LOCUS       NM_032341              10667 bp    mRNA    linear   PRI 27-JUN-2024
DEFINITION  Homo sapiens DNA damage inducible 1 homolog 2 (DDI2), mRNA.
ACCESSION   NM_032341 XM_496347
VERSION     NM_032341.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10667)
  AUTHORS   Wang,Y., Zhu,Y., Wang,Y., Chang,Y., Geng,F., Ma,M., Gu,Y., Yu,A.,
            Zhu,R., Yu,P., Sha,Z., Qi,S., Li,J., Zhao,W., Pan,W., Zhang,R. and
            Yu,F.X.
  TITLE     Proteolytic activation of angiomotin by DDI2 promotes angiogenesis
  JOURNAL   EMBO J 42 (15), e112900 (2023)
   PUBMED   37350545
REFERENCE   2  (bases 1 to 10667)
  AUTHORS   Hu,X., Zou,R., Zhang,Z., Ji,J., Li,J., Huo,X.Y., Liu,D., Ge,M.X.,
            Cui,M.K., Wu,M.Z., Li,Z.P., Wang,Q., Zhang,X. and Zhang,Z.R.
  TITLE     UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated
            NRF1 cleavage
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1866 (2), 194937 (2023)
   PUBMED   37084817
  REMARK    GeneRIF: UBE4A catalyzes NRF1 ubiquitination and facilitates
            DDI2-mediated NRF1 cleavage.
REFERENCE   3  (bases 1 to 10667)
  AUTHORS   Lei,L., Cao,Q., An,G., Lv,Y., Tang,J. and Yang,J.
  TITLE     DDI2 promotes tumor metastasis and resists antineoplastic
            drugs-induced apoptosis in colorectal cancer
  JOURNAL   Apoptosis 28 (3-4), 458-470 (2023)
   PUBMED   36520320
REFERENCE   4  (bases 1 to 10667)
  AUTHORS   Ribeiro,S.T., de Gassart,A., Bettigole,S., Zaffalon,L.,
            Chavarria,C., Op,M., Nugraha,K. and Martinon,F.
  TITLE     The protease DDI2 regulates NRF1 activation in response to cadmium
            toxicity
  JOURNAL   iScience 25 (10), 105227 (2022)
   PUBMED   36248746
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10667)
  AUTHORS   Dirac-Svejstrup,A.B., Walker,J., Faull,P., Encheva,V., Akimov,V.,
            Puglia,M., Perkins,D., Kumper,S., Hunjan,S.S., Blagoev,B.,
            Snijders,A.P., Powell,D.J. and Svejstrup,J.Q.
  TITLE     DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage
            of Transcription Factor NRF1
  JOURNAL   Mol Cell 79 (2), 332-341 (2020)
   PUBMED   32521225
  REMARK    GeneRIF: DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for
            Cleavage of Transcription Factor NRF1.
REFERENCE   6  (bases 1 to 10667)
  AUTHORS   Kottemann,M.C., Conti,B.A., Lach,F.P. and Smogorzewska,A.
  TITLE     Removal of RTF2 from Stalled Replisomes Promotes Maintenance of
            Genome Integrity
  JOURNAL   Mol Cell 69 (1), 24-35 (2018)
   PUBMED   29290612
REFERENCE   7  (bases 1 to 10667)
  AUTHORS   Sha,Z. and Goldberg,A.L.
  TITLE     Reply to Vangala et al.: Complete inhibition of the proteasome
            reduces new proteasome production by causing Nrf1 aggregation
  JOURNAL   Curr Biol 26 (18), R836-R837 (2016)
   PUBMED   27676298
REFERENCE   8  (bases 1 to 10667)
  AUTHORS   Koizumi,S., Irie,T., Hirayama,S., Sakurai,Y., Yashiroda,H.,
            Naguro,I., Ichijo,H., Hamazaki,J. and Murata,S.
