LOCUS       NM_006182              10086 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2),
            transcript variant 2, mRNA.
ACCESSION   NM_006182
VERSION     NM_006182.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10086)
  AUTHORS   Audun Klingen,T., Chen,Y., Aas,H. and Akslen,L.A.
  TITLE     DDR2 expression in breast cancer is associated with blood vessel
            invasion, basal-like tumors, tumor associated macrophages,
            regulatory T cells, detection mode and prognosis
  JOURNAL   Hum Pathol 150, 29-35 (2024)
   PUBMED   38914168
  REMARK    GeneRIF: DDR2 expression in breast cancer is associated with blood
            vessel invasion, basal-like tumors, tumor associated macrophages,
            regulatory T cells, detection mode and prognosis.
REFERENCE   2  (bases 1 to 10086)
  AUTHORS   Vessella,T., Xiang,S., Xiao,C., Stilwell,M., Fok,J., Shohet,J.,
            Rozen,E., Zhou,H.S. and Wen,Q.
  TITLE     DDR2 signaling and mechanosensing orchestrate neuroblastoma cell
            fate through different transcriptome mechanisms
  JOURNAL   FEBS Open Bio 14 (5), 867-882 (2024)
   PUBMED   38538106
  REMARK    GeneRIF: DDR2 signaling and mechanosensing orchestrate
            neuroblastoma cell fate through different transcriptome mechanisms.
REFERENCE   3  (bases 1 to 10086)
  AUTHORS   Zhi,D., Zhou,K., Liu,S., Yu,W., Dong,M. and Yan,C.
  TITLE     METTL3/YTHDF1 m6A axis promotes tumorigenesis by enhancing DDR2
            expression in ovarian cancer
  JOURNAL   Pathol Res Pract 253, 155047 (2024)
   PUBMED   38154356
  REMARK    GeneRIF: METTL3/YTHDF1 m[6]A axis promotes tumorigenesis by
            enhancing DDR2 expression in ovarian cancer.
REFERENCE   4  (bases 1 to 10086)
  AUTHORS   Akinjiyan,F.A., Ibitoye,Z., Zhao,P., Shriver,L.P., Patti,G.J.,
            Longmore,G.D. and Fuh,K.C.
  TITLE     DDR2-regulated arginase activity in ovarian cancer-associated
            fibroblasts promotes collagen production and tumor progression
  JOURNAL   Oncogene 43 (3), 189-201 (2024)
   PUBMED   37996700
  REMARK    GeneRIF: DDR2-regulated arginase activity in ovarian
            cancer-associated fibroblasts promotes collagen production and
            tumor progression.
REFERENCE   5  (bases 1 to 10086)
  AUTHORS   Mitchell,A.V., Wu,J., Meng,F., Dong,L., Block,C.J., Song,W.M.,
            Zhang,B., Li,J. and Wu,G.
  TITLE     DDR2 coordinates EMT and metabolic reprogramming as a shared
            effector of FOXQ1 and SNAI1
  JOURNAL   Cancer Res Commun 2 (11), 1388-1403 (2022)
   PUBMED   36713812
  REMARK    GeneRIF: DDR2 coordinates EMT and metabolic reprogramming as a
            shared effector of FOXQ1 and SNAI1.
REFERENCE   6  (bases 1 to 10086)
  AUTHORS   Mohan,R.R., Mohan,R.R. and Wilson,S.E.
  TITLE     Discoidin domain receptor (DDR) 1 and 2: collagen-activated
            tyrosine kinase receptors in the cornea
  JOURNAL   Exp Eye Res 72 (1), 87-92 (2001)
   PUBMED   11133186
REFERENCE   7  (bases 1 to 10086)
  AUTHORS   Vogel,W., Gish,G.D., Alves,F. and Pawson,T.
  TITLE     The discoidin domain receptor tyrosine kinases are activated by
            collagen
  JOURNAL   Mol Cell 1 (1), 13-23 (1997)
   PUBMED   9659899
REFERENCE   8  (bases 1 to 10086)
  AUTHORS   Karn,T., Holtrich,U., Brauninger,A., Bohme,B., Wolf,G.,
            Rubsamen-Waigmann,H. and Strebhardt,K.
