LOCUS       NM_001369373            8973 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens doublecortin (DCX), transcript variant 9, mRNA.
ACCESSION   NM_001369373 XM_011530880
VERSION     NM_001369373.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8973)
  AUTHORS   Procopio,R., Fortunato,F., Gagliardi,M., Talarico,M., Sammarra,I.,
            Sarubbi,M.C., Malanga,D., Annesi,G. and Gambardella,A.
  TITLE     Phenotypic Variability in Novel Doublecortin Gene Variants
            Associated with Subcortical Band Heterotopia
  JOURNAL   Int J Mol Sci 25 (10), 5505 (2024)
   PUBMED   38791543
  REMARK    GeneRIF: Phenotypic Variability in Novel Doublecortin Gene Variants
            Associated with Subcortical Band Heterotopia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8973)
  AUTHORS   Cho,T.H., Kim,M., Kim,S.H., Lee,J.E., Kim,S.H., Kim,H.J.,
            Hong,J.E., Yeo,I.S. and Yang,H.M.
  TITLE     Reconsidering Neurogenetic Indication in the Human Brain: Broad
            Expression of Doublecortin Transcript in the Hippocampal and
            Cortical Cell Populations
  JOURNAL   Cells Tissues Organs 213 (5), 382-389 (2024)
   PUBMED   39191219
  REMARK    GeneRIF: Reconsidering Neurogenetic Indication in the Human Brain:
            Broad Expression of Doublecortin Transcript in the Hippocampal and
            Cortical Cell Populations.
REFERENCE   3  (bases 1 to 8973)
  AUTHORS   Lin,J.R., Cheng,J.F., Liu,Y.T., Hsu,T.R., Lin,K.M., Chen,C.,
            Lin,C.L., Tsai,M.H. and Tsai,J.W.
  TITLE     Novel lissencephaly-associated DCX variants in the C-terminal DCX
            domain affect microtubule binding and dynamics
  JOURNAL   Epilepsia 63 (5), 1253-1265 (2022)
   PUBMED   35213059
  REMARK    GeneRIF: Novel lissencephaly-associated DCX variants in the
            C-terminal DCX domain affect microtubule binding and dynamics.
REFERENCE   4  (bases 1 to 8973)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8973)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8973)
  AUTHORS   des Portes,V., Francis,F., Pinard,J.M., Desguerre,I., Moutard,M.L.,
            Snoeck,I., Meiners,L.C., Capron,F., Cusmai,R., Ricci,S., Motte,J.,
            Echenne,B., Ponsot,G., Dulac,O., Chelly,J. and Beldjord,C.
  TITLE     doublecortin is the major gene causing X-linked subcortical laminar
            heterotopia (SCLH)
  JOURNAL   Hum Mol Genet 7 (7), 1063-1070 (1998)
   PUBMED   9618162
REFERENCE   7  (bases 1 to 8973)
  AUTHORS   Gleeson,J.G., Allen,K.M., Fox,J.W., Lamperti,E.D., Berkovic,S.,
            Scheffer,I., Cooper,E.C., Dobyns,W.B., Minnerath,S.R., Ross,M.E.
            and Walsh,C.A.
  TITLE     Doublecortin, a brain-specific gene mutated in human X-linked
            lissencephaly and double cortex syndrome, encodes a putative
            signaling protein
  JOURNAL   Cell 92 (1), 63-72 (1998)
   PUBMED   9489700
REFERENCE   8  (bases 1 to 8973)
  AUTHORS   des Portes,V., Pinard,J.M., Billuart,P., Vinet,M.C., Koulakoff,A.,
            Carrie,A., Gelot,A., Dupuis,E., Motte,J., Berwald-Netter,Y.,
            Catala,M., Kahn,A., Beldjord,C. and Chelly,J.
