaaattgaat tgctgagttt tgtgtatcct ttaaattaaa aaccacaagt gtttattgta
     3001 gtggttaaac tgtagcatct cagcatctgg gtggaagctg cctatatttc ttcccagttt
     3061 aactggggac catctgtgaa attaattttc catccagaca gctgctgtga gcaaatgaac
     3121 ataaatgctc gctggaaatt tactaaccag tttttatatt gacctgcagt gtaaaaagca
     3181 catttaatta taaacaatat attcaaaatg ggcaaatttt attttcaaat gcagtgtaga
     3241 gctagattaa aagcaactct ttgccaccta ctctgccctt ttggcaaagt taccttgaac
     3301 aaagaatctt aagggtttat taagaactct ttattttctt cataccctgt tctctgcagt
     3361 gctttctaac agcttctggg tgcagatttt cttcggcatc cttttgcact cagcttatta
     3421 caggtaggta gtgcttaaga aaagtcatgg aggactaaag cctaagtcct tttcactttt
     3481 cctccatctg aaggtaggtg agttcatcct cttcatggta atgctgtttt accaagactt
     3541 tatagcagat ggacccagaa agaattttct gctattgtgt tcactacaac aggataggga
     3601 catcagacag ccccagaaac cccttccaga tctgatatgg gactattaat ttttatgctg
     3661 ttaattggta ttcattcaca atgcagttga agggggaagg ctccactgca ttctttggct
     3721 aaggcctgaa tgcttgctca tctgtaagat ctatactcga ggttttgttt tccttttaaa
     3781 attctttagg gagagaggga tggtttctga ggggttctga aagtatgatt caatgtgcaa
     3841 catacaggta ggtcttcagc ataagctgaa atatatgcat gtaaaaactt tgacatcttt
     3901 ttttttaatt ttccactttc ttcttaactt tacttctctt tttgtccccc ccccatctta
     3961 cagaagttga ggccaaggga gaatggtagg cacagaagaa acatggcaaa ctgctctgtg
     4021 ctttcaaacc aaagtgttcc ccccaacccc aaatttgtct aagcactggc cagtctgttg
     4081 tgggcattgt tttctacaac caaattctgg gtttttttct tctttcttta aacatagagg
     4141 taccaccaca agggatgccc tactctctcg cagctcttga aagcatctgt ttgagggaaa
     4201 ggtctctggg caagcaagtg gttatttgga ttgcttgctt ccctttttcc acctgggaca
     4261 ttgtaatcat aaaataacag taaattccaa acctcaaaaa ctattatggc ctgagcacag
     4321 ctgaaatcta gcagagttta actcttctgc ctccatgtct gtcacttata attcaggttc
     4381 tgctgttggc ttcagaacat gagcagaaga atcgttttat gctagttatt gcattcatgg
     4441 ttgaaactca acttagggaa agggttccaa tgtattaagc aatgggctgc ttctccccaa
     4501 tcctccctaa caattcgttg tgtggacttc tcatctaaaa ggttagtggc ttttgcttgg
     4561 gatcagtgct ctctattgat gttcttgctg gtctccagac acattcctgt tgcattaaga
     4621 cttgaaagac ttgtagatgt gtgatgttca ggcacaggat gctgaaagct atgttactat
     4681 tcttagtttg taaattgtcc ttttgatacc atcatcttgt tttctttttg taggtataaa
     4741 taaaaacact gttgacaata a
//
