LOCUS       NM_024050               4043 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DET1 and DDB1 associated 1 (DDA1), mRNA.
ACCESSION   NM_024050
VERSION     NM_024050.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Faust,T.B., Yoon,H., Nowak,R.P., Donovan,K.A., Li,Z., Cai,Q.,
            Eleuteri,N.A., Zhang,T., Gray,N.S. and Fischer,E.S.
  TITLE     Structural complementarity facilitates E7820-mediated degradation
            of RBM39 by DCAF15
  JOURNAL   Nat Chem Biol 16 (1), 7-14 (2020)
   PUBMED   31686031
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Shabek,N., Ruble,J., Waston,C.J., Garbutt,K.C., Hinds,T.R., Li,T.
            and Zheng,N.
  TITLE     Structural insights into DDA1 function as a core component of the
            CRL4-DDB1 ubiquitin ligase
  JOURNAL   Cell Discov 4, 67 (2018)
   PUBMED   30564455
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Olma,M.H., Roy,M., Le Bihan,T., Sumara,I., Maerki,S., Larsen,B.,
            Quadroni,M., Peter,M., Tyers,M. and Pintard,L.
  TITLE     An interaction network of the mammalian COP9 signalosome identifies
            Dda1 as a core subunit of multiple Cul4-based E3 ligases
  JOURNAL   J Cell Sci 122 (Pt 7), 1035-1044 (2009)
   PUBMED   19295130
  REMARK    GeneRIF: Cells depleted of Dda1 spontaneously accumulated
            double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or
            Wdr23-depleted cells, indicating that Dda1 interacts physically and
            functionally with cullin-RING E3 ligases complexes.
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Pick,E., Lau,O.S., Tsuge,T., Menon,S., Tong,Y., Dohmae,N.,
            Plafker,S.M., Deng,X.W. and Wei,N.
  TITLE     Mammalian DET1 regulates Cul4A activity and forms stable complexes
            with E2 ubiquitin-conjugating enzymes
  JOURNAL   Mol Cell Biol 27 (13), 4708-4719 (2007)
   PUBMED   17452440
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Li,Z.M., Wen,Y.J., Lai,S.T., Ni,R., Deng,H.X., Kan,B., Li,J.,
            Liu,J., Jing,X.M., Cheng,P., Shi,W. and Jia,Y.X.
  TITLE     [Searching for genes interacting with human PCIA1 gene by using the
            bacterial two-hybrid system]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24 (3), 279-283 (2007)
   PUBMED   17557237
  REMARK    GeneRIF: PCIA1 gene expression correlates with tumor formation,
            invasion and metastasis
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000615.2 and AC010463.6.
            
            On Nov 22, 2018 this sequence version replaced NM_024050.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic and transcript sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.14282.1,
                                           SRR1163657.15470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359866.9/ ENSP00000352928.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-625               BC000615.2         11-635
            626-4043            AC010463.6         51192-54609         c
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..4043
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /note="DET1 and DDB1 associated 1"
                     /db_xref="GeneID:79016"
                     /db_xref="HGNC:HGNC:28360"
     exon            1..95
