LOCUS       NM_001368174            2123 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens D-aspartate oxidase (DDO), transcript variant 7, mRNA.
ACCESSION   NM_001368174
VERSION     NM_001368174.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Rabattoni,V., Motta,Z., Miceli,M., Molla,G., Fissore,A.,
            Adinolfi,S., Pollegioni,L. and Sacchi,S.
  TITLE     On the regulation of human D-aspartate oxidase
  JOURNAL   Protein Sci 32 (11), e4802 (2023)
   PUBMED   37805834
  REMARK    GeneRIF: On the regulation of human D-aspartate oxidase.
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Lombardo,B., Pagani,M., De Rosa,A., Nunziato,M., Migliarini,S.,
            Garofalo,M., Terrile,M., D'Argenio,V., Galbusera,A., Nuzzo,T.,
            Ranieri,A., Vitale,A., Leggiero,E., Di Maio,A., Barsotti,N.,
            Borello,U., Napolitano,F., Mandarino,A., Carotenuto,M.,
            Heresco-Levy,U., Pasqualetti,M., Malatesta,P., Gozzi,A., Errico,F.,
            Salvatore,F., Pastore,L. and Usiello,A.
  TITLE     D-aspartate oxidase gene duplication induces social recognition
            memory deficit in mice and intellectual disabilities in humans
  JOURNAL   Transl Psychiatry 12 (1), 305 (2022)
   PUBMED   35915065
  REMARK    GeneRIF: D-aspartate oxidase gene duplication induces social
            recognition memory deficit in mice and intellectual disabilities in
            humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Chen,A.S., Liu,H., Wu,Y., Luo,S., Patz,E.F. Jr., Glass,C., Su,L.,
            Du,M., Christiani,D.C. and Wei,Q.
  TITLE     Genetic variants in DDO and PEX5L in peroxisome-related pathways
            predict non-small cell lung cancer survival
  JOURNAL   Mol Carcinog 61 (7), 619-628 (2022)
   PUBMED   35502931
  REMARK    GeneRIF: Genetic variants in DDO and PEX5L in peroxisome-related
            pathways predict non-small cell lung cancer survival.
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Rabattoni,V., Pollegioni,L., Tedeschi,G., Maffioli,E. and Sacchi,S.
  TITLE     Cellular studies of the two main isoforms of human d-aspartate
            oxidase
  JOURNAL   FEBS J 288 (16), 4939-4954 (2021)
   PUBMED   33650155
  REMARK    GeneRIF: Cellular studies of the two main isoforms of human
            d-aspartate oxidase.
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Molla,G., Chaves-Sanjuan,A., Savinelli,A., Nardini,M. and
            Pollegioni,L.
  TITLE     Structure and kinetic properties of human d-aspartate oxidase, the
            enzyme-controlling d-aspartate levels in brain
  JOURNAL   FASEB J 34 (1), 1182-1197 (2020)
   PUBMED   31914658
  REMARK    GeneRIF: three-dimensional structural analysis contributes insights
            into the structure-function relationships of human DASPO
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Setoyama,C. and Miura,R.
  TITLE     Structural and functional characterization of the human brain
            D-aspartate oxidase
  JOURNAL   J Biochem 121 (4), 798-803 (1997)
   PUBMED   9163533
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Simonic,T., Duga,S., Negri,A., Tedeschi,G., Malcovati,M.,
            Tenchini,M.L. and Ronchi,S.
  TITLE     cDNA cloning and expression of the flavoprotein D-aspartate oxidase
            from bovine kidney cortex
  JOURNAL   Biochem J 322 (Pt 3) (Pt 3), 729-735 (1997)
   PUBMED   9148742
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Nagasaki,H.
  TITLE     Gender-related differences of mouse liver D-aspartate oxidase in
            the activity and response to administration of D-aspartate and
            peroxisome proliferators
  JOURNAL   Int J Biochem 26 (3), 415-423 (1994)
   PUBMED   8187937
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Van Veldhoven,P.P., Brees,C. and Mannaerts,G.P.
  TITLE     D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man
  JOURNAL   Biochim Biophys Acta 1073 (1), 203-208 (1991)
   PUBMED   1991137
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   Barker,R.F. and Hopkinson,D.A.
  TITLE     The genetic and biochemical properties of the D-amino acid oxidases
            in human tissues
  JOURNAL   Ann Hum Genet 41 (1), 27-42 (1977)
   PUBMED   21608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050350.14.
            
            Summary: The protein encoded by this gene is a peroxisomal
            flavoprotein that catalyzes the oxidative deamination of
            D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide
            or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor
            in this reaction. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jan
            2019].