  TITLE     Structure, expression and chromosomal mapping of TKT from man and
            mouse: a new subclass of receptor tyrosine kinases with a factor
            VIII-like domain
  JOURNAL   Oncogene 8 (12), 3433-3440 (1993)
   PUBMED   8247548
REFERENCE   9  (bases 1 to 10086)
  AUTHORS   Abedinia,M., Layfield,R., Jones,S.M., Nixon,P.F. and Mattick,J.S.
  TITLE     Nucleotide and predicted amino acid sequence of a cDNA clone
            encoding part of human transketolase
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1159-1166 (1992)
   PUBMED   1567394
REFERENCE   10 (bases 1 to 10086)
  AUTHORS   Lapsys,N.M., Layfield,R., Baker,E., Callen,D.F., Sutherland,G.R.,
            Abedinia,M., Nixon,P.F. and Mattick,J.S.
  TITLE     Chromosomal location of the human transketolase gene
  JOURNAL   Cytogenet Cell Genet 61 (4), 274-275 (1992)
   PUBMED   1486804
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA852104.1, AK314388.1,
            AL596325.5, AL445197.4 and BX537651.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006182.3.
            
            Summary: This gene encodes a member of the discoidin domain
            receptor subclass of the receptor tyrosine kinase (RTKs) protein
            family. RTKs play a key role in the communication of cells with
            their microenvironment. The encoded protein is a collagen-induced
            receptor that activates signal transduction pathways involved in
            cell adhesion, proliferation, and extracellular matrix remodeling.
            This protein is expressed in numerous cell types and may alos be
            involved in wound repair and regulate tumor growth and
            invasiveness. Mutations in this gene are the cause of short
            limb-hand type spondylometaepiphyseal dysplasia. [provided by
            RefSeq, Aug 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.185646.1,
                                           SRR1803613.136417.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367921.8/ ENSP00000356898.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA852104.1         84-108
            26-187              AK314388.1         1-162
            188-188             AL596325.5         123664-123664
            189-1618            AK314388.1         164-1593
            1619-1619           AL445197.4         84990-84990
            1620-2927           AK314388.1         1595-2902
            2928-8988           AL445197.4         97911-103971
            8989-9254           BX537651.1         4195-4460
            9255-10086          AL445197.4         104238-105069
FEATURES             Location/Qualifiers
     source          1..10086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..10086
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="discoidin domain receptor tyrosine kinase 2"
                     /db_xref="GeneID:4921"
                     /db_xref="HGNC:HGNC:2731"
                     /db_xref="MIM:191311"
     exon            1..168
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            169..332
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            333..441
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..2927
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /EC_number="2.7.10.1"
                     /note="neurotrophic tyrosine kinase receptor related 3;
