LOCUS       NM_015086               3815 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dendrin (DDN), mRNA.
ACCESSION   NM_015086 XM_290598
VERSION     NM_015086.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3815)
  AUTHORS   Levin,A., Schwarz,A., Hulkko,J., He,L., Sun,Y., Barany,P.,
            Bruchfeld,A., Herthelius,M., Wennberg,L., Ebefors,K., Patrakka,J.,
            Betsholtz,C., Nystrom,J., Molne,J., Hultenby,K., Witasp,A. and
            Wernerson,A.
  TITLE     The role of dendrin in IgA nephropathy
  JOURNAL   Nephrol Dial Transplant 38 (2), 311-321 (2023)
   PUBMED   35767852
  REMARK    GeneRIF: The role of dendrin in IgA nephropathy.
REFERENCE   2  (bases 1 to 3815)
  AUTHORS   Mizdrak,M., Vukojevic,K., Filipovic,N., Capkun,V., Benzon,B. and
            Durdov,M.G.
  TITLE     Expression of DENDRIN in several glomerular diseases and
            correlation to pathological parameters and renal failure -
            preliminary study
  JOURNAL   Diagn Pathol 13 (1), 90 (2018)
   PUBMED   30458823
  REMARK    GeneRIF: The number of dendrin positive nuclei was higher in
            podocytopathies than in inflammatory glomerular diseases and
            correlated with chronic tubulointerstitial changes and lower
            creatinine clearance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3815)
  AUTHORS   Kodama,F., Asanuma,K., Takagi,M., Hidaka,T., Asanuma,E., Fukuda,H.,
            Seki,T., Takeda,Y., Hosoe-Nagai,Y., Asao,R., Horikoshi,S. and
            Tomino,Y.
  TITLE     Translocation of dendrin to the podocyte nucleus in acute
            glomerular injury in patients with IgA nephropathy
  JOURNAL   Nephrol Dial Transplant 28 (7), 1762-1772 (2013)
   PUBMED   23143340
  REMARK    GeneRIF: Increasing number of dendrin-positive nuclei in the
            glomeruli suggest acute glomerular injury in IgA nephropathy.
REFERENCE   4  (bases 1 to 3815)
  AUTHORS   Campbell,K.N., Wong,J.S., Gupta,R., Asanuma,K., Sudol,M., He,J.C.
            and Mundel,P.
  TITLE     Yes-associated protein (YAP) promotes cell survival by inhibiting
            proapoptotic dendrin signaling
  JOURNAL   J Biol Chem 288 (24), 17057-17062 (2013)
   PUBMED   23667252
  REMARK    GeneRIF: YAP binding to dendrin is a prosurvival mechanism in
            podocytes.
REFERENCE   5  (bases 1 to 3815)
  AUTHORS   Asanuma,K., Akiba-Takagi,M., Kodama,F., Asao,R., Nagai,Y.,
            Lydia,A., Fukuda,H., Tanaka,E., Shibata,T., Takahara,H., Hidaka,T.,
            Asanuma,E., Kominami,E., Ueno,T. and Tomino,Y.
  TITLE     Dendrin location in podocytes is associated with disease
            progression in animal and human glomerulopathy
  JOURNAL   Am J Nephrol 33 (6), 537-549 (2011)
   PUBMED   21606645
  REMARK    GeneRIF: Relocation of dendrin to the podocyte nuclei is useful as
            a novel marker of podocyte injury in human glomerulopathy.
REFERENCE   6  (bases 1 to 3815)
  AUTHORS   Duner,F., Patrakka,J., Xiao,Z., Larsson,J., Vlamis-Gardikas,A.,
            Pettersson,E., Tryggvason,K., Hultenby,K. and Wernerson,A.
  TITLE     Dendrin expression in glomerulogenesis and in human minimal change
            nephrotic syndrome
  JOURNAL   Nephrol Dial Transplant 23 (8), 2504-2511 (2008)
   PUBMED   18356187
  REMARK    GeneRIF: In minimal change nephrotic syndrome, dendrin and ZO-1 are
            re-distributed within the podocytes. Whether this is a cause or a
            consequence of foot process effacement remains unclear.
REFERENCE   7  (bases 1 to 3815)
  AUTHORS   Kawata,A., Iida,J., Ikeda,M., Sato,Y., Mori,H., Kansaku,A.,
            Sumita,K., Fujiwara,N., Rokukawa,C., Hamano,M., Hirabayashi,S. and
            Hata,Y.
  TITLE     CIN85 is localized at synapses and forms a complex with S-SCAM via
            dendrin
  JOURNAL   J Biochem 139 (5), 931-939 (2006)
   PUBMED   16751601
REFERENCE   8  (bases 1 to 3815)
  AUTHORS   Kremerskothen,J., Kindler,S., Finger,I., Veltel,S. and Barnekow,A.
  TITLE     Postsynaptic recruitment of Dendrin depends on both dendritic mRNA
            transport and synaptic anchoring
  JOURNAL   J Neurochem 96 (6), 1659-1666 (2006)
   PUBMED   16464232
REFERENCE   9  (bases 1 to 3815)
  AUTHORS   Kremerskothen,J., Plaas,C., Buther,K., Finger,I., Veltel,S.,
            Matanis,T., Liedtke,T. and Barnekow,A.
