LOCUS       NM_001303007            1193 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DDAH family member 2, ADMA-independent (DDAH2),
            transcript variant 1, mRNA.
ACCESSION   NM_001303007
VERSION     NM_001303007.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1193)
  AUTHORS   Mendes,F.S., Luizon,M.R., Lopes,A.C.D.S., Pereira,D.A.,
            Evangelista,F.C.G., Godoi,L.C., Dusse,L.M. and Alpoim,P.N.
  TITLE     Early and late-onset preeclampsia: effects of DDAH2 polymorphisms
            on ADMA levels and association with DDAH2 haplotypes
  JOURNAL   Rev Bras Ginecol Obstet 46 (2024)
   PUBMED   38765527
  REMARK    GeneRIF: Early and late-onset preeclampsia: effects of DDAH2
            polymorphisms on ADMA levels and association with DDAH2 haplotypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1193)
  AUTHORS   Ragavan,V.N., Nair,P.C., Jarzebska,N., Angom,R.S., Ruta,L.,
            Bianconi,E., Grottelli,S., Tararova,N.D., Ryazanskiy,D.,
            Lentz,S.R., Tommasi,S., Martens-Lobenhoffer,J., Suzuki-Yamamoto,T.,
            Kimoto,M., Rubets,E., Chau,S., Chen,Y., Hu,X., Bernhardt,N.,
            Spieth,P.M., Weiss,N., Bornstein,S.R., Mukhopadhyay,D.,
            Bode-Boger,S.M., Maas,R., Wang,Y., Macchiarulo,A., Mangoni,A.A.,
            Cellini,B. and Rodionov,R.N.
  TITLE     A multicentric consortium study demonstrates that dimethylarginine
            dimethylaminohydrolase 2 is not a dimethylarginine
            dimethylaminohydrolase
  JOURNAL   Nat Commun 14 (1), 3392 (2023)
   PUBMED   37296100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1193)
  AUTHORS   Kozlova,A.A., Vaganova,A.N., Rodionov,R.N., Gainetdinov,R.R. and
            Bernhardt,N.
  TITLE     Assessment of DDAH1 and DDAH2 Contributions to Psychiatric
            Disorders via In Silico Methods
  JOURNAL   Int J Mol Sci 23 (19), 11902 (2022)
   PUBMED   36233204
  REMARK    GeneRIF: Assessment of DDAH1 and DDAH2 Contributions to Psychiatric
            Disorders via In Silico Methods.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1193)
  AUTHORS   Faramarzi,E., Aftabi,Y., Ansarin,K., Somi,M.H., Gilani,N. and
            Seyedrezazadeh,E.
  TITLE     Polymorphism (-499C/G) in DDAH2 promoter may act as a protective
            factor for metabolic syndrome: A case-control study in Azar-Cohort
            population
  JOURNAL   Arch Endocrinol Metab 65 (4), 443-449 (2021)
   PUBMED   34283907
  REMARK    GeneRIF: Polymorphism (-499C/G) in DDAH2 promoter may act as a
            protective factor for metabolic syndrome: A case-control study in
            Azar-Cohort population.
REFERENCE   5  (bases 1 to 1193)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1193)
  AUTHORS   Cillero-Pastor,B., Mateos,J., Fernandez-Lopez,C., Oreiro,N.,
            Ruiz-Romero,C. and Blanco,F.J.
  TITLE     Dimethylarginine dimethylaminohydrolase 2, a newly identified
            mitochondrial protein modulating nitric oxide synthesis in normal
            human chondrocytes
  JOURNAL   Arthritis Rheum 64 (1), 204-212 (2012)
   PUBMED   21898353
  REMARK    GeneRIF: DDAH-2 could play an important role in IL-1beta-induced NO
            production and in osteoarthritis pathogenesis.
REFERENCE   7  (bases 1 to 1193)
  AUTHORS   Birdsey,G.M., Leiper,J.M. and Vallance,P.
  TITLE     Intracellular localization of dimethylarginine
            dimethylaminohydrolase overexpressed in an endothelial cell line
  JOURNAL   Acta Physiol Scand 168 (1), 73-79 (2000)
   PUBMED   10691782
REFERENCE   8  (bases 1 to 1193)
  AUTHORS   Leiper,J.M., Santa Maria,J., Chubb,A., MacAllister,R.J.,
            Charles,I.G., Whitley,G.S. and Vallance,P.
  TITLE     Identification of two human dimethylarginine
            dimethylaminohydrolases with distinct tissue distributions and
            homology with microbial arginine deiminases
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 209-214 (1999)
   PUBMED   10493931
REFERENCE   9  (bases 1 to 1193)
  AUTHORS   Ribas,G., Neville,M., Wixon,J.L., Cheng,J. and Campbell,R.D.
