LOCUS       NM_013993               3892 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1),
            transcript variant 2, mRNA.
ACCESSION   NM_013993
VERSION     NM_013993.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3892)
  AUTHORS   Xue,L., Tan,Q., Xu,J., Feng,L., Li,W., Yan,L. and Li,Y.
  TITLE     [MiR-6838-5p overexpression inhibits proliferation of breast cancer
            MCF-7 cells by downregulating DDR1 expression]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (9), 1677-1684 (2024)
   PUBMED   39505335
  REMARK    GeneRIF: [MiR-6838-5p overexpression inhibits proliferation of
            breast cancer MCF-7 cells by downregulating DDR1 expression].
REFERENCE   2  (bases 1 to 3892)
  AUTHORS   Wei,Z., Li,J., Zhong,L., Yang,D., Li,W., Chen,W., Zhou,H., He,Y.,
            Song,W., Wang,B. and Zeng,L.
  TITLE     DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing
            HIF-1alpha Ubiquitination and Degradation
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308395 (2024)
   PUBMED   39024501
  REMARK    GeneRIF: DDR1 Drives Malignant Progression of Gastric Cancer by
            Suppressing HIF-1alpha Ubiquitination and Degradation.
REFERENCE   3  (bases 1 to 3892)
  AUTHORS   Garcia-Ruiz,B., Jimenez,E., Aranda,S., Verdolini,N.,
            Gutierrez-Zotes,A., Saez,C., Losantos,E., Alonso-Lana,S.,
            Fatjo-Vilas,M., Sarro,S., Torres,L., Panicalli,F., Bonnin,C.D.M.,
            Pomarol-Clotet,E., Vieta,E. and Vilella,E.
  TITLE     Associations of altered leukocyte DDR1 promoter methylation and
            childhood trauma with bipolar disorder and suicidal behavior in
            euthymic patients
  JOURNAL   Mol Psychiatry 29 (8), 2478-2486 (2024)
   PUBMED   38503928
  REMARK    GeneRIF: Associations of altered leukocyte DDR1 promoter
            methylation and childhood trauma with bipolar disorder and suicidal
            behavior in euthymic patients.
REFERENCE   4  (bases 1 to 3892)
  AUTHORS   Anand,M.A.V., Manjula,K.S. and Wang,C.Z.
  TITLE     Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in
            Association with Myelination and Remyelination Process in the
            Central Nerve System
  JOURNAL   J Physiol Investig 67 (4), 161-173 (2024)
   PUBMED   39175192
  REMARK    GeneRIF: Functional Role of DDR1 in Oligodendrocyte Signaling
            Mechanism in Association with Myelination and Remyelination Process
            in the Central Nerve System.
            Review article
REFERENCE   5  (bases 1 to 3892)
  AUTHORS   Reger De Moura,C., Louveau,B., Jouenne,F., Vilquin,P.,
            Battistella,M., Bellahsen-Harrar,Y., Sadoux,A., Menashi,S.,
            Dumaz,N., Lebbe,C. and Mourah,S.
  TITLE     Inactivation of kindlin-3 increases human melanoma aggressiveness
            through the collagen-activated tyrosine kinase receptor DDR1
  JOURNAL   Oncogene 43 (21), 1620-1630 (2024)
   PUBMED   38570692
  REMARK    GeneRIF: Inactivation of kindlin-3 increases human melanoma
            aggressiveness through the collagen-activated tyrosine kinase
            receptor DDR1.
REFERENCE   6  (bases 1 to 3892)
  AUTHORS   Alves,F., Saupe,S., Ledwon,M., Schaub,F., Hiddemann,W. and
            Vogel,W.F.
  TITLE     Identification of two novel, kinase-deficient variants of discoidin
            domain receptor 1: differential expression in human colon cancer
            cell lines
  JOURNAL   FASEB J 15 (7), 1321-1323 (2001)
   PUBMED   11344127
REFERENCE   7  (bases 1 to 3892)
  AUTHORS   Shelling,A.N., Butler,R., Jones,T., Laval,S., Boyle,J.M. and
            Ganesan,T.S.
