LOCUS       NM_173475               6136 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens defective in cullin neddylation 1 domain containing 3
            (DCUN1D3), mRNA.
ACCESSION   NM_173475
VERSION     NM_173475.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6136)
  AUTHORS   Wu,X., Xu,Q., Li,T., Wei,Y., Zeng,R., Lin,R., Xu,L., Ye,L. and
            Liu,Z.
  TITLE     Bladder Cancer Progression Is Suppressed Through the Heart and
            Neural Crest Derivatives Expressed 2-Antisense RNA
            1/microRNA-93-5p/Defective in Cullin Neddylation 1 Domain
            Containing 3 Axis
  JOURNAL   Appl Biochem Biotechnol 195 (7), 4116-4133 (2023)
   PUBMED   36656536
  REMARK    GeneRIF: Bladder Cancer Progression Is Suppressed Through the Heart
            and Neural Crest Derivatives Expressed 2-Antisense RNA
            1/microRNA-93-5p/Defective in Cullin Neddylation 1 Domain
            Containing 3 Axis.
            Erratum:[Appl Biochem Biotechnol. 2023 Dec;195(12):7898-7899. doi:
            10.1007/s12010-023-04478-x.. PMID: 37052864]
REFERENCE   2  (bases 1 to 6136)
  AUTHORS   Zhang,S., Huang,J., Shi,T., Hu,F., Zhang,L., Zhou,P.K., Ma,D.,
            Ma,T. and Qiu,X.
  TITLE     DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell
            cycle progression under UV damage
  JOURNAL   Oncotarget 7 (36), 58483-58491 (2016)
   PUBMED   27542266
  REMARK    GeneRIF: DCUN1D3 has a role in activating SCFSKP2 ubiquitin E3
            ligase activity through cullin-1 neddylation and cell cycle
            progression in tumor cells with UV damage
REFERENCE   3  (bases 1 to 6136)
  AUTHORS   Keuss,M.J., Thomas,Y., Mcarthur,R., Wood,N.T., Knebel,A. and
            Kurz,T.
  TITLE     Characterization of the mammalian family of DCN-type NEDD8 E3
            ligases
  JOURNAL   J Cell Sci 129 (7), 1441-1454 (2016)
   PUBMED   26906416
REFERENCE   4  (bases 1 to 6136)
  AUTHORS   Huang,G., Stock,C., Bommelje,C.C., Weeda,V.B., Shah,K., Bains,S.,
            Buss,E., Shaha,M., Rechler,W., Ramanathan,S.Y. and Singh,B.
  TITLE     SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity
            of SCCRO (DCUN1D1)
  JOURNAL   J Biol Chem 289 (50), 34728-34742 (2014)
   PUBMED   25349211
  REMARK    GeneRIF: SCCRO3 functions as a tumor suppressor by antagonizing the
            neddylation activity of SCCRO
REFERENCE   5  (bases 1 to 6136)
  AUTHORS   Monda,J.K., Scott,D.C., Miller,D.J., Lydeard,J., King,D.,
            Harper,J.W., Bennett,E.J. and Schulman,B.A.
  TITLE     Structural conservation of distinctive N-terminal
            acetylation-dependent interactions across a family of mammalian
            NEDD8 ligation enzymes
  JOURNAL   Structure 21 (1), 42-53 (2013)
   PUBMED   23201271
REFERENCE   6  (bases 1 to 6136)
  AUTHORS   Meyer-Schaller,N., Chou,Y.C., Sumara,I., Martin,D.D., Kurz,T.,
            Katheder,N., Hofmann,K., Berthiaume,L.G., Sicheri,F. and Peter,M.
  TITLE     The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at
            membranes
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12365-12370 (2009)
   PUBMED   19617556
REFERENCE   7  (bases 1 to 6136)
  AUTHORS   Ma,T., Shi,T., Huang,J., Wu,L., Hu,F., He,P., Deng,W., Gao,P.,
            Zhang,Y., Song,Q., Ma,D. and Qiu,X.
  TITLE     DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle
            progression and cell growth
  JOURNAL   Cancer Sci 99 (11), 2128-2135 (2008)
   PUBMED   18823379
  REMARK    GeneRIF: DCUN1D3 is a novel UVC-response gene involved in cell
            cycle regulation and cell survival.
REFERENCE   8  (bases 1 to 6136)
  AUTHORS   Kurz,T., Ozlu,N., Rudolf,F., O'Rourke,S.M., Luke,B., Hofmann,K.,
            Hyman,A.A., Bowerman,B. and Peter,M.