  TITLE     Characterization of KIBRA, a novel WW domain-containing protein
  JOURNAL   Biochem Biophys Res Commun 300 (4), 862-867 (2003)
   PUBMED   12559952
REFERENCE   10 (bases 1 to 3815)
  AUTHORS   Neuner-Jehle,M., Denizot,J.P., Borbely,A.A. and Mallet,J.
  TITLE     Characterization and sleep deprivation-induced expression
            modulation of dendrin, a novel dendritic protein in rat brain
            neurons
  JOURNAL   J Neurosci Res 46 (2), 138-151 (1996)
   PUBMED   8915891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011603.37, BC039264.1 and AB018292.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015086.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039264.1, AB018292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421952.3/ ENSP00000390590.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC011603.37        159543-159612
            71-256              BC039264.1         5-190
            257-3814            AB018292.1         71-3628
            3815-3815           AC011603.37        163769-163769
FEATURES             Location/Qualifiers
     source          1..3815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..3815
                     /gene="DDN"
                     /note="dendrin"
                     /db_xref="GeneID:23109"
                     /db_xref="HGNC:HGNC:24458"
                     /db_xref="MIM:610588"
     exon            1..297
                     /gene="DDN"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2224
                     /gene="DDN"
                     /codon_start=1
                     /product="dendrin"
                     /protein_id="NP_055901.2"
                     /db_xref="CCDS:CCDS31791.2"
                     /db_xref="GeneID:23109"
                     /db_xref="HGNC:HGNC:24458"
                     /db_xref="MIM:610588"
                     /translation="MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCH
                     YSRRAPSRQPMDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPL
                     AEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPPGRPRPEPRNAPRVAQLAGLP
                     APLRPERLAPVGRAPRPSAQPQSDPGSAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPR
                     RRWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAATPARTDGGRTKKRLDPR
                     IYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQ
                     AKATGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEGEQIWFPKCWIPSPKK
                     QPPRHSQTLPRPWAPGGTGWRESLGLGEGAGPETLEGWKATRRAHTLPRSSQGLSRGE
                     GVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPGKEEGEGATVFPS
                     PCQKRLSSSRLLHQPGGGRGGEAEGGRPGDSTLEERTFRILGLPAPEVNLRDAPTQPG
                     SPEHQALGPAASGAQGRAEGSEVAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAP
                     DSDTDEAEELSVHSGSSDGSDTEAPGASWRNERTLPEVGNSSPEEDGKTAELSDSVGE
                     ILDVISQTEEVLFGVRDIRGTQQGNRKRQ"
     exon            298..3815
                     /gene="DDN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3794..3799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDN"
                     /note="hexamer: AATAAA"
     polyA_site      3815
                     /gene="DDN"
                     /note="major polyA site"
ORIGIN      
        1 ggctctgcag tgggcgccgg ctccctgggc tgggaggggg ctcctggggc gggtgggagg
       61 gtggggggcc ggggtggggt ggggcaggat gctggatggc ccactgttct ccgaggggcc
      121 tgacagcccc cgggagctcc aggatgagga gtctggcagc tgcctctggg tgcagaagtc
      181 caagctattg gtgatagaag tgaagactat ttcctgtcat tatagtcgcc gcgccccttc
      241 tcgacagccc atggacttcc aggccagcca ctgggctcgc gggttccaga accgcacgtg
      301 tgggccgcgc ccgggatccc cacagccgcc gccccgccgg ccctgggcct ccagggtgct
      361 gcaggaggcg accaactggc gggcggggcc cctggccgag gtccgagctc gggagcaaga
      421 gaaaaggaaa gcggcgtcgc aggagcggga ggccaaggag accgagcgaa aaaggcgcaa
      481 ggctggtggg gcccgacgga gccccccggg tcgaccccgc ccggagcccc gcaacgcccc
      541 tcgggtggcc cagctggcag ggctccctgc tcccttgcgg ccggagcgcc tggcgcctgt
