LOCUS       NM_004939               2484 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens DEAD-box helicase 1 (DDX1), mRNA.
ACCESSION   NM_004939
VERSION     NM_004939.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Liu,J., Yang,T., Luo,Y., Ma,Z., Yu,Z., Zhang,L., Liu,G., Wen,J.,
            Lu,G., Zhang,G., Zhao,Y., Luo,W., Li,Y., Yang,N., Zhou,J., Lu,Y.,
            Chen,S. and Zeng,X.
  TITLE     DEAD-box helicase 1 inhibited CD8+ T cell antitumor activity by
            inducing PD-L1 expression in hepatocellular carcinoma
  JOURNAL   Cancer Sci 115 (3), 763-776 (2024)
   PUBMED   38243657
  REMARK    GeneRIF: DEAD-box helicase 1 inhibited CD8[+] T cell antitumor
            activity by inducing PD-L1 expression in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Garg,M., Li,L. and Godbout,R.
  TITLE     Role of DDX1 in the oxidative response of ataxia telangiectasia
            patient-derived fibroblasts
  JOURNAL   Redox Biol 69, 102988 (2024)
   PUBMED   38096740
  REMARK    GeneRIF: Role of DDX1 in the oxidative response of ataxia
            telangiectasia patient-derived fibroblasts.
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Sharma,M., Mason,A.C., Dawson,T.R. and Wente,S.R.
  TITLE     Phosphorylation impacts GLE1 nuclear localization and association
            with DDX1
  JOURNAL   Adv Biol Regul 90, 100990 (2023)
   PUBMED   37801910
  REMARK    GeneRIF: Phosphorylation impacts GLE1 nuclear localization and
            association with DDX1.
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Cao,L., Hui,X., Xu,T., Mao,H., Lin,X., Huang,K., Zhao,L. and Jin,M.
  TITLE     The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication
            by Suppressing Innate Immunity via Interaction with RNA Helicase
            DDX1
  JOURNAL   J Immunol 211 (6), 1020-1031 (2023)
   PUBMED   37556111
  REMARK    GeneRIF: The RNA-Splicing Ligase RTCB Promotes Influenza A Virus
            Replication by Suppressing Innate Immunity via Interaction with RNA
            Helicase DDX1.
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Lodola,C., Secchi,M., Sinigiani,V., De Palma,A., Rossi,R.,
            Perico,D., Mauri,P.L. and Maga,G.
  TITLE     Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA
            Helicases DDX1 and DDX3X Modulates Their Activities on
            Double-Stranded RNA
  JOURNAL   Int J Mol Sci 24 (6), 5784 (2023)
   PUBMED   36982856
  REMARK    GeneRIF: Interaction of SARS-CoV-2 Nucleocapsid Protein and Human
            RNA Helicases DDX1 and DDX3X Modulates Their Activities on
            Double-Stranded RNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Golembowski,S., Gellrich,S., von Zimmermann,M., Rutz,S.,
            Lippert,S., Audring,H., Lorenz,P., Sterry,W. and Jahn,S.
  TITLE     Clonal evolution in a primary cutaneous follicle center B cell
            lymphoma revealed by single cell analysis in sequential biopsies
  JOURNAL   Immunobiology 201 (5), 631-644 (2000)
   PUBMED   10834319
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Akiyama,K., Akao,Y., Yokoyama,M., Nakagawa,Y., Noguchi,T., Yagi,K.
            and Nishi,Y.
  TITLE     Expression of two dead box genes (DDX1 and DDX6) is independent of
            that of MYCN in human neuroblastoma cell lines
  JOURNAL   Biochem Mol Biol Int 47 (4), 563-568 (1999)
   PUBMED   10319407
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   Kitajima,Y., Yatsuki,H., Zhang,R., Matsuhashi,S. and Hori,K.
  TITLE     A novel human homologue of a dead-box RNA helicase family
  JOURNAL   Biochem Biophys Res Commun 199 (2), 748-754 (1994)
   PUBMED   8135819
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   Godbout,R. and Squire,J.
  TITLE     Amplification of a DEAD box protein gene in retinoblastoma cell
            lines
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7578-7582 (1993)
   PUBMED   7689221
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Schmid,S.R. and Linder,P.
