LOCUS       NM_004398               3217 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.
ACCESSION   NM_004398
VERSION     NM_004398.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Quan,X., Zhao,C., Gao,Z., Zhang,Y., Zhao,R., Wang,J. and Zhang,Q.
  TITLE     DDX10 and BYSL as the potential targets of chondrosarcoma and
            glioma
  JOURNAL   Medicine (Baltimore) 100 (46), e27669 (2021)
   PUBMED   34797290
  REMARK    GeneRIF: DDX10 and BYSL as the potential targets of chondrosarcoma
            and glioma.
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Liu,C., Tang,J., Duan,X., Du,Y., Wang,X. and Cui,Y.
  TITLE     DDX10 promotes human lung carcinoma proliferation by U3 small
            nucleolar ribonucleoprotein IMP4
  JOURNAL   Thorac Cancer 12 (12), 1873-1880 (2021)
   PUBMED   33973712
  REMARK    GeneRIF: DDX10 promotes human lung carcinoma proliferation by U3
            small nucleolar ribonucleoprotein IMP4.
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Popova,B., Wang,D., Patz,C., Akkermann,D., Lazaro,D.F., Galka,D.,
            Kolog Gulko,M., Bohnsack,M.T., Mobius,W., Bohnsack,K.E.,
            Outeiro,T.F. and Braus,G.H.
  TITLE     DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of alpha-synuclein
            toxicity and oligomerization
  JOURNAL   PLoS Genet 17 (3), e1009407 (2021)
   PUBMED   33657088
  REMARK    GeneRIF: DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of
            alpha-synuclein toxicity and oligomerization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3217)
  AUTHORS   Zhao,S., Lin,M. and Zhang,Y.
  TITLE     [DDX10 promotes AIM2-inflammasome activation by maintaining AIM2
            protein stability]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 36 (4), 289-296 (2020)
   PUBMED   32519665
  REMARK    GeneRIF: [DDX10 promotes AIM2-inflammasome activation by
            maintaining AIM2 protein stability].
REFERENCE   6  (bases 1 to 3217)
  AUTHORS   Zuber,J., Tchernitsa,O.I., Hinzmann,B., Schmitz,A.C., Grips,M.,
            Hellriegel,M., Sers,C., Rosenthal,A. and Schafer,R.
  TITLE     A genome-wide survey of RAS transformation targets
  JOURNAL   Nat Genet 24 (2), 144-152 (2000)
   PUBMED   10655059
REFERENCE   7  (bases 1 to 3217)
  AUTHORS   Ikeda,T., Ikeda,K., Sasaki,K., Kawakami,K. and Takahara,J.
  TITLE     The inv(11)(p15q22) chromosome translocation of therapy-related
            myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts
  JOURNAL   Int J Hematol 69 (3), 160-164 (1999)
   PUBMED   10222653
REFERENCE   8  (bases 1 to 3217)
  AUTHORS   Liang,W.Q., Clark,J.A. and Fournier,M.J.
  TITLE     The rRNA-processing function of the yeast U14 small nucleolar RNA
            can be rescued by a conserved RNA helicase-like protein
  JOURNAL   Mol Cell Biol 17 (7), 4124-4132 (1997)
   PUBMED   9199348
  REMARK    GeneRIF: The rRNA-processing function of the yeast U14 small
            nucleolar RNA can be rescued by a conserved RNA helicase-like
            protein.
REFERENCE   9  (bases 1 to 3217)
  AUTHORS   Arai,Y., Hosoda,F., Kobayashi,H., Arai,K., Hayashi,Y., Kamada,N.,
            Kaneko,Y. and Ohki,M.
  TITLE     The inv(11)(p15q22) chromosome translocation of de novo and
            therapy-related myeloid malignancies results in fusion of the
            nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10
  JOURNAL   Blood 89 (11), 3936-3944 (1997)
   PUBMED   9166830
REFERENCE   10 (bases 1 to 3217)
  AUTHORS   Savitsky,K., Ziv,Y., Bar-Shira,A., Gilad,S., Tagle,D.A., Smith,S.,
            Uziel,T., Sfez,S., Nahmias,J., Sartiel,A., Eddy,R.L., Shows,T.B.,
            Collins,F.S., Shiloh,Y. and Rotman,G.
