LOCUS       NM_001372108            2130 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens D-aspartate oxidase (DDO), transcript variant 9, mRNA.
ACCESSION   NM_001372108
VERSION     NM_001372108.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Rabattoni,V., Motta,Z., Miceli,M., Molla,G., Fissore,A.,
            Adinolfi,S., Pollegioni,L. and Sacchi,S.
  TITLE     On the regulation of human D-aspartate oxidase
  JOURNAL   Protein Sci 32 (11), e4802 (2023)
   PUBMED   37805834
  REMARK    GeneRIF: On the regulation of human D-aspartate oxidase.
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Lombardo,B., Pagani,M., De Rosa,A., Nunziato,M., Migliarini,S.,
            Garofalo,M., Terrile,M., D'Argenio,V., Galbusera,A., Nuzzo,T.,
            Ranieri,A., Vitale,A., Leggiero,E., Di Maio,A., Barsotti,N.,
            Borello,U., Napolitano,F., Mandarino,A., Carotenuto,M.,
            Heresco-Levy,U., Pasqualetti,M., Malatesta,P., Gozzi,A., Errico,F.,
            Salvatore,F., Pastore,L. and Usiello,A.
  TITLE     D-aspartate oxidase gene duplication induces social recognition
            memory deficit in mice and intellectual disabilities in humans
  JOURNAL   Transl Psychiatry 12 (1), 305 (2022)
   PUBMED   35915065
  REMARK    GeneRIF: D-aspartate oxidase gene duplication induces social
            recognition memory deficit in mice and intellectual disabilities in
            humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Chen,A.S., Liu,H., Wu,Y., Luo,S., Patz,E.F. Jr., Glass,C., Su,L.,
            Du,M., Christiani,D.C. and Wei,Q.
  TITLE     Genetic variants in DDO and PEX5L in peroxisome-related pathways
            predict non-small cell lung cancer survival
  JOURNAL   Mol Carcinog 61 (7), 619-628 (2022)
   PUBMED   35502931
  REMARK    GeneRIF: Genetic variants in DDO and PEX5L in peroxisome-related
            pathways predict non-small cell lung cancer survival.
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Rabattoni,V., Pollegioni,L., Tedeschi,G., Maffioli,E. and Sacchi,S.
  TITLE     Cellular studies of the two main isoforms of human d-aspartate
            oxidase
  JOURNAL   FEBS J 288 (16), 4939-4954 (2021)
   PUBMED   33650155
  REMARK    GeneRIF: Cellular studies of the two main isoforms of human
            d-aspartate oxidase.
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Molla,G., Chaves-Sanjuan,A., Savinelli,A., Nardini,M. and
            Pollegioni,L.
  TITLE     Structure and kinetic properties of human d-aspartate oxidase, the
            enzyme-controlling d-aspartate levels in brain
  JOURNAL   FASEB J 34 (1), 1182-1197 (2020)
   PUBMED   31914658
  REMARK    GeneRIF: three-dimensional structural analysis contributes insights
            into the structure-function relationships of human DASPO
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Setoyama,C. and Miura,R.
  TITLE     Structural and functional characterization of the human brain
            D-aspartate oxidase
  JOURNAL   J Biochem 121 (4), 798-803 (1997)
   PUBMED   9163533
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Simonic,T., Duga,S., Negri,A., Tedeschi,G., Malcovati,M.,
            Tenchini,M.L. and Ronchi,S.
  TITLE     cDNA cloning and expression of the flavoprotein D-aspartate oxidase
            from bovine kidney cortex
  JOURNAL   Biochem J 322 (Pt 3) (Pt 3), 729-735 (1997)
   PUBMED   9148742
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Nagasaki,H.
  TITLE     Gender-related differences of mouse liver D-aspartate oxidase in
            the activity and response to administration of D-aspartate and
            peroxisome proliferators
  JOURNAL   Int J Biochem 26 (3), 415-423 (1994)
   PUBMED   8187937
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Van Veldhoven,P.P., Brees,C. and Mannaerts,G.P.
  TITLE     D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man
  JOURNAL   Biochim Biophys Acta 1073 (1), 203-208 (1991)
   PUBMED   1991137
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   Barker,R.F. and Hopkinson,D.A.
  TITLE     The genetic and biochemical properties of the D-amino acid oxidases
            in human tissues
  JOURNAL   Ann Hum Genet 41 (1), 27-42 (1977)
   PUBMED   21608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050350.14.
            
            On Jan 21, 2020 this sequence version replaced NM_001372108.1.