  TITLE     Localization of an epithelial-specific receptor kinase (EDDR1) to
            chromosome 6q16
  JOURNAL   Genomics 25 (2), 584-587 (1995)
   PUBMED   7789998
REFERENCE   8  (bases 1 to 3892)
  AUTHORS   Edelhoff,S., Sweetser,D.A. and Disteche,C.M.
  TITLE     Mapping of the NEP receptor tyrosine kinase gene to human
            chromosome 6p21.3 and mouse chromosome 17C
  JOURNAL   Genomics 25 (1), 309-311 (1995)
   PUBMED   7774938
REFERENCE   9  (bases 1 to 3892)
  AUTHORS   Laval,S., Butler,R., Shelling,A.N., Hanby,A.M., Poulsom,R. and
            Ganesan,T.S.
  TITLE     Isolation and characterization of an epithelial-specific receptor
            tyrosine kinase from an ovarian cancer cell line
  JOURNAL   Cell Growth Differ 5 (11), 1173-1183 (1994)
   PUBMED   7848919
REFERENCE   10 (bases 1 to 3892)
  AUTHORS   Weiner,T.M., Liu,E.T., Craven,R.J. and Cance,W.G.
  TITLE     Expression of growth factor receptors, the focal adhesion kinase,
            and other tyrosine kinases in human soft tissue tumors
  JOURNAL   Ann Surg Oncol 1 (1), 18-27 (1994)
   PUBMED   7834423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662870.16, CN362335.1,
            L11315.1 and BC008716.2.
            
            On Aug 13, 2020 this sequence version replaced NM_013993.2.
            
            Summary: Receptor tyrosine kinases play a key role in the
            communication of cells with their microenvironment. These kinases
            are involved in the regulation of cell growth, differentiation and
            metabolism. The protein encoded by this gene belongs to a subfamily
            of tyrosine kinase receptors with homology to Dictyostelium
            discoideum protein discoidin I in their extracellular domain, and
            that are activated by various types of collagen. Expression of this
            protein is restricted to epithelial cells, particularly in the
            kidney, lung, gastrointestinal tract, and brain. In addition, it
            has been shown to be significantly overexpressed in several human
            tumors. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11315.1, SRR18074969.588081.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL662870.16        37977-38007
            32-150              CN362335.1         1-119
            151-162             L11315.1           1-12
            163-874             BC008716.2         206-917
            875-2786            L11315.1           726-2637
            2787-3892           BC008716.2         2719-3824
FEATURES             Location/Qualifiers
     source          1..3892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3892
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="discoidin domain receptor tyrosine kinase 1"
                     /db_xref="GeneID:780"
                     /db_xref="HGNC:HGNC:2730"
                     /db_xref="MIM:600408"
     exon            1..192
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            193..248
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            249..375
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..3032
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cell adhesion kinase; neurotrophic tyrosine
                     kinase, receptor, type 4; neuroepithelial tyrosine kinase;
                     PTK3A protein tyrosine kinase 3A; epithelial discoidin
                     domain-containing receptor 1; tyrosine kinase DDR; mammary
                     carcinoma kinase 10; tyrosine-protein kinase CAK;
                     protein-tyrosine kinase RTK-6; CD167 antigen-like family
                     member A"
                     /codon_start=1
                     /product="epithelial discoidin domain-containing receptor
                     1 isoform 2 precursor"