  TITLE     The conserved protein DCN-1/Dcn1p is required for cullin
            neddylation in C. elegans and S. cerevisiae
  JOURNAL   Nature 435 (7046), 1257-1261 (2005)
   PUBMED   15988528
REFERENCE   9  (bases 1 to 6136)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA545688.1, BC040442.1, AC002394.1, AC004381.1 and AK027199.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173475.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.13472.1, BC040442.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324344.9/ ENSP00000319482.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA545688.1         1-20
            21-353              BC040442.1         1-333
            354-354             AC002394.1         7700-7700           c
            355-1256            BC040442.1         335-1236
            1257-1521           AC002394.1         4795-5059           c
            1522-2987           BC040442.1         1501-2966
            2988-3874           AC002394.1         2442-3328           c
            3875-5584           AC004381.1         211832-213541       c
            5585-6136           AK027199.1         1550-2101
FEATURES             Location/Qualifiers
     source          1..6136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..6136
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /note="defective in cullin neddylation 1 domain containing
                     3"
                     /db_xref="GeneID:123879"
                     /db_xref="HGNC:HGNC:28734"
                     /db_xref="MIM:616167"
     exon            1..155
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /inference="alignment:Splign:2.1.0"
     exon            156..691
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1175
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /EC_number="3.1.-.-"
                     /note="DCUN1 domain-containing protein 3; defective in
                     cullin neddylation protein 1-like protein 3; squamous cell
                     carcinoma-related oncogene 3; DCN1, defective in cullin
                     neddylation 1, domain containing 3"
                     /codon_start=1
                     /product="DCN1-like protein 3"
                     /protein_id="NP_775746.1"
                     /db_xref="CCDS:CCDS10592.1"
                     /db_xref="GeneID:123879"
                     /db_xref="HGNC:HGNC:28734"
                     /db_xref="MIM:616167"
                     /translation="MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPC
                     GKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDER
                     EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
                     GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNP
                     PVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
                     EMERRKREGEGRGALSSGPEGLCPEEQT"
     exon            692..6136
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /note="hexamer: AATAAA"
     polyA_site      2987
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /note="major polyA site"
     regulatory      6117..6122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /note="hexamer: AATAAA"
     polyA_site      6136
                     /gene="DCUN1D3"
                     /gene_synonym="44M2.4; DCNL3; SCCRO3"
                     /note="major polyA site"
ORIGIN      
        1 agatgaagag gaggcggtgg cagtggtgga agaagaggcg gcggcggcgg gggtagggag
       61 cctggaaacg cgagcgggga tggtaggtgg tttggacccg ccgggccgcc gtcgtttcca
      121 gaaagggttt gactggagga acctctggag cagctgttgg ctggctcctc tggctgatgg
      181 catgttgagg tacatgggcc agcggcagcg agggcatcca atccagaggg gtccactcta