                     discoidin domain receptor family, member 2;
                     hydroxyaryl-protein kinase; cell migration-inducing
                     protein 20; migration-inducing gene 16 protein;
                     tyrosine-protein kinase TYRO10; CD167 antigen-like family
                     member B; receptor protein-tyrosine kinase TKT; discoidin
                     domain-containing receptor tyrosine kinase 2; discoidin
                     domain receptor 2; discoidin domain-containing receptor 2"
                     /codon_start=1
                     /product="discoidin domain-containing receptor 2
                     precursor"
                     /protein_id="NP_006173.2"
                     /db_xref="CCDS:CCDS1241.1"
                     /db_xref="GeneID:4921"
                     /db_xref="HGNC:HGNC:2731"
                     /db_xref="MIM:191311"
                     /translation="MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDE
                     DITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGT
                     QGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIV
                     ARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYD
                     GAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFD
                     RIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFV
                     TVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLK
                     VDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSD
                     SSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVK
                     PVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFK
                     EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK
                     EIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTV
                     SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDY
                     YRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI
                     ENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE"
     exon            442..544
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            545..776
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            777..924
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1030
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1214
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1458
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1521
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1652
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1863
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2087
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2215
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2407
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2642
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2792
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..10086
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3512
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="major polyA site"
     regulatory      6665..6670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="hexamer: AATAAA"
     polyA_site      6689
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
     regulatory      6989..6994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="hexamer: AAGAAA"
     polyA_site      7009
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="major polyA site"
