LOCUS       NM_012137               3939 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens dimethylarginine dimethylaminohydrolase 1 (DDAH1),
            transcript variant 1, mRNA.
ACCESSION   NM_012137
VERSION     NM_012137.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3939)
  AUTHORS   Bigiotti,C., Bianconi,E., Ruta,L., Grottelli,S., Coletti,A.,
            Dindo,M., Carotti,A., Cellini,B. and Macchiarulo,A.
  TITLE     Molecular Dynamics-Ensemble Docking and Biophysical Studies for
            Structure-Based Identification of Non-Amino Acidic Ligands of
            DDAH-1
  JOURNAL   J Chem Inf Model 64 (17), 6866-6879 (2024)
   PUBMED   39177258
  REMARK    GeneRIF: Molecular Dynamics-Ensemble Docking and Biophysical
            Studies for Structure-Based Identification of Non-Amino Acidic
            Ligands of DDAH-1.
REFERENCE   2  (bases 1 to 3939)
  AUTHORS   Asha Parveen,S.M., Kami Reddy,K.R. and Ummanni,R.
  TITLE     Dimethylarginine Dimethylaminohydrolase - 1 expression is increased
            under tBHP-induced oxidative stress regulates nitric oxide
            production in PCa cells attenuates mitochondrial ROS-mediated
            apoptosis
  JOURNAL   Nitric Oxide 138-139, 70-84 (2023)
   PUBMED   37423418
  REMARK    GeneRIF: Dimethylarginine Dimethylaminohydrolase - 1 expression is
            increased under tBHP-induced oxidative stress regulates nitric
            oxide production in PCa cells attenuates mitochondrial ROS-mediated
            apoptosis.
REFERENCE   3  (bases 1 to 3939)
  AUTHORS   Wu,M., Li,T., Li,G., Niu,B., Wu,T., Yan,L., Wang,S., He,S.,
            Huang,C., Tong,W., Li,N. and Jiang,J.
  TITLE     LncRNA DANCR deficiency promotes high glucose-induced endothelial
            to mesenchymal transition in cardiac microvascular cells via the
            FoxO1/DDAH1/ADMA signaling pathway
  JOURNAL   Eur J Pharmacol 950, 175732 (2023)
   PUBMED   37116560
  REMARK    GeneRIF: LncRNA DANCR deficiency promotes high glucose-induced
            endothelial to mesenchymal transition in cardiac microvascular
            cells via the FoxO1/DDAH1/ADMA signaling pathway.
REFERENCE   4  (bases 1 to 3939)
  AUTHORS   Ragavan,V.N., Nair,P.C., Jarzebska,N., Angom,R.S., Ruta,L.,
            Bianconi,E., Grottelli,S., Tararova,N.D., Ryazanskiy,D.,
            Lentz,S.R., Tommasi,S., Martens-Lobenhoffer,J., Suzuki-Yamamoto,T.,
            Kimoto,M., Rubets,E., Chau,S., Chen,Y., Hu,X., Bernhardt,N.,
            Spieth,P.M., Weiss,N., Bornstein,S.R., Mukhopadhyay,D.,
            Bode-Boger,S.M., Maas,R., Wang,Y., Macchiarulo,A., Mangoni,A.A.,
            Cellini,B. and Rodionov,R.N.
  TITLE     A multicentric consortium study demonstrates that dimethylarginine
            dimethylaminohydrolase 2 is not a dimethylarginine
            dimethylaminohydrolase
  JOURNAL   Nat Commun 14 (1), 3392 (2023)
   PUBMED   37296100
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3939)
  AUTHORS   Wang,S., Deng,Z., Zhang,H., Zhang,R., Yan,D., Zheng,X., Jia,W. and
            Hu,C.
  TITLE     The effect of haptoglobin genotype on the association of asymmetric
            dimethylarginine and DDAH 1 polymorphism with diabetic
            macroangiopathy
  JOURNAL   Cardiovasc Diabetol 21 (1), 265 (2022)
   PUBMED   36461077
  REMARK    GeneRIF: The effect of haptoglobin genotype on the association of
            asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic
            macroangiopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3939)
  AUTHORS   Birdsey,G.M., Leiper,J.M. and Vallance,P.