  TITLE     A human gene (DDX10) encoding a putative DEAD-box RNA helicase at
            11q22-q23
  JOURNAL   Genomics 33 (2), 199-206 (1996)
   PUBMED   8660968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC401755.1 and BC091521.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004398.3.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            and it may be involved in ribosome assembly. Fusion of this gene
            and the nucleoporin gene, NUP98, by inversion 11 (p15q22)
            chromosome translocation is found in the patients with de novo or
            therapy-related myeloid malignancies. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.195133.1, BC091521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322536.8/ ENSP00000314348.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DC401755.1         45-52
            9-3217              BC091521.1         1-3209
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..3217
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /note="DEAD-box helicase 10"
                     /db_xref="GeneID:1662"
                     /db_xref="HGNC:HGNC:2735"
                     /db_xref="MIM:601235"
     exon            1..271
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2713
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10
                     (RNA helicase); DDX10-NUP98 fusion protein type 2; DEAD
                     box protein 10; DEAD (Asp-Glu-Ala-Asp) box polypeptide 10"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX10"
                     /protein_id="NP_004389.2"
                     /db_xref="CCDS:CCDS8342.1"
                     /db_xref="GeneID:1662"
                     /db_xref="HGNC:HGNC:2735"
                     /db_xref="MIM:601235"
                     /translation="MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKP
                     EWQVERESISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGL
                     ALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEV
                     LRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQM
                     LVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV
                     HEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFC
                     RLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDC
                     PEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQKKVPVKEIKINPEKLIDV
                     QKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEYALSLGLAVAP
                     RVRFLQKMQKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRL
                     EGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFL
                     DRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPSKSSIKKKMTKVAEAKKVMKRNF
                     KVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGINLHKAKERLQEEDKFDKEEY
                     RKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDGFDPSTLPDP
                     DKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDT
                     GLSLAEDEELVLHLLRSQS"
     exon            272..332
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            333..463
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            464..622
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            623..743
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            744..933
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1060
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1223
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1308
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1407
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1495
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1584
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..2050
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2170
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2332
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2389
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2535
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..3217
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /note="hexamer: AATAAA"
     polyA_site      3217
