LOCUS       NM_145244               2604 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DNA damage inducible transcript 4 like (DDIT4L), mRNA.
ACCESSION   NM_145244
VERSION     NM_145244.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2604)
  AUTHORS   Simonson,B., Subramanya,V., Chan,M.C., Zhang,A., Franchino,H.,
            Ottaviano,F., Mishra,M.K., Knight,A.C., Hunt,D., Ghiran,I.,
            Khurana,T.S., Kontaridis,M.I., Rosenzweig,A. and Das,S.
  TITLE     DDiT4L promotes autophagy and inhibits pathological cardiac
            hypertrophy in response to stress
  JOURNAL   Sci Signal 10 (468) (2017)
   PUBMED   28246202
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2604)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2604)
  AUTHORS   Koga,Y., Pelizzola,M., Cheng,E., Krauthammer,M., Sznol,M.,
            Ariyan,S., Narayan,D., Molinaro,A.M., Halaban,R. and Weissman,S.M.
  TITLE     Genome-wide screen of promoter methylation identifies novel markers
            in melanoma
  JOURNAL   Genome Res 19 (8), 1462-1470 (2009)
   PUBMED   19491193
  REMARK    GeneRIF: Promoter methylation and differential gene expression of
            five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated
            by sequencing of bisulfite-modified DNA and real-time reverse
            transcriptase PCR, respectively.
REFERENCE   7  (bases 1 to 2604)
  AUTHORS   Imen,J.S., Billiet,L., Cuaz-Perolin,C., Michaud,N. and Rouis,M.
  TITLE     The regulated in development and DNA damage response 2 (REDD2) gene
            mediates human monocyte cell death through a reduction in
            thioredoxin-1 expression
  JOURNAL   Free Radic Biol Med 46 (10), 1404-1410 (2009)
   PUBMED   19268525
  REMARK    GeneRIF: mediates monocyte cell death through a reduction in
            thioredoxin-1 expression
REFERENCE   8  (bases 1 to 2604)
  AUTHORS   Corradetti,M.N., Inoki,K. and Guan,K.L.
  TITLE     The stress-inducted proteins RTP801 and RTP801L are negative
            regulators of the mammalian target of rapamycin pathway
  JOURNAL   J Biol Chem 280 (11), 9769-9772 (2005)
   PUBMED   15632201
  REMARK    GeneRIF: RTP801 and RTP801L work downstream of AKT and upstream of
            TSC2 to inhibit mTOR functions
REFERENCE   9  (bases 1 to 2604)
  AUTHORS   Cuaz-Perolin,C., Furman,C., Larigauderie,G., Legedz,L.,
            Lasselin,C., Copin,C., Jaye,M., Searfoss,G., Yu,K.T., Duverger,N.,
            Negre-Salvayre,A., Fruchart,J.C. and Rouis,M.
  TITLE     REDD2 gene is upregulated by modified LDL or hypoxia and mediates
            human macrophage cell death
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (10), 1830-1835 (2004)
   PUBMED   15308555
REFERENCE   10 (bases 1 to 2604)
  AUTHORS   Ellisen,L.W., Ramsayer,K.D., Johannessen,C.M., Yang,A., Beppu,H.,
            Minda,K., Oliner,J.D., McKeon,F. and Haber,D.A.
  TITLE     REDD1, a developmentally regulated transcriptional target of p63
            and p53, links p63 to regulation of reactive oxygen species
  JOURNAL   Mol Cell 10 (5), 995-1005 (2002)
   PUBMED   12453409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK094236.1 and BC013592.2.
            
            On Nov 22, 2018 this sequence version replaced NM_145244.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094236.1, SRR1803611.125486.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273990.6/ ENSP00000354830.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2578              AK094236.1         1-2578
            2579-2604           BC013592.2         2567-2592
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2604
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /note="DNA damage inducible transcript 4 like"
                     /db_xref="GeneID:115265"
                     /db_xref="HGNC:HGNC:30555"
                     /db_xref="MIM:607730"
     exon            1..166
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /inference="alignment:Splign:2.1.0"
     exon            167..306
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..797
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /note="homolog of mouse SMHS1; regulated in development
                     and DNA damage response 2; REDD-2; HIF-1 responsive
                     protein RTP801-like; protein regulated in development and