                     /protein_id="NP_054699.2"
                     /db_xref="CCDS:CCDS34385.1"
                     /db_xref="GeneID:780"
                     /db_xref="HGNC:HGNC:2730"
                     /db_xref="MIM:600408"
                     /translation="MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPD
                     SDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGT
                     QGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMV
                     ARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGH
                     TVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDR
                     LRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAV
                     SVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPP
                     TNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKA
                     ERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLL
                     SNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSV
                     PHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEV
                     HLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDP
                     NIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISY
                     PMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR
                     VQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIEN
                     AGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV"
     exon            376..478
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            479..707
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            708..855
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            856..955
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1142
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1389
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1485
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1637
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1803
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1914
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2159
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2287
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2506
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2741
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2891
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3892
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3870..3875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="hexamer: AATAAA"
     polyA_site      3892
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="major polyA site"
ORIGIN      
        1 gctcctctcc ccggaacagg cccccgacag ctgctctcgg gagccgcctc ccgacacccg
       61 agccccgccg gcgcctcccg ctcccggctc ccggctcctg gctccctccg cctcccccgc
      121 ccctcgcccc gccgccgaag aggccccgct cccgggtcgg acgcctgggt ctgccgggaa
      181 gagcgatgag aggtgtctga aggtggctat tcactgagcg atggggttgg acttgaagga
      241 atgccaagag atgctgcccc caccccctta ggcccgaggg atcaggagct atgggaccag
      301 aggccctgtc atctttactg ctgctgctct tggtggcaag tggagatgct gacatgaagg
      361 gacattttga tcctgccaag tgccgctatg ccctgggcat gcaggaccgg accatcccag
      421 acagtgacat ctctgcttcc agctcctggt cagattccac tgccgcccgc cacagcaggt
      481 tggagagcag tgacggggat ggggcctggt gccccgcagg gtcggtgttt cccaaggagg
      541 aggagtactt gcaggtggat ctacaacgac tgcacctggt ggctctggtg ggcacccagg
      601 gacggcatgc cgggggcctg ggcaaggagt tctcccggag ctaccggctg cgttactccc
      661 gggatggtcg ccgctggatg ggctggaagg accgctgggg tcaggaggtg atctcaggca
      721 atgaggaccc tgagggagtg gtgctgaagg accttgggcc ccccatggtt gcccgactgg
      781 ttcgcttcta cccccgggct gaccgggtca tgagcgtctg tctgcgggta gagctctatg
      841 gctgcctctg gagggatgga ctcctgtctt acaccgcccc tgtggggcag acaatgtatt
