LOCUS       NM_001014283            3032 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens defective in cullin neddylation 1 domain containing 2
            (DCUN1D2), mRNA.
ACCESSION   NM_001014283
VERSION     NM_001014283.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Keuss,M.J., Thomas,Y., Mcarthur,R., Wood,N.T., Knebel,A. and
            Kurz,T.
  TITLE     Characterization of the mammalian family of DCN-type NEDD8 E3
            ligases
  JOURNAL   J Cell Sci 129 (7), 1441-1454 (2016)
   PUBMED   26906416
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Monda,J.K., Scott,D.C., Miller,D.J., Lydeard,J., King,D.,
            Harper,J.W., Bennett,E.J. and Schulman,B.A.
  TITLE     Structural conservation of distinctive N-terminal
            acetylation-dependent interactions across a family of mammalian
            NEDD8 ligation enzymes
  JOURNAL   Structure 21 (1), 42-53 (2013)
   PUBMED   23201271
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Meyer-Schaller,N., Chou,Y.C., Sumara,I., Martin,D.D., Kurz,T.,
            Katheder,N., Hofmann,K., Berthiaume,L.G., Sicheri,F. and Peter,M.
  TITLE     The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at
            membranes
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12365-12370 (2009)
   PUBMED   19617556
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Kurz,T., Ozlu,N., Rudolf,F., O'Rourke,S.M., Luke,B., Hofmann,K.,
            Hyman,A.A., Bowerman,B. and Peter,M.
  TITLE     The conserved protein DCN-1/Dcn1p is required for cullin
            neddylation in C. elegans and S. cerevisiae
  JOURNAL   Nature 435 (7046), 1257-1261 (2005)
   PUBMED   15988528
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL442125.13, BM836766.1, AK001566.1 and AK000099.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001014283.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.79048.1,
                                           SRR1803613.91220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000478244.6/ ENSP00000417706.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL442125.13        26421-26423         c
            4-45                BM836766.1         4-45
            46-562              AK001566.1         26-542
            563-2930            AK001566.1         695-3062
            2931-3032           AK000099.1         2525-2626
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..3032
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /note="defective in cullin neddylation 1 domain containing
                     2"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
     exon            1..45
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..822
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /note="DCUN1 domain-containing protein 2; defective in
                     cullin neddylation protein 1-like protein 2; DCN1,
                     defective in cullin neddylation 1, domain containing 2"
                     /codon_start=1
                     /product="DCN1-like protein 2"
                     /protein_id="NP_001014305.1"
                     /db_xref="CCDS:CCDS32013.1"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
                     /translation="MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSF
                     FQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISV
                     LVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQF
                     TFTFAKNPGQKGLDLEMAVAYWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLD
                     FGNMIADDMSNYDEEGAWPVLIDDFVEYARPVVTGGKRSLF"
     exon            46..262
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..431
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..562
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..645
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..742
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..3032
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /note="hexamer: ATTAAA"
