LOCUS       NM_001195553            9086 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens doublecortin (DCX), transcript variant 5, mRNA.
ACCESSION   NM_001195553
VERSION     NM_001195553.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9086)
  AUTHORS   Procopio,R., Fortunato,F., Gagliardi,M., Talarico,M., Sammarra,I.,
            Sarubbi,M.C., Malanga,D., Annesi,G. and Gambardella,A.
  TITLE     Phenotypic Variability in Novel Doublecortin Gene Variants
            Associated with Subcortical Band Heterotopia
  JOURNAL   Int J Mol Sci 25 (10), 5505 (2024)
   PUBMED   38791543
  REMARK    GeneRIF: Phenotypic Variability in Novel Doublecortin Gene Variants
            Associated with Subcortical Band Heterotopia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9086)
  AUTHORS   Cho,T.H., Kim,M., Kim,S.H., Lee,J.E., Kim,S.H., Kim,H.J.,
            Hong,J.E., Yeo,I.S. and Yang,H.M.
  TITLE     Reconsidering Neurogenetic Indication in the Human Brain: Broad
            Expression of Doublecortin Transcript in the Hippocampal and
            Cortical Cell Populations
  JOURNAL   Cells Tissues Organs 213 (5), 382-389 (2024)
   PUBMED   39191219
  REMARK    GeneRIF: Reconsidering Neurogenetic Indication in the Human Brain:
            Broad Expression of Doublecortin Transcript in the Hippocampal and
            Cortical Cell Populations.
REFERENCE   3  (bases 1 to 9086)
  AUTHORS   Lin,J.R., Cheng,J.F., Liu,Y.T., Hsu,T.R., Lin,K.M., Chen,C.,
            Lin,C.L., Tsai,M.H. and Tsai,J.W.
  TITLE     Novel lissencephaly-associated DCX variants in the C-terminal DCX
            domain affect microtubule binding and dynamics
  JOURNAL   Epilepsia 63 (5), 1253-1265 (2022)
   PUBMED   35213059
  REMARK    GeneRIF: Novel lissencephaly-associated DCX variants in the
            C-terminal DCX domain affect microtubule binding and dynamics.
REFERENCE   4  (bases 1 to 9086)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 9086)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 9086)
  AUTHORS   des Portes,V., Francis,F., Pinard,J.M., Desguerre,I., Moutard,M.L.,
            Snoeck,I., Meiners,L.C., Capron,F., Cusmai,R., Ricci,S., Motte,J.,
            Echenne,B., Ponsot,G., Dulac,O., Chelly,J. and Beldjord,C.
  TITLE     doublecortin is the major gene causing X-linked subcortical laminar
            heterotopia (SCLH)
  JOURNAL   Hum Mol Genet 7 (7), 1063-1070 (1998)
   PUBMED   9618162
REFERENCE   7  (bases 1 to 9086)
  AUTHORS   Gleeson,J.G., Allen,K.M., Fox,J.W., Lamperti,E.D., Berkovic,S.,
            Scheffer,I., Cooper,E.C., Dobyns,W.B., Minnerath,S.R., Ross,M.E.
            and Walsh,C.A.
  TITLE     Doublecortin, a brain-specific gene mutated in human X-linked
            lissencephaly and double cortex syndrome, encodes a putative
            signaling protein
  JOURNAL   Cell 92 (1), 63-72 (1998)
   PUBMED   9489700
REFERENCE   8  (bases 1 to 9086)
  AUTHORS   des Portes,V., Pinard,J.M., Billuart,P., Vinet,M.C., Koulakoff,A.,
            Carrie,A., Gelot,A., Dupuis,E., Motte,J., Berwald-Netter,Y.,
            Catala,M., Kahn,A., Beldjord,C. and Chelly,J.
  TITLE     A novel CNS gene required for neuronal migration and involved in
            X-linked subcortical laminar heterotopia and lissencephaly syndrome
  JOURNAL   Cell 92 (1), 51-61 (1998)
   PUBMED   9489699
REFERENCE   9  (bases 1 to 9086)
  AUTHORS   des Portes,V., Pinard,J.M., Smadja,D., Motte,J.,
            Boespflug-Tanguy,O., Moutard,M.L., Desguerre,I., Billuart,P.,
            Carrie,A., Bienvenu,T., Vinet,M.C., Bachner,L., Beldjord,C.,
            Dulac,O., Kahn,A., Ponsot,G. and Chelly,J.
