LOCUS       NM_145018               3524 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DNA damage induced apoptosis suppressor (DDIAS),
            transcript variant 1, mRNA.
ACCESSION   NM_145018
VERSION     NM_145018.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3524)
  AUTHORS   Im,J.Y., Kim,B.K., Lee,J.Y., Park,S.H., Ban,H.S., Jung,K.E. and
            Won,M.
  TITLE     DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC
            formation and destabilizing caspase-8 in cancer cells
  JOURNAL   Oncogene 37 (9), 1251-1262 (2018)
   PUBMED   29242605
  REMARK    GeneRIF: High DDIAS expression suppresses TRAIL-mediated apoptosis
            by inhibiting DISC formation and destabilizing caspase-8 in lung
            and liver cancer.
REFERENCE   2  (bases 1 to 3524)
  AUTHORS   Zhang,X., Zhang,Y., Fan,C., Wang,L., Liu,Y., Li,A., Jiang,G.,
            Zhou,H., Cai,L. and Miao,Y.
  TITLE     Noxin promotes proliferation of breast cancer cells via P38-ATF2
            signaling pathway
  JOURNAL   Tumour Biol 39 (6), 1010428317705515 (2017)
   PUBMED   28618963
  REMARK    GeneRIF: Noxin facilitated the expression of Cyclin D1 and Cyclin
            E1 through activating P38-activating transcription factor 2
            signaling pathway, thus enhanced cell growth of breast cancer
REFERENCE   3  (bases 1 to 3524)
  AUTHORS   Won,K.J., Im,J.Y., Kim,B.K., Ban,H.S., Jung,Y.J., Jung,K.E. and
            Won,M.
  TITLE     Stability of the cancer target DDIAS is regulated by the CHIP/HSP70
            pathway in lung cancer cells
  JOURNAL   Cell Death Dis 8 (1), e2554 (2017)
   PUBMED   28079882
  REMARK    GeneRIF: these findings indicate that the stability of the DDIAS
            protein is regulated by CHIP/HSP70-mediated proteasomal degradation
            and that CHIP overexpression stimulates the apoptosis of lung
            cancer cells in response to DNA-damaging agents
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3524)
  AUTHORS   Im,J.Y., Yoon,S.H., Kim,B.K., Ban,H.S., Won,K.J., Chung,K.S.,
            Jung,K.E. and Won,M.
  TITLE     DNA damage induced apoptosis suppressor (DDIAS) is upregulated via
            ERK5/MEF2B signaling and promotes beta-catenin-mediated invasion
  JOURNAL   Biochim Biophys Acta 1859 (11), 1449-1458 (2016)
   PUBMED   27412911
  REMARK    GeneRIF: EGF activates the ERK5/MEF2 pathway, which in turn induces
            DDIAS expression to promote cancer cell invasion by activating
            beta-catenin target genes
REFERENCE   5  (bases 1 to 3524)
  AUTHORS   Im,J.Y., Lee,K.W., Won,K.J., Kim,B.K., Ban,H.S., Yoon,S.H.,
            Lee,Y.J., Kim,Y.J., Song,K.B. and Won,M.
  TITLE     DNA damage-induced apoptosis suppressor (DDIAS), a novel target of
            NFATc1, is associated with cisplatin resistance in lung cancer
  JOURNAL   Biochim Biophys Acta 1863 (1), 40-49 (2016)
   PUBMED   26493727
  REMARK    GeneRIF: DDIAS is a target of NFATc1 and is associated with
            cisplatin resistance in lung cancer cells.
REFERENCE   6  (bases 1 to 3524)
  AUTHORS   Zhang,Z.Z., Huang,J., Wang,Y.P., Cai,B. and Han,Z.G.