  TITLE     The aspartyl protease DDI2 activates Nrf1 to compensate for
            proteasome dysfunction
  JOURNAL   Elife 5, e18357 (2016)
   PUBMED   27528193
  REMARK    GeneRIF: Here the authors show that the aspartyl protease
            DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and
            activate Nrf1.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 10667)
  AUTHORS   Siva,M., Svoboda,M., Veverka,V., Trempe,J.F., Hofmann,K.,
            Kozisek,M., Hexnerova,R., Sedlak,F., Belza,J., Brynda,J., Sacha,P.,
            Hubalek,M., Starkova,J., Flaisigova,I., Konvalinka,J. and
            Saskova,K.G.
  TITLE     Human DNA-Damage-Inducible 2 Protein Is Structurally and
            Functionally Distinct from Its Yeast Ortholog
  JOURNAL   Sci Rep 6, 30443 (2016)
   PUBMED   27461074
  REMARK    GeneRIF: the 3D structures of the human Ddi2 UBL and RVP domains
            were solved and identified a new helical domain that extends on
            either side of the Rretroviral protease-like dimer.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 10667)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK293006.1, BC006011.1, AL598343.1, AK057374.1 and AL121992.24.
            
            On Nov 24, 2018 this sequence version replaced NM_032341.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293006.1, SRR1803612.204530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000480945.6/ ENSP00000417748.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AK293006.1         1-212
            213-845             BC006011.1         128-760
            846-1669            AK293006.1         846-1669
            1670-1675           AL598343.1         506-511
            1676-2680           AK057374.1         1072-2076
            2681-10667          AL121992.24        125234-133220
FEATURES             Location/Qualifiers
     source          1..10667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..10667
                     /gene="DDI2"
                     /note="DNA damage inducible 1 homolog 2"
                     /db_xref="GeneID:84301"
                     /db_xref="HGNC:HGNC:24578"
                     /db_xref="MIM:620871"
     exon            1..351
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1413
                     /gene="DDI2"
                     /note="DNA-damage inducible protein 2 (DDI2); DDI1,
                     DNA-damage inducible 1, homolog 2"
                     /codon_start=1
                     /product="protein DDI1 homolog 2"
                     /protein_id="NP_115717.3"
                     /db_xref="CCDS:CCDS30607.1"
                     /db_xref="GeneID:84301"
                     /db_xref="HGNC:HGNC:24578"
                     /db_xref="MIM:620871"
                     /translation="MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAE
                     SQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPPVQFPNLPRIDFSSIAVP
                     GTSSPRQRQPPGTQQSHSSPGEITSSPQGLDNPALLRDMLLANPHELSLLKERNPPLA
                     EALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEEN
                     MTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDR
                     RWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSI
                     DLKKNVLVIGTTGSQTTFLPEGELPECARLAYGAGREDVRPEEIADQELAEALQKSAE
                     DAERQKP"
     exon            352..481
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..718
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..845
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..973
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1102
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1206
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1396
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1459
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..10667
                     /gene="DDI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10647..10652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDI2"
                     /note="hexamer: AATAAA"
     polyA_site      10667
                     /gene="DDI2"
                     /note="major polyA site"
ORIGIN      
        1 agacggactc gcaggcgtgt ggcggcggcc gtgcttgcta gtgagggcgg gagggagtga
       61 ctcactgagc gtgtgtgagg gagggagcga gcgagcgaac gagcagccgg cgccgtcctc
      121 ccgcagcacc agccaggcca cgccgccgcc tcttcccctg cgccccgcgc ccaggccggg
      181 ccgagccgag ccgagccggg tcgggcccgg gccatgctgc tcaccgtgta ctgtgtgcgg
      241 agggacctct ccgaggtgac cttttccctc caggtcgacg ccgacttcga gctgcacaac
      301 ttccgcgcgc tgtgcgagct cgagtctggc atccccgcag ccgagagcca gatcgtctat
      361 gcggaaagac ctctcacaga caaccacaga tcattggctt cttatggctt gaaagatggg
      421 gacgttgtga ttttacgaca gaaggagaat gcagaccctc gacctccagt gcagttccca
      481 aacttacccc gaatagattt cagtagtata gctgtgcctg gcacatcaag tccccggcag
      541 cgccagccac caggaacaca gcagtcccac tcatctcctg gagaaataac ttcatctcct
      601 cagggcttgg acaatccagc cttgctccga gatatgttgc tggccaaccc gcatgagctg
      661 tccttgctga aggaacgcaa tccacccctg gcagaagctc tgctcagtgg agaccttgag
      721 aaattttcta gagtcctggt ggagcagcag caggaccgag cccggagaga gcaagaaagg
      781 attcgtctgt tttctgctga tccctttgac cttgaagctc aggcaaagat agaagaagat
      841 ataaggcaac agaacattga ggaaaacatg acaatagcta tggaagaggc tccggaaagt
      901 tttggccaag tagtgatgct ttatattaac tgcaaagtga atggacatcc tgtgaaagcc
      961 tttgttgact caggtgccca gatgactatc atgagccaag cttgtgcaga aaggtgtaac
     1021 ataatgagac tggtggaccg tcggtgggca gggattgcca aaggagtggg cacccagaag
     1081 attattggaa gggtacatct agctcaggtt cagattgaag gagatttttt gccatgttcc
     1141 ttctctatac ttgaggaaca gcccatggac atgcttctgg gactggacat gcttaaacgg
     1201 caccagtgtt ccatcgacct gaagaaaaat gtactcgtga tcggcaccac aggctcccag
     1261 accacctttc ttcctgaggg agagctacca gagtgtgccc ggttggcata tggggctgga
