LOCUS       NP_006377                729 aa            linear   PRI 27-APR-2025
DEFINITION  probable ATP-dependent RNA helicase DDX17 isoform 1 precursor [Homo
            sapiens].
ACCESSION   NP_006377
VERSION     NP_006377.2
DBSOURCE    REFSEQ: accession NM_006386.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 729)
  AUTHORS   Chapus,F., Giraud,G., Huchon,P., Roda,M., Grand,X., Charre,C.,
            Goldsmith,C., Roca Suarez,A.A., Martinez,M.G., Fresquet,J.,
            Diederichs,A., Locatelli,M., Polveche,H., Scholtes,C., Chemin,I.,
            Hernandez Vargas,H., Rivoire,M., Bourgeois,C.F., Zoulim,F. and
            Testoni,B.
  TITLE     Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription
            termination in infected human hepatocytes
  JOURNAL   J Hepatol 81 (4), 609-620 (2024)
   PUBMED   38782119
  REMARK    GeneRIF: Helicases DDX5 and DDX17 promote heterogeneity in HBV
            transcription termination in infected human hepatocytes.
REFERENCE   2  (residues 1 to 729)
  AUTHORS   Ding,C.Z., Wang,G.L., Jiang,G.Q., Wang,H.T., Liu,Y.Y., Zhang,H.L.,
            Sun,F. and Wei,L.
  TITLE     [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation
            and apoptosis of non-small cell lung cancer cells]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 46 (3), 239-248 (2024)
   PUBMED   38494770
  REMARK    GeneRIF: [circDDX17 targets miR-223-3p / RIP3 to regulate the
            proliferation and apoptosis of non-small cell lung cancer cells].
REFERENCE   3  (residues 1 to 729)
  AUTHORS   Yao,C., Zeng,L., Liu,Q., Qiu,X. and Chen,C.
  TITLE     LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell
            Invasion and Migration via Modulating Transcription Factor DDX17
  JOURNAL   Breast J 2023, 3970444 (2023)
   PUBMED   37720188
  REMARK    GeneRIF: LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer
            Cell Invasion and Migration via Modulating Transcription Factor
            DDX17.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 729)
  AUTHORS   Zhao,G., Wang,Q., Zhang,Y., Gu,R., Liu,M., Li,Q., Zhang,J.,
            Yuan,H., Feng,T., Ou,D., Li,S., Li,S., Li,K., Mo,C. and Lin,P.
  TITLE     DDX17 induces epithelial-mesenchymal transition and metastasis
            through the miR-149-3p/CYBRD1 pathway in colorectal cancer
  JOURNAL   Cell Death Dis 14 (1), 1 (2023)
   PUBMED   36593242
  REMARK    GeneRIF: DDX17 induces epithelial-mesenchymal transition and
            metastasis through the miR-149-3p/CYBRD1 pathway in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 729)
  AUTHORS   Boleslavska,B., Oravetzova,A., Shukla,K., Nascakova,Z., Ibini,O.N.,
            Hasanova,Z., Andrs,M., Kanagaraj,R., Dobrovolna,J. and Janscak,P.
  TITLE     DDX17 helicase promotes resolution of R-loop-mediated
            transcription-replication conflicts in human cells
  JOURNAL   Nucleic Acids Res 50 (21), 12274-12290 (2022)
   PUBMED   36453994
  REMARK    GeneRIF: DDX17 helicase promotes resolution of R-loop-mediated
            transcription-replication conflicts in human cells.
REFERENCE   6  (residues 1 to 729)
  AUTHORS   Lee,C.G.
  TITLE     RH70, a bidirectional RNA helicase, co-purifies with U1snRNP
  JOURNAL   J Biol Chem 277 (42), 39679-39683 (2002)
   PUBMED   12193588
  REMARK    GeneRIF: has a role in pre-mRNA splicing, in particular, at the
            early stages of the splicing reaction involving U1snRNP
REFERENCE   7  (residues 1 to 729)
  AUTHORS   Honig,A., Auboeuf,D., Parker,M.M., O'Malley,B.W. and Berget,S.M.
  TITLE     Regulation of alternative splicing by the ATP-dependent DEAD-box
            RNA helicase p72
  JOURNAL   Mol Cell Biol 22 (16), 5698-5707 (2002)
   PUBMED   12138182
  REMARK    GeneRIF: Results show that the abundant DEAD-box RNA helicase p72,
            but not its close relative p68, affects the splicing of alternative
            exons containing AC-rich exon enhancer elements.
REFERENCE   8  (residues 1 to 729)
  AUTHORS   Uhlmann-Schiffler,H., Rossler,O.G. and Stahl,H.
  TITLE     The mRNA of DEAD box protein p72 is alternatively translated into
            an 82-kDa RNA helicase
  JOURNAL   J Biol Chem 277 (2), 1066-1075 (2002)
   PUBMED   11675387
  REMARK    GeneRIF: Alternate protein isoforms arise through the use of a
            non-AUG (CUG) and a downstream in-frame AUG translation initiation
            codons.