  TITLE     A novel CNS gene required for neuronal migration and involved in
            X-linked subcortical laminar heterotopia and lissencephaly syndrome
  JOURNAL   Cell 92 (1), 51-61 (1998)
   PUBMED   9489699
REFERENCE   9  (bases 1 to 8973)
  AUTHORS   des Portes,V., Pinard,J.M., Smadja,D., Motte,J.,
            Boespflug-Tanguy,O., Moutard,M.L., Desguerre,I., Billuart,P.,
            Carrie,A., Bienvenu,T., Vinet,M.C., Bachner,L., Beldjord,C.,
            Dulac,O., Kahn,A., Ponsot,G. and Chelly,J.
  TITLE     Dominant X linked subcortical laminar heterotopia and lissencephaly
            syndrome (XSCLH/LIS): evidence for the occurrence of mutation in
            males and mapping of a potential locus in Xq22
  JOURNAL   J Med Genet 34 (3), 177-183 (1997)
   PUBMED   9132485
REFERENCE   10 (bases 1 to 8973)
  AUTHORS   Hehr,U., Uyanik,G., Aigner,L., Couillard-Despres,S. and Winkler,J.
  TITLE     DCX-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450490.6 and AL031117.1.
            
            On Apr 8, 2019 this sequence version replaced XM_011530880.3.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene is a cytoplasmic protein and contains
            two doublecortin domains, which bind microtubules. In the
            developing cortex, cortical neurons must migrate over long
            distances to reach the site of their final differentiation. The
            encoded protein appears to direct neuronal migration by regulating
            the organization and stability of microtubules. In addition, the
            encoded protein interacts with LIS1, the regulatory gamma subunit
            of platelet activating factor acetylhydrolase, and this interaction
            is important to proper microtubule function in the developing
            cortex. Mutations in this gene cause abnormal migration of neurons
            during development and disrupt the layering of the cortex, leading
            to epilepsy, cognitive disability, subcortical band heterotopia
            ('double cortex' syndrome) in females and lissencephaly ('smooth
            brain' syndrome) in males. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.693321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN02400288
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL450490.6         43272-43326         c
            56-441              AL450490.6         41169-41554         c
            442-782             AL450490.6         32124-32464         c
            783-885             AL031117.1         119460-119562       c
            886-1008            AL031117.1         117328-117450       c
            1009-8973           AL031117.1         80188-88152         c
FEATURES             Location/Qualifiers
     source          1..8973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..8973
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="doublecortin"
                     /db_xref="GeneID:1641"
                     /db_xref="HGNC:HGNC:2714"
                     /db_xref="MIM:300121"
     exon            1..55
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            56..441
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1037