  TITLE     Dominant X linked subcortical laminar heterotopia and lissencephaly
            syndrome (XSCLH/LIS): evidence for the occurrence of mutation in
            males and mapping of a potential locus in Xq22
  JOURNAL   J Med Genet 34 (3), 177-183 (1997)
   PUBMED   9132485
REFERENCE   10 (bases 1 to 9086)
  AUTHORS   Hehr,U., Uyanik,G., Aigner,L., Couillard-Despres,S. and Winkler,J.
  TITLE     DCX-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA497601.1, AK290455.1 and
            AL031117.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001195553.1.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene is a cytoplasmic protein and contains
            two doublecortin domains, which bind microtubules. In the
            developing cortex, cortical neurons must migrate over long
            distances to reach the site of their final differentiation. The
            encoded protein appears to direct neuronal migration by regulating
            the organization and stability of microtubules. In addition, the
            encoded protein interacts with LIS1, the regulatory gamma subunit
            of platelet activating factor acetylhydrolase, and this interaction
            is important to proper microtubule function in the developing
            cortex. Mutations in this gene cause abnormal migration of neurons
            during development and disrupt the layering of the cortex, leading
            to epilepsy, cognitive disability, subcortical band heterotopia
            ('double cortex' syndrome) in females and lissencephaly ('smooth
            brain' syndrome) in males. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2010].
            
            Transcript Variant: This variant (5) has an alternate 5' exon,
            resulting in a downstream AUG start codon, and an additional
            segment and additional 3 nts in two different 3' CDS regions
            respectively, as compared to variant 1. The resulting isoform (d)
            has a shorter N-terminus, and has an extra segment and an extra aa
            in two different C-terminal regions respectively, compared to
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290455.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636035.2/ ENSP00000490614.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA497601.1         41-53
            14-1356             AK290455.1         1-1343
            1357-9086           AL031117.1         80188-87917         c
FEATURES             Location/Qualifiers
     source          1..9086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..9086
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="doublecortin"
                     /db_xref="GeneID:1641"
                     /db_xref="HGNC:HGNC:2714"
                     /db_xref="MIM:300121"
     exon            1..55
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            56..441
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1178
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="isoform d is encoded by transcript variant 5;
                     doublecortex; doublin; lissencephalin-X; neuronal
                     migration protein doublecortin; lis-X"
                     /codon_start=1