     1321 agagaggatg tacggccaga ggagattgca gaccaagaat tagcagaagc ccttcaaaaa
     1381 tcagcagagg atgcagagcg tcagaagcca tgatgcatgt agtgtgtgtg tactgcagct
     1441 ggagtgggcc ccagaccaga gaaaagtggt aaagaatcta cctcactggg aatgtcatca
     1501 ttaccaactt cagatgggtt taaccatccc gcccgttctt caggacagag tcctgatgtt
     1561 ggtaatccta tgagtcttgc tcgctctgtc tctgcttcag tctgccctat caagcccagt
     1621 gactcagatc gcattgaacc taaagctgtg aaggctttga aggcttcagc tgaattccag
     1681 ctaaactctg aaaagaaaga acatctttct ttacaagatc tttctgatca tgcttcctca
     1741 gcagaccatg ctccaacaga ccagagtcca gctatgccta tgcagaattc atccgaagaa
     1801 ataactgttg caggtaatct ggagaaatct gctgaaagaa gcacccaggg cctcaaattt
     1861 catctccata caagacagga agctagttta tctgtcacat ctactaggat gcatgaacca
     1921 cagatgtttc taggtgaaaa ggattggcat ccagaaaatc agaacctgag tcaagtgagt
     1981 gaccctcagc agcacgaaga accagggaat gaacagtatg aggttgcaca acaaaaagct
     2041 tcacatgacc aagaatatct ttgtaacata ggggaccttg agcttcctga agaaaggcaa
     2101 cagaatcaac acaaaattgt tgatttggaa gctacgatga aaggaaatgg gctcccacag
     2161 aatgtggatc ctccaagtgc gaagaaaagt attccatctt cagaatgcag tggctgctca
     2221 aattcagaaa catttatgga aatcgataca gctcaacagt ccctagttac tttgcttaat
     2281 tcaacaggca ggcagaatgc caatgtcaag aacattggtg cattggatct cactttagat
     2341 aatcccttga tggaagtaga aacatcaaaa tgtaaccctt catctgaaat tttgaatgat
     2401 tccatttcca ctcaggattt acagccccca gaaactaatg ttgaaatacc tggaacaaat
     2461 aaagaatatg gccattactc ctctccaagt ctctgtggca gttgtcagcc ttctgtggag
     2521 tcagcagaag aatcttgccc gtctataacg gcagccttga aagaacttca tgaacttttg
     2581 gttgttagca gtaaaccagc ttcagaaaat acatctgaag aagtaatctg tcaatcagaa
     2641 accatagctg agggccaaac cagtattaaa gacctttctg aaagatggac ccaaaatgag
     2701 catcttaccc agaatgaaca gtgtccacaa gtctcctttc atcaggccat atctgtatca
     2761 gtggagacag aaaaattaac aggtacttca tctgacactg gaagagaagc tgtagaaaat
     2821 gtaaacttca ggagtctagg tgatggcctg tcaaccgata aggaaggtgt ccccaaatct
     2881 agggaatcca taaataagaa ccgttctgtc actgtaacct cagctaaaac atccaatcag
     2941 ttacactgca ccttaggtgt agaaatttca cccaaacttt tagcaggtga ggaggatgca
     3001 ctcaatcaga cttctgagca aactaagtct ttgtcatcca atttcatatt ggttaaagac
     3061 ttaggtcagg gcatacagaa ttcagtaaca gacaggcctg aaaccagaga aaatgtctgt
     3121 cctgatgctt cgaggccatt acttgaatat gaaccaccta ccagccatcc atcatcaagt
     3181 cctgccattc ttccaccatt gatttttcct gccacagata ttgaccgcat tctccgtgct
     3241 ggctttactt tgcaggaagc tcttggagct ttgcatcgag ttggtgggaa tgcagacctt
     3301 gcacttcttg ttttgctcgc aaaaaacatc gtagttccta catgactgtg ggaaagtggg
     3361 ctagaccgtt ctccattccc tttaaacaaa agaaagctct ctctatatac acgcacacat
     3421 acacactcac cacatataca gtatatatag aaacctgcaa gcagaatgtt gagccagatt
     3481 ttttttaaag atttttttcg gccaaagtaa tttatgatct tttgtctgat gaatttgtct
     3541 atcctacttg ttaaaattta ggccttttta aatgtattgg cagtatgtgc atacagaagc
     3601 tttttattct cattaagatg tatcctggaa taaaatggat ggttttgtgt gtagcatact
