LOCUS       NM_001297654            3836 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1),
            transcript variant 9, mRNA.
ACCESSION   NM_001297654 XM_005249386 XM_005272874 XM_005275028 XM_005275163
            XM_005275458
VERSION     NM_001297654.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3836)
  AUTHORS   Xue,L., Tan,Q., Xu,J., Feng,L., Li,W., Yan,L. and Li,Y.
  TITLE     [MiR-6838-5p overexpression inhibits proliferation of breast cancer
            MCF-7 cells by downregulating DDR1 expression]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (9), 1677-1684 (2024)
   PUBMED   39505335
  REMARK    GeneRIF: [MiR-6838-5p overexpression inhibits proliferation of
            breast cancer MCF-7 cells by downregulating DDR1 expression].
REFERENCE   2  (bases 1 to 3836)
  AUTHORS   Wei,Z., Li,J., Zhong,L., Yang,D., Li,W., Chen,W., Zhou,H., He,Y.,
            Song,W., Wang,B. and Zeng,L.
  TITLE     DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing
            HIF-1alpha Ubiquitination and Degradation
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308395 (2024)
   PUBMED   39024501
  REMARK    GeneRIF: DDR1 Drives Malignant Progression of Gastric Cancer by
            Suppressing HIF-1alpha Ubiquitination and Degradation.
REFERENCE   3  (bases 1 to 3836)
  AUTHORS   Garcia-Ruiz,B., Jimenez,E., Aranda,S., Verdolini,N.,
            Gutierrez-Zotes,A., Saez,C., Losantos,E., Alonso-Lana,S.,
            Fatjo-Vilas,M., Sarro,S., Torres,L., Panicalli,F., Bonnin,C.D.M.,
            Pomarol-Clotet,E., Vieta,E. and Vilella,E.
  TITLE     Associations of altered leukocyte DDR1 promoter methylation and
            childhood trauma with bipolar disorder and suicidal behavior in
            euthymic patients
  JOURNAL   Mol Psychiatry 29 (8), 2478-2486 (2024)
   PUBMED   38503928
  REMARK    GeneRIF: Associations of altered leukocyte DDR1 promoter
            methylation and childhood trauma with bipolar disorder and suicidal
            behavior in euthymic patients.
REFERENCE   4  (bases 1 to 3836)
  AUTHORS   Anand,M.A.V., Manjula,K.S. and Wang,C.Z.
  TITLE     Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in
            Association with Myelination and Remyelination Process in the
            Central Nerve System
  JOURNAL   J Physiol Investig 67 (4), 161-173 (2024)
   PUBMED   39175192
  REMARK    GeneRIF: Functional Role of DDR1 in Oligodendrocyte Signaling
            Mechanism in Association with Myelination and Remyelination Process
            in the Central Nerve System.
            Review article
REFERENCE   5  (bases 1 to 3836)
  AUTHORS   Reger De Moura,C., Louveau,B., Jouenne,F., Vilquin,P.,
            Battistella,M., Bellahsen-Harrar,Y., Sadoux,A., Menashi,S.,
            Dumaz,N., Lebbe,C. and Mourah,S.
  TITLE     Inactivation of kindlin-3 increases human melanoma aggressiveness
            through the collagen-activated tyrosine kinase receptor DDR1
  JOURNAL   Oncogene 43 (21), 1620-1630 (2024)
   PUBMED   38570692
  REMARK    GeneRIF: Inactivation of kindlin-3 increases human melanoma
            aggressiveness through the collagen-activated tyrosine kinase
            receptor DDR1.
REFERENCE   6  (bases 1 to 3836)
  AUTHORS   Alves,F., Saupe,S., Ledwon,M., Schaub,F., Hiddemann,W. and
            Vogel,W.F.
  TITLE     Identification of two novel, kinase-deficient variants of discoidin
            domain receptor 1: differential expression in human colon cancer
            cell lines
  JOURNAL   FASEB J 15 (7), 1321-1323 (2001)
   PUBMED   11344127
REFERENCE   7  (bases 1 to 3836)
  AUTHORS   Shelling,A.N., Butler,R., Jones,T., Laval,S., Boyle,J.M. and
            Ganesan,T.S.
