LOCUS       NM_001001711            2557 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DNA damage inducible 1 homolog 1 (DDI1), mRNA.
ACCESSION   NM_001001711
VERSION     NM_001001711.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2557)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2557)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2557)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2557)
  AUTHORS   Ramirez,J., Lectez,B., Osinalde,N., Siva,M., Elu,N., Aloria,K.,
            Prochazkova,M., Perez,C., Martinez-Hernandez,J., Barrio,R.,
            Saskova,K.G., Arizmendi,J.M. and Mayor,U.
  TITLE     Quantitative proteomics reveals neuronal ubiquitination of
            Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for
            the complexity of Angelman syndrome
  JOURNAL   Hum Mol Genet 27 (11), 1955-1971 (2018)
   PUBMED   29788202
  REMARK    GeneRIF: Using human neuroblastoma SH-SY5Y cells in culture, we
            also observed that human DDI1 is ubiquitinated by UBE3A, without
            being targeted for degradation
REFERENCE   6  (bases 1 to 2557)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2557)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 2557)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 2557)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2557)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093336.1, AF429971.1, AP003043.2 and DB513526.1.
            
            On May 17, 2019 this sequence version replaced NM_001001711.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK093336.1, BC022017.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302259.5/ ENSP00000302805.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1367              AK093336.1         41-1407
            1368-2122           AF429971.1         1424-2178
            2123-2529           AK093336.1         2163-2569
            2530-2530           AP003043.2         169862-169862
            2531-2555           DB513526.1         217-241
            2556-2557           AP003043.2         169888-169889
FEATURES             Location/Qualifiers
     source          1..2557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..2557
                     /gene="DDI1"
                     /note="DNA damage inducible 1 homolog 1"
                     /db_xref="GeneID:414301"
                     /db_xref="HGNC:HGNC:18961"
                     /db_xref="MIM:620870"
     exon            1..2557
                     /gene="DDI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1374
                     /gene="DDI1"
                     /note="DNA-damage inducible protein 1; DDI1, DNA-damage
                     inducible 1, homolog 1"
                     /codon_start=1
                     /product="protein DDI1 homolog 1"
                     /protein_id="NP_001001711.1"
                     /db_xref="CCDS:CCDS31660.1"
                     /db_xref="GeneID:414301"
                     /db_xref="HGNC:HGNC:18961"
                     /db_xref="MIM:620870"
                     /translation="MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEE
                     IQIIHMERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVP
                     GTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLL
                     KERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEI
                     RQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERC
                     NIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDM
                     LRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSG
                     RKEH"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDI1"