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="isoform f is encoded by transcript variant 9;
                     doublecortex; doublin; lissencephalin-X; neuronal
                     migration protein doublecortin; lis-X"
                     /codon_start=1
                     /product="neuronal migration protein doublecortin isoform
                     f"
                     /protein_id="NP_001356302.1"
                     /db_xref="CCDS:CCDS94653.1"
                     /db_xref="GeneID:1641"
                     /db_xref="HGNC:HGNC:2714"
                     /db_xref="MIM:300121"
                     /translation="MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQ
                     ALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVR
                     YIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQ
                     SLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAI
                     KLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKG
                     NPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGPVPASVLG"
     exon            442..782
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            783..885
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1008
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..8973
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8954..8959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="hexamer: AATAAA"
     polyA_site      8973
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="major polyA site"
ORIGIN      
        1 atagagagat tggttttctt tctctcagca tctccaccca accagcagaa aaccggtctc
       61 tgaggttcca ccaaaatatg gaacttgatt ttggacactt tgacgaaaga gataagacat
      121 ccaggaacat gcgaggctcc cggatgaatg ggttgcctag ccccactcac agcgcccact
      181 gtagcttcta ccgaaccaga accttgcagg cactgagtaa tgagaagaaa gccaagaagg
      241 tacgtttcta ccgcaatggg gaccgctact tcaaggggat tgtgtacgct gtgtcctctg
      301 accgttttcg cagctttgac gccttgctgg ctgacctgac gcgatctctg tctgacaaca
      361 tcaacctgcc tcagggagtg cgttacattt acaccattga tggatccagg aagatcggaa
      421 gcatggatga actggaggaa ggggaaagct atgtctgttc ctcagacaac ttctttaaaa
      481 aggtggagta caccaagaat gtcaatccca actggtctgt caacgtaaaa acatctgcca
      541 atatgaaagc cccccagtcc ttggctagca gcaacagtgc acaggccagg gagaacaagg
      601 actttgtgcg ccccaagctg gttaccatca tccgcagtgg ggtgaagcct cggaaggctg
      661 tgcgtgtgct tctgaacaag aagacagccc actcttttga gcaagtcctc actgatatca
      721 cagaagccat caaactggag accggggttg tcaaaaaact ctacactctg gatggaaaac
      781 aggtaacttg tctccatgat ttctttggtg atgatgatgt gtttattgcc tgtggtcctg
      841 aaaaatttcg ctatgctcag gatgattttt ctctggatga aaatgaatgc cgagtcatga
      901 agggaaaccc atcagccaca gctggcccaa aggcatcccc aacacctcag aagacttcag
      961 ccaagagccc tggtcctatg cgccgaagca agtctccagc tgactcagga cctgtacctg
     1021 cctctgtcct tggatgactc ggactcgctt ggtgattcca tgtaaaggag gggagagtgc
     1081 tcagagtcca gagtacaaat ccaagcctat cattgtagta gggtacttct gctcaagtgt
     1141 ccaacagggc tattggtgct ttcaagtttt tattttgttg ttgttgttat tttgaaaaac
     1201 acattgtaat atgttgggtt tattttcctg tgatttctcc tctgggccac tgatccacag
     1261 ttaccaatta tgagagatag attgataacc atcctttggg gcagcattcc agggatgcaa