      241 gaggccaggc caccagcacc atgggccagt gtgtcaccaa gtgtaagaat ccctcatcga
      301 ccctgggcag caaaaatgga gaccgtgagc ccagcaacaa gtcacatagc aggaggggtg
      361 caggccaccg tgaggagcag gtaccaccct gtggcaagcc aggtggagat atcctcgtca
      421 acgggaccaa gaaggccgag gctgccactg aggcctgcca gctgccaacg tcctcgggag
      481 atgctgggag ggagtccaag tccaatgccg aggagtcttc cttgcaaaga ttggaagaac
      541 tgttcaggcg ctacaaggat gagcgggaag atgcaatttt ggaggaaggc atggagcgct
      601 tttgcaatga cctgtgtgtt gaccccacag aatttcgagt gctgctcttg gcttggaagt
      661 tccaggctgc aaccatgtgc aaattcacca ggaaggagtt ttttgatggc tgcaaagcaa
      721 taagtgcaga cagcattgac ggaatctgtg cacggttccc tagcctctta acagaagcca
      781 aacaagagga taaattcaag gatctctacc ggtttacatt tcagtttggc ctggactctg
      841 aagaagggca gcggtcactg catcgggaaa tagccattgc cctgtggaaa ctagtcttta
      901 cccagaacaa tcctccggta ttggaccaat ggctaaactt cctaacagag aacccctcgg
      961 ggatcaaggg catctcccgg gacacttgga acatgttcct taacttcact caggtgattg
     1021 gccctgacct cagcaactac agtgaagatg aggcctggcc aagtctcttt gacacctttg
     1081 tggagtggga aatggagcga aggaaaagag aaggggaagg gagaggtgca ctcagctcag
     1141 ggcctgaggg cttgtgtccc gaggagcaga cttagtggct ctgtcccagg agcagcagca
     1201 aggatctgcc agctgccctg cagccaactg aggaattgga ccattttgga aattactgaa
     1261 gatccggata ttttctactt tacacctttc tctgccttgt atctgaaagg gctctaaaat
     1321 gctgtatcat gttttaggca ctttcttcat ttttttggtt attttggtta tttccttttt
     1381 ggggggatct cccagaatat ttgaacctgg ttacatgttg tgtatctttt tttgaagcct
     1441 tcagatagaa taagcctgcc atttcttgca caaatttagg tttttttttt gttttttttt
     1501 gttttttttt tttttttttt ggtaggggag ggcatagagc agggcggggg gatgggactg
     1561 ttaggttgaa ttaacattac aaaatgatac agtgccagat ctcagtttcg catattgttt
     1621 ttcagggcag gtctgtactg tgtgtagtgc tgtttacata gatgaattta ggttgtaata
     1681 attattttta aagatttaca cagatttgaa tagcagtgtt aactgttaac cacattgcat
     1741 taattcccag gcgatttaga gctcttggag agccaaggcc agccaagagc atttgtagtc
     1801 tggtgacaac ccccttttaa gctaatttat ccagaaccct gatttccctc acttcttgct
     1861 cattccttct ttgacctatt gcatttcatg ttgagttttt ccatcaacat gctgcacctg
     1921 tcagtcaagt gagcattttt taagaacaca ttgtactgag aaccacttaa gcattgaatg
     1981 cggagaaagc agtgctacct cagttttgct ggaagtagac ttctttgata gttttctttc
     2041 tttgatgaag tttctgtatt ttcatgttgt aagtggaaat actttttttt gtttgtttgt
     2101 ttcatttgcc ttggagccaa agtttctgtt cctggtggtc gggaaactgc ctgccggcca
     2161 actgacttga aggaaaactg tggtatggag ctctgcttga attttttttt ttttaatatt
     2221 tttatttttt tctttgaata tcatcagctt acttgtctgg caagggcaga agcctggggt
     2281 tggcctgaac tctgccaaac aaatatcaaa gtgtatttaa tagttaaatt tgtgcccttt
     2341 cccttcttgc tgcacccatg ttgtcactta acccccagga gttatttatt atctttttgt
     2401 taaagtcagg ctcatttggg gtaatgtgat gactgtttag gtttacatga ccctcctctc
     2461 ctttccctac ccccaaatat gtatatatac atatataaaa tatgtatata ttttacctat
     2521 ataaaatata tatatataca catatatgta tctatattcc tttgtttctt tgcctgctta
     2581 tactggccat aaaagaggga gctgccttca atgtataaag tataagaaga gtgccaggga
     2641 atgccataat ggaggctttt ggatctgaat ttggaccatt tcactaaaga gaacatgagt
     2701 ttgctcagcc ctttcctcac aagagggagg gccccggttc cccagacttc tccacgcgct
     2761 ggctccataa aggccagctt tggccaggct gccacagggg cctgaggagc tcactctggg
     2821 cctacctggt ttcagttaga gggtcctcct gttatttttc catttaaaaa gtatgtcctc
     2881 agaaaactgt actggaagga tgggtggcag gaacttgtat agttcagctt ccaacacttt
     2941 ggaacagatt aaaaagggaa tcttttaaat aaaaacgtat aaaaatattt atactcttga
     3001 ggtaatgaga ctttgtctgt taaacatttg gaggtttctc ccttaaccta ataccccgct
     3061 gcgtcccagg tatgtttctc agcctgggca ggaattgcat gttttgagtt ccattgtgag
     3121 cagccttaca gctctgggct cccatcttaa ggattattaa agagttttgg cagttggtat