      601 ggggcgagcg ccccgtccat ccgcgcagcc gcagagcgac ccagggtcgg cgtgggcggg
      661 gccctgggga ggtcggcggc ccgggccccc aagctacgag gctcacctgc tgctgagagg
      721 ttctgccggg accgccccac gacgccgctg ggaccggccg ccaccctacg tggctccacc
      781 ttcttacgaa ggcccccata ggaccttggg gactaagaga ggccccggga actctcaggt
      841 gcccacttca tcagccccag ctgcgactcc agccaggaca gacggagggc gcacaaagaa
      901 gaggctggat cctcggatct accgggacgt cctcggggct tggggtctcc gacaggggca
      961 aggtctcttg gggggatccc caggctgtgg agcggccaga gcaaggccag agcccggcaa
     1021 gggggtcgtg gagaaaagcc tggggctggc tgctgctgac ctgaacagtg gtagcgacag
     1081 ccatccccaa gccaaagcta cagggagcgc aggcaccgag atagctcctg cggggtctgc
     1141 aactgcggct ccctgtgccc cgcatcccgc tcccagatcc aggcaccacc tcaagggctc
     1201 gagggaaggg aaagaaggag aacagatctg gtttcccaaa tgctggattc cctcccctaa
     1261 aaagcagccg ccccgccata gccagacact ccccagaccc tgggctcccg gaggcaccgg
     1321 atggagagaa tctctgggtc ttggagaggg ggcaggaccg gagaccctgg agggttggaa
     1381 ggcgacccgc cgtgcccaca ccttgccccg cagttcccag ggcctgtccc gtggggaagg
     1441 cgtctttgtc attgacgcca cgtgcgtagt gatacgatcc caatatgttc caaccccccg
     1501 aacccagcag gtgcagcttt tgccctctgg ggtgacacgc gtggtggggg attcccccag
     1561 ccaatcgaag cccggcaagg aggagggtga aggggccacg gtctttcctt ccccttgtca
     1621 aaagcggctg tcgagcagtc gccttttaca ccagcccggc gggggccgcg ggggcgaagc
     1681 tgagggcggg aggccggggg actccacact ggaggagcgc actttccgca tcttggggct
     1741 cccggccccc gaagtaaacc tgcgggacgc ccccacgcag ccaggtagcc cagagcacca
     1801 agccttaggc ccagcagctt cgggagccca gggcagagcc gaggggtcgg aagtggcggt
     1861 ggtccagcgg cgcgccggcc ggggctgggc gcggacccca gggccctacg ccggggccct
     1921 gcgagaagcc gtgtcccgta tccgccgcca cacagcccct gactcggaca cggacgaagc
     1981 tgaggagctc agcgtccata gcggctcctc tgatggaagc gacacagaag ccccgggcgc
     2041 ctcctggcgg aatgagagga ccctgcccga ggttggaaac agttcgccag aggaagatgg
     2101 gaagacagcg gaactgagcg acagtgtcgg ggagatccta gatgtcataa gccaaaccga
     2161 ggaggtcctc ttcggggtga gggacatcag agggacccaa cagggaaata ggaagaggca
     2221 gtgagaggcc ccttcttgta tttgtgtccc caacgcatcc atccttgggt ccactggtcc
     2281 ccattcttcc ccacagactt cctttgcttc tcttttcctt gtatctttac ccatacctgt
     2341 tctcatcctt gaaatataaa tgaaaggaag ggaagcatat gcccattaat gattttgttt
     2401 caggagaggt gagaatgagc agatttaatt aatgtctgtt atgttcaggg cacaagggtg
     2461 agctcttcgc aggggctgat gcactgggtg tggagctgag cagagaggcc taaccaggat
     2521 caggcaggag ggcagggatg gtggcagcca taggagggca gggtagggta gggcctctga
     2581 ggaggaggga aaaagtgaag gagaggcttt ggacctggtg acagagtgat cagatgacag
     2641 aggggttctt gggagaagag gcataggtcc agcaacaacc aacaaagcag aaggagggct
     2701 caccttggtg tcacaagtct tggatttcaa tcccaactct gccactgagt tgctggttga
     2761 ctgaggccag tcactttccc tctccaggcc tccaggcctc ctggtatata aaatgatggt
     2821 attctaaggt ccatccttcc gtctctgaca ttttgagatc tttggaaagg actctatctc
     2881 atcctcccct cgacaagcca agaatgagaa ttgggaataa gtgaacagag tttgagggtt
     2941 tctgggcggc ctccgtgtca cccaaagtca tgatcaattc aggagactgc ccaaggcttg
     3001 cagaagaggt aagggagtga ggcactccta tcccagtctc ccaggtttgg ttgagggctc
     3061 cccaaggcag ggcaagatag cggccctgtc actgaccctg gcctgtggtg gtctgagctg
     3121 gggagggaag gacaccaatg aatcagcttg ggacctcttt aggccttccc cttttcctcc
     3181 accccgatgc tccttagtga tgctctgagg cgtggccacg atctccctcc caggtggtat
     3241 cgcccacctg aaaaaatcct gagaatttct cccatcttgg cctcttccag aaaccggcca
     3301 ggcaaggaaa gaggccggtc accagaagcc agcaggcgtg gggtgtgata ctctctatag
     3361 ccactacagg gcgcgcgcag gtcgcggatc tccccagttg ctaatcccgg ctctgccact
     3421 caatcctatc cctagttccc gagcgcgggt cccccgcctt gcagtctcca gccgtgcggg
     3481 gccgggagca ggcctccggc ctcccagact tctagagccc gccgggccca tctttgtact
     3541 catccacccc agccggcttg ggactcagac accgaagtct tttttttttt ctctccgatc
     3601 cttggacacc tcctctgtct gccatttatt agccatgtga acttggccac atcacttcac
     3661 ctccctgagc ctcagtttcc tcatctgtca aatgggggtt tataaacacc tacctcgcag
     3721 ggttgttgtg aggatttaat gcgataatgt atgtaaagcg ccttgcacac tgcctggcac
     3781 acagtaggcg ctcaataaat ctaagcttcc cttta
//
