LOCUS       NM_001923               4245 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens damage specific DNA binding protein 1 (DDB1), mRNA.
ACCESSION   NM_001923 XM_938117 XM_943548 XM_943551 XM_943552 XM_943557
VERSION     NM_001923.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Gu,Q., Chang,Y., Jin,Y., Fang,J., Ji,T., Lin,J., Zhu,X., Dong,B.,
            Ying,H., Fan,X., Li,Z., Gao,Z., Zhu,Y., Tong,Y. and Cai,X.
  TITLE     Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but
            aggravates liver inflammation and fibrosis in MASH
  JOURNAL   Hepatol Commun 8 (7), e0474 (2024)
   PUBMED   38934719
  REMARK    GeneRIF: Hepatocyte-specific loss of DDB1 attenuates hepatic
            steatosis but aggravates liver inflammation and fibrosis in MASH.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Wu,R., Wu,X., Zou,L., Zhou,L. and Mao,Y.
  TITLE     DDB1 regulates the activation-induced apoptosis of T cells via
            downregulating the expression of histone methyltransferase SETD7
  JOURNAL   Med Oncol 40 (5), 146 (2023)
   PUBMED   37043057
  REMARK    GeneRIF: DDB1 regulates the activation-induced apoptosis of T cells
            via downregulating the expression of histone methyltransferase
            SETD7.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Wick,E.T., Treadway,C.J., Li,Z., Nicely,N.I., Ren,Z., Baldwin,A.S.,
            Xiong,Y., Harrison,J.S. and Brown,N.G.
  TITLE     Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through
            Structural Analysis of the pUL145-DDB1 Complex
  JOURNAL   J Virol 96 (17), e0082622 (2022)
   PUBMED   35938868
  REMARK    GeneRIF: Insight into Viral Hijacking of CRL4 Ubiquitin Ligase
            through Structural Analysis of the pUL145-DDB1 Complex.
REFERENCE   4  (bases 1 to 4245)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4245)
  AUTHORS   Zhang,Y., Yu,H., Zhang,J., Gao,H., Wang,S., Li,S., Wei,P.,
            Liang,J., Yu,G., Wang,X., Li,X., Li,D. and Yang,W.
  TITLE     Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate
            dehydrogenase promotes colorectal cancer metastasis via increased
            S-adenosylmethionine
  JOURNAL   J Clin Invest 131 (21) (2021)
   PUBMED   34720086
  REMARK    GeneRIF: Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate
            dehydrogenase promotes colorectal cancer metastasis via increased
            S-adenosylmethionine.
REFERENCE   6  (bases 1 to 4245)
  AUTHORS   Dualan,R., Brody,T., Keeney,S., Nichols,A.F., Admon,A. and Linn,S.
  TITLE     Chromosomal localization and cDNA cloning of the genes (DDB1 and
            DDB2) for the p127 and p48 subunits of a human damage-specific DNA
            binding protein
  JOURNAL   Genomics 29 (1), 62-69 (1995)
   PUBMED   8530102
REFERENCE   7  (bases 1 to 4245)
  AUTHORS   Lee,T.H., Elledge,S.J. and Butel,J.S.
  TITLE     Hepatitis B virus X protein interacts with a probable cellular DNA
            repair protein
  JOURNAL   J Virol 69 (2), 1107-1114 (1995)
   PUBMED   7815490
REFERENCE   8  (bases 1 to 4245)
  AUTHORS   Keeney,S., Eker,A.P., Brody,T., Vermeulen,W., Bootsma,D.,
            Hoeijmakers,J.H. and Linn,S.
  TITLE     Correction of the DNA repair defect in xeroderma pigmentosum group
            E by injection of a DNA damage-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 91 (9), 4053-4056 (1994)
   PUBMED   8171034
REFERENCE   9  (bases 1 to 4245)
  AUTHORS   Keeney,S., Chang,G.J. and Linn,S.