     regulatory      9234..9239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="hexamer: ATTAAA"
     polyA_site      9252
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
     regulatory      9415..9420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="hexamer: AATAGA"
     polyA_site      9431
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
     regulatory      9992..9997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="hexamer: AATAAA"
     polyA_site      10019
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
     regulatory      10060..10065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
                     /note="hexamer: ATTAAA"
     polyA_site      10086
                     /gene="DDR2"
                     /gene_synonym="MIG20a; NTRKR3; TKT; TYRO10; WRCN"
ORIGIN      
        1 caaaggcatc ttgcatcagc ctgtggatgt atgcctacca ccgggctcct tcaccagcaa
       61 agtggaaaaa gaagcgtttc acaacaaatt cttctttttg ggttggggaa acgcagtgga
      121 ttatagctct gttttcttct ttccaaaact gtgcacccct ggatgaaacc tccatcaagg
      181 gagacctgca agttgcctgg ggttcagtgc tctagaaagt tccaaggttt gtggcttgaa
      241 ttattctaaa gaagctgaaa taattgaaga gaagcagagg ccagctgttt ttgaggatcc
      301 tgctccacag agaatgctct gcacccgttg atactccagt tccaacacca tcttctgaga
      361 tgatcctgat tcccagaatg ctcttggtgc tgttcctgct gctgcctatc ttgagttctg
      421 caaaagctca ggttaatcca gctatatgcc gctatcctct gggcatgtca ggaggccaga
      481 ttccagatga ggacatcaca gcttccagtc agtggtcaga gtccacagct gccaaatatg
      541 gaaggctgga ctcagaagaa ggggatggag cctggtgccc tgagattcca gtggaacctg
      601 atgacctgaa ggagtttctg cagattgact tgcacaccct ccattttatc actctggtgg
      661 ggacccaggg gcgccatgca ggaggtcatg gcatcgagtt tgcccccatg tacaagatca
      721 attacagtcg ggatggcact cgctggatct cttggcggaa ccgtcatggg aaacaggtgc
      781 tggatggaaa tagtaacccc tatgacattt tcctaaagga cttggagccg cccattgtag
      841 ccagatttgt ccggttcatt ccagtcaccg accactccat gaatgtgtgt atgagagtgg
      901 agctttacgg ctgtgtctgg ctagatggct tggtgtctta caatgctcca gctgggcagc
      961 agtttgtact ccctggaggt tccatcattt atctgaatga ttctgtctat gatggagctg
     1021 ttggatacag catgacagaa gggctaggcc aattgaccga tggtgtgtct ggcctggacg
     1081 atttcaccca gacccatgaa taccacgtgt ggcccggcta tgactatgtg ggctggcgga
     1141 acgagagtgc caccaatggc tacattgaga tcatgtttga atttgaccgc atcaggaatt
     1201 tcactaccat gaaggtccac tgcaacaaca tgtttgctaa aggtgtgaag atctttaagg
     1261 aggtacagtg ctacttccgc tctgaagcca gtgagtggga acctaatgcc atttccttcc
     1321 cccttgtcct ggatgacgtc aaccccagtg ctcggtttgt cacggtgcct ctccaccacc
     1381 gaatggccag tgccatcaag tgtcaatacc attttgcaga tacctggatg atgttcagtg
     1441 agatcacctt ccaatcagat gctgcaatgt acaacaactc tgaagccctg cccacctctc
     1501 ctatggcacc cacaacctat gatccaatgc ttaaagttga tgacagcaac actcggatcc
     1561 tgattggctg cttggtggcc atcatcttta tcctcctggc catcattgtc atcatcctct
     1621 ggaggcagtt ctggcagaaa atgctggaga aggcttctcg gaggatgctg gatgatgaaa
     1681 tgacagtcag cctttccctg ccaagtgatt ctagcatgtt caacaataac cgctcctcat
     1741 cacctagtga acaagggtcc aactcgactt acgatcgcat ctttcccctt cgccctgact
     1801 accaggagcc atccaggctg atacgaaaac tcccagaatt tgctccaggg gaggaggagt
     1861 caggctgcag cggtgttgtg aagccagtcc agcccagtgg ccctgagggg gtgccccact
     1921 atgcagaggc tgacatagtg aacctccaag gagtgacagg aggcaacaca tactcagtgc
     1981 ctgccgtcac catggacctg ctctcaggaa aagatgtggc tgtggaggag ttccccagga