  TITLE     Localization of an epithelial-specific receptor kinase (EDDR1) to
            chromosome 6q16
  JOURNAL   Genomics 25 (2), 584-587 (1995)
   PUBMED   7789998
REFERENCE   8  (bases 1 to 3836)
  AUTHORS   Edelhoff,S., Sweetser,D.A. and Disteche,C.M.
  TITLE     Mapping of the NEP receptor tyrosine kinase gene to human
            chromosome 6p21.3 and mouse chromosome 17C
  JOURNAL   Genomics 25 (1), 309-311 (1995)
   PUBMED   7774938
REFERENCE   9  (bases 1 to 3836)
  AUTHORS   Laval,S., Butler,R., Shelling,A.N., Hanby,A.M., Poulsom,R. and
            Ganesan,T.S.
  TITLE     Isolation and characterization of an epithelial-specific receptor
            tyrosine kinase from an ovarian cancer cell line
  JOURNAL   Cell Growth Differ 5 (11), 1173-1183 (1994)
   PUBMED   7848919
REFERENCE   10 (bases 1 to 3836)
  AUTHORS   Weiner,T.M., Liu,E.T., Craven,R.J. and Cance,W.G.
  TITLE     Expression of growth factor receptors, the focal adhesion kinase,
            and other tyrosine kinases in human soft tissue tumors
  JOURNAL   Ann Surg Oncol 1 (1), 18-27 (1994)
   PUBMED   7834423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662870.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 14, 2020 this sequence version replaced NM_001297654.1.
            
            Summary: Receptor tyrosine kinases play a key role in the
            communication of cells with their microenvironment. These kinases
            are involved in the regulation of cell growth, differentiation and
            metabolism. The protein encoded by this gene belongs to a subfamily
            of tyrosine kinase receptors with homology to Dictyostelium
            discoideum protein discoidin I in their extracellular domain, and
            that are activated by various types of collagen. Expression of this
            protein is restricted to epithelial cells, particularly in the
            kidney, lung, gastrointestinal tract, and brain. In addition, it
            has been shown to be significantly overexpressed in several human
            tumors. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20817.1, SRR18074967.431301.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376568.8/ ENSP00000365752.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL662870.16        37977-38168
            193-319             AL662870.16        42146-42272
            320-422             AL662870.16        42366-42468
            423-651             AL662870.16        42660-42888
            652-799             AL662870.16        44431-44578
            800-899             AL662870.16        44838-44937
            900-1086            AL662870.16        45460-45646
            1087-1333           AL662870.16        45754-46000
            1334-1429           AL662870.16        46526-46621
            1430-1581           AL662870.16        46730-46881
            1582-1747           AL662870.16        47964-48129
            1748-1858           AL662870.16        48862-48972
            1859-2103           AL662870.16        50079-50323
            2104-2231           AL662870.16        50472-50599
            2232-2450           AL662870.16        50837-51055
            2451-2685           AL662870.16        51531-51765
            2686-2835           AL662870.16        52346-52495
            2836-3836           AL662870.16        52614-53614
FEATURES             Location/Qualifiers
     source          1..3836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3836
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="discoidin domain receptor tyrosine kinase 1"
                     /db_xref="GeneID:780"
                     /db_xref="HGNC:HGNC:2730"
                     /db_xref="MIM:600408"
     exon            1..192
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            193..319
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2976
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 9; cell adhesion kinase; neurotrophic tyrosine
                     kinase, receptor, type 4; neuroepithelial tyrosine kinase;