                     /product="neuronal migration protein doublecortin isoform
                     d"
                     /protein_id="NP_001182482.1"
                     /db_xref="CCDS:CCDS83483.1"
                     /db_xref="GeneID:1641"
                     /db_xref="HGNC:HGNC:2714"
                     /db_xref="MIM:300121"
                     /translation="MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQ
                     ALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVR
                     YIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQ
                     SLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAI
                     KLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKG
                     NPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPI
                     STPTSPGSLRKHKVDLYLPLSLDDSDSLGDSM"
     exon            442..782
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            783..885
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1023
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1121
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..9086
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9067..9072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="hexamer: AATAAA"
     polyA_site      9086
                     /gene="DCX"
                     /gene_synonym="DBCN; DC; LISX; SCLH; XLIS"
                     /note="major polyA site"
ORIGIN      
        1 atagagagat tggttttctt tctctcagca tctccaccca accagcagaa aaccggtctc
       61 tgaggttcca ccaaaatatg gaacttgatt ttggacactt tgacgaaaga gataagacat
      121 ccaggaacat gcgaggctcc cggatgaatg ggttgcctag ccccactcac agcgcccact
      181 gtagcttcta ccgaaccaga accttgcagg cactgagtaa tgagaagaaa gccaagaagg
      241 tacgtttcta ccgcaatggg gaccgctact tcaaggggat tgtgtacgct gtgtcctctg
      301 accgttttcg cagctttgac gccttgctgg ctgacctgac gcgatctctg tctgacaaca
      361 tcaacctgcc tcagggagtg cgttacattt acaccattga tggatccagg aagatcggaa
      421 gcatggatga actggaggaa ggggaaagct atgtctgttc ctcagacaac ttctttaaaa
      481 aggtggagta caccaagaat gtcaatccca actggtctgt caacgtaaaa acatctgcca
      541 atatgaaagc cccccagtcc ttggctagca gcaacagtgc acaggccagg gagaacaagg
      601 actttgtgcg ccccaagctg gttaccatca tccgcagtgg ggtgaagcct cggaaggctg
      661 tgcgtgtgct tctgaacaag aagacagccc actcttttga gcaagtcctc actgatatca
      721 cagaagccat caaactggag accggggttg tcaaaaaact ctacactctg gatggaaaac
      781 aggtaacttg tctccatgat ttctttggtg atgatgatgt gtttattgcc tgtggtcctg
      841 aaaaatttcg ctatgctcag gatgattttt ctctggatga aaatgaatgc cgagtcatga
      901 agggaaaccc atcagccaca gctggcccaa aggcatcccc aacacctcag aagacttcag
      961 ccaagagccc tggtcctatg cgccgaagca agtctccagc tgactcaggt aacgaccaag
     1021 acgcaaacgg aacctccagc agccagctct ctacccccaa gtctaagcag tctcccatct
     1081 ctacgcccac cagtcctggc agcctccgga agcacaaggt agacctgtac ctgcctctgt
     1141 ccttggatga ctcggactcg cttggtgatt ccatgtaaag gaggggagag tgctcagagt
     1201 ccagagtaca aatccaagcc tatcattgta gtagggtact tctgctcaag tgtccaacag
     1261 ggctattggt gctttcaagt ttttattttg ttgttgttgt tattttgaaa aacacattgt
     1321 aatatgttgg gtttattttc ctgtgatttc tcctctgggc cactgatcca cagttaccaa