  TITLE     D-E-A-D protein family of putative RNA helicases
  JOURNAL   Mol Microbiol 6 (3), 283-291 (1992)
   PUBMED   1552844
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X70649.1 and BC053673.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004939.2.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein
            that acts as an ATP-dependent RNA helicase that has been found to
            promote coronaviruses replication. [provided by RefSeq, Aug 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70649.1, SRR1803614.49929.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000233084.8/ ENSP00000233084.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                X70649.1           223-238
            17-2484             BC053673.1         1-2468
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.3"
     gene            1..2484
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /note="DEAD-box helicase 1"
                     /db_xref="GeneID:1653"
                     /db_xref="HGNC:HGNC:2734"
                     /db_xref="MIM:601257"
     exon            1..82
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2289
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1;
                     DEAD box-1; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD
                     box polypeptide 1; DEAD box protein 1; DEAD box protein
                     retinoblastoma; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1;
                     DEAD/H-box helicase 1; DEAD-box RNA helicase DDX1"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX1"
                     /protein_id="NP_004930.1"
                     /db_xref="CCDS:CCDS1686.1"
                     /db_xref="GeneID:1653"
                     /db_xref="HGNC:HGNC:2734"
                     /db_xref="MIM:601257"
                     /translation="MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLM
                     AAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAF
                     AIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGT
                     DKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEI
                     PPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQ
                     VTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLS
                     VLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIP
                     QVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNP
                     KTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQ
                     AIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDV
                     RFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKE
                     KVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVD
                     EFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
                     "
     exon            83..134
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            135..198
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            199..228
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            229..325
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            326..373
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            374..457
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            458..541
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            542..618
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            619..691
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            692..768
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            769..883
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1022
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1083
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1182
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1272
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1461
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1513
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1660
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1752
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1825
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1898
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1941
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2037
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2158
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2484
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2466..2471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="DDX1"
                     /gene_synonym="DBP-RB; UKVH5d"
                     /note="major polyA site"
ORIGIN      
        1 actgccacgc cgtgtcagtc gggagggagg gagcgagcag gcgaagccgc ggaggacggg
       61 gtgaagatgg cggccttctc cgagatgggt gtaatgcctg agattgcaca agctgtggaa
      121 gagatggatt ggctcctccc aactgatatc caggctgaat ctatcccatt gatcttagga
      181 ggaggtgatg tacttatggc tgcagaaaca ggaagtggca aaactggtgc ttttagtatt
      241 ccagttatcc agatagttta tgaaactctg aaagaccaac aggaaggcaa aaaaggaaaa
      301 acaacaatta aaactggtgc ttcagtgctg aacaaatggc agatgaaccc atatgacaga
      361 ggatctgctt ttgcaattgg gtcagatggt ctttgttgtc aaagcagaga agtaaaggaa
      421 tggcatgggt gtagagctac taaaggatta atgaaaggga aacactacta tgaagtatcc
      481 tgtcatgacc aagggttatg cagggtcggg tggtctacca tgcaggcctc tttggaccta
      541 ggtactgaca agtttggatt tggctttggt ggaacaggaa agaaatccca taacaaacaa
      601 tttgataatt atggagagga attcactatg catgatacca ttggatgtta cctggatata
      661 gataagggac atgtcaagtt ctccaaaaat ggaaaagatc ttggtctggc atttgaaata
      721 ccaccacata tgaaaaacca agccctcttt cctgcctgtg ttttgaagaa tgctgaactg
      781 aaatttaact tcggtgaaga ggaatttaag tttccaccaa aagatggctt tgttgctctt
      841 tccaaggcac cggatggtta cattgtcaaa tcacagcact caggtaatgc acaggtgaca
      901 caaacaaagt ttctccccaa tgctccgaaa gctctcattg ttgaaccttc ccgggagtta
      961 gctgaacaaa ctttgaacaa catcaagcag tttaagaaat acattgataa tcctaaatta
     1021 agggagcttc tgataattgg aggtgttgca gcccgggatc agctctctgt tttggaaaat
     1081 ggagtagata tagttgtagg tactccggga agactagatg acttggtgtc aactggaaag
     1141 ctgaacttat ctcaagttag attcctggtc ctggatgaag ctgatgggct tctttctcaa
     1201 ggttattctg attttataaa taggatgcac aatcagattc ctcaggttac ctctgatgga
     1261 aaaagacttc aggtgattgt ttgctctgcc actttgcatt ctttcgatgt aaagaaactg
     1321 tccgagaaga taatgcattt tcctacatgg gttgacttaa aaggagaaga ctctgttcca
     1381 gatactgtac accatgttgt tgtcccagta aatcccaaaa ctgacagact ctgggaaagg
     1441 cttggaaaga gccacattag aactgatgat gtacatgcaa aagataacac aagacctggt
     1501 gctaatagtc cagagatgtg gtctgaagct attaaaatcc tgaaagggga gtatgctgtc
     1561 cgggcaatca aggaacataa gatggatcaa gcaattatct tctgtagaac caaaattgac
     1621 tgtgataact tggagcagta ctttatacaa caaggaggag gacctgataa aaaaggacac
     1681 cagttctcat gtgtttgtct tcatggtgac agaaagcctc atgagagaaa gcaaaacttg
     1741 gaaagattta agaaaggaga tgtaagattc ttgatttgca cagatgtagc tgctagagga
     1801 attgatatcc acggtgttcc ttatgttata aatgtcactc tgcccgatga aaagcaaaac
     1861 tacgtacatc gaattggcag agtaggaaga gctgaaagga tgggtctggc aatttccctg
     1921 gtggcaacag aaaaagaaaa ggtttggtac catgtatgta gcagccgtgg aaaagggtgt
     1981 tataacacaa gactcaagga agatggaggc tgtaccatat ggtacaacga gatgcagtta
     2041 ctatctgaga tagaagaaca cctgaactgt accatttctc aggttgagcc ggatataaag
     2101 gtaccagtgg atgaatttga tgggaaagtt acctacggtc agaaaagggc tgctggtggt
     2161 ggaagctata aaggccatgt ggatattttg gcacctactg ttcaagagtt ggctgccctt
     2221 gaaaaggagg cgcagacatc tttcctgcat cttggctacc ttcctaacca gctgttcaga
     2281 accttctgat ttttacattt actgaataag atttgagtaa tgaaagtctg tagtcttaaa
     2341 actctaaaac agttgtactg cttccaagca gcagtattta tagtaacgta agctattaat
     2401 gctaactctt gcatgtcaag aaacattagt cttaggaatt cttcaaaaaa tggcatccca
     2461 atgaaaataa atttgatgac tata
//