     1321 aatgtgctag tccatgacct ttcaatggaa agcttaggtg cctgcgttat atttgccctg
     1381 tctaattttg cccatacagt cttccttctg tagagggctg tttacatata cagcacttaa
     1441 aatgtttgtg tgggaaaaaa aaaactcatt ggcagatcca agaatgacaa acacaagtgc
     1501 cccttttctc tggatctcaa gaatggtgga ggaccctgga aggacagcaa ggcagctccc
     1561 cagcctcact cttcactcct gattgaggcc cgggtttgtt gtccagcacc aattctggct
     1621 gtcaatgggg agaaataaac caacaactta taattgtgac accagatgct taggatcctg
     1681 gtgctgggtt agctaagaga atagacagaa ttggaaaata ctgcagacat ttccgaagag
     1741 tttataaagc acagtgaatt cctggtcaat ctctccactg aggcaatttg gaatcaataa
     1801 gcaattgata atagtttgga gtaagggact tcatatacct gattcctcta gaaggctgtc
     1861 taacatacca catgattaca tgaactgtat ggtatccatc tatctctgtt ctattgaatg
     1921 ccttgttaac agccaacact gaaaacactg tgagaatttg ttttcaggtc tgacaccttt
     1981 cagtctcttt ttatagcaag aaatcaatat cctttttata aaaattcatg tctgtatttc
     2041 aggagcaaac tcttcaggct ccttttttat aaactggtga tttttctttt gtctaaaaaa
     2101 cacatgaaga aaatttacca aaaaaaaaaa aaaaagcaga agaataatgt agtttagaaa
     2161 ttatgctgtc actgccaaac agtaacctcc aggagaaaac aagatgaata gcagaggcca
     2221 attcaataga atcagttttt tgatagcttt ttaacagtta tgcttgcatt aataatttca
     2281 atgtggacca gacattctaa ttatatttta aatgaaatgt tacagcatat tttaagcaac
     2341 tctttttatc tataatccta atatttcata ctgaagacac agaaatcttt cacttgtctt
     2401 taacattaga aaggatttct ctttactaag gactgatcat ttgaaatagt tttcagtctt
     2461 ttgagataca ggtttataac actgcttttt tttttctgta atcatagccc ataatggcaa
     2521 agacaactaa atttaagtga aggtcatgca tgccaattct gtgtttgctt ttagcagata
     2581 tgaagatttc cttatttctt tgtaattgtg cagatatttt gaaaggcaca gcattcgaag
     2641 ccaagctgct gtttggctac tgaatggctt gcagttgttc ctccactcta aatggaatga
     2701 gcttgctgtg tgtgtgtgtg gtggtggtgg gagggggtgg tgcatgtgtg tgtgtgtgtg
     2761 tgcatctgca gctgcttcaa aattaggaaa tactacagga cacccctgta atggattggt
     2821 ggcaactggg tggcactgct gatgtgcact gtgtaggggg gaacccagtg gtggtggggt
     2881 agctcagatg cccctagaca agcttcagat gtctgtagct accagaaaca ttttcggttc
     2941 aggaaaagtg agatgatggt agtactggtt tctggtgaaa ttgaagaacc ccaaatgatg
     3001 aggatctctt tttgccccct ctcctttttt tgtagaccca ttcaaaacca ttaataagcc
     3061 cattttacta agcccctatt tctttctaga agctcagggt tttcttagtg cctcccagaa
     3121 cattttgtag ttaattggga aaaagtgata cttggattag ggggtgtggg cataaagaat
     3181 ggtgggaggc ctgattttaa acttcaggcc agaaccccca atgactccac ccatagtctc
     3241 actttaggtc tcatttagtc catcaccttt attttaagtt gaggaagtgg aggctggtaa
     3301 agagcaggac cagaggaaga atccagattt ccttatgctt gggcctcaca ctagctctct
     3361 gagtatttcc ttgattgcgg tatatgtact actagaaaat accaaatgga tatattttct
     3421 ttaggataac ctttgaacca acaatcttca ataacaatag tacatcttcc atcttacttt
     3481 taatcgagta taaggaaatg tttctttatg gccattttgg agggagcagg ggatgaggct
     3541 tggcatagtc caaaatttaa gtctccaata attaattgca ttttaaattg gcccactttc
     3601 aaggcaattt tttttgtgtg tctgtaactg agctcctcca cccctgtcat tcacttccaa
     3661 ttttacccaa tccaatttta gcactcaagt tccattgtgt taatttctgc acggtcaaca
     3721 aacatcaagt cagcaagcat ttgccaccac tccctatact tctccctcct tcttacacac
     3781 acacacacac acacacacac aatccatctc ttgcttgttc ctacctcctg atttttcttc
     3841 cctacagaaa tagaaatagg gacaaagaag gggaaaatgt atatattggg gctgggctga