                     /gene="DDX10"
                     /gene_synonym="Dbp4; HRH-J8"
                     /note="major polyA site"
ORIGIN      
        1 gcgtttgtcc catgctggtt ccgtgagtct ggccttaggt gtctcgtgtc tggggttgat
       61 ccgagctgtc gccgccgccg ccgcaatggg caaaacggcc aactctccgg gttcgggagc
      121 ccgacccgac ccggtgcgga gcttcaatcg ctggaagaaa aaacacagcc ataggcagaa
      181 caaaaagaag cagttgagga agcaactgaa gaaacccgaa tggcaggtcg agcgcgagag
      241 tatcagccgc ctcatgcaga actatgaaaa gataaatgta aatgaaatca caagattttc
      301 agattttccc ttgtccaaaa aaacattgaa aggtttgcaa gaagctcagt accgtttggt
      361 gactgagata cagaagcaga ccattggatt ggctttgcaa ggtaaagatg tacttggagc
      421 ggccaaaact ggatctggca agactctggc ttttcttgtt ccagtgctgg aagccttata
      481 tcgtctgcaa tggacttcaa cagatgggct gggggttctc ataatatcac ctacgagaga
      541 actggcctat cagacctttg aggttctccg aaaagtagga aagaatcatg acttctcagc
      601 tggtctcatc attggtggaa aggatctaaa acacgaagct gagaggatca acaacataaa
      661 tatactcgtg tgcacaccag gtcggcttct tcaacacatg gatgaaacag tatcttttca
      721 tgctaccgac ctccaaatgt tagttcttga tgaagcagat agaatcttgg atatgggctt
      781 tgctgatacc atgaatgctg ttattgaaaa tctccccaag aaacgtcaga ctttactttt
      841 ctcagcaaca caaactaaat ctgtaaagga ccttgcacgc ttgagtttga aaaaccctga
      901 gtatgtctgg gttcatgaaa aagcaaaata tagcacccct gccactttgg aacagaacta
      961 catagtctgt gagctgcagc aaaaaataag tgtgctgtat tcctttttga gaagccatct
     1021 gaagaagaag agcattgtat ttttttccag ttgcaaagag gtccagtatc tgtaccgagt
     1081 gttttgccgg ctacgtcctg gtgtttctat ccttgcactc catggtcgac agcagcaaat
     1141 gagaagaatg gaagtctata atgagtttgt ccgtaagaga gctgcagtac tctttgctac
     1201 tgatattgca gccaggggtc tggatttccc ggccgtgaat tgggttcttc agtttgattg
     1261 tcctgaggat gccaacacat atattcacag agcaggtaga actgccaggt acaaagagga
     1321 tggtgaagct ttgctaattt tgctaccctc agaaaaagct atggtgcagc agcttcttca
     1381 gaagaaagta cctgtgaagg aaatcaaaat caatccagaa aaacttatag atgtccagaa
     1441 aaaattggaa tctattttag ctcaagatca agatttaaaa gaaagagctc aaaggtgttt
     1501 cgtctcctat gtacgatctg tatatctgat gaaggataaa gaagtatttg atgtgagcaa
     1561 gttacctata cctgaatatg ccctgtctct tggtcttgct gtggcaccac gcgtaagatt
     1621 tcttcagaaa atgcagaaac aacccaccaa agaattggta aggagccaag ccgataaagt
     1681 aattgagcca agggctccct ccctcaccaa tgacgaagtg gaagaattta gagcctactt
     1741 caatgagaaa atgtccatcc ttcaaaaagg tggaaaaaga ctcgaaggga cagagcacag
     1801 acaggataat gatactggta atgaagaaca ggaagaagaa gaagacgatg aagaagaaat
     1861 ggaagagaaa ctggcaaaag caaaaggatc tcaagcccca tctcttccta acaccagtga
     1921 ggcacagaag atcaaggaag ttcctacaca gttcttggac agagatgagg aggaagaaga
     1981 tgctgatttc ttgaaggtga agcggcataa tgtgtttgga ttggacctta aagacgagaa
     2041 aacattacag aagaaagaac cttctaaatc cagcatcaag aaaaaaatga ccaaagttgc
     2101 agaagcaaaa aaagtaatga agagaaattt taaagtgaat aagaagataa catttactga
     2161 tgaaggggag ttggttcagc agtggccaca aatgcagaaa tctgccatca aggatgctga
     2221 ggaagatgat gacacaggtg gtatcaactt acataaagca aaggaaagac ttcaggaaga
     2281 ggacaaattt gacaaagaag aatataggaa aaaaattaag gcaaagcatc gggagaaaag
     2341 actgaaagaa agggaagcca gaagagaagc caacaagaga caagcaaagg ccaaagatga
     2401 agaggaagcc tttctggatt ggagtgatga tgatgatgat gatgatgatg gatttgatcc
     2461 aagcacactc ccagatccag ataaatacag aagctctgaa gattcagata gtgaagatat
     2521 ggaaaataaa ataagtgata ccaagaagaa gcaggggatg aagaagagga gcaacagtga
     2581 agtggaagac gtgggaccaa caagtcataa cagaaagaag gccaggtggg acactttaga
     2641 gcctttggat accggcctgt ctttagcaga ggatgaagag ctggtgttac atctgctaag
     2701 aagtcaaagc taaatacttc ctgcgcctgc cttctccttg aaaccttggt tatgactgcg
     2761 taggcaagaa gttgaaaaac agttgatttg ggggcactta ggtaccatat gccccattcc
     2821 caaagggcac atttctggat agaagcgatc gtatctccaa gtccctctca caggacatgc
     2881 tttgtgccat cactgagcat actcagatcg agggtggatg ataccatttc ctgaccccgt
     2941 tttccagcat gtgttctgtt agatttttat ccatgggttc ctacgccttg tcattggaaa
     3001 cactgccttt gtcttactgg caagttctgg agctcttgtg tcattgttag aaatccctgt
     3061 cttgcttact gtacagaagt ttctgttgct gttaaaattg ctcatgattt cgacgtattt
     3121 aatattttca aagagactat gatggaccag ccctgagaaa gaatgagtat ttttgaattg
     3181 agatgatcaa taataaacat atttcctata aaagaaa
//