     2041 aactcctaac tttcaaagag aagctgggag aaggacagtt tggggaggtt catctctgtg
     2101 aagtggaggg aatggaaaaa ttcaaagaca aagattttgc cctagatgtc agtgccaacc
     2161 agcctgtcct ggtggctgtg aaaatgctcc gagcagatgc caacaagaat gccaggaatg
     2221 attttcttaa ggagataaag atcatgtctc ggctcaagga cccaaacatc atccatctat
     2281 tagctgtgtg tatcactgat gaccctctct gtatgatcac tgaatacatg gagaatggag
     2341 atctcaatca gtttctttcc cgccacgagc cccctaattc ttcctccagc gatgtacgca
     2401 ctgtcagtta caccaatctg aagtttatgg ctacccaaat tgcctctggc atgaagtacc
     2461 tttcctctct taattttgtt caccgagatc tggccacacg aaactgttta gtgggtaaga
     2521 actacacaat caagatagct gactttggaa tgagcaggaa cctgtacagt ggtgactatt
     2581 accggatcca gggccgggca gtgctcccta tccgctggat gtcttgggag agtatcttgc
     2641 tgggcaagtt cactacagca agtgatgtgt gggcctttgg ggttactttg tgggagactt
     2701 tcaccttttg tcaagaacag ccctattccc agctgtcaga tgaacaggtt attgagaata
     2761 ctggagagtt cttccgagac caagggaggc agacttacct ccctcaacca gccatttgtc
     2821 ctgactctgt gtataagctg atgctcagct gctggagaag agatacgaag aaccgtccct
     2881 cattccaaga aatccacctt ctgctccttc aacaaggcga cgagtgatgc tgtcagtgcc
     2941 tggccatgtt cctacggctc aggtcctccc tacaagacct accactcacc catgcctatg
     3001 ccactccatc tggacattta atgaaactga gagacagagg cttgtttgct ttgccctctt
     3061 ttcctggtca cccccactcc ctacccctga ctcatataca cttttttttt tttttacatt
     3121 aaagaactaa aaaaggaaaa aaaaaagcct agggcagata caatctagta aaagaaaatc
     3181 tttgatatac caaagtgttg gataacaaag gctagaaaat tcagataatt tataaaggtt
     3241 aactatactt gtgcttataa atgtgcagat tctacaatat ttttccatgt cattctaaaa
     3301 gaatcttcag aaagaaaaac ttgaagaata ctaatgtctt gggaaacatg agattaagtt
     3361 tagggaaaac acttgataga tgtggagaat ctgaggactc agaattcagc aactaatcac
     3421 aggtggtttt ctaatttggc ctctggacat gtctcactgt ttgtatttct ctctcctgtc
     3481 aaagtgaatg atatattctt gaaaaccccc aatttcttga aatgggtgtt ctgttcattc
     3541 atgggcaggg gtcaggattg aagttcatat atgaaacaac tggggatgta gataggaaag
     3601 aatgtctgct gcaagagtgt atgaaggggg attgtcattt acaaaaaaaa agtacctcat
     3661 ggatggaagg attcatgaat agataatgga cataggaaag gaggtcaatg gaggacacat
     3721 aacagacatg ctatccacca tttatttgtg attttgtaag agggttctct tctttgtctt
     3781 gttcagatat tttcatgtgt gtgttttagt gagaatctga gtttttaatc agtaaagtct
     3841 gatgttttga tatcttgatg ttttgatggt agactcttga gttcatcttg tccaaatctt
     3901 ctagcatttt caaggatgaa gcctctgtgg gatctttggg cttggggctg aatttctcag
     3961 gcataaatac ctaatggcct tgtctaagag ggaatagatc tgttctgagt gtccccaaaa
     4021 aagttgtcct aggaactgat gtggagaagt tacagggaga ctgatttcca ttccttattg
     4081 gggaaaacga agcactcaga acatacaagg ataaatgggc tgccaccaga ggtgaggagt
     4141 ctcttgtcac tggagaggtt aagatagagg ctcaagaaca atgcaaggaa aatggaggtt
     4201 ttcaaacaca aagtggatgg tggtatgaga caatgtttaa tgtccttcta actccgagag
     4261 tccttgattc tggagaggca caggatgaac atctgttgct actgctgagt atacacactc
     4321 ttgcctctga gatggcgtga ccagcagaaa agaaagctca gggctgtggc ttcagaattc
     4381 atggaaacag agccactgtc aagaaggaat ctgctcagag cagattctga gttttcacac
     4441 tccacaaatc ctcagattta gtgggaagct ggaaaaagga actcttaatt ccaattgagg
     4501 agaaacaaga aaacattaca aatcagtttc ccaagctgag aaggattagc cttgacccct
     4561 tgggtctgcc tctgttgccc tcaccagttt accttctaca acagtttctc aggaacatgt
     4621 gtatttcccc attcagcttt cagcattgct ccacgccaca gcataagcat agatcccaag