  TITLE     Intracellular localization of dimethylarginine
            dimethylaminohydrolase overexpressed in an endothelial cell line
  JOURNAL   Acta Physiol Scand 168 (1), 73-79 (2000)
   PUBMED   10691782
REFERENCE   7  (bases 1 to 3939)
  AUTHORS   Leiper,J.M., Santa Maria,J., Chubb,A., MacAllister,R.J.,
            Charles,I.G., Whitley,G.S. and Vallance,P.
  TITLE     Identification of two human dimethylarginine
            dimethylaminohydrolases with distinct tissue distributions and
            homology with microbial arginine deiminases
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 209-214 (1999)
   PUBMED   10493931
REFERENCE   8  (bases 1 to 3939)
  AUTHORS   Kimoto,M., Miyatake,S., Sasagawa,T., Yamashita,H., Okita,M.,
            Oka,T., Ogawa,T. and Tsuji,H.
  TITLE     Purification, cDNA cloning and expression of human
            NG,NG-dimethylarginine dimethylaminohydrolase
  JOURNAL   Eur J Biochem 258 (2), 863-868 (1998)
   PUBMED   9874257
REFERENCE   9  (bases 1 to 3939)
  AUTHORS   MacAllister,R.J., Parry,H., Kimoto,M., Ogawa,T., Russell,R.J.,
            Hodson,H., Whitley,G.S. and Vallance,P.
  TITLE     Regulation of nitric oxide synthesis by dimethylarginine
            dimethylaminohydrolase
  JOURNAL   Br J Pharmacol 119 (8), 1533-1540 (1996)
   PUBMED   8982498
REFERENCE   10 (bases 1 to 3939)
  AUTHORS   Kimoto,M., Whitley,G.S., Tsuji,H. and Ogawa,T.
  TITLE     Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human
            tissues using a monoclonal antibody
  JOURNAL   J Biochem 117 (2), 237-238 (1995)
   PUBMED   7608105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC324361.1, AK312432.1,
            BX648145.1 and AW051386.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012137.3.
            
            Summary: This gene belongs to the dimethylarginine
            dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays
            a role in nitric oxide generation by regulating cellular
            concentrations of methylarginines, which in turn inhibit nitric
            oxide synthase activity. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043235.2, SRR1803617.202507.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284031.13/ ENSP00000284031.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DC324361.1         48-80
            34-972              AK312432.1         42-980
            973-1355            BX648145.1         939-1321
            1356-1834           AW051386.1         3-481
            1835-2556           BX648145.1         1798-2519
            2557-3939           BX648145.1         2521-3903
FEATURES             Location/Qualifiers
     source          1..3939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..3939
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /note="dimethylarginine dimethylaminohydrolase 1"
                     /db_xref="GeneID:23576"
                     /db_xref="HGNC:HGNC:2715"
                     /db_xref="MIM:604743"
     exon            1..417
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..972
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /EC_number="3.5.3.18"
                     /note="isoform 1 is encoded by transcript variant 1; NG,
                     NG-dimethylarginine dimethylaminohydrolase;
                     n(G),N(G)-dimethylarginine dimethylaminohydrolase 1;