  TITLE     Characterization of a human DNA damage binding protein implicated
            in xeroderma pigmentosum E
  JOURNAL   J Biol Chem 268 (28), 21293-21300 (1993)
   PUBMED   8407967
REFERENCE   10 (bases 1 to 4245)
  AUTHORS   Chu,G. and Chang,E.
  TITLE     Xeroderma pigmentosum group E cells lack a nuclear factor that
            binds to damaged DNA
  JOURNAL   Science 242 (4878), 564-567 (1988)
   PUBMED   3175673
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050530.1 and AA665872.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001923.4.
            
            Summary: The protein encoded by this gene is the large subunit
            (p127) of the heterodimeric DNA damage-binding (DDB) complex while
            another protein (p48) forms the small subunit. This protein complex
            functions in nucleotide-excision repair and binds to DNA following
            UV damage. Defective activity of this complex causes the repair
            defect in patients with xeroderma pigmentosum complementation group
            E (XPE) - an autosomal recessive disorder characterized by
            photosensitivity and early onset of carcinomas. However, it remains
            for mutation analysis to demonstrate whether the defect in XPE
            patients is in this gene or the gene encoding the small subunit. In
            addition, Best vitelliform mascular dystrophy is mapped to the same
            region as this gene on 11q, but no sequence alternations of this
            gene are demonstrated in Best disease patients. The protein encoded
            by this gene also functions as an adaptor molecule for the cullin 4
            (CUL4) ubiquitin E3 ligase complex by facilitating the binding of
            substrates to this complex and the ubiquitination of proteins.
            [provided by RefSeq, May 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050530.1, U32986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301764.12/ ENSP00000301764.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4241              BC050530.1         1-4241
            4242-4245           AA665872.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..4245
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /note="damage specific DNA binding protein 1"
                     /db_xref="GeneID:1642"
                     /db_xref="HGNC:HGNC:2717"
                     /db_xref="MIM:600045"
     exon            1..198
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3560
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /note="DDB p127 subunit; damage-specific DNA binding
                     protein 1, 127kDa; XAP-1; UV-DDB 1; XPE-binding factor;
                     HBV X-associated protein 1; DNA damage-binding protein a;
                     UV-damaged DNA-binding factor; UV-damaged DNA-binding
                     protein 1; xeroderma pigmentosum group E-complementing
                     protein"
                     /codon_start=1
                     /product="DNA damage-binding protein 1"
                     /protein_id="NP_001914.3"
                     /db_xref="CCDS:CCDS31576.1"
                     /db_xref="GeneID:1642"
                     /db_xref="HGNC:HGNC:2717"
                     /db_xref="MIM:600045"
                     /translation="MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVV
                     TAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIIT
                     RAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLE
                     ELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASM
                     VIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDM
                     EGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLV
                     KLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRN
                     GIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMG
                     FVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQV
                     VVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISA
                     RILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLS
                     DRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPL
                     NSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRI
                     EVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHT
                     FEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDG
                     KLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYL
                     KTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAF
                     NLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLF
                     GTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGF
                     IDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH"
     exon            199..347
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            348..464
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            465..686
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            687..801
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            802..899
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1058
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1142
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1259
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1362
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1438
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1547
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1726
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1890
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1998
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2206
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2302
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2414
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2538
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2703
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2798
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2969
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3079
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3249
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3352
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3476
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..4245
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4222..4227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /note="hexamer: AATAAA"
     polyA_site      4245
                     /gene="DDB1"
                     /gene_synonym="DDBA; UV-DDB1; WHIKERS; XAP1; XPCE; XPE;
                     XPE-BF"
                     /note="major polyA site"
ORIGIN      
        1 ggcctgcaac gtgtctctgg ggcggaggca gcggcagtgg agttcgctgc gcgctgttgg
       61 gggccacctg tcttttcgct tgtgtccctc tttctagtgt cgcgctcgag tcccgacggg
      121 ccgctccaag cctcgacatg tcgtacaact acgtggtaac ggcccagaag cccaccgccg
      181 tgaacggctg cgtgaccgga cactttactt cggccgaaga cttaaacctg ttgattgcca
      241 aaaacacgag attagagatc tatgtggtca ccgccgaggg gcttcggccc gtcaaagagg
      301 tgggcatgta tgggaagatt gcggtcatgg agcttttcag gcccaagggg gagagcaagg
      361 acctgctgtt tatcttgaca gcgaagtaca atgcctgcat cctggagtat aaacagagtg
      421 gcgagagcat tgacatcatt acgcgagccc atggcaatgt ccaggaccgc attggccgcc
      481 cctcagagac cggcattatt ggcatcattg accctgagtg ccggatgatt ggcctgcgtc
      541 tctatgatgg ccttttcaag gttattccac tagatcgcga taataaagaa ctcaaggcct
      601 tcaacatccg cctggaggag ctgcatgtca ttgatgtcaa gttcctatat ggttgccaag
      661 cacctactat ttgctttgtc taccaggacc ctcaggggcg gcacgtaaaa acctatgagg
      721 tgtctctccg agaaaaggaa ttcaataagg gcccttggaa acaggaaaat gtcgaagctg
      781 aagcttccat ggtgatcgca gtcccagagc cctttggggg ggccatcatc attggacagg
      841 agtcaatcac ctatcacaat ggtgacaaat acctggctat tgcccctcct atcatcaagc
      901 aaagcacgat tgtgtgccac aatcgagtgg accctaatgg ctcaagatac ctgctgggag
      961 acatggaagg ccggctcttc atgctgcttt tggagaagga ggaacagatg gatggcaccg