      901 tatctgaggc cgtgtacctc aacgactcca cctatgacgg acataccgtg ggcggactgc
      961 agtatggggg tctgggccag ctggcagatg gtgtggtggg gctggatgac tttaggaaga
     1021 gtcaggagct gcgggtctgg ccaggctatg actatgtggg atggagcaac cacagcttct
     1081 ccagtggcta tgtggagatg gagtttgagt ttgaccggct gagggccttc caggctatgc
     1141 aggtccactg taacaacatg cacacgctgg gagcccgtct gcctggcggg gtggaatgtc
     1201 gcttccggcg tggccctgcc atggcctggg agggggagcc catgcgccac aacctagggg
     1261 gcaacctggg ggaccccaga gcccgggctg tctcagtgcc ccttggcggc cgtgtggctc
     1321 gctttctgca gtgccgcttc ctctttgcgg ggccctggtt actcttcagc gaaatctcct
     1381 tcatctctga tgtggtgaac aattcctctc cggcactggg aggcaccttc ccgccagccc
     1441 cctggtggcc gcctggccca cctcccacca acttcagcag cttggagctg gagcccagag
     1501 gccagcagcc cgtggccaag gccgagggga gcccgaccgc catcctcatc ggctgcctgg
     1561 tggccatcat cctgctcctg ctgctcatca ttgccctcat gctctggcgg ctgcactggc
     1621 gcaggctcct cagcaaggct gaacggaggg tgttggaaga ggagctgacg gttcacctct
     1681 ctgtccctgg ggacactatc ctcatcaaca accgcccagg tcctagagag ccacccccgt
     1741 accaggagcc ccggcctcgt gggaatccgc cccactccgc tccctgtgtc cccaatggct
     1801 ctgcgttgct gctctccaat ccagcctacc gcctccttct ggccacttac gcccgtcccc
     1861 ctcgaggccc gggccccccc acacccgcct gggccaaacc caccaacacc caggcctaca
     1921 gtggggacta tatggagcct gagaagccag gcgccccgct tctgccccca cctccccaga
     1981 acagcgtccc ccattatgcc gaggctgaca ttgttaccct gcagggcgtc accgggggca
     2041 acacctatgc tgtgcctgca ctgcccccag gggcagtcgg ggatgggccc cccagagtgg
     2101 atttccctcg atctcgactc cgcttcaagg agaagcttgg cgagggccag tttggggagg
     2161 tgcacctgtg tgaggtcgac agccctcaag atctggttag tcttgatttc ccccttaatg
     2221 tgcgtaaggg acaccctttg ctggtagctg tcaagatctt acggccagat gccaccaaga
     2281 atgccaggaa tgatttcctg aaagaggtga agatcatgtc gaggctcaag gacccaaaca
     2341 tcattcggct gctgggcgtg tgtgtgcagg acgaccccct ctgcatgatt actgactaca
     2401 tggagaacgg cgacctcaac cagttcctca gtgcccacca gctggaggac aaggcagccg
     2461 agggggcccc tggggacggg caggctgcgc aggggcccac catcagctac ccaatgctgc
     2521 tgcatgtggc agcccagatc gcctccggca tgcgctatct ggccacactc aactttgtac
     2581 atcgggacct ggccacgcgg aactgcctag ttggggaaaa tttcaccatc aaaatcgcag
     2641 actttggcat gagccggaac ctctatgctg gggactatta ccgtgtgcag ggccgggcag
     2701 tgctgcccat ccgctggatg gcctgggagt gcatcctcat ggggaagttc acgactgcga
     2761 gtgacgtgtg ggcctttggt gtgaccctgt gggaggtgct gatgctctgt agggcccagc
     2821 cctttgggca gctcaccgac gagcaggtca tcgagaacgc gggggagttc ttccgggacc
     2881 agggccggca ggtgtacctg tcccggccgc ctgcctgccc gcagggccta tatgagctga
     2941 tgcttcggtg ctggagccgg gagtctgagc agcgaccacc cttttcccag ctgcatcggt
     3001 tcctggcaga ggatgcactc aacacggtgt gaatcacaca tccagctgcc cctccctcag
     3061 ggagcgatcc aggggaagcc agtgacacta aaacaagagg acacaatggc acctctgccc
     3121 ttcccctccc gacagcccat cacctctaat agaggcagtg agactgcagg tgggctgggc
     3181 ccacccaggg agctgatgcc ccttctcccc ttcctggaca cactctcatg tccccttcct
     3241 gttcttcctt cctagaagcc cctgtcgccc acccagctgg tcctgtggat gggatcctct
     3301 ccaccctcct ctagccatcc cttggggaag ggtggggaga aatataggat agacactgga
     3361 catggcccat tggagcacct gggccccact ggacaacact gattcctgga gaggtggctg
     3421 cgcccccagc ttctctctcc ctgtcacaca ctggacccca ctggctgaga atctgggggt
     3481 gaggaggaca agaaggagag gaaaatgttt ccttgtgcct gctcctgtac ttgtcctcag
     3541 cttgggcttc ttcctcctcc atcacctgaa acactggacc tgggggtagc cccgccccag
     3601 ccctcagtca cccccacttc ccacttgcag tcttgtagct agaacttctc taagcctata
     3661 cgtttctgtg gagtaaatat tgggattggg gggaaagagg gagcaacggc ccatagcctt
     3721 ggggttggac atctctagtg tagctgccac attgattttt ctataatcac ttggggtttg
     3781 tacatttttg gggggagaga cacagatttt tacactaata tatggaccta gcttgaggca
     3841 attttaatcc cctgcactag gcaggtaata ataaaggttg agttttccac aa
//