                     epididymis secretory protein Li 16; dimethylargininase-1"
                     /codon_start=1
                     /product="N(G),N(G)-dimethylarginine
                     dimethylaminohydrolase 1 isoform 1"
                     /protein_id="NP_036269.1"
                     /db_xref="CCDS:CCDS705.1"
                     /db_xref="GeneID:23576"
                     /db_xref="HGNC:HGNC:2715"
                     /db_xref="MIM:604743"
                     /translation="MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAE
                     RQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEV
                     DMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKD
                     YAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDI
                     AANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCS
                     VLINKKVDS"
     exon            418..517
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /inference="alignment:Splign:2.1.0"
     exon            518..591
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /inference="alignment:Splign:2.1.0"
     exon            592..711
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /inference="alignment:Splign:2.1.0"
     exon            712..855
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /inference="alignment:Splign:2.1.0"
     exon            856..3939
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /note="hexamer: AATAAA"
     polyA_site      3939
                     /gene="DDAH1"
                     /gene_synonym="DDAH; DDAH-1; DDAHI; HEL-S-16"
                     /note="major polyA site"
ORIGIN      
        1 acattcagcg gctgccaaga ggagccgacg ggcgctcgca ggctcagcgc gcgctgcccg
       61 cggcaggacc cggccgcctc cgccgccgcc gccgccccta agcctcccga agccatggcc
      121 gggctcggcc accccgccgc cttcggccgg gccacccacg ccgtggtgcg ggcgctaccc
      181 gagtcgctcg gccagcacgc gctgagaagc gccaagggcg aggaggtgga cgtcgcccgc
      241 gcggaacggc agcaccagct ctacgtgggc gtgctgggca gcaagctggg gctgcaggtg
      301 gtggagctgc cggccgacga gagccttccg gactgcgtct tcgtggagga cgtggccgtg
      361 gtgtgcgagg agacggccct catcacccga cccggggcgc cgagccggag gaaggaggtt
      421 gacatgatga aagaagcatt agaaaaactt cagctcaata tagtagagat gaaagatgaa
      481 aatgcaactt tagatggcgg agatgtttta ttcacaggca gagaattttt tgtgggcctt
      541 tccaaaagga caaatcaacg aggtgctgaa atcttggctg atacttttaa ggactatgca
      601 gtctccacag tgccagtggc agatgggttg catttgaaga gtttctgcag catggctggg
      661 cctaacctga tcgcaattgg gtctagtgaa tctgcacaga aggcccttaa gatcatgcaa
      721 cagatgagtg accaccgcta cgacaaactc actgtgcctg atgacatagc agcaaactgt
      781 atatatctaa atatccccaa caaagggcac gtcttgctgc accgaacccc ggaagagtat
      841 ccagaaagtg caaaggttta tgagaaactg aaggaccata tgctgatccc cgtgagcatg
      901 tctgaactgg aaaaggtgga tgggctgctc acctgctgct cagttttaat taacaagaaa
      961 gtagactcct gagctgcaga gtcccccccg gtagccggca agaccgcaca ggcaaggccg
     1021 atgactctgt gcccactcct gttgttttcc ttgacaatct actgtgccac tgtgctacta
     1081 actcttgttt acaaaatttg attctaagtt gaattgcttc attcaacacc cccaccctcc
     1141 ctcccctcga ggtggtacct aagctgtgga tttgctaaat gaattaagca acctagaaga
     1201 tacagagcta atgaattatc aaaatgtgat taatcccagt aaggaaacac tcatttagtg
     1261 tctgtatttt tggtgtgaaa attatttagt tgccagtata ttctgaagaa tgtcttcttg