  TITLE     Genes encoding three new members of the leukocyte antigen 6
            superfamily and a novel member of Ig superfamily, together with
            genes encoding the regulatory nuclear chloride ion channel protein
            (hRNCC) and an N omega-N omega-dimethylarginine
            dimethylaminohydrolase homologue, are found in a 30-kb segment of
            the MHC class III region
  JOURNAL   J Immunol 163 (1), 278-287 (1999)
   PUBMED   10384126
REFERENCE   10 (bases 1 to 1193)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK026191.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001303007.1.
            
            Summary: This gene encodes a dimethylarginine
            dimethylaminohydrolase. The encoded enzyme functions in nitric
            oxide generation by regulating the cellular concentrations of
            methylarginines, which in turn inhibit nitric oxide synthase
            activity. The protein may be localized to the mitochondria.
            Alternative splicing resulting in multiple transcript variants.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026191.1, SRR1163658.234091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 21898353
            MANE Ensembl match                 :: ENST00000375789.7/
                                                  ENSP00000364945.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1193              AK026191.1         494-1686
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1193
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /note="DDAH family member 2, ADMA-independent"
                     /db_xref="GeneID:23564"
                     /db_xref="HGNC:HGNC:2716"
                     /db_xref="MIM:604744"
     exon            1..435
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..996
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /EC_number="3.5.3.18"
                     /note="dimethylarginine dimethylaminohydrolase II;
                     n(G),N(G)-dimethylarginine dimethylaminohydrolase 2;
                     S-phase protein; dimethylargininase-2; epididymis
                     secretory protein Li 277; testis tissue sperm-binding
                     protein Li 54e; inactive dimethylarginine
                     dimethylaminohydrolase 2; inactive
                     N(G),N(G)-dimethylarginine dimethylaminohydrolase 2"
                     /codon_start=1
                     /product="putative hydrolase DDAH2"
                     /protein_id="NP_001289936.1"
                     /db_xref="CCDS:CCDS4718.1"
                     /db_xref="GeneID:23564"
                     /db_xref="HGNC:HGNC:2716"
                     /db_xref="MIM:604744"
                     /translation="MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQRE
                     HGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDG
                     VRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFA
                     VSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAA
                     DCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLC
                     LVLSTRPHS"
     exon            436..535
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            536..609
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            610..729
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            730..879
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1193
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1171..1176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /note="hexamer: AATAAA"
     polyA_site      1193
                     /gene="DDAH2"
                     /gene_synonym="DDAH; DDAHII; G6a; HEL-S-277; NG30"
                     /note="major polyA site"
ORIGIN      
        1 gctcttaacc acccccaacg cccttgtctg catgtctttt tctctgtctc ctccttttct
       61 gtttcttctc ccagacaggt gaagaaacaa gaaaactaag aaatccgagc ggttggaggg
      121 ggagtctgtg tggatgggat ggggacgccg ggggaggggc tgggccgctg ctcccatgcc
      181 ctgatccggg gagtcccaga gagcctggcg tcgggggaag gtgcgggggc tggccttccc
      241 gctctggatc tggccaaagc tcaaagggag cacggggtgc tgggaggtaa actgaggcaa
      301 cgactggggc tacagctgct agaactgcca cctgaggagt cattgccgct gggaccgctg
      361 cttggcgaca cggccgtgat ccaaggggac acggccctaa tcacgcggcc ctggagcccc
      421 gctcgtaggc cagaggtcga tggagtccgc aaagccctgc aagacctggg gctccgaatt
      481 gtggaaatag gagacgagaa cgcgacgctg gatggcactg acgttctctt caccggccgg
      541 gagtttttcg taggcctctc caaatggacc aatcaccgag gagctgagat cgtggcggac
      601 acgttccggg acttcgccgt ctccactgtg ccagtctcgg gtccctccca cctgcgcggt
      661 ctctgcggca tggggggacc tcgcactgtt gtggcaggca gcagcgacgc tgcccaaaag
      721 gctgtccggg caatggcagt gctgacagat cacccatatg cctccctgac cctcccagat
      781 gacgcagctg ctgactgtct ctttcttcgt cctgggttgc ctggtgtgcc ccctttcctc
      841 ctgcaccgtg gaggtgggga tctgcccaac agccaggagg cactgcagaa gctctctgat
      901 gtcaccctgg tacctgtgtc ctgctcagaa ctggagaagg ctggcgccgg gctcagctcc
      961 ctctgcttgg tgctcagcac acgcccccac agctgagggc ctggccttgg ggtactgctg
     1021 gccaggggta ggatagtata ggaagtagaa ggggaaggag ggttagatag agaatgctga
     1081 ataggcagta gttgggagag agcctcaata ttgggggagg ggagagtgta gggaaaagga
     1141 tccactgggt gaatcctccc tctcagaacc aataaaatag aattgacctt tta
//
