LOCUS       NM_019058               1744 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens DNA damage inducible transcript 4 (DDIT4), mRNA.
ACCESSION   NM_019058
VERSION     NM_019058.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Campoy-Campos,G., Solana-Balaguer,J., Guisado-Corcoll,A.,
            Chicote-Gonzalez,A., Garcia-Segura,P., Perez-Sisques,L.,
            Torres,A.G., Canal,M., Molina-Porcel,L., Fernandez-Irigoyen,J.,
            Santamaria,E., Ribas de Pouplana,L., Alberch,J., Marti,E.,
            Giralt,A., Perez-Navarro,E. and Malagelada,C.
  TITLE     RTP801 interacts with the tRNA ligase complex and dysregulates its
            RNA ligase activity in Alzheimer's disease
  JOURNAL   Nucleic Acids Res 52 (18), 11158-11176 (2024)
   PUBMED   39268577
  REMARK    GeneRIF: RTP801 interacts with the tRNA ligase complex and
            dysregulates its RNA ligase activity in Alzheimer's disease.
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Li,F., Miao,J., Liu,R., Zhang,R. and He,A.
  TITLE     Pan-cancer analysis of DDIT4 identifying its prognostic value and
            function in acute myeloid leukemia
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 144 (2024)
   PUBMED   38507057
  REMARK    GeneRIF: Pan-cancer analysis of DDIT4 identifying its prognostic
            value and function in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   McCurry,C.M., Sunilkumar,S., Subrahmanian,S.M., Yerlikaya,E.I.,
            Toro,A.L., VanCleave,A.M., Stevens,S.A., Barber,A.J.,
            Sundstrom,J.M. and Dennis,M.D.
  TITLE     NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires
            REDD1-Dependent Activation of GSK3beta
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 34 (2024)
   PUBMED   38546584
  REMARK    GeneRIF: NLRP3 Inflammasome Priming in the Retina of Diabetic Mice
            Requires REDD1-Dependent Activation of GSK3beta.
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Tajik,F., Fattahi,F., Rezagholizadeh,F., Bouzari,B.,
            Babaheidarian,P., Baghai Wadji,M. and Madjd,Z.
  TITLE     Nuclear overexpression of DNA damage-inducible transcript 4 (DDIT4)
            is associated with aggressive tumor behavior in patients with
            pancreatic tumors
  JOURNAL   Sci Rep 13 (1), 19403 (2023)
   PUBMED   37938616
  REMARK    GeneRIF: Nuclear overexpression of DNA damage-inducible transcript
            4 (DDIT4) is associated with aggressive tumor behavior in patients
            with pancreatic tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Chudakova,D.A., Trubetskoy,D., Baida,G., Bhalla,P., Readhead,B. and
            Budunova,I.
  TITLE     REDD1 (regulated in development and DNA damage 1) modulates the
            glucocorticoid receptor function in keratinocytes
  JOURNAL   Exp Dermatol 32 (10), 1725-1733 (2023)
   PUBMED   37483165
  REMARK    GeneRIF: REDD1 (regulated in development and DNA damage 1)
            modulates the glucocorticoid receptor function in keratinocytes.
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Lee,M., Bikram,M., Oh,S., Bull,D.A. and Kim,S.W.
  TITLE     Sp1-dependent regulation of the RTP801 promoter and its application
            to hypoxia-inducible VEGF plasmid for ischemic disease
  JOURNAL   Pharm Res 21 (5), 736-741 (2004)
   PUBMED   15180327
  REMARK    GeneRIF: co-transfection with antisense Sp1 oligonucleotide
            suggests that hypoxia induction of the RTP801 promoter is mediated
            by Sp1
REFERENCE   7  (bases 1 to 1744)
  AUTHORS   Kim,J.R., Lee,S.R., Chung,H.J., Kim,S., Baek,S.H., Kim,J.H. and
            Kim,Y.S.
  TITLE     Identification of amyloid beta-peptide responsive genes by cDNA
            microarray technology: involvement of RTP801 in amyloid
            beta-peptide toxicity
  JOURNAL   Exp Mol Med 35 (5), 403-411 (2003)
   PUBMED   14646594
  REMARK    GeneRIF: RTP801 might play important roles in Abeta toxicity and
            the pathogenesis of Alzheimer's disease
REFERENCE   8  (bases 1 to 1744)
  AUTHORS   Ellisen,L.W., Ramsayer,K.D., Johannessen,C.M., Yang,A., Beppu,H.,
            Minda,K., Oliner,J.D., McKeon,F. and Haber,D.A.
  TITLE     REDD1, a developmentally regulated transcriptional target of p63
            and p53, links p63 to regulation of reactive oxygen species
  JOURNAL   Mol Cell 10 (5), 995-1005 (2002)
   PUBMED   12453409
REFERENCE   9  (bases 1 to 1744)
  AUTHORS   Shoshani,T., Faerman,A., Mett,I., Zelin,E., Tenne,T., Gorodin,S.,
            Moshel,Y., Elbaz,S., Budanov,A., Chajut,A., Kalinski,H., Kamer,I.,
            Rozen,A., Mor,O., Keshet,E., Leshkowitz,D., Einat,P., Skaliter,R.
            and Feinstein,E.