     3901 acaactaact tcataagtag tattaactag gggtaaattg agagaaaagc tccttttctc
     3961 ttcactgttt tggaaaggat agccattagc atgactgctt tgtgtcctta tggactttag
     4021 tattagccta gattgaatta tagcgttttc tagctggaag gaaccttaag atcacatcat
     4081 ctactcctct actccaaatt tctcattctt caggccagga aaccgagaca cagaggtaaa
     4141 gtaatttccc caaggtcaca cagctggctg gggcaggatt gggtttacaa cccacatctc
     4201 ctggctctta ttccagggcc ttttcccact aagtagtatt gccttccatt aggctcctga
     4261 gagttatttc tcagggtcat gttgcatctt ggagccacat gctgctgccc tgatctcagt
     4321 gggaaatcca cccagcaacc taatacagcc ccttttccct gcattcacct ggttcccatc
     4381 cacatgggtt gcagatgtcc ttgaagagag tgaggcattg agggccaata ggagcaatgg
     4441 ggtccctggc cttgtccatc tgattcagga gatcactgct ccatcgtgag gagccctctg
     4501 aatagccccc cactgaatgc ttgccttgcc caaatggaat ggaggaagat tgattttctc
     4561 catcagttca ccttgtgtca tctcataatg gttggtcttt ccaggctgag ggaaatgttt
     4621 cttgtttcca gagtagaaaa agaaagagtg gaacaatagc tttgttcatc ctaactttct
     4681 gagatggctt ttcaacattt taaaaaaact agtgtggcta ccattcactg gcaatgattt
     4741 cttttagaat atgggagtaa gatgagctag agaaaataac ctggtctcac tgtggttgcc
     4801 ctcatccaca atgtccccaa agccatcctg ctctgatgag gacaatttcc aggtataagc
     4861 aaggggcttt gtgacaaaaa tgtaccctgg ctgatgttaa acattggctc ctgtgtttgc
     4921 accaaaatag caagctgtgt gctctataca ctcttcccat cgtcttgtgt acactgctcc
     4981 tgtggccttc cacagcagaa accagggcaa aagggtccaa acacatggtt ttccttgctg
     5041 caaggctctt cctgggaact aagggggtat ttattagttc agttctaaga gacctccttc
     5101 tgggcttacc ccactcctca ggtacttctc tctccttcct ccttctcctc cacagtcaca
     5161 agtaaccaag gaacctgaaa gtggatgtgt agctatttga agaaggcaag gaaccctgag
     5221 attcttcttt gaatcctcta gtccaagtct tagaccagtg attggtgctt accttgaaca
     5281 aaattttgtc tgtgttccta atcccttcaa tactctgggt acaatgctcc caatcaccct
     5341 gcacatttga ttctaaatgg cttttatttt ttaaaaatcc atatccctag gacaagagaa
     5401 caggatgcct atatccccaa aatgagctcc aggacactga tgggaatgat cccaaagatc
     5461 accccacctc agaaacgtct gtgccaagag acttccccag atagaaacac tgggacagtg
     5521 gtttgaacga cttcttttat ggttgtccag tttgctatgg aaataaaagg cattgatttt
     5581 ttaaaaagat gattggaacc tgtctttggc cacatagggc cacttggatc catttccagg
     5641 ccttactcat atattgcctt cactgaaggg ctttggcttt aagtcccaga ctggtctccc
     5701 aagtgaacca taagtgtttt ggagctcatc tggggtgagg catgagaatg ttgccccatc
     5761 tatcccttca ggaaaaggtg ccttccctcc ctttctccta aagcctggtc cccagaaatt
     5821 gtttttgtct ccaaaagtct agtatggtct ttatacaccc agactcttag tgttgcgtcc
     5881 tgccttgttt ccttgttaag gatctatgca gacctcccgc tttggcttag ctagcgtgac
     5941 attggctatc atttgacaag actaactttt tttttttttt ttttttgact gagtctccct
     6001 ctgtcaccta ggctggagtg cagtggcaca atcttggctc gctgcaacct tcacccttca
     6061 cctcccaggt cgaagcgatt ctcctgcctc agtctcccga gtagctggga ttacaggcgt
     6121 gcgccaccaa atctggctat ttttttatta ttattatttt tagtagagat ggggtttcac
     6181 catgttggcc agactggtct tgaactcttg gcctcaaatt atctgcccac ctcggcctcc
     6241 caaagtgctg ggattacagg catgagccac catgcccagc tgacaagact aattttttat
     6301 cccttggttt attggcttca acatcttctg gaatcagagg tgattttttc ttaccttgga
     6361 tgcctgagac taggggagta tagaattcca attggtaatt aaggcatctt tctgctcctg