     4681 tccacaggct ccattttgca ggtcatcttc tgatcctagc aaatgtcctt tccccatagt
     4741 tgtcctatgc ctttgggctt tagtctatcc caggactaac tgtggagaaa tcattggttt
     4801 gagagtcaag agagcattgg tttgggagct ttaatcctct ttctgcttca cactaagtgt
     4861 gtcatcttgg ctaaatcact tggtctttct gcattttgtt ttcttattta taggatgagg
     4921 aaattagatt aaatggtttt gaggtccttt cttgttctga tatgtccagt actcactgga
     4981 aaattggatc tataactgat gggtttagta atctggtcat ttcttgctct gaaaattgta
     5041 gtcagcaaaa gagatcatgg aagaaatcac tgtaatggta gtaatagtaa cacatgccat
     5101 ttgtattgtg ccttaggttt accaggtgtt tccaaataca ttagcatatt tgatatgtgc
     5161 aggactagat accttgggac ctgccacact ccactttcaa gatatgtatt agcttcatta
     5221 gaattaaagg gacttgaact caggacctgc agcctattct tctttatcca catgtctctg
     5281 gtagggctac atccagatca caccatgact tcttatagag caagagaaaa taatattatt
     5341 atatcttcct ttgcctaaaa tctctccact tattcttttt tatgattctg caccagttca
     5401 ctgggttatt ctatgattcc atattttttt taaaaaaaat catatttaaa atgaacttac
     5461 aatgtctgaa ttttcctggc cttgagtcac agaagtaata tgtttcagat ggctgcccaa
     5521 tatgtattat catgtaatac atatctgtgt ccttttctgg gatgaggaag gcttcaactt
     5581 ctggcactga gaactttgta ttacagacac aggtttagtt tctagcttag tcatgccttt
     5641 agagtttagt agcacaaatc catgcaaccc aacagaatac atggtgaggg cctagtatgt
     5701 agaatttgaa agtagttcaa atttgaatta gaagaatgaa gctaggactt atttggaaaa
     5761 ggagatagaa aaaaaatgat cagaaactgt ggggccttat tacctttgca gtaagttatc
     5821 ttcttcatga tatatgtgaa ttattttatg tgcagattgt gttttgggat tgtcagatct
     5881 aaacttatat tcttgctggc taatgtgctg atagccaggt ctgaaacttg atgtgctatc
     5941 cagacacata tgatcagaaa agatctagag tgcaaagagg tgcctgagga gcaaaatgtg
     6001 gttttaatgt tgtggaaaga tcacttgcaa gtatataaga ctgtataaag aagaggactg
     6061 tgtgcaagtg gggtgaaaaa aaaggatacg tgaatgtgca tatgactgaa tagggaggaa
     6121 ggtcagggct agaaaggagg ctacataaaa aggggcaatg gagaatgcac aggaaagaca
     6181 caggggaagg tcaagtcgag caaggtagaa acaggagtag ctagagccat tgggaatcca
     6241 ttttgaaaca agaaggagtt ttgaaaggga ataggaaagt aagtgtcttg aagtaaaaga
     6301 taaatatgga tggagaaaga agaaattctg gatgatagag atgataaaaa tatttattaa
     6361 gaaatgaagt caggttcagt gtatgaaatg gaaaggaatt tttcagaatt ttaagaaagg
     6421 ggaagttcct cttggaaaag atatagcaac catcggggaa tgaccttttc atttcagaag
     6481 tggatgagga aggtggtgtg agcatcaggt atattctgga ccatttcaag tgctggtgag
     6541 aagaaaggaa ctctttgcct gaactgggct tggttttcca agtgctgctt tggaaatgaa
     6601 gacccagaga tgcagagctt atggtagttc ataaatcttc atgttctatt atctttcatc
     6661 tgccaataaa gttcattttc aataatgtcc accattgctg tgcccagaat aaccacaggc
     6721 aaacatcaaa acaatacgca taagttagac aagattaaat cttgtctgat atctgcacaa
     6781 acagatatgc accatgttgg aaacatgtgt tttcctagtc ccatccaggc ttcccacaag
     6841 aaagccatga tgtgggtcta aaccatatgt tttgagtaaa ggagaataga agaaggggag
     6901 tgtccgcaaa atggaaagag atgaagatgt tccaaggaag tatgctgaaa cagaacagtg
     6961 aatgttttgc ccaaaactac aaaaataaaa gaaaaaaaga aaattgcaat acatggctac
     7021 taagtctttg atcataagtc gaatttatag acctggaatt tgccatccta gtctttcctt
     7081 tttagtaaga cttctgtcct ctggcagtgc atatggtagg tctctaatgt ttcttcatct
     7141 ccaggaagat gcagatcctt atttttgctg ggaaatcctt ctaaatagaa atgtaacatt
     7201 tttataaaaa cagattaatg tgtttttcac ttagtaaatg ttttcaagag ctgaattgag
     7261 aaggaaagag actggagtgg ttaatggtga tttgatttct ggcattctga gttttctgct
     7321 acaattagct gcattacttg gtgccaaaga gcagtgggga attgttgagt tgctgtatcc