REFERENCE   9  (residues 1 to 729)
  AUTHORS   Luking,A., Stahl,U. and Schmidt,U.
  TITLE     The protein family of RNA helicases
  JOURNAL   Crit Rev Biochem Mol Biol 33 (4), 259-296 (1998)
   PUBMED   9747670
  REMARK    Review article
REFERENCE   10 (residues 1 to 729)
  AUTHORS   Lamm,G.M., Nicol,S.M., Fuller-Pace,F.V. and Lamond,A.I.
  TITLE     p72: a human nuclear DEAD box protein highly related to p68
  JOURNAL   Nucleic Acids Res 24 (19), 3739-3747 (1996)
   PUBMED   8871553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP353248.1, AK024985.1,
            CB215934.1, Z97056.1 and AL080113.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 7, 2003 this sequence version replaced NP_006377.1.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure, such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and splicesosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            which is an ATPase activated by a variety of RNA species, but not
            by dsDNA. This protein, and that encoded by DDX5 gene, are more
            closely related to each other than to any other member of the DEAD
            box family. This gene can encode multiple isoforms due to both
            alternative splicing and the use of alternative translation
            initiation codons, including a non-AUG (CUG) start codon. [provided
            by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1 (also known
            as p82) through the use of a non-AUG (CUG) translation initiation
            codon. Alternate translation from an in-frame, downstream AUG
            results in a shorter isoform (known as p72).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.25535.1, AK024985.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000403230.3/ ENSP00000385536.2
            non-AUG initiation codon :: PMID: 11675387
            RefSeq Select criteria   :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     Protein         1..729
                     /product="probable ATP-dependent RNA helicase DDX17
                     isoform 1 precursor"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17
                     (72kD); DEAD (Asp-Glu-Ala-Asp) box polypeptide 17;
                     probable ATP-dependent RNA helicase DDX17; DEAD box
                     protein p72; RNA-dependent helicase p72; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 17; DEAD box protein p82;
                     p72 RNA helicase"
                     /calculated_mol_wt=78078
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2213
     Region          20..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q92841.2)"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000269|PubMed:20663877; propagated from
                     UniProtKB/Swiss-Prot (Q92841.2)"
     Site            109
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000269|PubMed:20663877; propagated from
                     UniProtKB/Swiss-Prot (Q92841.2)"
     Region          111..579
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Site            121
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000269|PubMed:20663877; propagated from
                     UniProtKB/Swiss-Prot (Q92841.2)"
     Region          171..199
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     Site            order(191,193..195,198,216..223)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350808"
     Region          325..328
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     Site            523
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16964243; propagated from
                     UniProtKB/Swiss-Prot (Q92841.2)"
     Region          547..729
                     /region_name="Transactivation domain"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     Region          551..623
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     Region          659..729
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     Site            684
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q92841.2)"
     Region          718..726
                     /region_name="Interaction with YAP1.
                     /evidence=ECO:0000269|PubMed:24581491"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92841.2)"
     CDS             1..729
                     /gene="DDX17"
                     /gene_synonym="P72; RH70"
                     /coded_by="NM_006386.5:75..2264"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; non-AUG (CUG) translation initiation codon"
                     /db_xref="CCDS:CCDS33646.1"
                     /db_xref="GeneID:10521"
                     /db_xref="HGNC:HGNC:2740"
                     /db_xref="MIM:608469"
ORIGIN      
        1 mptgfvapil cvllpsptre aatvasatgd saseresaap aaaptaeapp psvvtrpepq
       61 alpspairap lpdlypfgtm rgggfgdrdr drdrggfgar gggglppkkf gnpgerlrkk
      121 kwdlselpkf eknfyvehpe varltpyevd elrrkkeitv rggdvcpkpv fafhhanfpq
      181 yvmdvlmdqh fteptpiqcq gfplalsgrd mvgiaqtgsg ktlayllpai vhinhqpyle
      241 rgdgpiclvl aptrelaqqv qqvaddygkc srlkstciyg gapkgpqird lergveicia
      301 tpgrlidfle sgktnlrrct ylvldeadrm ldmgfepqir kivdqirpdr qtlmwsatwp
      361 kevrqlaedf lrdytqinvg nlelsanhni lqivdvcmes ekdhkliqlm eeimaekenk
      421 tiifvetkrr cddltrrmrr dgwpamcihg dksqperdwv lnefrsgkap iliatdvasr
      481 gldvedvkfv inydypnsse dyvhrigrta rstnkgtayt fftpgnlkqa relikvleea
      541 nqainpklmq lvdhrggggg gggrsryrtt ssannpnlmy qdecdrrlrg vkdggrrdsa
      601 syrdrsetdr agyangsgyg spnsafgaqa gqytygqgty gaaaygtssy taqeygagty
      661 gassttstgr ssqsssqqfs gigrsgqqpq plmsqqfaqp pgatnmigym gqtayqyppp
      721 ppppppsrk
//