     6421 atcagaaggg caggttagtt gggagaggtc agatggcaca acagaagtca ccttgtaagt
     6481 aaggcaaaga cttgaaggca ttagcgtttc tcattactag gtcaataacc tgagggaatc
     6541 aatggctttt tgccgctcta cctcttgtgt atctctttga cttttctttc tctgtctagt
     6601 ttcctctgtt ctcagtttat attctatgtt atcagtctct ctttccacag tacaaacatc
     6661 catcctttct cctgtgcaat tctgtctctc cctcttatta tctttatttg tactttttcc
     6721 ttcctccctg tctaggcatt gggcatgtgc ctcttcttag cctgtgattt tgccttggga
     6781 ctgatgataa attatttcca gattcaatca gccctggtcc taccccagtc caatcagaag
     6841 tatgttggtg ggaatcaacc tgatcctggc cctttcttct tctccatttt cattcgtaat
     6901 ccccctcagc agatctttac aagcagtttc cttatagctc atgtatcttt aggtctttgc
     6961 cttccaagca ctgtacagaa tactttgtgg ttccttttta gtctgacatt ttgtggagca
     7021 gtgaagcgtg ctcagagaca taatcagctg aagagaaaaa atccacccat ggatttatat
     7081 cagctaaata ctaataattg attttgtttg atgtgcccat aatttttaaa gctgcaatat
     7141 aatataatga gggaccacag gtaatttctc ctgtcatttg ttttggctgg atgggggtgg
     7201 gggagtaatt gcttaaagtt ttaccattac acattaaact ctctataata atcttgtttg
     7261 gggcttgcta actgttgagc tgttttaact aaactggtag gcaatcggag ttgatttaaa
     7321 tgaaaagata atttaacaaa tctatactat aaaaagagac atttgcttaa ttgacatgta
     7381 ttttttcctt ctgagtcacc taaacattta ctcttgacac caactgttca tgatactgaa
     7441 tagacagtcc atataagaga aattagtgga cctaaagaag ccagattgta ggtgttaatt
     7501 tattaaacag agtgcaaagc ccttggaaat gtcactgctt ggcaatacca tatggaatgc
     7561 caaaatttac aatgactttt ctttataagt tatccaaaag ggatttgaac aagtaagagg
     7621 ttatgccaaa atgtctccaa tgtatggtcc tgtaatatat tgcagcttga agccaatgat
     7681 cccttatgac ttgtatacaa ctaatgcatg ttttattgaa ttttgcattt cccacgtgtg
     7741 gtaagttctt taaaatgttt ttgatcacct ttttgtgcca ttaaacttgt acagaaaatg
     7801 tttttatggc cattttcaaa gggagaaagt ttaaaatgga aacagcccac cctttctgcc
     7861 ctatagctgt agttagaatt gagtacctgt agcaaaacag ctgtaattgg tggttgtagt
     7921 gttagaggtg ttagcttgct agtgactagc tttggagagt aaatgcatgg tattgtacat
     7981 cacatttctt aactcgtttt aacctctgaa aagaatatat tcttctttgt agtccttctt
     8041 cccaccccct tgccctctcc ctctccctgc tcccagttgt cttacagttg taaatatctg
     8101 atttgaggcc caataactct tgccaagtaa agtcagcaaa caacaaacaa accaaaatgt
     8161 ggggaaaagg catttctcaa ccatctctca gcagttattg atcatttctt aaggaacagc
     8221 attgtgatca aagactcaac tttacgtaaa aatcagtggt aaattggggt tgtatttggc
     8281 catttgatta catttcagga ttgaatagtt ttcagaatca catgtaatcc aaagacagta
     8341 ggtagtgatg tcccttatcc ctgcagctgt tttaagatag agacctcaga agactctgct
     8401 tgaccgatga ccaataatta tttgaaaaaa aaagaaaaaa tgagagaaat aaaacagata
     8461 tttaagaact ttagccacct atttagaata gttatagcca gaaaaaaaaa caagggcatg
     8521 agttcaaatg cattactatc agtgtcctag gcaataccta acctactctg aaattgtgat
     8581 tcaaaagcag tatttcaaga ggcattctcc ttttttggtt tgctgacccc acttggactg
     8641 gtaggtttgg tgaggccccc ataaaccagc tggagcagac ccttttcatc tcctgtgcct
     8701 gtaacacccc tcttccccca ccccctccgc aattcaatga gggctttctt gggtcagagg
     8761 acttcaaggt tgtctagaga agtttgccat gtgtgtaagg tgctgtgaac tgtgagtgct
     8821 gaagattcgc agcattcaat accaggcagc caaagagctg ctcttgcaat tattttggct
     8881 ctcaagctct gttcttcatc gcattctcat ttctgtgtac atttgcaaga tgtgtgtaat
     8941 gtcattttcc aaaaataaaa tttgatttca ata
//