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..401
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /note="cross-immune reaction antigen PCIA1; placenta
                     cross-immune reaction antigen 1"
                     /codon_start=1
                     /product="DET1- and DDB1-associated protein 1"
                     /protein_id="NP_076955.1"
                     /db_xref="CCDS:CCDS12357.1"
                     /db_xref="GeneID:79016"
                     /db_xref="HGNC:HGNC:28360"
                     /translation="MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSE
                     QIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT
                     "
     exon            96..176
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            177..228
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..290
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..4043
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1017..1022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /note="hexamer: AATAAA"
     polyA_site      1040
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /note="major polyA site"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
                     /note="hexamer: AATAAA"
     polyA_site      4043
                     /gene="DDA1"
                     /gene_synonym="C19orf58; PCIA1"
ORIGIN      
        1 aagttactgt gaggcggcgg ctaagaaggc ggctctggtg gcggcggtgg aggctgaggc
       61 ggcggccgag gcggcgacgg aggaaacaga agatggcaga ttttttgaaa ggactgcctg
      121 tctacaacaa aagcaatttt agtcgatttc acgcggactc cgtgtgcaaa gcctcgaacc
      181 gacggccctc agtctacctg cctacccgcg agtacccgtc tgaacagatc atcgtgacag
      241 aaaagacaaa catcctcctg cgctacctgc atcagcaatg ggacaaaaag aacgctgcca
      301 agaagagaga ccaggagcaa gtggagctgg aaggcgagag ctccgcacct ccccgcaagg
      361 tggcgcggac cgacagccca gacatgcacg aggacactta agactctcaa ctccacaggc
      421 gcctcctgcc aggtctgctc ctcggtcgcc cacccgcctg cccgccatgt gtaagcaccc
      481 cgcccgcccg cctccctgcc ggcccatcca caccctgcgt ccacaccact tccaacctca
      541 taggagccga tgtatttatt ttccttgagt ttttatttat gctgtaacct gtatcaagcg
      601 ttggttaaag gggacatcag acccagtagt gtgatgttgg tagatgcttt ttaaaaaaaa
      661 caacattgtc cccccgaccc ccgccttcca tcgggccagt tccccgattc ctgcccccag
      721 ttctccagag aaccagagtg tgtctgtgag agtctctagc gggggcttta ctgtggccgg
      781 gcgacagggg cgggcccggg gtggcctgac ctaccaggac agccgagtgg ccttctcccc
      841 cccaacaccg gtccaggcca ttgagactcg gtcttgtccc acgcttcgcc cggaactttc
      901 ccatgcccag gcctcactca gcgtgcacgc acgttgggga gaagtcggcc cttgggatct
      961 ttctcttgag tcattttatt tttatcatgg actagtgcgt gctccgtgtc caccccaata
     1021 aaagggtctt tcctacttga cctcgcgtct ttgctccaca caccttggct gcagaggacg
     1081 gagcccctgg gagtcatccc tgttgtcacc aagaggagtg agaagggccc cccacgccag
     1141 gggccccagg accggctgga ttctctcgtg ggcttgctga ggccaccatg ttcaaggcca
     1201 agacctgcct ggaccatccc ctctgcctct cctgtcaagg tgaccccaag gacaggtcat
     1261 tcctgagaga cggtccatgg tgccaaggat ggagcggggt cagccccctg cctgggatac
     1321 cgccaagcag ggcagcgcac ctgtcagaca ccgcagagat ggccggcctc atccgggggc
     1381 ctggggtctc tggcctctgc tgctcccctg aggcatggtg acagtacaga cggcatctgg
     1441 ccggtcttgc tgtcctaggt ggtggcctca cccttgctgg gtcatagagg agctgtacag