                     PTK3A protein tyrosine kinase 3A; epithelial discoidin
                     domain-containing receptor 1; tyrosine kinase DDR; mammary
                     carcinoma kinase 10; tyrosine-protein kinase CAK;
                     protein-tyrosine kinase RTK-6; CD167 antigen-like family
                     member A"
                     /codon_start=1
                     /product="epithelial discoidin domain-containing receptor
                     1 isoform 2 precursor"
                     /protein_id="NP_001284583.1"
                     /db_xref="CCDS:CCDS34385.1"
                     /db_xref="GeneID:780"
                     /db_xref="HGNC:HGNC:2730"
                     /db_xref="MIM:600408"
                     /translation="MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPD
                     SDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGT
                     QGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMV
                     ARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGH
                     TVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDR
                     LRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAV
                     SVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPP
                     TNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKA
                     ERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLL
                     SNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSV
                     PHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEV
                     HLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDP
                     NIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISY
                     PMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR
                     VQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIEN
                     AGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV"
     exon            320..422
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            423..651
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            652..799
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            800..899
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1086
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1333
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1429
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1581
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1747
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1858
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2103
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2231
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2450
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2685
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2835
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..3836
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3814..3819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="hexamer: AATAAA"
     polyA_site      3836
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="major polyA site"
ORIGIN      
        1 gctcctctcc ccggaacagg cccccgacag ctgctctcgg gagccgcctc ccgacacccg
       61 agccccgccg gcgcctcccg ctcccggctc ccggctcctg gctccctccg cctcccccgc
      121 ccctcgcccc gccgccgaag aggccccgct cccgggtcgg acgcctgggt ctgccgggaa
      181 gagcgatgag agagatgctg cccccacccc cttaggcccg agggatcagg agctatggga
      241 ccagaggccc tgtcatcttt actgctgctg ctcttggtgg caagtggaga tgctgacatg
      301 aagggacatt ttgatcctgc caagtgccgc tatgccctgg gcatgcagga ccggaccatc
      361 ccagacagtg acatctctgc ttccagctcc tggtcagatt ccactgccgc ccgccacagc
      421 aggttggaga gcagtgacgg ggatggggcc tggtgccccg cagggtcggt gtttcccaag
      481 gaggaggagt acttgcaggt ggatctacaa cgactgcacc tggtggctct ggtgggcacc
      541 cagggacggc atgccggggg cctgggcaag gagttctccc ggagctaccg gctgcgttac
      601 tcccgggatg gtcgccgctg gatgggctgg aaggaccgct ggggtcagga ggtgatctca