                     DNA damage response 2"
                     /codon_start=1
                     /product="DNA damage-inducible transcript 4-like protein"
                     /protein_id="NP_660287.1"
                     /db_xref="CCDS:CCDS34036.1"
                     /db_xref="GeneID:115265"
                     /db_xref="HGNC:HGNC:30555"
                     /db_xref="MIM:607730"
                     /translation="MVATGSLSSKNPASISELLDCGYHPESLLSDFDYWDYVVPEPNL
                     NEVIFEESTCQNLVKMLENCLSKSKQTKLGCSKVLVPEKLTQRIAQDVLRLSSTEPCG
                     LRGCVMHVNLEIENVCKKLDRIVCDSSVVPTFELTLVFKQENCSWTSFRDFFFSRGRF
                     SSGFRRTLILSSGFRLVKKKLYSLIGTTVIEGS"
     exon            307..2604
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /note="hexamer: AATAAA"
     polyA_site      2604
                     /gene="DDIT4L"
                     /gene_synonym="REDD2; Rtp801L"
                     /note="major polyA site"
ORIGIN      
        1 gctactgcga ggagccggcg cagggtggcc cgggaggggt gagcagggtg ccgctggctg
       61 ctggggtctg caggtcaccg agtccccagg agaggggact cctaagaagc cacctgcctg
      121 tgtttacccg gcagcgagcg cgcaggcccc cgcgaactcc tggcagcgct caggaaaggc
      181 cgttgcgcct cgcgaaggaa acagagccgt tgaccatggt tgcaactggc agtttgagca
      241 gcaagaaccc ggccagcatt tcagaattgc tggactgtgg ctatcaccca gagagcctgc
      301 taagtgattt tgactactgg gattatgttg ttcctgaacc caacctcaac gaggtaatat
      361 ttgaggaatc aacttgccag aatttggtta aaatgctgga gaactgtctg tccaaatcaa
      421 agcaaactaa acttggttgc tcaaaggtcc ttgtccctga gaaactgacc cagagaattg
      481 ctcaagatgt cctgcggctt tcctcaacgg agccctgcgg cttgcgaggt tgtgttatgc
      541 acgtgaactt ggaaattgaa aatgtatgta aaaagctgga taggattgtg tgtgattcta
      601 gcgtcgtacc tacttttgag cttacacttg tgtttaagca ggagaactgc tcatggacta
      661 gcttcaggga ctttttcttt agtagaggtc gcttctcctc tggtttcagg agaactctga
      721 tcctcagctc aggatttcga cttgttaaga aaaaacttta ctcactgatt ggaacaacag
      781 tgattgaagg gtcctaaaaa gggaaaatat ataaagatta tttcatgatt gggtagtaaa
      841 actattcagc tagtcagcta aagtcatttg tagtttgccc cacctgccct aaataagaaa
      901 ccccaaatgt agtctctttt ctttctgtgt ttcacattca tagcaactgc agctaacagg
      961 ctgattttct ggcctttgga gaagtgattc aaaatagtgt agattttctg catagatccc
     1021 atttttgtac agaattgaat gggatggaat aggtaagcaa aagtagaagc ccatttgagt
     1081 tttacatttg attccacaat ttggtttcag gtaggcttgg taatagacta tataaaccag
     1141 atttgcctat tttgattttc atatggcttt tttttctgta agttttcaga ggatttttta
     1201 aatcacagaa tcatactaaa tgatatttag cctatcaaaa cttccaaaag cccacaccac
     1261 cagttcctga ctcaaatttg aagggttttt agacaggagg gtaggattaa gtaggtgagt
     1321 ttaattaaag cttaacccta ggtaagagta aatgagaaat attacggcaa taatggaact
     1381 gcttcactgt ttcttggtga cttcctcact ctaatgtttt aaagaggcaa caaaagcttg
     1441 tggtgccatt tcagtaacca cggtgttgtt ttagatgcct ttataagctc agtttcccct
     1501 gttcttaagt gttgaatact gtctttaaac tagaaaaatg caaaatattg aactgatatt
     1561 tttgtgtgta gttgattact cttccattga gtgaatgatg aatacctgtg aggataggaa
     1621 attagttctg agatctagtc cctctctgat tcacttagta atctatcctc ttttcagtat
     1681 tacatgtgct taatctcaga tgaaccattt caccatggca gtgttatctc atctctgggc
     1741 ttttctggga attgaagtat ctctccttaa ccccaattgt caagggtagt agctgtatac
     1801 taccactttg aattattgaa acgggtcaat ttacgaagtc tgcattggct atggagatat
     1861 ggtttatagt acagcctaga gaatgaaact caccgtccag ataaccatgc atgcacccag
     1921 attttttcca ccttggatac ctgtcactag ggaataataa aggcctgatt ttttgtctta
     1981 ttccaactaa gtagatcatt atctctttcc ttttttatgt taatgagaga atttagcctc
     2041 cactcaacaa tgttcaattc agcaaggctt tcatatcctt gctgtgggtc gtggataagg
     2101 agcttattca ggtttcctgc cctagctatt agctccactt cacatgctgg agaccggcgt
     2161 agggacagat gtattcatcc tggtgttact gaaaaacagg tgtgatcctg ttactgatac
     2221 tataagtgac ctaaaatgtc actgttcaaa ttagccagtg ttctaacaaa ctaaactctt
     2281 caaatgcttg gaaagatact acaaagccaa tctttataga attgggccaa gataaatcta
     2341 tgttgttttg catggctatt gttaagctcc aaaggttcac tgtgtttctg ccgctgtcct
     2401 ggagttgtca ccactgactg ggcaaggctt cttgggcatg gatgtagaac tgttgtcctt
     2461 ttcccactaa cagttatctt tgactctctt gcctgttatg cttacaaaat ggtgatggct
     2521 tatggaaggc tgttaaatta atattcctgt taaaggaaat taaagtttgt ctatttttga
     2581 caataaaaca ttatatattt ttaa
//