     polyA_site      3032
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /note="major polyA site"
ORIGIN      
        1 gcagaaggcc ggggccggcc agaagcgggc ggcgcggggg agatgcataa gcttaaatcg
       61 tctcagaagg acaaggtccg ccagtttatg gcgtgcactc aggctggcga gagaactgct
      121 atctactgct taacgcagaa tgagtggaga ctagacgagg ccacggacag cttcttccaa
      181 aacccagact cgctccacag ggagtccatg cggaacgctg tggacaagaa gaagctggag
      241 cggctgtacg gcaggtacaa agatccacaa gatgaaaaca aaattggagt cgatgggatt
      301 caacagtttt gtgatgatct gagcctggat cctgccagta tcagtgtatt ggtcatagcg
      361 tggaagttca gggcagcaac tcagtgtgaa tttagcagaa aggaatttct agatggcatg
      421 acagaacttg ggtgtgacag catggagaag ctaaaggctc ttctgccaag actggagcag
      481 gagctgaagg acacagccaa gtttaaagat ttttatcagt ttaccttcac cttcgctaag
      541 aacccagggc agaaaggttt agacttagaa atggctgttg cgtattggaa attagtgtta
      601 tctggaaggt ttaaattttt agatctctgg aacacattct taatggaaca tcacaaaaga
      661 tcaattccaa gggacacctg gaacctcctg ctggactttg gaaacatgat tgcggatgat
      721 atgtctaact acgatgaaga aggagcttgg cccgttctta tagatgattt tgtagaatat
      781 gcacggccag tagtcacagg tggaaaacgc agccttttct aggcagcaag ttaagcagga
      841 gtaagattat gaaatgattt gtatcctgca aggagattgc agtcagttcc tgggtgcatt
      901 gtcgctgatt ccagaagtca ttcttgacca gccatgaaac cagaggcgcc atcccattct
      961 gccggaggac agccagcggc tgctttgtgg acaccgcagg aagttcctcg ggacacggct
     1021 gctttgggat gtttggagat ttgtcatcat agcttttgcg ttaggaaatt tctgcatgat
     1081 tttttaatat ttacaaaata ctaaggtaga gccatagcgc cgcctgtggg accgcagagc
     1141 atgctgcgta gctcgcgcgt caggcgaacc agcgtccggc agcgtcccgc cgaatgacgt
     1201 tgcggtggca ctggcaacac ggcatgtgtc ctctgcaggg cgctgcgttt ttatacacgt
     1261 caaagctgtt aagaatgtgc cctaagggag aggatcttgt cgtagagtct aatgtttttt
     1321 aaaattggtg ccagcaattc acgatttata ttttttgaat taccaaatat ctagatttac
     1381 cagctctatt tttgttttca ttttctctag acattcatct gaaaatcatt ttatggttct
     1441 caatccccat gtagctttgc atagcaacgg cacacgtggc acgattccag cagagtttat
     1501 ctcacaccgt ttatatatca ctgggcctct cttacttaaa tattatttga cctgcctgag
     1561 aagcttcata aagtatgttt ttttaaaata tattttaatt acatttaaaa agacattttt
     1621 ccatgaaaaa catttatttt atgagtgatg aattatagat tttaaaatca aggccgggcg
     1681 tggtggctca cacctgtaat cccagcattt tgggaggccg aggcaggtgg atcacctgag
     1741 gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc ctgtctctac taaaaataca
     1801 aaaattagcc gggcatggtg gcacatgcct gtaatcccag ctactcagga ggctgaggca
     1861 ggagattcgc ttgaactcag gagacggagg ttacagtgag tcgagatcgc gccactgcac
     1921 tccagcctgg acgacagagt gagattctgt ctcaaaataa atacatacat acatacaata
     1981 aaaccgaatg agctggttct ttccatcctc ttgtggtacc cgtagtgccc agcatccaga
     2041 cctttgtgcc cctgtgcaca tttggaagct aaaatgtaca tcgttgtctg aaaaaaccca
     2101 accccaaaac cttcatctga ttggtgagct gaagtctgtc cttgcaccat gttatcatct
     2161 gtttctcgtg tccgcctggt tgaggaggac ccacgagtgc tgccgaggtg tggagggctg
     2221 gtattgagtt gtggacatca ctgttgaccc tacctcacgt gccgagactc tcatgtcaca
     2281 ggcgtgcctt gctgcccccc tgcagcactg tgcaggacgt ggaccagctg gagctgctgc
     2341 ccagcacaga ggagagtcgc cgcagatgac ctagctgcgg tgtgagagag catggcccag
     2401 acaagcagct gggttggctt ctgagaacag gacttaccct gggcttcagg aacatctgat
     2461 ggctgaggtt agtgtgcttg gaggctgcag gacgaactgt cgatgtttct tagcagagat
     2521 ggtcacagag ggcagcaggg acaggactgg aagggacctg cagcctgcag accccgcctg
     2581 gcccccgctg gcttctggct ggtccagtga tgggcaagtg acagaccttc cccaggctct
     2641 gcttccagaa ctctaatggg aaactgggcc tgtctacctt tagaagtctt cgattctcag
     2701 agagcatttg tctaatacaa taaaaactgg cattaataca aacctcaaaa acgtgagcgt
     2761 atcttccagg cttcatggat tcttgacatg taattgtttt gttcagaaaa gtttatagaa
     2821 ttcacataat tctgtataaa ctatggagat ccacagtact tttttgtttt tgagatttaa
     2881 agttctaagg gattgtcaat agatatcaaa atattaatca ttggacaaag gcttttccaa
     2941 aaattgtggg tttttttctt ctgttgtatc catttgagtc ctgcatgctg tgaaatgctg
     3001 agaacagaag cattaaattg gtttttctcg gg
//
