LOCUS       NM_001202522            3222 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1),
            transcript variant 5, mRNA.
ACCESSION   NM_001202522
VERSION     NM_001202522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3222)
  AUTHORS   Xue,L., Tan,Q., Xu,J., Feng,L., Li,W., Yan,L. and Li,Y.
  TITLE     [MiR-6838-5p overexpression inhibits proliferation of breast cancer
            MCF-7 cells by downregulating DDR1 expression]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (9), 1677-1684 (2024)
   PUBMED   39505335
  REMARK    GeneRIF: [MiR-6838-5p overexpression inhibits proliferation of
            breast cancer MCF-7 cells by downregulating DDR1 expression].
REFERENCE   2  (bases 1 to 3222)
  AUTHORS   Wei,Z., Li,J., Zhong,L., Yang,D., Li,W., Chen,W., Zhou,H., He,Y.,
            Song,W., Wang,B. and Zeng,L.
  TITLE     DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing
            HIF-1alpha Ubiquitination and Degradation
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308395 (2024)
   PUBMED   39024501
  REMARK    GeneRIF: DDR1 Drives Malignant Progression of Gastric Cancer by
            Suppressing HIF-1alpha Ubiquitination and Degradation.
REFERENCE   3  (bases 1 to 3222)
  AUTHORS   Garcia-Ruiz,B., Jimenez,E., Aranda,S., Verdolini,N.,
            Gutierrez-Zotes,A., Saez,C., Losantos,E., Alonso-Lana,S.,
            Fatjo-Vilas,M., Sarro,S., Torres,L., Panicalli,F., Bonnin,C.D.M.,
            Pomarol-Clotet,E., Vieta,E. and Vilella,E.
  TITLE     Associations of altered leukocyte DDR1 promoter methylation and
            childhood trauma with bipolar disorder and suicidal behavior in
            euthymic patients
  JOURNAL   Mol Psychiatry 29 (8), 2478-2486 (2024)
   PUBMED   38503928
  REMARK    GeneRIF: Associations of altered leukocyte DDR1 promoter
            methylation and childhood trauma with bipolar disorder and suicidal
            behavior in euthymic patients.
REFERENCE   4  (bases 1 to 3222)
  AUTHORS   Anand,M.A.V., Manjula,K.S. and Wang,C.Z.
  TITLE     Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in
            Association with Myelination and Remyelination Process in the
            Central Nerve System
  JOURNAL   J Physiol Investig 67 (4), 161-173 (2024)
   PUBMED   39175192
  REMARK    GeneRIF: Functional Role of DDR1 in Oligodendrocyte Signaling
            Mechanism in Association with Myelination and Remyelination Process
            in the Central Nerve System.
            Review article
REFERENCE   5  (bases 1 to 3222)
  AUTHORS   Reger De Moura,C., Louveau,B., Jouenne,F., Vilquin,P.,
            Battistella,M., Bellahsen-Harrar,Y., Sadoux,A., Menashi,S.,
            Dumaz,N., Lebbe,C. and Mourah,S.
  TITLE     Inactivation of kindlin-3 increases human melanoma aggressiveness
            through the collagen-activated tyrosine kinase receptor DDR1
  JOURNAL   Oncogene 43 (21), 1620-1630 (2024)
   PUBMED   38570692
  REMARK    GeneRIF: Inactivation of kindlin-3 increases human melanoma
            aggressiveness through the collagen-activated tyrosine kinase
            receptor DDR1.
REFERENCE   6  (bases 1 to 3222)
  AUTHORS   Alves,F., Saupe,S., Ledwon,M., Schaub,F., Hiddemann,W. and
            Vogel,W.F.
  TITLE     Identification of two novel, kinase-deficient variants of discoidin
            domain receptor 1: differential expression in human colon cancer
            cell lines
  JOURNAL   FASEB J 15 (7), 1321-1323 (2001)
   PUBMED   11344127
REFERENCE   7  (bases 1 to 3222)
  AUTHORS   Shelling,A.N., Butler,R., Jones,T., Laval,S., Boyle,J.M. and
            Ganesan,T.S.
  TITLE     Localization of an epithelial-specific receptor kinase (EDDR1) to
            chromosome 6q16
  JOURNAL   Genomics 25 (2), 584-587 (1995)
   PUBMED   7789998
REFERENCE   8  (bases 1 to 3222)
  AUTHORS   Edelhoff,S., Sweetser,D.A. and Disteche,C.M.
  TITLE     Mapping of the NEP receptor tyrosine kinase gene to human
            chromosome 6p21.3 and mouse chromosome 17C
  JOURNAL   Genomics 25 (1), 309-311 (1995)
   PUBMED   7774938
REFERENCE   9  (bases 1 to 3222)
  AUTHORS   Laval,S., Butler,R., Shelling,A.N., Hanby,A.M., Poulsom,R. and
            Ganesan,T.S.
