LOCUS       NM_016286                852 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dicarbonyl and L-xylulose reductase (DCXR), transcript
            variant 1, mRNA.
ACCESSION   NM_016286
VERSION     NM_016286.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Jin,Y., Zhang,M., Tong,Y., Qiu,L., Ye,Y. and Zhao,B.
  TITLE     DCXR promotes cell proliferation by promoting the activity of
            aerobic glycolysis in breast cancer
  JOURNAL   Mol Med Rep 27 (2) (2023)
   PUBMED   36562355
  REMARK    GeneRIF: DCXR promotes cell proliferation by promoting the activity
            of aerobic glycolysis in breast cancer.
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 852)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Yang,S., Jan,Y.H., Mishin,V., Heck,D.E., Laskin,D.L. and
            Laskin,J.D.
  TITLE     Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in
            Lung Epithelial Cells
  JOURNAL   Chem Res Toxicol 30 (7), 1406-1418 (2017)
   PUBMED   28595002
  REMARK    GeneRIF: identification of DCXR as an enzyme activity mediating
            chemical redox cycling suggests that it may be important in
            generating cytotoxic reactive oxygen species in the lung
REFERENCE   6  (bases 1 to 852)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Xia,X.Y., Xu,X.F., Gao,Y. and Huang,Y.F.
  TITLE     [Molecular cloning of human sperm surface protein P34H gene and
            semi-quantitative analysis of its expression in testis and
            epididymidis]
  JOURNAL   Zhonghua Nan Ke Xue 9 (1), 24-27 (2003)
   PUBMED   12680326
REFERENCE   8  (bases 1 to 852)
  AUTHORS   El-Kabbani,O., Chung,R.P., Ishikura,S., Usami,N., Nakagawa,J. and
            Hara,A.
  TITLE     Crystallization and preliminary crystallographic analysis of human
            L-xylulose reductase
  JOURNAL   Acta Crystallogr D Biol Crystallogr 58 (Pt 8), 1379-1380 (2002)
   PUBMED   12136162
  REMARK    GeneRIF: crystallization and preliminary crystallographic analysis
REFERENCE   9  (bases 1 to 852)
  AUTHORS   Nakagawa,J., Ishikura,S., Asami,J., Isaji,T., Usami,N., Hara,A.,
            Sakurai,T., Tsuritani,K., Oda,K., Takahashi,M., Yoshimoto,M.,
            Otsuka,N. and Kitamura,K.
  TITLE     Molecular characterization of mammalian dicarbonyl/L-xylulose
            reductase and its localization in kidney
  JOURNAL   J Biol Chem 277 (20), 17883-17891 (2002)
   PUBMED   11882650
  REMARK    GeneRIF: highly expressed in kidney and liver
REFERENCE   10 (bases 1 to 852)
  AUTHORS   Legare,C., Gaudreault,C., St-Jacques,S. and Sullivan,R.
  TITLE     P34H sperm protein is preferentially expressed by the human corpus
            epididymidis
  JOURNAL   Endocrinology 140 (7), 3318-3327 (1999)
   PUBMED   10385429
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG434209.1, AF113123.1 and
            AC137723.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016286.3.
            
            Summary: The protein encoded by this gene acts as a homotetramer to
            catalyze diacetyl reductase and L-xylulose reductase reactions. The
            encoded protein may play a role in the uronate cycle of glucose
            metabolism and in the cellular osmoregulation in the proximal renal
            tubules. Defects in this gene are a cause of pentosuria. Two
            transcript variants encoding different isoforms have been found for
            this gene.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891392.1, SRR7410570.637394.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306869.7/ ENSP00000303356.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BG434209.1         1-12
            13-829              AF113123.1         1-817
            830-852             AC137723.6         54842-54864         c
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..852
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /note="dicarbonyl and L-xylulose reductase"
                     /db_xref="GeneID:51181"
                     /db_xref="HGNC:HGNC:18985"
                     /db_xref="MIM:608347"
     exon            1..67
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..750
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /EC_number="1.1.1.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kidney dicarbonyl reductase; dicarbonyl/L-xylulose
                     reductase; carbonyl reductase 2; carbonyl reductase II;
                     sperm surface protein P34H; short chain
                     dehydrogenase/reductase family 20C member 1; epididymis
                     secretory sperm binding protein; human carbonyl reductase
                     2"
                     /codon_start=1
                     /product="L-xylulose reductase isoform 1"
                     /protein_id="NP_057370.1"
                     /db_xref="CCDS:CCDS11799.1"
                     /db_xref="GeneID:51181"
                     /db_xref="HGNC:HGNC:18985"
                     /db_xref="MIM:608347"
                     /translation="MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADL
                     DSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDR
                     SFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT
                     KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNA
                     ILFLLSDRSGMTTGSTLPVEGGFWAC"
     exon            68..165
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            166..320
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            321..363
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            364..463
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            464..528
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            529..646
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            647..852
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      807..812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /note="hexamer: AATAAA"
     polyA_site      829
                     /gene="DCXR"
                     /gene_synonym="DCR; HCR2; HCRII; KIDCR; P34H; PNTSU;
                     SDR20C1; XR"
                     /note="major polyA site"
ORIGIN      
        1 ggagactgcg ccgacatgga gctgttcctc gcgggccgcc gggtgctggt caccggggca
       61 ggcaaaggta tagggcgcgg cacggtccag gcgctgcacg cgacgggcgc gcgggtggtg
      121 gctgtgagcc ggactcaggc ggatcttgac agccttgtcc gcgagtgccc ggggatagaa
      181 cccgtgtgcg tggacctggg tgactgggag gccaccgagc gggcgctggg cagcgtgggc
      241 cccgtggacc tgctggtgaa caacgccgct gtcgccctgc tgcagccctt cctggaggtc
      301 accaaggagg cctttgacag atcctttgag gtgaacctgc gtgcggtcat ccaggtgtcg
      361 cagattgtgg ccaggggctt aatagcccgg ggagtcccag gggccatcgt gaatgtctcc
      421 agccagtgct cccagcgggc agtaactaac catagcgtct actgctccac caagggtgcc
      481 ctggacatgc tgaccaaggt gatggcccta gagctcgggc cccacaagat ccgagtgaat
      541 gcagtaaacc ccacagtggt gatgacgtcc atgggccagg ccacctggag tgacccccac
      601 aaggccaaga ctatgctgaa ccgaatccca cttggcaagt ttgctgaggt agagcacgtg
      661 gtgaacgcca tcctctttct gctgagtgac cgaagtggca tgaccacggg ttccactttg
      721 ccggtggaag ggggcttctg ggcctgctga gctccctcca cacacctcaa gccccatgcc
      781 gtgctcatcc tacccccaat ccctccaata aacctgattc tgctgcccag actatgtgct
      841 attcctaggc tg
//