     1381 ttatgagaga tagattgata accatccttt ggggcagcat tccagggatg caaaatgtgc
     1441 tagtccatga cctttcaatg gaaagcttag gtgcctgcgt tatatttgcc ctgtctaatt
     1501 ttgcccatac agtcttcctt ctgtagaggg ctgtttacat atacagcact taaaatgttt
     1561 gtgtgggaaa aaaaaaactc attggcagat ccaagaatga caaacacaag tgcccctttt
     1621 ctctggatct caagaatggt ggaggaccct ggaaggacag caaggcagct ccccagcctc
     1681 actcttcact cctgattgag gcccgggttt gttgtccagc accaattctg gctgtcaatg
     1741 gggagaaata aaccaacaac ttataattgt gacaccagat gcttaggatc ctggtgctgg
     1801 gttagctaag agaatagaca gaattggaaa atactgcaga catttccgaa gagtttataa
     1861 agcacagtga attcctggtc aatctctcca ctgaggcaat ttggaatcaa taagcaattg
     1921 ataatagttt ggagtaaggg acttcatata cctgattcct ctagaaggct gtctaacata
     1981 ccacatgatt acatgaactg tatggtatcc atctatctct gttctattga atgccttgtt
     2041 aacagccaac actgaaaaca ctgtgagaat ttgttttcag gtctgacacc tttcagtctc
     2101 tttttatagc aagaaatcaa tatccttttt ataaaaattc atgtctgtat ttcaggagca
     2161 aactcttcag gctccttttt tataaactgg tgatttttct tttgtctaaa aaacacatga
     2221 agaaaattta ccaaaaaaaa aaaaaaaagc agaagaataa tgtagtttag aaattatgct
     2281 gtcactgcca aacagtaacc tccaggagaa aacaagatga atagcagagg ccaattcaat
     2341 agaatcagtt ttttgatagc tttttaacag ttatgcttgc attaataatt tcaatgtgga
     2401 ccagacattc taattatatt ttaaatgaaa tgttacagca tattttaagc aactcttttt
     2461 atctataatc ctaatatttc atactgaaga cacagaaatc tttcacttgt ctttaacatt
     2521 agaaaggatt tctctttact aaggactgat catttgaaat agttttcagt cttttgagat
     2581 acaggtttat aacactgctt ttttttttct gtaatcatag cccataatgg caaagacaac
     2641 taaatttaag tgaaggtcat gcatgccaat tctgtgtttg cttttagcag atatgaagat
     2701 ttccttattt ctttgtaatt gtgcagatat tttgaaaggc acagcattcg aagccaagct
     2761 gctgtttggc tactgaatgg cttgcagttg ttcctccact ctaaatggaa tgagcttgct
     2821 gtgtgtgtgt gtggtggtgg tgggaggggg tggtgcatgt gtgtgtgtgt gtgtgcatct
     2881 gcagctgctt caaaattagg aaatactaca ggacacccct gtaatggatt ggtggcaact
     2941 gggtggcact gctgatgtgc actgtgtagg ggggaaccca gtggtggtgg ggtagctcag
     3001 atgcccctag acaagcttca gatgtctgta gctaccagaa acattttcgg ttcaggaaaa
     3061 gtgagatgat ggtagtactg gtttctggtg aaattgaaga accccaaatg atgaggatct
     3121 ctttttgccc cctctccttt ttttgtagac ccattcaaaa ccattaataa gcccatttta
     3181 ctaagcccct atttctttct agaagctcag ggttttctta gtgcctccca gaacattttg
     3241 tagttaattg ggaaaaagtg atacttggat tagggggtgt gggcataaag aatggtggga
     3301 ggcctgattt taaacttcag gccagaaccc ccaatgactc cacccatagt ctcactttag
     3361 gtctcattta gtccatcacc tttattttaa gttgaggaag tggaggctgg taaagagcag
     3421 gaccagagga agaatccaga tttccttatg cttgggcctc acactagctc tctgagtatt
     3481 tccttgattg cggtatatgt actactagaa aataccaaat ggatatattt tctttaggat
     3541 aacctttgaa ccaacaatct tcaataacaa tagtacatct tccatcttac ttttaatcga
     3601 gtataaggaa atgtttcttt atggccattt tggagggagc aggggatgag gcttggcata
     3661 gtccaaaatt taagtctcca ataattaatt gcattttaaa ttggcccact ttcaaggcaa
     3721 ttttttttgt gtgtctgtaa ctgagctcct ccacccctgt cattcacttc caattttacc
     3781 caatccaatt ttagcactca agttccattg tgttaatttc tgcacggtca acaaacatca
     3841 agtcagcaag catttgccac cactccctat acttctccct ccttcttaca cacacacaca
     3901 cacacacaca cacaatccat ctcttgcttg ttcctacctc ctgatttttc ttccctacag