  TITLE     NOXIN as a cofactor of DNA polymerase-primase complex could promote
            hepatocellular carcinoma
  JOURNAL   Int J Cancer 137 (4), 765-775 (2015)
   PUBMED   25612832
  REMARK    GeneRIF: NOXIN overexpression, as a result of genomic DNA gain or
            amplification, promotes HCC tumorigenesis by accelerating DNA
            synthesis and cell cycle progression, where NOXIN functions as a
            cofactor of DNA polymerase-primase complex
REFERENCE   7  (bases 1 to 3524)
  AUTHORS   Won,K.J., Im,J.Y., Yun,C.O., Chung,K.S., Kim,Y.J., Lee,J.S.,
            Jung,Y.J., Kim,B.K., Song,K.B., Kim,Y.H., Chun,H.K., Jung,K.E.,
            Kim,M.H. and Won,M.
  TITLE     Human Noxin is an anti-apoptotic protein in response to DNA damage
            of A549 non-small cell lung carcinoma
  JOURNAL   Int J Cancer 134 (11), 2595-2604 (2014)
   PUBMED   24214091
REFERENCE   8  (bases 1 to 3524)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   9  (bases 1 to 3524)
  AUTHORS   Nakaya,N., Hemish,J., Krasnov,P., Kim,S.Y., Stasiv,Y.,
            Michurina,T., Herman,D., Davidoff,M.S., Middendorff,R. and
            Enikolopov,G.
  TITLE     noxin, a novel stress-induced gene involved in cell cycle and
            apoptosis
  JOURNAL   Mol Cell Biol 27 (15), 5430-5444 (2007)
   PUBMED   17515607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB454086.1, AK096157.1, DB023053.1, BC039268.1 and AA477171.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145018.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039268.1, SRR1803613.27568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533655.6/ ENSP00000435421.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               DB454086.1         45-473
            430-1582            AK096157.1         436-1588
            1583-1776           DB023053.1         363-556
            1777-2726           BC039268.1         1786-2735
            2727-2855           AA477171.1         117-245
            2856-3524           BC039268.1         2865-3533
FEATURES             Location/Qualifiers
     source          1..3524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..3524
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /note="DNA damage induced apoptosis suppressor"
                     /db_xref="GeneID:220042"
                     /db_xref="HGNC:HGNC:26351"
                     /db_xref="MIM:618045"
     exon            1..87
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            88..187
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            188..316
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..3200
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /note="nitric oxide-inducible gene protein"
                     /codon_start=1
                     /product="DNA damage-induced apoptosis suppressor protein"
                     /protein_id="NP_659455.3"
                     /db_xref="CCDS:CCDS8263.1"
                     /db_xref="GeneID:220042"
                     /db_xref="HGNC:HGNC:26351"
                     /db_xref="MIM:618045"
                     /translation="MNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKC
                     GSTGESGNANYRYKLSLKVAESNKLFVITVFGSCLDTFFGLTATGLHRYIQDPNKIPE
                     TLDNDTTQNLLTKAVETCFVGQSFIFGVTNFENQPGQGSDASNFLQQCSDHKRKAKAL
                     VACQIVLPDPGIAGFTVIDYFHQLLQTFNFRKLQCDSQAPNNHLLALDHSNSDLSSIY
                     TSDSTSDFFKSCSKDTFSKFWQPSLEFTCIVSQLTDNDDFSASEQSKAFGTLQQNRKS
                     ISIAEATGSSSCHDPIQDSWSLVSYMDKKSTAEKLGKELGLQAKELSAVHSSHHEIGV
                     NDSNLFSLEMREPLESSNTKSFHSAVEIKNRSQHELPCFQHHGIDTPTSLQKRSACCP
                     PSLLRLEETASSSQDGDPQIWDDLPFSESLNKFLAVLESEIAVTQADVSSRKHHVDND
                     IDKFHADHSRLSVTPQRTTGALHTPPIALRSSQVIVKANCSKDDFLFNCKGNLSPSVE
                     KESQPDNKVEAVSVNHNGRDMSEYFLPNPYLSALSSSSKDLETIVTLKKTIRISPHRE
                     SDHSSLNNKYLNGCGEISVSEMNEKLTTLCYRKYNDVSDLCKLENKQYCRWSKNQDDS
                     FTICRKLTYPLETLCNSPNRSTNTLKEMPWGHINNNVTQSYSIGYEGSYDASADLFDD
                     IAKEMDIATEITKKSQDILLKWGTSLAESHPSESDFSLRSLSEDFIQPSQKLSLQSLS
                     DSRHSRTCSPTPHFQSDSEYNFENSQDFVPCSQSTPISGFHQTRIHGINRAFKKPVFY
                     SDLDGNYEKIRIFPENDKQQASPSCPKNIKTPSQKIRSPIVSGVSQPDVFNHYPFAEC
                     HETDSDEWVPPTTQKIFPSDMLGFQGIGLGKCLAAYHFPDQQELPRKKLKHIRQGTNK
                     GLIKKKLKNMLAAVVTKKKTHKYNCKSSGWISKCPDIQVLAAPQLHPILGPDSCSEVK
                     CCLPFSEKGPPSVCETRSAWSPELFS"
     exon            317..478
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            479..596
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            597..3524
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3502..3507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /note="hexamer: AATAAA"
     polyA_site      3524
                     /gene="DDIAS"
                     /gene_synonym="C11orf82; noxin"
                     /note="major polyA site"
ORIGIN      
        1 gattggaagg ctgccggcgt gctactgagt tcggccggtc cgagtcactg tgcgtcgcct
       61 gggcccgttc ctggtcttct cccccagggt cttgctctgt cacccaggct ggagtgccat
      121 ggcatcatca tagctcacta tggccttgat cctcctgcct tagcctccca agcagctggt
      181 attacagacc acggtgtgaa cacatgaaca gaagacgaaa atttcttcta gcctcagtac
      241 ttgctctcca gaattcaagt tttatatatc catcatgtca gaagtgcttc tctaggataa
      301 tcctggtctc caaaaggtct aattgtccaa aatgtggctc tactggtgaa tctggaaatg
      361 ccaattacag atacaaactt tccttaaaag ttgcagaatc aaacaaattg tttgttatta
      421 ctgtatttgg aagttgctta gatacatttt ttggtcttac tgccactggt ttgcacaggt
      481 acattcagga tcctaataaa attccagaaa cactggacaa tgatacaact cagaatctat
      541 taactaaagc agttgaaact tgctttgttg gacaaagctt tatttttgga gtgacgaatt
      601 ttgaaaacca acctggacaa ggttcagatg ccagtaactt cttacagcaa tgctctgacc
      661 acaaaagaaa agccaaagca ctagtggctt gccagattgt tctaccagac ccaggtattg
      721 caggctttac tgtcattgac tacttccatc aacttttgca gacttttaat ttcaggaaac
      781 ttcagtgtga ctctcaggca cctaacaatc acttacttgc tttagatcac tcaaatagtg
      841 atctcagcag catatatact tctgacagca cttctgattt tttcaagtcc tgcagcaagg
      901 atactttttc aaaattctgg cagccatcac ttgaattcac ttgcattgtt tcacaactaa
      961 cagataatga tgatttttca gcttcagaac aaagtaaggc ctttggtact cttcagcaga