      661 ggcaatgagg accctgaggg agtggtgctg aaggaccttg ggccccccat ggttgcccga
      721 ctggttcgct tctacccccg ggctgaccgg gtcatgagcg tctgtctgcg ggtagagctc
      781 tatggctgcc tctggaggga tggactcctg tcttacaccg cccctgtggg gcagacaatg
      841 tatttatctg aggccgtgta cctcaacgac tccacctatg acggacatac cgtgggcgga
      901 ctgcagtatg ggggtctggg ccagctggca gatggtgtgg tggggctgga tgactttagg
      961 aagagtcagg agctgcgggt ctggccaggc tatgactatg tgggatggag caaccacagc
     1021 ttctccagtg gctatgtgga gatggagttt gagtttgacc ggctgagggc cttccaggct
     1081 atgcaggtcc actgtaacaa catgcacacg ctgggagccc gtctgcctgg cggggtggaa
     1141 tgtcgcttcc ggcgtggccc tgccatggcc tgggaggggg agcccatgcg ccacaaccta
     1201 gggggcaacc tgggggaccc cagagcccgg gctgtctcag tgccccttgg cggccgtgtg
     1261 gctcgctttc tgcagtgccg cttcctcttt gcggggccct ggttactctt cagcgaaatc
     1321 tccttcatct ctgatgtggt gaacaattcc tctccggcac tgggaggcac cttcccgcca
     1381 gccccctggt ggccgcctgg cccacctccc accaacttca gcagcttgga gctggagccc
     1441 agaggccagc agcccgtggc caaggccgag gggagcccga ccgccatcct catcggctgc
     1501 ctggtggcca tcatcctgct cctgctgctc atcattgccc tcatgctctg gcggctgcac
     1561 tggcgcaggc tcctcagcaa ggctgaacgg agggtgttgg aagaggagct gacggttcac
     1621 ctctctgtcc ctggggacac tatcctcatc aacaaccgcc caggtcctag agagccaccc
     1681 ccgtaccagg agccccggcc tcgtgggaat ccgccccact ccgctccctg tgtccccaat
     1741 ggctctgcgt tgctgctctc caatccagcc taccgcctcc ttctggccac ttacgcccgt
     1801 ccccctcgag gcccgggccc ccccacaccc gcctgggcca aacccaccaa cacccaggcc
     1861 tacagtgggg actatatgga gcctgagaag ccaggcgccc cgcttctgcc cccacctccc
     1921 cagaacagcg tcccccatta tgccgaggct gacattgtta ccctgcaggg cgtcaccggg
     1981 ggcaacacct atgctgtgcc tgcactgccc ccaggggcag tcggggatgg gccccccaga
     2041 gtggatttcc ctcgatctcg actccgcttc aaggagaagc ttggcgaggg ccagtttggg
     2101 gaggtgcacc tgtgtgaggt cgacagccct caagatctgg ttagtcttga tttccccctt
     2161 aatgtgcgta agggacaccc tttgctggta gctgtcaaga tcttacggcc agatgccacc
     2221 aagaatgcca ggaatgattt cctgaaagag gtgaagatca tgtcgaggct caaggaccca
     2281 aacatcattc ggctgctggg cgtgtgtgtg caggacgacc ccctctgcat gattactgac
     2341 tacatggaga acggcgacct caaccagttc ctcagtgccc accagctgga ggacaaggca
     2401 gccgaggggg cccctgggga cgggcaggct gcgcaggggc ccaccatcag ctacccaatg
     2461 ctgctgcatg tggcagccca gatcgcctcc ggcatgcgct atctggccac actcaacttt
     2521 gtacatcggg acctggccac gcggaactgc ctagttgggg aaaatttcac catcaaaatc
     2581 gcagactttg gcatgagccg gaacctctat gctggggact attaccgtgt gcagggccgg
     2641 gcagtgctgc ccatccgctg gatggcctgg gagtgcatcc tcatggggaa gttcacgact
     2701 gcgagtgacg tgtgggcctt tggtgtgacc ctgtgggagg tgctgatgct ctgtagggcc
     2761 cagccctttg ggcagctcac cgacgagcag gtcatcgaga acgcggggga gttcttccgg
     2821 gaccagggcc ggcaggtgta cctgtcccgg ccgcctgcct gcccgcaggg cctatatgag
     2881 ctgatgcttc ggtgctggag ccgggagtct gagcagcgac cacccttttc ccagctgcat
     2941 cggttcctgg cagaggatgc actcaacacg gtgtgaatca cacatccagc tgcccctccc
     3001 tcagggagcg atccagggga agccagtgac actaaaacaa gaggacacaa tggcacctct
     3061 gcccttcccc tcccgacagc ccatcacctc taatagaggc agtgagactg caggtgggct
     3121 gggcccaccc agggagctga tgccccttct ccccttcctg gacacactct catgtcccct
     3181 tcctgttctt ccttcctaga agcccctgtc gcccacccag ctggtcctgt ggatgggatc
     3241 ctctccaccc tcctctagcc atcccttggg gaagggtggg gagaaatata ggatagacac
     3301 tggacatggc ccattggagc acctgggccc cactggacaa cactgattcc tggagaggtg
     3361 gctgcgcccc cagcttctct ctccctgtca cacactggac cccactggct gagaatctgg
     3421 gggtgaggag gacaagaagg agaggaaaat gtttccttgt gcctgctcct gtacttgtcc
     3481 tcagcttggg cttcttcctc ctccatcacc tgaaacactg gacctggggg tagccccgcc
     3541 ccagccctca gtcaccccca cttcccactt gcagtcttgt agctagaact tctctaagcc
     3601 tatacgtttc tgtggagtaa atattgggat tggggggaaa gagggagcaa cggcccatag
     3661 ccttggggtt ggacatctct agtgtagctg ccacattgat ttttctataa tcacttgggg
     3721 tttgtacatt tttgggggga gagacacaga tttttacact aatatatgga cctagcttga
     3781 ggcaatttta atcccctgca ctaggcaggt aataataaag gttgagtttt ccacaa
//