  TITLE     Identification of a novel hypoxia-inducible factor 1-responsive
            gene, RTP801, involved in apoptosis
  JOURNAL   Mol Cell Biol 22 (7), 2283-2293 (2002)
   PUBMED   11884613
REFERENCE   10 (bases 1 to 1744)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE882343.1, BC015236.1, BC007714.1 and AF335324.2.
            
            On Nov 22, 2018 this sequence version replaced NM_019058.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000507.1, AL136668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307365.4/ ENSP00000307305.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BE882343.1         527-606
            81-990              BC015236.1         60-969
            991-1246            BC007714.1         984-1239
            1247-1744           AF335324.2         1236-1733
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..1744
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /note="DNA damage inducible transcript 4"
                     /db_xref="GeneID:54541"
                     /db_xref="HGNC:HGNC:24944"
                     /db_xref="MIM:607729"
     exon            1..137
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..402
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..896
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /note="HIF-1 responsive protein RTP801; protein regulated
                     in development and DNA damage response 1"
                     /codon_start=1
                     /product="DNA damage-inducible transcript 4 protein"
                     /protein_id="NP_061931.1"
                     /db_xref="CCDS:CCDS7315.1"
                     /db_xref="GeneID:54541"
                     /db_xref="HGNC:HGNC:24944"
                     /db_xref="MIM:607729"
                     /translation="MPSLWDRFSSSSTSSSPSSLPRTPTPDRPPRSAWGSATREEGFD
                     RSTSLESSDCESLDSSNSGFGPEEDTAYLDGVSLPDFELLSDPEDEHLCANLMQLLQE
                     SLAQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSV
                     GQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSANSPFLPGFSQSLTLSTGFRVIK
                     KKLYSSEQLLIEEC"
     exon            403..1744
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1723..1728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /note="hexamer: AATAAA"
     polyA_site      1744
                     /gene="DDIT4"
                     /gene_synonym="Dig2; REDD-1; REDD1"
                     /note="major polyA site"
ORIGIN      
        1 gcagcaggcc aagggggagg tgcgagcgtg gacctgggac gggtctgggc ggctctcggt
       61 ggttggcacg ggttcgcaca cccattcaag cggcaggacg cacttgtctt agcagttctc
      121 gctgaccgcg ctagctgcgg cttctacgct ccggcactct gagttcatca gcaaacgccc
      181 tggcgtctgt cctcaccatg cctagccttt gggaccgctt ctcgtcgtcg tccacctcct
      241 cttcgccctc gtccttgccc cgaactccca ccccagatcg gccgccgcgc tcagcctggg
      301 ggtcggcgac ccgggaggag gggtttgacc gctccacgag cctggagagc tcggactgcg
      361 agtccctgga cagcagcaac agtggcttcg ggccggagga agacacggct tacctggatg
      421 gggtgtcgtt gcccgacttc gagctgctca gtgaccctga ggatgaacac ttgtgtgcca
      481 acctgatgca gctgctgcag gagagcctgg cccaggcgcg gctgggctct cgacgccctg
      541 cgcgcctgct gatgcctagc cagttggtaa gccaggtggg caaagaacta ctgcgcctgg
      601 cctacagcga gccgtgcggc ctgcgggggg cgctgctgga cgtctgcgtg gagcagggca
      661 agagctgcca cagcgtgggc cagctggcac tcgaccccag cctggtgccc accttccagc
      721 tgaccctcgt gctgcgcctg gactcacgac tctggcccaa gatccagggg ctgtttagct
      781 ccgccaactc tcccttcctc cctggcttca gccagtccct gacgctgagc actggcttcc
      841 gagtcatcaa gaagaagctg tacagctcgg aacagctgct cattgaggag tgttgaactt
      901 caacctgagg gggccgacag tgccctccaa gacagagacg actgaacttt tggggtggag
      961 actagaggca ggagctgagg gactgattcc tgtggttgga aaactgaggc agccacctaa
     1021 ggtggaggtg ggggaatagt gtttcccagg aagctcattg agttgtgtgc gggtggctgt
     1081 gcattgggga cacatacccc tcagtactgt agcatgaaac aaaggcttag gggccaacaa
     1141 ggcttccagc tggatgtgtg tgtagcatgt accttattat ttttgttact gacagttaac
     1201 agtggtgtga catccagaga gcagctgggc tgctcccgcc ccagcccggc ccagggtgaa
     1261 ggaagaggca cgtgctcctc agagcagccg gagggagggg ggaggtcgga ggtcgtggag
     1321 gtggtttgtg tatcttactg gtctgaaggg accaagtgtg tttgttgttt gttttgtatc
     1381 ttgtttttct gatcggagca tcactactga cctgttgtag gcagctatct tacagacgca
     1441 tgaatgtaag agtaggaagg ggtgggtgtc agggatcact tgggatcttt gacacttgaa
     1501 aaattacacc tggcagctgc gtttaagcct tcccccatcg tgtactgcag agttgagctg
     1561 gcaggggagg ggctgagagg gtgggggctg gaacccctcc ccgggaggag tgccatctgg
     1621 gtcttccatc tagaactgtt tacatgaaga taagatactc actgttcatg aatacacttg
     1681 atgttcaagt attaagacct atgcaatatt ttttactttt ctaataaaca tgtttgttaa
     1741 aaca
//