     1021 acagaaagtc catctccatt gcagaggcca ctggttccag tagctgccat gatcccattc
     1081 aggattcatg gagccttgtt tcatatatgg ataaaaagag tacagcagaa aagttgggta
     1141 aagaacttgg cttacaagct aaggagctga gtgcagttca cagcagtcat catgaaattg
     1201 gagttaatga ctctaattta ttctctttgg aaatgcgaga gccccttgag tcaagtaata
     1261 caaaatcctt ccacagtgca gtggaaatta aaaataggtc ccagcatgag ctaccatgtt
     1321 ttcagcatca tggtatagat accccaacta gccttcagaa gagatctgca tgttgtccac
     1381 cttcgttact cagacttgaa gagacagcca gcagttccca ggatggtgac cctcaaattt
     1441 gggatgatct gccattctct gaaagcctga acaagtttct ggcagttctt gaaagtgaga
     1501 ttgctgtaac ccaggcagat gtcagtagta ggaaacatca tgtagataat gacattgata
     1561 aatttcatgc agaccacagc aggttatctg tgactcccca gagaactact ggagccctgc
     1621 atacaccacc tatagcttta agatcatcac aagtaatagt caaagcaaac tgtagcaaag
     1681 atgacttcct tttcaactgt aaaggaaatc taagtcctag tgttgaaaag gagtcacaac
     1741 cagataacaa agtagaggct gtctctgtaa atcataatgg aagagatatg tcagaatatt
     1801 ttttaccgaa tccttacctg tcagctctgt cttcatcttc aaaagattta gaaacaatag
     1861 ttactcttaa gaagactatc agaatctcac cacacaggga gagtgaccat tctagtctaa
     1921 ataacaaata tttgaatgga tgtggagaaa tatcagtttc agaaatgaat gaaaagttga
     1981 caactctgtg ttataggaag tataatgatg tctctgatct ttgcaaatta gaaaataaac
     2041 aatattgtag gtggtccaag aaccaagatg acagttttac aatttgcagg aaacttacat
     2101 atcctttaga aactctttgc aatagtccaa atagaagtac aaatacattg aaagaaatgc
     2161 cttggggaca tatcaataac aacgtaacac agagctattc tattggttat gaaggtagct
     2221 atgatgcctc tgctgatctc tttgatgata ttgctaaaga aatggacatt gcaactgaga
     2281 ttaccaaaaa atcacaggat attttgttaa aatggggaac atctttggca gaaagtcacc
     2341 cttcagagtc tgatttttca ctgagatcac tttctgaaga cttcatccag ccttcacaaa
     2401 aattatcctt gcaaagccta tctgactcta ggcattcaag aacatgctct ccaacacctc
     2461 attttcaatc agattcagaa tataattttg aaaatagtca agactttgtt ccatgttcac
     2521 agtcaactcc aatttcaggg ttccaccaaa caagaattca tgggataaac agagctttca
     2581 aaaaacctgt attttattca gatcttgatg gtaactatga aaaaataagg attttccctg
     2641 aaaatgacaa acagcaagcc agcccaagct gtccaaaaaa tataaaaaca cctagccaga
     2701 aaatcagaag ccctattgta tctggtgttt cacaaccaga cgttttcaat cactaccctt
     2761 ttgctgagtg ccatgaaact gatagtgatg aatgggtccc tcctaccaca caaaaaatat
     2821 ttccttcaga tatgcttgga ttccaaggca taggtctagg gaaatgcctt gctgcctatc
     2881 atttccctga tcaacaagag ttaccaagaa agaaactgaa acatattaga caaggaacca
     2941 ataaaggttt aattaagaag aaattaaaga atatgcttgc agcagttgtt acgaaaaaga
     3001 aaactcataa atataactgt aaaagttcag gctggatttc caaatgtcca gacattcaag
     3061 tcttagcagc acctcagctg caccctattc ttggacctga ttcttgttca gaagtcaaat
     3121 gttgccttcc attttcagaa aaaggcccac cttcagtgtg tgaaactcga agtgcttggt
     3181 cacctgaatt gttttcataa aaagtcacct gaacccaatt cctgaacttt taaatctgtt
     3241 tggaaatgtt tgccttcagg ggtacggaaa gcattcttta cattttgaac acttggagag
     3301 aagcaaattg aaaacaggac tctgctggga gctactgtgc cttttaaaat ataaagccat
     3361 tgttttcccc agggttttat ctagaatact atgattaggt agttgagcac tttatcttat
     3421 actgtttatt gtactttaat aatattgtta agattgtttt tgaaagtatt aatgtttgtt
     3481 aaaatcacat atacatccag aaataaagac tttgcaaacc aaaa
//