     3661 gttttagaat gagagtaaat gctttgaaaa gcagaagcca tgagaaatcc cactacccat
     3721 ccagctaaaa acagatgaac tctccacact gtgactgtgt gtctgtgctg atggcaaggt
     3781 atggtttgct ggctcagttg tcaatttaga aacttttgac cacataattt ggtgtttgga
     3841 attctaccca gtgctctgtg tatcatgatt cattaattat aacaggaaat tggagaataa
     3901 ttgaatatct tatcgtagag tggtatgttt ttatttgtgt gcttaggatt tgacatttta
     3961 atagggcgag caggagggtt taaatcttgg gctactttgt gcatcacagg ctgctgcatg
     4021 gattgccatg aatccttatt acattggatg ggatattgtg ggggagttac aatgcaagtg
     4081 aaacgtggtg ctacccagat tcttaaaaga acagaacaac cataattcca tttgcagatg
     4141 tcaagaactg tgagggaaaa ataatggcct aaacactgga atttgctaga gtttgggttt
     4201 gctagcatct cactgataac acctcaaccc ttaatgacta atggtggaat taagttcagg
     4261 aatggattca ttgccagcag cttatttcct ttctagactc ttctgccagg aagttcttca
     4321 aacgctcagt gtgagctgtg atctgagtga aatactaagt gtgataacct tgtcactggt
     4381 taatcttggt gcttggaacg gtcagtctat ttggagagtg tcctttgtgg cagtggaaat
     4441 agtaattaca gtttctgact taagtggcct tggtagagtt ttccatcctt ttctttcctc
     4501 aggagtttct tttttaagca aaattcatct tatttgtgtt taccatgtca agttagagtg
     4561 gggcataata tatagatgta tttattgtgg ccttttttta tataaggact agcccttgga
     4621 aatcattgtc ctgtgggccc cactgtgcaa taatcctact ggataggttt tagataattc
     4681 tttcctggca aactgctctt ttgggtacct agcaggaatc tgaagtcttg gttttattga
     4741 aaagaatttt gagattcata atttctgatt ctagattata gtttgtaaca tgtttgaaac
     4801 agaagcttcg aaagagtgat ttctcaactt agtgttaaat gattttgtct gaagtctgac
     4861 tctttgtaag cttgtttgtt tcatcaaatt ttaagtcatt gagcacaatc aaaatggagg
     4921 ctcatatctc aggagttttt gaaattttaa tttaggggca cttagagaca tttttttcta
     4981 ccccatccaa cttctttctt tccttttgct atgatgtttg tatgtatgtt ataagacttt
     5041 agtgatggga tggcgtgtca cgtagattca tcatgatcct ttatgtagtt aggaaatggt
     5101 tgacagaagg aattgtagtt tactgctttt cagagggcgt gaagaacaac aggtcagcca
     5161 ggttgtcttt aagatgttct tttagacagc tgcacattgt agaccctttc acctgcccta
     5221 caccaaagat gtacgatgca ctaggaaact gctcatagga tttctgtcag ctgacttaaa
     5281 gctgtgattg taattaaata gttggtgcta tgattgatgc aaaatctagt agcaatgcaa
     5341 tgggaccctg tatttgcttt atgggtggtg gtttgggaat gtattctaag cttataaatc
     5401 tttggaacca cggggtggga agggtggggg aacttactga tgacaataga ctccctccta
     5461 aagggccttc catgtaagca gaacgaacct tggcacacaa ttcagtgtgg atatttggga
     5521 aacagttcca agtggaatat ataatatcag tcgggaaaag atttcattag gatagctttt
     5581 tgtgtatgta tatgtatatt tatttttagg aatagatcta tagttgtaca tgaattcctg
     5641 ttaggaatac tctgaatgag cttaacccac ttgccaaata tccttgtccc ttccatcatt
     5701 ttatttttga gatggggtct tgcagtgttg cccaggctgg actcaaactc tggggcttaa
     5761 tcatccttct gagtagctgg gactacataa aggccaaagt ataattgctt ttgattttta
     5821 aaatcttctt gcccatcatt tttataaaaa taaagctgtt tgtccaacac ggtgaaacct
     5881 catctctact aaaaatacaa aaaattagct gggcatggtg gcacacgcct gtaatcccag
     5941 ctacttggga gactgaggca ggagaattgc ttgaacctgg gagatggggg ttgcagtgag