     1021 tcactctcaa ggatctccgt gtagaactcc ttggagagac ctctattgct gagtgcttga
     1081 cataccttga taatggtgtt gtgtttgtcg ggtctcgcct gggtgactcc cagcttgtga
     1141 agctcaacgt tgacagtaat gaacaaggct cctatgtagt ggccatggaa acctttacca
     1201 acttaggacc cattgtcgat atgtgcgtgg tggacctgga gaggcagggg caggggcagc
     1261 tggtcacttg ctctggggct ttcaaggaag gttctttgcg gatcatccgg aatggaattg
     1321 gaatccacga gcatgccagc attgacttac caggcatcaa aggattatgg ccactgcggt
     1381 ctgaccctaa tcgtgagact gatgacactt tggtgctctc ttttgtgggc cagacaagag
     1441 ttctcatgtt aaatggagag gaggtagaag aaaccgaact gatgggtttc gtggatgatc
     1501 agcagacttt cttctgtggc aacgtggctc atcagcagct tatccagatc acttcagcat
     1561 cggtgaggtt ggtctctcaa gaacccaaag ctctggtcag tgaatggaag gagcctcagg
     1621 ccaagaacat cagtgtggcc tcctgcaata gcagccaggt ggtggtggct gtaggcaggg
     1681 ccctctacta tctgcagatc catcctcagg agctccggca gatcagccac acagagatgg
     1741 aacatgaagt ggcttgcttg gacatcaccc cattaggaga cagcaatgga ctgtcccctc
     1801 tttgtgccat tggcctctgg acggacatct cggctcgtat cttgaagttg ccctcttttg
     1861 aactactgca caaggagatg ctgggtggag agatcattcc tcgctccatc ctgatgacca
     1921 cctttgagag tagccattac ctcctttgtg ccttgggaga tggagcgctt ttctactttg
     1981 ggctcaacat tgagacaggt ctgttgagcg accgtaagaa ggtgactttg ggcacccagc
     2041 ccaccgtatt gaggactttt cgttctcttt ctaccaccaa cgtctttgct tgttctgacc
     2101 gccccactgt catctatagc agcaaccaca aattggtctt ctcaaatgtc aacctcaagg
     2161 aagtgaacta catgtgtccc ctcaattcag atggctatcc tgacagcctg gcgctggcca
     2221 acaatagcac cctcaccatt ggcaccatcg atgagatcca gaagctgcac attcgcacag
     2281 ttcccctcta tgagtctcca aggaagatct gctaccagga agtgtcccag tgtttcgggg
     2341 tcctctccag ccgcattgaa gtccaagaca cgagtggggg cacgacagcc ttgaggccca
     2401 gcgctagcac ccaggctctg tccagcagtg taagctccag caagctgttc tccagcagca
     2461 ctgctcctca tgagacctcc tttggagaag aggtggaggt gcacaaccta cttatcattg
     2521 accaacacac ctttgaagtg cttcatgccc accagtttct gcagaatgaa tatgccctca
     2581 gtctggtttc ctgcaagctg ggcaaagacc ccaacactta cttcattgtg ggcacagcaa
     2641 tggtgtatcc tgaagaggca gagcccaagc agggtcgcat tgtggtcttt cagtattcgg
     2701 atggaaaact acagactgtg gctgaaaagg aagtgaaagg ggccgtgtac tctatggtgg
     2761 aatttaacgg gaagctgtta gccagcatca atagcacggt gcggctctat gagtggacaa
     2821 cagagaagga gctgcgcact gagtgcaacc actacaacaa catcatggcc ctctacctga
     2881 agaccaaggg cgacttcatc ctggtgggcg accttatgcg ctcagtgctg ctgcttgcct
     2941 acaagcccat ggaaggaaac tttgaagaga ttgctcgaga ctttaatccc aactggatga
     3001 gtgctgtgga aatcttggat gatgacaatt ttctgggggc tgaaaatgcc tttaacttgt
     3061 ttgtgtgtca aaaggatagc gctgccacca ctgacgagga gcggcagcac ctccaggagg
     3121 ttggtctttt ccacctgggc gagtttgtca atgtcttttg ccacggctct ctggtaatgc
     3181 agaatctggg tgagacttcc acccccacac aaggctcggt gctcttcggc acggtcaacg
     3241 gcatgatagg gctggtgacc tcactgtcag agagctggta caacctcctg ctggacatgc
     3301 agaatcgact caataaagtc atcaaaagtg tggggaagat cgagcactcc ttctggagat
     3361 cctttcacac cgagcggaag acagaaccag ccacaggttt catcgacggt gacttgattg
     3421 agagtttcct ggatattagc cgccccaaga tgcaggaggt ggtggcaaac ctacagtatg
     3481 acgatggcag cggtatgaag cgagaggcca ctgcagacga cctcatcaag gttgtggagg
     3541 agctaactcg gatccattag ccaagggcag ggggcccctt tgctgaccct ccccaaaggc
     3601 tttgccctgc tgccctcccc ctcctctcca ccatcgtctt cttggccatg ggaggccttt
     3661 ccctaagcca gctgccccca gagccacagt tcccctatgt ggaagtgggg cgggcttcat
     3721 agagacttgg gaatgagctg aaggtgaaac attttctccc tggattttta ccagtctcac
     3781 atgattccag ccatcacctt agaccaccaa gccttgattg gtgttgccag ttgtcctcct
     3841 tccggggaag gattttgcag ttctttggct gaaaggaagc tgtgcgtgtg tgtgtgtgta
     3901 tgtgtgtgtg tgtatgtgta tctcacactc atgcattgtc ctctttttat ttagattggc
     3961 agtgtaggga gttgtgggta gtggggaaga gggttaggag ggtttcattg tctgtgaagt
     4021 gagaccttcc ttttactttt cttctattgc ctctgagagc atcaggccta gaggcctgac
     4081 tgccaagcca tgggtagcct gggtgtaaaa cctggagatg gtggatgatc cccacgccac
     4141 agcccttttg tctctgcaaa ctgccttctt cggaaagaag aaggtgggag gatgtgaatt
     4201 gttagtttct gagttttacc aaataaagta gaatataaga agaaa
//