     1321 atcagtcaga taagcttgct tttttttttt ttttttttca tgaatcatgt ttggttcctg
     1381 tgaaagtccc tggtccaggg atcctcctcc tttctctttt acttctgaat tctgaaattc
     1441 agttagttac ttttgccttt cgctcttcta tcacagccac cttgaccttg ggtaaaaccc
     1501 aaggtctttc cttctggcta ccttcctgca ggtccaccct gtctgccatt ggtctcctct
     1561 gcctctgact acatctgcca ccaacaaccc tcccctcacc cctgccaggg gcagacaggc
     1621 ttctcagcag aactgtgact gaaatcagag ctgctgtctg gggcagtgtt aactacacag
     1681 aggcacatcc tgacagggtt tgccccagag atctaaattc cagaaggagg gcaccacacc
     1741 taggaaggta aatccagtat cagaaggttg ctaaaagatt aaagatcaag aagcttggaa
     1801 acatcccatg ggtacaatgt cttagaaagt ctttaagtca cataccatga atttttgctt
     1861 cattactgac catatatgac cttggaggaa ctcttttttt tttttccttc tactcatttc
     1921 tgtttccacc taccctgact caccgtattt ccagtcttct acccctgcag ttatcctagt
     1981 ccagcaaagt catttctttc aaaagagaca tcatgtctga aaataattac tggtagtcta
     2041 atatgagcca gagtaaacag ctcctcatgg tcaatgaaca tgttcaggaa gcgatcacct
     2101 tgatgcttga acccaacccc agacagtgga caattctact ttgaaatatc cgtgaatatt
     2161 tactgtggga tccaatttaa acttctttct tctctagcct ttaaattaca caactttgaa
     2221 ctgacacgga tctcttacaa agaacaatgc ggcactgaag gaagagatga ttcctttact
     2281 caaacctgca ggaatcagcc tattaacagg caggggaaac ggtactttcc aatgaatggt
     2341 aactgatcca ggcacattat cacacttcct agtcatctcc acctttcctg tattgcctgt
     2401 ggcttgttgt ttaagattaa gaatcaaaga gattaagaag tatcacttca aatcttgctc
     2461 tgctcacttc tatgtttgca gtcaaattat tccttatgtt ggtgacctaa agagaattac
     2521 tttcattcat ttcatttccc ccgtagcaga tggaaggaga aacctctgag aaaatgaaaa
     2581 catccttaac cactatcttt cccttttatt tgattatttt atgtcagaaa tttgcaaaag
     2641 tttttttctc ctccttctct tccttgttgc ttaacttttt aattcatgcc atatgcagat
     2701 atccaattat gtgcatcctg tgaataaacc acgtcttggt cactgtcata ttttgaacca
     2761 tctcatcaga gatgaataat atctttttac cagagagaga acgaatgtta gccacatgcc
     2821 caagttaaca aagaaaaaat gttctcaagg ttgtcctttt gggttaaatc tggcccttcc
     2881 ttggcaaaag caaaaattct ccctgtgaga gctcaacatc tcaaatacaa ccacaggaaa
     2941 aatggcccaa tctgccagtt taggcttacc agcatataat ttttaatatc tttacttcta
     3001 tcatcccaaa tcaaagaact cttctctatt atgtttaatc aattgcaagc aaatagattt
     3061 ttctttgtaa caatttgttc tgcagaaggc tgtttttcac ttttcctttc ttttgcttct
     3121 ttctgtcttt ccttctcttt tgtctggaga aatcacttag actctgtgtg cctcttctac
     3181 attgcattct gctctgctat gttacctgct aggctggctt ctttggactc cctatatgat
     3241 tgatgatgtg aaaacctaaa ttacttgcag catagtatta cttctttgat gttctcatta
     3301 gcataatgtt atttttgaaa aggaaagata ctatcacata agttttcctc atctgttgtg
     3361 atatacacca atggataaac taacggaaac tgctttttga cattaaaaga caggagaaat
     3421 tatatttaac taagtaaaag ttaagtcaga attacttggg tgatgtgatt caatttagtt
     3481 aaaggatgat atagagaaaa tacattattt agcattattt cttcagctat aatgaattgc
     3541 tatagaaatc aggcagatct ttctaatgtg tattgattgg tcttttcagc tactctgaac
     3601 agattactaa ggccatctcc tcatctctaa gggagaaaaa tagtctgtag atgaataatg
     3661 taaggtaaag agttgcatgt cagtctttgt aattatttac actttaactt tctccagaac
     3721 tcagacatga tttcaacatg gtgttagatt tgtgcatttt attttcctga ccacctcatt
     3781 ccagccaatg tatggttatc cactctgtgt gccaaaacca atcatgcctt tcacggccct
     3841 ttagttcaga gaagttctgc actgattttt agtctcttga tgtctcaatc ttacatgtat
     3901 accaatcaca atggaataaa gtgttgagtt gtactgtga
//