  TITLE     Isolation and characterization of an epithelial-specific receptor
            tyrosine kinase from an ovarian cancer cell line
  JOURNAL   Cell Growth Differ 5 (11), 1173-1183 (1994)
   PUBMED   7848919
REFERENCE   10 (bases 1 to 3222)
  AUTHORS   Weiner,T.M., Liu,E.T., Craven,R.J. and Cance,W.G.
  TITLE     Expression of growth factor receptors, the focal adhesion kinase,
            and other tyrosine kinases in human soft tissue tumors
  JOURNAL   Ann Surg Oncol 1 (1), 18-27 (1994)
   PUBMED   7834423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L20817.1, AF353183.1 and
            BC008716.2.
            
            Summary: Receptor tyrosine kinases play a key role in the
            communication of cells with their microenvironment. These kinases
            are involved in the regulation of cell growth, differentiation and
            metabolism. The protein encoded by this gene belongs to a subfamily
            of tyrosine kinase receptors with homology to Dictyostelium
            discoideum protein discoidin I in their extracellular domain, and
            that are activated by various types of collagen. Expression of this
            protein is restricted to epithelial cells, particularly in the
            kidney, lung, gastrointestinal tract, and brain. In addition, it
            has been shown to be significantly overexpressed in several human
            tumors. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN02400288
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1389              L20817.1           151-1539
            1390-1506           AF353183.1         70-186
            1507-3222           BC008716.2         2125-3840
FEATURES             Location/Qualifiers
     source          1..3222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3222
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="discoidin domain receptor tyrosine kinase 1"
                     /db_xref="GeneID:780"
                     /db_xref="HGNC:HGNC:2730"
                     /db_xref="MIM:600408"
     exon            1..127
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2346
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /EC_number="2.7.10.1"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5; cell adhesion kinase; neurotrophic tyrosine
                     kinase, receptor, type 4; neuroepithelial tyrosine kinase;
                     PTK3A protein tyrosine kinase 3A; epithelial discoidin
                     domain-containing receptor 1; tyrosine kinase DDR; mammary
                     carcinoma kinase 10; tyrosine-protein kinase CAK;
                     protein-tyrosine kinase RTK-6; CD167 antigen-like family
                     member A"
                     /codon_start=1
                     /product="epithelial discoidin domain-containing receptor
                     1 isoform 5 precursor"
                     /protein_id="NP_001189451.1"
                     /db_xref="CCDS:CCDS75419.1"
                     /db_xref="GeneID:780"
                     /db_xref="HGNC:HGNC:2730"
                     /db_xref="MIM:600408"
                     /translation="MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPD
                     SDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGT
                     QGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMV
                     ARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGH
                     TVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDR
                     LRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAV
                     SVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPP
                     TNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKV
                     LESHPRTRSPGLVGIRPTPLPVSPMALVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV
                     KILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF
                     LSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATR
                     NCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWA
                     FGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLR
                     CWSRESEQRPPFSQLHRFLAEDALNTV"
     exon            128..230
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            231..459
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            460..607
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            608..707
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            708..894
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1141
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1237
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1389