     1501 aaggttggca cctggcagtt ggcatgtgcc atggccgctc atggggaccc ctcttccgcc
     1561 agctgggctg ggtttggggc tgagcttggg tatgtagggg tgttcgggct ctgggcagaa
     1621 ggtttgtggc cctgaccact gagcctgggg ctgggggaac accgcttctc cccttattgc
     1681 ccccactggt ggtggtgggg atctcagttt tcttttgttt tgttttgttt gtttgtttga
     1741 gttggggtct tgtactcttt cccaggctgg agtgcagtgg cgtaatcaca gctcactgca
     1801 gcctcgacct caagccttcc tcccacctca gccttccaag ccgctgggac cacaggcacc
     1861 caccaccatg cctggctaat tttttttttt ttttgagatg gagtctcgct gtgtctccca
     1921 ggctggagtg cagtggcaag atctcagctc actacaacct ctgcctccca ggttcaagtg
     1981 attctcctac ctcagcctcc tgagtagctg ggattacacg cgtgcgcccc tacacccagc
     2041 taatttttct atttttagtg gagacggcgt tttgtcatgt tggccaggct ggtctcgaac
     2101 tcctgacctc aggtgcttcg cctgcctcgg cctcccaaag tgctgtgacc gcacctggct
     2161 gcctggctaa tattttaaaa attttttgta gagacagggt ttcaccatgt tgcccaggct
     2221 ggtctcaaac tcctgggctc aagtcatcca ccttcctcag cctcccaaag tgctggggtt
     2281 acagacgtga accaccgtgc ctggcagagg tctctgtttt gagagctgag tctgagggcg
     2341 ttgggatggt gtagggttgg gccacagagc tagcagacac tccgggctat ggagggtccg
     2401 cctgccccag attccactgt ggagggccct gcctgtgtca gaccctcggg cctaggcggc
     2461 ccatctctcc caaggacgga gagtgccagg gtgggctccc gtcctacaca aggagtggct
     2521 gaccaggccc aggcacagca cagccaccct gctgtacctc ccagctcccg gcagtgtcta
     2581 caccacagtg atggtgctac aggggccatg tggtcacagg acaggtggtc aggaaatgca
     2641 cacttgactg cggtcgatgg tgccgggtcc ggctgaatgc cctggaggct cccaggccag
     2701 ctggggagtc ccagtcccca gggttggtgt gacctgggca ggcctgcggt gtccatctgt
     2761 gaatgactga gatggtggga cttcagcttc caaggccagg ggccagagtg ggagcagggg
     2821 gcactcccgc ctttcccctc ggcctgtcta gacctctctg gctcccagtt tctgctttga
     2881 gtggctgggg gctgtctcct gcctgtgctg tctgcccgtc gctctgcagg gctgctgggc
     2941 gggcacctcc ttcccctccc ctacctcagc tccctccttt ggggtctgag ggctgtgccc
     3001 cagcttgcct ccctgtggcc tccccctaga acccctgggt ctgtcgggac atgccccacc
     3061 tggcacacac accctgtgta gctcccactg cctgtgggag gacgctgggc ccctgagccg
     3121 gcctctgtct acccctcctg cctttggggt cccctttacc ccactgttcc cccaaactgc
     3181 cttccacctt ctccgccttt gcacaggctg ttctcctgcc tccagtgaac tctgacttct
     3241 ccacagcctc ccaaagggcc ccttgctcac actggcccag ccctgcagca tggccatgtt
     3301 ggtctctgag ccttaagcct ttggatgtgg acacatttgt cctcttcctg aaaaatgtga
     3361 gggtctgaga ggccacgttc ctgttcctga gtcatacgac agagtcccag tgacttgggt
     3421 ctgatgtctg tcccacagtg ggacatccct gctgcatccc aatgccaccc cgtgtcctgg
     3481 ggacacccaa atgtgccatt ctctcagtat cacaagtcgg ggactgcagg aggctcaggt
     3541 gccaggtgcc ttctgatgtt catgccacaa gctcttccca ctgtctctgg ctccccagac
     3601 gatgttccag gaggcgggtg tgccagaagg ggccacgtct tgcaaaccac cgcgctgtcc
     3661 tctttgagaa ggagtcttac tcaggactgg ggcctgtgca cacattgtcg cctcttttca
     3721 gcacttagag attccttcct ttgtctagtg gctgaagcca gggctgaagt tggcctccaa
     3781 atctgggccg tctcagaggc ggcgcagcct ggagttttcc atctgtggcc aagacccagt
     3841 ttttgggagg aggccctcat gggtcaagcc agcctgtacc aggatggggg gagggggttc
     3901 ccaacctagg ccccagccac ccagactccc ccacccccac tcccttttcc actgctctga
     3961 cctcgggcac tgttgaaata tagtttttat tgcatttctg ccgttttaca aaaatatgac
     4021 aaaataaatt aaaaacaaat aaa
//