     6001 cctagatcac gccactgcac tccagtgtgg gcggcagagt gagactctgt ctcacccaaa
     6061 aaaaaaaaaa aaaagctatt gacactgtta atattttgga tgacttaaat ttagcagctc
     6121 tagaatgcaa agggtatatt aaggagcatt acaatagtga accttcatcg tcagctttta
     6181 ttcaattaag agctccagaa atgcagaaat tatgggttaa cttctaagaa taccatcaaa
     6241 tccctgtgaa ttctggttgc caacagtaat aaccagtaat gggcaccttt accggacagc
     6301 tcctttacca taaccagtag tgggcagttc tgcggtcagc acttaactac aagggcggtc
     6361 tctgtttctt caccagagag agaagatttt cctgtgtaat ttgtgccatt tccctgaagt
     6421 tggttcttga gcggaaagat gtgcttggta accagacagc agctttacat aggttataga
     6481 ttttgctcat tgatgctgtt aagaattatt tccactcata cctgttcagg gctccagaca
     6541 gccaatagcc ttcatcccac agtttgggct tcagctatta acacataaag ataaccagtt
     6601 gcagctaggc tcggtggctc acacctgtaa tcccagcact ttgggaggcc aaggcgggtg
     6661 gatcacctga gggcaggagt ttgagacagg cctggccaac atggtgaaac tccatctcta
     6721 ctaaaaatac aaaaattagc cgggtgtggt ggcccatgcc tgtaattcca gctactcggg
     6781 aggctgaggc aggagaatca cttaaacctg ggaggcggag gttgtggtga gcagagatca
     6841 cgccattgca ctccagcctg ggcaacaaga gcaaaactct gtctcaaaaa aaaaaaaaaa
     6901 aaaggtaacc agttgcttgg caaaggaagc tggagagatg gcgagtgcat gtgttaaaac
     6961 tcttctgcct tgcagcccac atcttctaga gctccctgtc ttcatatgta ctaaagggag
     7021 acacaaccct atgtgttttt tcccaaagca tgtctctagc aagagggtac atagaaatgg
     7081 aacatgaggc tttttgtcac tgattttatg ataaccagtt aatgtggaat ctgctggttg
     7141 tcttactaca gctttctatc tccggtgaaa gccataaaaa tttaggttaa cttttaagct
     7201 catgtctata tatatgtgtg taagctagca tatacatatg gtgattgaca agtatagtta
     7261 attttatatg gatttaaaag caagcaattt ttatatctac agacgtactc ttcacttatg
     7321 gtggctttta tcccgccaca tatataaata tatatatata tagcaaacag ccttgcaaat
     7381 catcggccag aaaagctgca gggcgttgca atggcctttt cctacctgtt tgccacctgt
     7441 ggtgagggtg agcaggatga ttgaactgct gcatatttca aacctgttat cactggcagt
     7501 gtgtcccaag agaagctgac cagattatgc attctactgt tctctagcac aagtactcac
     7561 caaaaagcca aatttcccct ttggagttgg tgacttagtg tagtctgtgg ctgacctaga
     7621 aagacacaga gttatcaaga gtttcccttc ctagaagatg aatgttacct tttgtgttag
     7681 gaggtagaga aaataaaaat agcttttttt tccctagaat tgctaattac tcttaacaac
     7741 aaattaaatt caaagcctgt ccttgagaac tggaaatgta aaatcatggt tcaagtttta
     7801 taccttagtg attcctcagt aggtgttact aggagttcac tgaatgaact taggagtgaa
     7861 ccttcgatgt gcttgatttt cttttgtgcc ttagtttctc tgaatagcag aggcatcaaa
     7921 ttttggtggg gaatgagagg agtattaggg gaaagtttga aaatagctct cctggagatg
     7981 gagggcacac agagtggtcc tcaggctcac cttgactgag ttgattcaca gttatcctgc
     8041 atcagaccat tagatttctt tagtgctatg attataatag ggatttttga atcaccaaaa
     8101 acagttttta gatgtttatg ttctttgttt tactatcaat gttgtgctgg ttaagggaga
     8161 gaaaagttca agaagatctt acatatttga aaggaaattg gtactcttga aggctatgca
     8221 acatgagtct ttgaacaaga attccttgct actttgattc attcatcaaa tactgagtgc
     8281 ctgtgtgcca ggcacaggtg aactctgggg attcaggggt aactaaaaca gattggaacc