                     /note="hexamer: ATTAAA"
     polyA_site      1483
                     /gene="DDI1"
                     /note="major polyA site"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDI1"
                     /note="hexamer: AATAAA"
     polyA_site      2126
                     /gene="DDI1"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDI1"
                     /note="hexamer: ATTAAA"
     polyA_site      2557
                     /gene="DDI1"
ORIGIN      
        1 actgaggctg ggagacagcc cccagacaga tgagtgtccg cgcctctctg agaggtgaat
       61 gagcccggac ggtccctacc taccaagtcc tgaggagcag cggcaccaac gacgcaggcc
      121 cgccccagcc cgccagtgag ccgcccatgc cctctgctag cccggcccgc ccgggccccc
      181 gccatgctga tcaccgtgta ctgcgtgcgg agggacctct ccgaggtcac cttctctctc
      241 caggtcagcc ccgactttga gctccgaaac ttcaaggtcc tctgcgaagc ggagtccaga
      301 gtccccgtcg aagagatcca gatcatccac atggagcgac tcctcatcga ggaccactgt
      361 tccctgggct cctacggcct caaagatggc gatatcgtgg ttttactgca gaaggacaat
      421 gtgggacctc gggctccagg gcgtgccccg aaccagcctc gtgtagactt cagtggcatt
      481 gcggtgcctg ggacgtccag ctcccgtcca cagcaccctg gacagcagca gcagcgcaca
      541 cccgctgccc agcggtcaca gggcttggcg tcaggagaga aggtggccgg cctgcaaggt
      601 ctgggcagcc ccgccctgat ccgcagcatg ctgctctcca acccccacga tctgtccctg
      661 ctcaaggaac gcaaccctcc cttggcggaa gccctgctca gcggaagcct tgagaccttt
      721 tctcaggtgc tgatggagca gcaaagggaa aaggccttga gagagcaaga gaggcttcgt
      781 ctctacacag ccgacccact ggatcgggaa gctcaggcca aaatagaaga ggaaatccgg
      841 cagcaaaaca ttgaagaaaa catgaatata gcgatagaag aggcccccga gagttttgga
      901 caagtgacga tgctctacat taactgcaaa gtgaatgggc atcctttgaa ggcttttgtt
      961 gactcgggcg cccagatgac cattatgagc caggcttgtg ccgagcgatg taacatcatg
     1021 aggctggtgg accgacggtg ggctggggtt gctaaaggag tgggcacaca gagaattatt
     1081 ggccgtgttc atctagctca gattcaaatt gaaggtgatt tcttacagtg ctctttctcc
     1141 atacttgagg atcaacccat ggatatgctt ctaggcctag atatgctccg gagacatcaa
     1201 tgttccatcg atttgaagaa aaatgtgctg gtcatcggca ccactggcac gcagacttat
     1261 tttcttcctg agggagagtt gcccttatgc tctaggatgg taagtgggca agatgagtct
     1321 tcggacaagg aaattacaca ttcagtcatg gattcaggac gaaaagagca ttaaagcacg
     1381 ttataaatat gttaccacct tgagggagcc tcaggtcccc ggcaattata agttaagagc
     1441 ttactggcaa tgtaatcatt aaaaaacatc agtaacaact aaacctggcc ttgggactac
     1501 gttctcagat gggtaactaa cgtcaatcct gattccttgg tcttggtccc tcttccattt
     1561 cccttgtcca gagatcactg aaaggcatcc tgggaaggct ctggaggctc cagctgattt
     1621 ccagataatc catgaaaaag aaaaccagct tcttccttta gagacactat cctatcagat
     1681 tacaggtggc ttatccaaat cattgctatt ttgcagaatt ccctggaaaa atgctatggc
     1741 tgcagacctt acaaggcatc cacataaaac tatttcacat cagcactaat aattctttct
     1801 actgagagaa atatgcccat tttcacaggt tttgttttct ttgggaaggg tattagaaat
     1861 ggtaggtcag ttacactatg atgttaacta atacttatac atgtctgttt ggggcagcat
     1921 aaagaccaat ttcctcatat ttacaccttc ccttcccctg gatcccctgc agtcaccctg
     1981 caatccacag ctaaagacta tttttgccat atttgagaaa gtggatttat ctccaaggat
     2041 gctacattaa ttttctattt ctcctgcatt caaagaaact ctggctataa aacaaaggca
     2101 ataaattaga ttttttaaaa aagaaattat ggtacttctt gggagtcaag ttgtacagtg
     2161 gtgggaatga gaggtgggga caggcagtgg tccaggttct ctaatagtca ttgcaactag
     2221 atcatctctc tctctttttc aaagtaaaaa tctgctttat acattaagct gctgctacat
     2281 cagtattgtt tgaacaaagg ttttcactgt taaaataaca tttgaaaact tttgaatgag
     2341 aagatctcta aggcctcatt cagaattatc cattctgaca atgttagtgt ttattacaac
     2401 tgacagtggg taatggaaga tcctagactt aattacaacc catggctaaa gcacctgaga
     2461 gaaaagtttc agcttcctga ggccatcaga tgcaggggaa atgtttcagg acaataattt
     2521 atcaaaacta gtattaaaac agcggattca aaatcaa
//