     3961 aaatagaaat agggacaaag aaggggaaaa tgtatatatt ggggctgggc tgaacaacta
     4021 acttcataag tagtattaac taggggtaaa ttgagagaaa agctcctttt ctcttcactg
     4081 ttttggaaag gatagccatt agcatgactg ctttgtgtcc ttatggactt tagtattagc
     4141 ctagattgaa ttatagcgtt ttctagctgg aaggaacctt aagatcacat catctactcc
     4201 tctactccaa atttctcatt cttcaggcca ggaaaccgag acacagaggt aaagtaattt
     4261 ccccaaggtc acacagctgg ctggggcagg attgggttta caacccacat ctcctggctc
     4321 ttattccagg gccttttccc actaagtagt attgccttcc attaggctcc tgagagttat
     4381 ttctcagggt catgttgcat cttggagcca catgctgctg ccctgatctc agtgggaaat
     4441 ccacccagca acctaataca gccccttttc cctgcattca cctggttccc atccacatgg
     4501 gttgcagatg tccttgaaga gagtgaggca ttgagggcca ataggagcaa tggggtccct
     4561 ggccttgtcc atctgattca ggagatcact gctccatcgt gaggagccct ctgaatagcc
     4621 ccccactgaa tgcttgcctt gcccaaatgg aatggaggaa gattgatttt ctccatcagt
     4681 tcaccttgtg tcatctcata atggttggtc tttccaggct gagggaaatg tttcttgttt
     4741 ccagagtaga aaaagaaaga gtggaacaat agctttgttc atcctaactt tctgagatgg
     4801 cttttcaaca ttttaaaaaa actagtgtgg ctaccattca ctggcaatga tttcttttag
     4861 aatatgggag taagatgagc tagagaaaat aacctggtct cactgtggtt gccctcatcc
     4921 acaatgtccc caaagccatc ctgctctgat gaggacaatt tccaggtata agcaaggggc
     4981 tttgtgacaa aaatgtaccc tggctgatgt taaacattgg ctcctgtgtt tgcaccaaaa
     5041 tagcaagctg tgtgctctat acactcttcc catcgtcttg tgtacactgc tcctgtggcc
     5101 ttccacagca gaaaccaggg caaaagggtc caaacacatg gttttccttg ctgcaaggct
     5161 cttcctggga actaaggggg tatttattag ttcagttcta agagacctcc ttctgggctt
     5221 accccactcc tcaggtactt ctctctcctt cctccttctc ctccacagtc acaagtaacc
     5281 aaggaacctg aaagtggatg tgtagctatt tgaagaaggc aaggaaccct gagattcttc
     5341 tttgaatcct ctagtccaag tcttagacca gtgattggtg cttaccttga acaaaatttt
     5401 gtctgtgttc ctaatccctt caatactctg ggtacaatgc tcccaatcac cctgcacatt
     5461 tgattctaaa tggcttttat tttttaaaaa tccatatccc taggacaaga gaacaggatg
     5521 cctatatccc caaaatgagc tccaggacac tgatgggaat gatcccaaag atcaccccac
     5581 ctcagaaacg tctgtgccaa gagacttccc cagatagaaa cactgggaca gtggtttgaa
     5641 cgacttcttt tatggttgtc cagtttgcta tggaaataaa aggcattgat tttttaaaaa
     5701 gatgattgga acctgtcttt ggccacatag ggccacttgg atccatttcc aggccttact
     5761 catatattgc cttcactgaa gggctttggc tttaagtccc agactggtct cccaagtgaa
     5821 ccataagtgt tttggagctc atctggggtg aggcatgaga atgttgcccc atctatccct
     5881 tcaggaaaag gtgccttccc tccctttctc ctaaagcctg gtccccagaa attgtttttg
     5941 tctccaaaag tctagtatgg tctttataca cccagactct tagtgttgcg tcctgccttg
     6001 tttccttgtt aaggatctat gcagacctcc cgctttggct tagctagcgt gacattggct
     6061 atcatttgac aagactaact tttttttttt tttttttttg actgagtctc cctctgtcac
     6121 ctaggctgga gtgcagtggc acaatcttgg ctcgctgcaa ccttcaccct tcacctccca
     6181 ggtcgaagcg attctcctgc ctcagtctcc cgagtagctg ggattacagg cgtgcgccac
     6241 caaatctggc tattttttta ttattattat ttttagtaga gatggggttt caccatgttg
     6301 gccagactgg tcttgaactc ttggcctcaa attatctgcc cacctcggcc tcccaaagtg
     6361 ctgggattac aggcatgagc caccatgccc agctgacaag actaattttt tatcccttgg
     6421 tttattggct tcaacatctt ctggaatcag aggtgatttt ttcttacctt ggatgcctga
     6481 gactagggga gtatagaatt ccaattggta attaaggcat ctttctgctc ctgatcagaa