     8341 ctgcccttgt gaagctttca gtctagaagg gagacgtgaa acaaatttta gcttcaaaag
     8401 caacatctat ttttgcctgt tagcatgcat ttattttaaa agtcatatta gagttacctg
     8461 gttccacttc agagcagact gggaaaatca ggcttacaat ggaatcagat gctgtgggcc
     8521 taaaacagct ctttaaaaat ctattttttt aggccaggtg cgttggctca cacctgtaat
     8581 cccagcactt tgggaggcca aggtgggtgg atatgaggtc aggaggtcga gaccagcctg
     8641 gccaatatga tgaaacctta cctctactaa aaataaaaaa ttagccgggc atggtggcac
     8701 atgcctgtag tcccagctac tcgggaaact gaggcagaag aatcgcttga acccgggagg
     8761 cggaggttgc agtgagccgg gatcacgtca ctgtactcca gcctgggcaa gagtgagaca
     8821 ccgtctcaaa aaaaaaaaaa attttttttt aaatggaatc agagaaacca acaaaatatg
     8881 taacatgtat aaatgcctga ggagatcagt tattgagaaa tccatttaca atgctggagg
     8941 agaggggatg gccaggaaag aagtgcaaca aataaatgga agatgaccct aaaaatgcac
     9001 cagtgacagt cagtcaatcc atcagaccac ctcacatgca gggtagaaac atggagtgtg
     9061 cggcagcatc ctcctcacat ccctttgtga gcacggctgc tccggaatac tgaccatctg
     9121 ggctagcacg acttagcaga gggttctgca ggatgtgcta ttttaaagca gctgggtgca
     9181 acttgtgaaa acgggaatct agagcagaac atgtaatcag cgatggctgg gattggtgga
     9241 caggattgac aggagtattt gaggctctac caggcctgtc tacaggacag cttcatcaaa
     9301 gggacatttt ttaacctgtt attttaaatg ccacatatat gttgtaatgc tgaagcatac
     9361 aggtagaatt tctggatcgt aactactagt gacttctgag gtttacagtt agaaaatgtt
     9421 ctcaaaggtt tatcagttat gtattgatga ttggtaatct agaccctctg gaggctgtag
     9481 aatgtgaaaa gatacagctg agctgacaag ttttagggca ctatcttctg gaatgaaatc
     9541 ggccaagaaa atggttcaag ggcatggggg ttagagaatg tttcttttac ctaaaaatgt
     9601 taagccaact atggaagatt ggggtcgtgg gggcatgaaa tacaaaatta tgataattta
     9661 tacagaacta ggtttcttta tgttctgcaa gaaggttttt attagctaat ttggggaggg
     9721 gggcatgctg cagtattttt tttcctggga acatgcattt ctgatgggaa gttattttgt
     9781 ttacaagagt tggttttaca cacaaccctg aatgaatgtg tctatggcct aaaaatggta
     9841 gacctgtatt tccttcccga ggcaggctga ttcgtttcct gattccttct gtctgagatt
     9901 acctgatgct gaccagactt atttttcctt tcctgaatct tcacagctga gtttatggca
     9961 cccatccaag accttcccat ttgaatgact agatttctat tctatccccg atcatccttt
    10021 tgaaatagtt ctagtgataa actcagagaa attcaatata ttgattgaat tttatttttt
    10081 cgctttgtat ctacaacaga aattgatttg ttcattttta tttcaaatct cttcatggca
    10141 agttgggcta atggactttg cactcaagaa aggtttgttt accagttttg tagccatgtt
    10201 tggcaaatct tagcaactag aaaccccgtc ctttcttttc cttctttata tgttcttgca
    10261 gttactcttg tattgcaaga ttttctgact ttaagctttg agactactgc atcttaaaag
    10321 aagaactagg ctgactggca aaaagtcttg ccagtggccc tgtcactccc atgatgcttt
    10381 ggttttgaga gttgggaaaa ctctgagaac ttaagggaac caaactcagg aatcccaaaa
    10441 ttggtggcat tgtgccattc gtttaggggc tgaacatagg acctgtctga aactgagtga
    10501 gctagatgca tttgggtttg aatttttgtc acatactgaa atgtaagtca gccctaaata
    10561 atcaaaacac tttattttat ttttcttttt ttaaatagga actttctgaa gaaaaagtgg
    10621 tgtgtaaaac atttgatatt taagacaata aagtttttat cataaga
//