            
            Transcript Variant: This variant (7), as well as variants 8 and 9,
            encodes isoform g.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.180568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AL050350.14        27038-27146
            110-285             AL050350.14        29147-29322
            286-394             AL050350.14        34171-34279
            395-564             AL050350.14        37670-37839
            565-2123            AL050350.14        49271-50829
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..2123
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="D-aspartate oxidase"
                     /db_xref="GeneID:8528"
                     /db_xref="HGNC:HGNC:2727"
                     /db_xref="MIM:124450"
     exon            1..109
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            110..285
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..394
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..564
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..1132
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /EC_number="1.4.3.1"
                     /note="isoform g is encoded by transcript variant 7;
                     aspartic oxidase; D-aspartate oxidase, DDO"
                     /codon_start=1
                     /product="D-aspartate oxidase isoform g"
                     /protein_id="NP_001355103.1"
                     /db_xref="GeneID:8528"
                     /db_xref="HGNC:HGNC:2727"
                     /db_xref="MIM:124450"
                     /translation="MTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTL
                     TRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSG
                     LTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLR
                     PYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPI
                     PKSNL"
     exon            565..2123
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="hexamer: AATAAA"
     polyA_site      1725
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="hexamer: AATAAA"
     polyA_site      2123
                     /gene="DDO"
                     /gene_synonym="DASOX; DASPO; DDO-1; DDO-2"
                     /note="major polyA site"
ORIGIN      
        1 agtttcgctt tctctctgtc tctcagggca tgagaccagc caggcactgg gaaacaaggt
       61 ttggtgccag agattttggt ggcttccaag actgcttttt cagagacagg ctcatggaca
      121 cagcacggat tgcagttgtc ggggcaggtg tggtggggct ctccacggct gtgtgcatct
      181 ccaaactggt gccccgatgc tccgttacca tcatttcaga caagtttact ccagatacca
      241 ccagtgatgt ggcagccgga atgcttattc ctcacactta tccagataca cccattcaca
      301 cgcagaagca gtggttcaga gaaaccttta atcacctctt tgcaattgcc aattctgcag
      361 aagctggaga tgctggtgtt catttggtat caggatattt cagagcactc cgactgaaga
      421 agtgccattc tgggctgacg tggttctggg atttcgaaag atgactgagg ctgagctgaa
      481 gaaattcccc cagtatgtgt ttggtcaggc ttttacaacc ctgaaatgtg aatgccctgc
      541 ctacctcccg tggttggaga aaaggataaa gggaagtgga ggctggacac tcactcggcg
      601 aatagaagac ctgtgggaac ttcatccgtc ctttgacatc gtggtcaact gttcaggcct
      661 tggaagcaga cagcttgcag gagactcaaa gattttccct gtaaggggcc aagtcctcca
      721 agttcaggct ccctgggtgg agcattttat ccgagatggc agtgggctga catatattta
      781 tcctggtaca tcccatgtaa ccctaggtgg aactaggcaa aaaggggact ggaatctgtc
      841 cccggatgca gaaaatagca gagagattct ttcccgatgc tgtgctctgg agccctccct
      901 ccacggagcc tgcaacatca gggagaaggt gggcttgagg ccctacaggc caggcgtgcg
      961 actgcagaca gagctccttg cgcgagatgg acagaggctg cctgtagtcc accactatgg
     1021 ccatgggagt gggggcatct cagtgcactg gggcactgct ctggaggccg ccaggctggt
     1081 gagcgagtgt gtccatgccc tcaggacccc cattcccaag tcaaacctgt agatgacata
     1141 aaatgacagc aaagagactg agagactgtt gatcaaagca cagaacaggt tcaaataact
     1201 tttccactgc atgaaagttt aattagacat ttctttgttt tcaacattag aagtggtgta
     1261 acatgtaagc tgagcacggt ggcatgccta tagtcccagc tacttgagag gctgaggcag
     1321 gaggattgtt gagcccagga gtttgagtgc aatctgggta acatttttta gaggtgccag
     1381 ttcccacctc taaaaaaaac accaacaaca aaagaaatga tgcaacatgt aggcttactt
     1441 aggaagtcca gcattaatgg catagggcat aaagctctat tttttgttaa aaatacttct
     1501 tatagagtaa aatttattta gaactgatgt ccaaggacct atgcagattt atatgaatgt
     1561 tggaagctat agagattttg atatcatttg gcttataaat ccacaggagg agataatgta
     1621 tggaaaacat ttaaatcact gtcaattgca gagctgcctg tgatcttctt aggttatagc
     1681 caagtcagca acataattcc tctaaataaa attacattgt gctcacacag tgctggatta
     1741 ttacatttaa ttgaagacaa agcatgcttg ctcctagtac tagcagcaag cttttcctcc
     1801 cctcagctgg taatgatggt aggagacaga gatgaagttg cctatgtatg tcatatcaat
     1861 tcaatagctg cctggggtca aacacctagg ggttgtacat tccattactg taaatgattg
     1921 agagctggtt tgtggtatgg ttggctttgc ctaagcattt ttgaagatga acagcatgtg
     1981 cagccaaaga actaatttgc taattaaggt ggaacaatca ttctgaatga aatataatca
     2041 gagtactccg cagtttgtta agaagtattg gggaggaggg gaatgtgtct cacaataaaa
     2101 tgagttggaa ttgttgagtt aaa
//