     7381 tttaaaaaaa aacaaaaaac ttgttatttt gaaagaactt aaggctcaca agatgttaca
     7441 aaaatagtag agtggcctta ccctagatcc agttttcccc atttataaca tttcacttag
     7501 tccattttcg gaaccagaaa attaacattg gcataatgct attaactaaa ctacagacct
     7561 tttttcaatt tcgccagttt ttccacacat attcatttag ttgctggata cttttaattc
     7621 ttgctgattt gtaaactggc cttgcttgga tacaacagga aagatactat ctggataaag
     7681 ttctacagtt ttagagagac tattaacaca ttaatgtgtt cctttgtcat gagcaatacc
     7741 ctgcctacac tgcttctaaa ttttctgatt tgtttggctg tttggcatct gaaacaatcc
     7801 aagacaaact tagaaagatt aggcaacaca aaacacagta agacctgttc atagcttgtt
     7861 gtctagaaaa ccaggtagca ggatattcta gatgcttcct gctgcttcta cgtgagtagg
     7921 attagcactg gggacaaaat aaggagttta gagtaaacca gtatttcagt caagagttag
     7981 ttggcactta gttaatggca ctggaaatag cttgtggaga gaatagaata caatggtata
     8041 gactcctaat gtttgataaa atactatttt cagagtggta gagaggtttt atttgcctaa
     8101 atagccgtta ttaaatggaa taacaaccac attagaccaa attaattgca aacacagcgg
     8161 caacctgggg agaagttgaa actccagttt tgtggattac agttttgagt tttatgattg
     8221 acatttttaa gtcccctatt taaggggtca agattataac aatgtgtgtc ttactaagtt
     8281 tctaggtcat tgtgagcact tgataaatat ttgctgaatg ttgttttttt gaatgaacat
     8341 aagatagaaa caaaaacttc tcatccagtt aactagagtg aatgtaggga gaattgtttt
     8401 gcttgtaaca tggagagttt attttcaagt gaggaaagag aaaaaaatta ctcagacttg
     8461 ttcctggtga agtgcattct ctgtttgtat actttttgat ggagaaattg atctatagaa
     8521 ctgcttaatt ttttgaggca tttagacagc aatgaaaggt agttctccac aggacaccga
     8581 atcaaaagga gagaccagac tctggcctca tacccagcct atttgaaaca agctatctag
     8641 tttctcctgc agacaccttg tcaacaacat gcaacagtgt caggtgcctt gcaggaaaat
     8701 aatctgagtc ccaagctagc ctgtgctcat ccacaatcac aatgaacatg tcaaggaaga
     8761 atttgcagag actcaaggga agcacaatgg gataaggtaa tcactttcag tgaaaaactg
     8821 ttttcttgaa aacaggcttg gacacaattg aaagctggct tcctgcaaac acaccaagag
     8881 tctgtaatct agcctatcca ttatatgtcc tttattattc atgatatcct attcttctac
     8941 cttgttgcct ggtaactttt tctgaggact gagtttctgc agcgatgtgg tgcactcttc
     9001 ctgtgatgag gaaacatctg ggcccccttc tgcaggcttt ggaagatgat gtgtcttgtc
     9061 aaggggtaaa gggcaaatgg atttaatttc tgcttaaaac tatcatagac gttccaaata
     9121 gaatatgtaa aatttctctg tattagaaaa agaaacgtga taccaattgt atattttctt
     9181 ttctttattt attctctgta agtctgtcag atgataaatt gtaaataaca atgattaaag
     9241 agtcatgcta ctgatggatc tccctttctg tataaacagt gccagttctg ggctttgtaa
     9301 cctttgctct ttatagtctt tcattcctgg ggaagtgatg gggcatgggc ccagagctgg
     9361 ggtgtatgtg gtatggacac ctgtttgtgg ggctttccag caaaggatta tttaaataga
     9421 cctctaacat atgagttgac tgtttattgg gaagaaagca tcttggtctc tgacatatcc
     9481 aaacatacga gacactggga ttttacgtcc tcacattaat tagtccagtt ctggggaatc
     9541 cagtctagaa ttaactggtg atcccttatc gttatggtta cagacttgtc ttgtttgata
     9601 cacagaaatc ctttttaaat ccaaatatag tctgtctcag actacctgca catgcacaaa
     9661 ccaaaaaaaa ctatgaaaac cagaatttag actcagtcat tatactagag attagaatga
     9721 aacgacccca aacaacccat ttcttacctg gtctctgaga ataagtttat acttttagtt
     9781 ttctgagaat atttctcaga atatgtgagt tttctgagca catttttcag catggggtat
     9841 ggtagataaa tcacagggcc aaggtttggc agggatagat gggatcattg tgtaccctat
     9901 tgttcttctg atttccagga gaacagaatg agcccatgca aaacataaac ttatgatgat
     9961 taaaaaaaac acacctatcc attcactcat caataaaaac atattatgat ggttatcaag
    10021 ctgtgtccta tgagtgataa aatatttgta aaatataaaa ttaaatggca tctattttga
    10081 actcta
//