            
            Summary: The protein encoded by this gene is a peroxisomal
            flavoprotein that catalyzes the oxidative deamination of
            D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide
            or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor
            in this reaction. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jan
            2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2647926.1, BC032786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000368924.9/
                                                ENSP00000357920.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AL050350.14        27038-27146
            110-285             AL050350.14        29147-29322
            286-394             AL050350.14        34171-34279
            395-571             AL050350.14        37663-37839
            572-2130            AL050350.14        49271-50829
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..2130
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="D-aspartate oxidase"
                     /db_xref="GeneID:8528"
                     /db_xref="HGNC:HGNC:2727"
                     /db_xref="MIM:124450"
     exon            1..109
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            110..285
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1139
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /EC_number="1.4.3.1"
                     /note="isoform h is encoded by transcript variant 9;
                     aspartic oxidase; D-aspartate oxidase, DDO"
                     /codon_start=1
                     /product="D-aspartate oxidase isoform h"
                     /protein_id="NP_001359037.1"
                     /db_xref="CCDS:CCDS5082.2"
                     /db_xref="GeneID:8528"
                     /db_xref="HGNC:HGNC:2727"
                     /db_xref="MIM:124450"
                     /translation="MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTS
                     DVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTP
                     TEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGW
                     TLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDG
                     SGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVG
                     LRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRT
                     PIPKSNL"
     exon            286..394
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..571
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..2130
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="hexamer: AATAAA"
     polyA_site      1732
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="hexamer: AATAAA"
     polyA_site      2130
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="major polyA site"
ORIGIN      
        1 agtttcgctt tctctctgtc tctcagggca tgagaccagc caggcactgg gaaacaaggt
       61 ttggtgccag agattttggt ggcttccaag actgcttttt cagagacagg ctcatggaca
      121 cagcacggat tgcagttgtc ggggcaggtg tggtggggct ctccacggct gtgtgcatct
      181 ccaaactggt gccccgatgc tccgttacca tcatttcaga caagtttact ccagatacca
      241 ccagtgatgt ggcagccgga atgcttattc ctcacactta tccagataca cccattcaca
      301 cgcagaagca gtggttcaga gaaaccttta atcacctctt tgcaattgcc aattctgcag
      361 aagctggaga tgctggtgtt catttggtat caggttggca gatatttcag agcactccga
      421 ctgaagaagt gccattctgg gctgacgtgg ttctgggatt tcgaaagatg actgaggctg
      481 agctgaagaa attcccccag tatgtgtttg gtcaggcttt tacaaccctg aaatgtgaat
      541 gccctgccta cctcccgtgg ttggagaaaa ggataaaggg aagtggaggc tggacactca
      601 ctcggcgaat agaagacctg tgggaacttc atccgtcctt tgacatcgtg gtcaactgtt
      661 caggccttgg aagcagacag cttgcaggag actcaaagat tttccctgta aggggccaag
      721 tcctccaagt tcaggctccc tgggtggagc attttatccg agatggcagt gggctgacat
      781 atatttatcc tggtacatcc catgtaaccc taggtggaac taggcaaaaa ggggactgga
      841 atctgtcccc ggatgcagaa aatagcagag agattctttc ccgatgctgt gctctggagc
      901 cctccctcca cggagcctgc aacatcaggg agaaggtggg cttgaggccc tacaggccag
      961 gcgtgcgact gcagacagag ctccttgcgc gagatggaca gaggctgcct gtagtccacc
     1021 actatggcca tgggagtggg ggcatctcag tgcactgggg cactgctctg gaggccgcca
     1081 ggctggtgag cgagtgtgtc catgccctca ggacccccat tcccaagtca aacctgtaga
     1141 tgacataaaa tgacagcaaa gagactgaga gactgttgat caaagcacag aacaggttca
     1201 aataactttt ccactgcatg aaagtttaat tagacatttc tttgttttca acattagaag
     1261 tggtgtaaca tgtaagctga gcacggtggc atgcctatag tcccagctac ttgagaggct
     1321 gaggcaggag gattgttgag cccaggagtt tgagtgcaat ctgggtaaca ttttttagag
     1381 gtgccagttc ccacctctaa aaaaaacacc aacaacaaaa gaaatgatgc aacatgtagg
     1441 cttacttagg aagtccagca ttaatggcat agggcataaa gctctatttt ttgttaaaaa
     1501 tacttcttat agagtaaaat ttatttagaa ctgatgtcca aggacctatg cagatttata
     1561 tgaatgttgg aagctataga gattttgata tcatttggct tataaatcca caggaggaga
     1621 taatgtatgg aaaacattta aatcactgtc aattgcagag ctgcctgtga tcttcttagg
     1681 ttatagccaa gtcagcaaca taattcctct aaataaaatt acattgtgct cacacagtgc
     1741 tggattatta catttaattg aagacaaagc atgcttgctc ctagtactag cagcaagctt
     1801 ttcctcccct cagctggtaa tgatggtagg agacagagat gaagttgcct atgtatgtca
     1861 tatcaattca atagctgcct ggggtcaaac acctaggggt tgtacattcc attactgtaa
     1921 atgattgaga gctggtttgt ggtatggttg gctttgccta agcatttttg aagatgaaca
     1981 gcatgtgcag ccaaagaact aatttgctaa ttaaggtgga acaatcattc tgaatgaaat
     2041 ataatcagag tactccgcag tttgttaaga agtattgggg aggaggggaa tgtgtctcac
     2101 aataaaatga gttggaattg ttgagttaaa
//