     6541 gggcaggtta gttgggagag gtcagatggc acaacagaag tcaccttgta agtaaggcaa
     6601 agacttgaag gcattagcgt ttctcattac taggtcaata acctgaggga atcaatggct
     6661 ttttgccgct ctacctcttg tgtatctctt tgacttttct ttctctgtct agtttcctct
     6721 gttctcagtt tatattctat gttatcagtc tctctttcca cagtacaaac atccatcctt
     6781 tctcctgtgc aattctgtct ctccctctta ttatctttat ttgtactttt tccttcctcc
     6841 ctgtctaggc attgggcatg tgcctcttct tagcctgtga ttttgccttg ggactgatga
     6901 taaattattt ccagattcaa tcagccctgg tcctacccca gtccaatcag aagtatgttg
     6961 gtgggaatca acctgatcct ggccctttct tcttctccat tttcattcgt aatccccctc
     7021 agcagatctt tacaagcagt ttccttatag ctcatgtatc tttaggtctt tgccttccaa
     7081 gcactgtaca gaatactttg tggttccttt ttagtctgac attttgtgga gcagtgaagc
     7141 gtgctcagag acataatcag ctgaagagaa aaaatccacc catggattta tatcagctaa
     7201 atactaataa ttgattttgt ttgatgtgcc cataattttt aaagctgcaa tataatataa
     7261 tgagggacca caggtaattt ctcctgtcat ttgttttggc tggatggggg tgggggagta
     7321 attgcttaaa gttttaccat tacacattaa actctctata ataatcttgt ttggggcttg
     7381 ctaactgttg agctgtttta actaaactgg taggcaatcg gagttgattt aaatgaaaag
     7441 ataatttaac aaatctatac tataaaaaga gacatttgct taattgacat gtattttttc
     7501 cttctgagtc acctaaacat ttactcttga caccaactgt tcatgatact gaatagacag
     7561 tccatataag agaaattagt ggacctaaag aagccagatt gtaggtgtta atttattaaa
     7621 cagagtgcaa agcccttgga aatgtcactg cttggcaata ccatatggaa tgccaaaatt
     7681 tacaatgact tttctttata agttatccaa aagggatttg aacaagtaag aggttatgcc
     7741 aaaatgtctc caatgtatgg tcctgtaata tattgcagct tgaagccaat gatcccttat
     7801 gacttgtata caactaatgc atgttttatt gaattttgca tttcccacgt gtggtaagtt
     7861 ctttaaaatg tttttgatca cctttttgtg ccattaaact tgtacagaaa atgtttttat
     7921 ggccattttc aaagggagaa agtttaaaat ggaaacagcc caccctttct gccctatagc
     7981 tgtagttaga attgagtacc tgtagcaaaa cagctgtaat tggtggttgt agtgttagag
     8041 gtgttagctt gctagtgact agctttggag agtaaatgca tggtattgta catcacattt
     8101 cttaactcgt tttaacctct gaaaagaata tattcttctt tgtagtcctt cttcccaccc
     8161 ccttgccctc tccctctccc tgctcccagt tgtcttacag ttgtaaatat ctgatttgag
     8221 gcccaataac tcttgccaag taaagtcagc aaacaacaaa caaaccaaaa tgtggggaaa
     8281 aggcatttct caaccatctc tcagcagtta ttgatcattt cttaaggaac agcattgtga
     8341 tcaaagactc aactttacgt aaaaatcagt ggtaaattgg ggttgtattt ggccatttga
     8401 ttacatttca ggattgaata gttttcagaa tcacatgtaa tccaaagaca gtaggtagtg
     8461 atgtccctta tccctgcagc tgttttaaga tagagacctc agaagactct gcttgaccga
     8521 tgaccaataa ttatttgaaa aaaaaagaaa aaatgagaga aataaaacag atatttaaga
     8581 actttagcca cctatttaga atagttatag ccagaaaaaa aaacaagggc atgagttcaa
     8641 atgcattact atcagtgtcc taggcaatac ctaacctact ctgaaattgt gattcaaaag
     8701 cagtatttca agaggcattc tccttttttg gtttgctgac cccacttgga ctggtaggtt
     8761 tggtgaggcc cccataaacc agctggagca gacccttttc atctcctgtg cctgtaacac
     8821 ccctcttccc ccaccccctc cgcaattcaa tgagggcttt cttgggtcag aggacttcaa
     8881 ggttgtctag agaagtttgc catgtgtgta aggtgctgtg aactgtgagt gctgaagatt
     8941 cgcagcattc aataccaggc agccaaagag ctgctcttgc aattattttg gctctcaagc
     9001 tctgttcttc atcgcattct catttctgtg tacatttgca agatgtgtgt aatgtcattt
     9061 tccaaaaata aaatttgatt tcaata
//