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1473
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1601
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1820
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2055
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2205
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..3206
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="DDR1"
                     /gene_synonym="CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP;
                     NTRK4; PTK3; PTK3A; RTK6; TRKE"
                     /note="major polyA site"
ORIGIN      
        1 agatgctgcc cccaccccct taggcccgag ggatcaggag ctatgggacc agaggccctg
       61 tcatctttac tgctgctgct cttggtggca agtggagatg ctgacatgaa gggacatttt
      121 gatcctgcca agtgccgcta tgccctgggc atgcaggacc ggaccatccc agacagtgac
      181 atctctgctt ccagctcctg gtcagattcc actgccgccc gccacagcag gttggagagc
      241 agtgacgggg atggggcctg gtgccccgca gggtcggtgt ttcccaagga ggaggagtac
      301 ttgcaggtgg atctacaacg actgcacctg gtggctctgg tgggcaccca gggacggcat
      361 gccgggggcc tgggcaagga gttctcccgg agctaccggc tgcgttactc ccgggatggt
      421 cgccgctgga tgggctggaa ggaccgctgg ggtcaggagg tgatctcagg caatgaggac
      481 cctgagggag tggtgctgaa ggaccttggg ccccccatgg ttgcccgact ggttcgcttc
      541 tacccccggg ctgaccgggt catgagcgtc tgtctgcggg tagagctcta tggctgcctc
      601 tggagggatg gactcctgtc ttacaccgcc cctgtggggc agacaatgta tttatctgag
      661 gccgtgtacc tcaacgactc cacctatgac ggacataccg tgggcggact gcagtatggg
      721 ggtctgggcc agctggcaga tggtgtggtg gggctggatg actttaggaa gagtcaggag
      781 ctgcgggtct ggccaggcta tgactatgtg ggatggagca accacagctt ctccagtggc
      841 tatgtggaga tggagtttga gtttgaccgg ctgagggcct tccaggctat gcaggtccac
      901 tgtaacaaca tgcacacgct gggagcccgt ctgcctggcg gggtggaatg tcgcttccgg
      961 cgtggccctg ccatggcctg ggagggggag cccatgcgcc acaacctagg gggcaacctg
     1021 ggggacccca gagcccgggc tgtctcagtg ccccttggcg gccgtgtggc tcgctttctg
     1081 cagtgccgct tcctctttgc ggggccctgg ttactcttca gcgaaatctc cttcatctct
     1141 gatgtggtga acaattcctc tccggcactg ggaggcacct tcccgccagc cccctggtgg
     1201 ccgcctggcc cacctcccac caacttcagc agcttggagc tggagcccag aggccagcag
     1261 cccgtggcca aggccgaggg gagcccgacc gccatcctca tcggctgcct ggtggccatc
     1321 atcctgctcc tgctgctcat cattgccctc atgctctggc ggctgcactg gcgcaggctc
     1381 ctcagcaagg tcctagagag ccacccccgt accaggagcc ccggcctcgt gggaatccgc
     1441 cccactccgc tccctgtgtc cccaatggct ctggtgcacc tgtgtgaggt cgacagccct
     1501 caagatctgg ttagtcttga tttccccctt aatgtgcgta agggacaccc tttgctggta
     1561 gctgtcaaga tcttacggcc agatgccacc aagaatgcca ggaatgattt cctgaaagag
     1621 gtgaagatca tgtcgaggct caaggaccca aacatcattc ggctgctggg cgtgtgtgtg
     1681 caggacgacc ccctctgcat gattactgac tacatggaga acggcgacct caaccagttc
     1741 ctcagtgccc accagctgga ggacaaggca gccgaggggg cccctgggga cgggcaggct
     1801 gcgcaggggc ccaccatcag ctacccaatg ctgctgcatg tggcagccca gatcgcctcc
     1861 ggcatgcgct atctggccac actcaacttt gtacatcggg acctggccac gcggaactgc
     1921 ctagttgggg aaaatttcac catcaaaatc gcagactttg gcatgagccg gaacctctat
     1981 gctggggact attaccgtgt gcagggccgg gcagtgctgc ccatccgctg gatggcctgg
     2041 gagtgcatcc tcatggggaa gttcacgact gcgagtgacg tgtgggcctt tggtgtgacc
     2101 ctgtgggagg tgctgatgct ctgtagggcc cagccctttg ggcagctcac cgacgagcag
     2161 gtcatcgaga acgcggggga gttcttccgg gaccagggcc ggcaggtgta cctgtcccgg
     2221 ccgcctgcct gcccgcaggg cctatatgag ctgatgcttc ggtgctggag ccgggagtct
     2281 gagcagcgac cacccttttc ccagctgcat cggttcctgg cagaggatgc actcaacacg
     2341 gtgtgaatca cacatccagc tgcccctccc tcagggagcg atccagggga agccagtgac
     2401 actaaaacaa gaggacacaa tggcacctct gcccttcccc tcccgacagc ccatcacctc
     2461 taatagaggc agtgagactg caggtgggct gggcccaccc agggagctga tgccccttct
     2521 ccccttcctg gacacactct catgtcccct tcctgttctt ccttcctaga agcccctgtc
     2581 gcccacccag ctggtcctgt ggatgggatc ctctccaccc tcctctagcc atcccttggg
     2641 gaagggtggg gagaaatata ggatagacac tggacatggc ccattggagc acctgggccc
     2701 cactggacaa cactgattcc tggagaggtg gctgcgcccc cagcttctct ctccctgtca
     2761 cacactggac cccactggct gagaatctgg gggtgaggag gacaagaagg agaggaaaat
     2821 gtttccttgt gcctgctcct gtacttgtcc tcagcttggg cttcttcctc ctccatcacc
     2881 tgaaacactg gacctggggg tagccccgcc ccagccctca gtcaccccca cttcccactt
     2941 gcagtcttgt agctagaact tctctaagcc tatacgtttc tgtggagtaa atattgggat
     3001 tggggggaaa gagggagcaa cggcccatag ccttggggtt ggacatctct agtgtagctg
     3061 ccacattgat ttttctataa tcacttgggg tttgtacatt tttgggggga gagacacaga
     3121 tttttacact aatatatgga cctagcttga ggcaatttta atcccctgca ctaggcaggt
     3181 aataataaag gttgagtttt ccacaaaaaa aaaaaaaaaa aa
//