     3181 ttttctaaaa ctgatattga ccatagggaa catacttgga atttgttttt ttttttaaat
     3241 cctaaacctg acagttcctc cttcagaggg gcaaatggga aactttaaga tcacccacgg
     3301 tatagtactg ctagaaagct gaagggggtc ttgggccaga tgcctggctt ctgttctagc
     3361 taaataagac tcttgaataa gtctccaggg gtcccagcag gttctgtggg atcagttgta
     3421 gctgggtacc cagactgagg ttttaaaaag actgcttttt cattaagcca gtttgcaact
     3481 cattttcccc ggttctggat tgggtagtgg ttgactgagg gaaaagccag gctgctcttg
     3541 gccagataag gccctttcca tcccagatca gagtgtatca gagaaagctg cacaaaagag
     3601 gcaggcagcc caggaccctg agtactctgg agaaactagg ttccttcccc accctttaag
     3661 aagacattcc gtgcattaga tgtactagag tggatgtatt ttgttgtttt ttaaattaac
     3721 tatttagcct cctcatcccc caccaaaaaa gccatttagt tattttttgg ttatattgat
     3781 ccatttgcaa atgagaagcc agaaaaggga gcagtcaggg agggacttac aagttccttt
     3841 caagtttgag tacttgatgc tcagcaaaga tttcaagctt ctgcagtagc tctgggccaa
     3901 tgcttgactc tttcatgacc acaagaaatg cagtttttct gcaaagggat ccaaggtgag
     3961 gtgtgtgtag ggtttgaagt tatacttctg ggaagtgaaa agtcttgttc ctttcaacct
     4021 agaaataggt ttgccactta atgagtgagc agtaagtctg tgtaagaggc tgaatgcatg
     4081 cccctcagat aagccagtac actccttgct tagcaacaga acatcagggt gatgtggaga
     4141 ggggcaggat gtggacgcca ctttggaaat cggcaacatc tgagggcaac aacaaacaag
     4201 tgtgttggga aataagaaat aactcagttt tgacaactgg ctttgtcagc ttttgtgatg
     4261 tttctttagc agtttattgg aaagatggta tgagatgacg tgctgcttca ttgaattgct
     4321 ctttccccca tctttgccaa atctcaatgt atcgttctta accccacctc ctgtaagggg
     4381 ctttgctatg cttcagctgg ttgtctcagc agctgaagtg ctgcccacct gtgtgagttg
     4441 ggtccaggaa accatgtctg cccttctgat aagggaagat gaatctagag ctgggtgaag
     4501 atctaaattt taaccaaacc cctgggccca ggaaaataac aattgaaaat gtacaaggca
     4561 gtgttttcaa tattaaactt ccccaaggaa agcacaaact agtctttttg gaaagggaga
     4621 aaggattaag ccacacagta ttagtctttg aagcagtact ggtctctagg ggctggtgcc
     4681 aaaatggagt cccatagtag ttacactcga tggcctcatg tactatatac tgtgccaaat
     4741 tgtattaaac agtggtgggg agttactggg ataagaactt gtctaaaagt ttacaaacca
     4801 aaacagatct gttaggttgg tgcaaaagta agtttttgcc atacttaatg tattgccatt
     4861 aagtatggca aaaaccacaa ttacttttac accaacctat gtatttaaga atgtttggtt
     4921 tgccagattc caaatgaggt cttcagtgca gcaaagccca aaaggtgtag actcagttat
     4981 gcaattataa ggttaaggcg tagaagaaag ctgctgctag gtttttgttg cattttactt
     5041 gactgctctg ctgtttttct tgtctctcat gtttggttag ctatgacttg agcatcttgg
     5101 taactgacaa aggtcttcct tgggggactt gaacatcttg gtaaatgaca ggtcttcttg
     5161 gaggactcca gcagtatctt gtttaaacga ctgaaaggac tattaaggtt gttgaattgt
     5221 gttaattggg actcattgag gaaatgcgac attgatcctc ctcttattcc acagtgtgtt
     5281 ttctgatcat ataaagaagg ttccgaacca tccatccccc tcagagttta ttcccctggt
     5341 aagctgtaat tgcatatcca gtttaaactg gactgggact gcatgttggt gaggatcggc
     5401 aggggttttc ccccttttcg aaagatgaaa tagattcttg agcactggtt gcagaagcca
     5461 aaatagttca aatagctttg cataaccatt gggttctgct tctgattcag gtgctgggca
     5521 tcatgtcctc cctattcttc tcttcttgga aacccagcct atctcataaa tacctacttc
     5581 cgccacccat ccaacctccc tgctcctttc aacacaaatc ttggatattg ccaaaggaag
     5641 ccattcagca gctgctgggg tttttcatcc ccctgacatg catacatttg ctctgggaga
     5701 agtgtcttcc ctctgaccct ggtccccagc tccgtctgtg cttaattgct cttacctgtt
     5761 gcactaatga atatgactag gttttaaagg gggaatgtga agcaataggc acatggggct
     5821 tggatgaatt ggtcccacag atataccctg ccttaagccg ctgaggtgat gagtccactg
     5881 ctcatgtgac cctccacctt tgtggatccc tcttggtttg tgaccagtgt gtctgtttgt
     5941 tgaggttgta caaacttgac aaaagttaat acttttgttt gtattttctg cactgttgca
     6001 ctctccaaat ggccccttga gtatttttat tgacttgtta cacacatttt tgtctttgat
     6061 gtctacattt tttcctttaa tgttttttat ttggaaggtt acctgctgtt ggatttaata
     6121 aatttgttta cttgaa
//
