LOCUS       NM_020640               7849 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens defective in cullin neddylation 1 domain containing 1
            (DCUN1D1), transcript variant 1, mRNA.
ACCESSION   NM_020640
VERSION     NM_020640.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7849)
  AUTHORS   Luo,X., Liu,J., Wang,X., Yuan,J. and Zhang,Y.
  TITLE     Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant
            progression by regulating DCUN1D1 expression
  JOURNAL   J Biochem Mol Toxicol 37 (11), e23462 (2023)
   PUBMED   37522575
  REMARK    GeneRIF: Circ-DTL sponges miR-758-3p to accelerate cervical cancer
            malignant progression by regulating DCUN1D1 expression.
REFERENCE   2  (bases 1 to 7849)
  AUTHORS   Vava,A., Paccez,J.D., Wang,Y., Gu,X., Bhasin,M.K., Myers,M.,
            Soares,N.C., Libermann,T.A. and Zerbini,L.F.
  TITLE     DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation
            and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A
            and 5 and Deregulation of Wnt/Catenin Pathway
  JOURNAL   Cells 12 (15), 1973 (2023)
   PUBMED   37566052
  REMARK    GeneRIF: DCUN1D1 Is an Essential Regulator of Prostate Cancer
            Proliferation and Tumour Growth That Acts through Neddylation of
            Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7849)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7849)
  AUTHORS   Chatziandreou,I., Psaraki,A., Paschidis,K., Lazaris,A.C. and
            Saetta,A.A.
  TITLE     Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy
            number amplification in squamous cell lung cancer
  JOURNAL   Pathol Res Pract 221, 153412 (2021)
   PUBMED   33862557
  REMARK    GeneRIF: Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene
            copy number amplification in squamous cell lung cancer.
REFERENCE   5  (bases 1 to 7849)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7849)
  AUTHORS   Sarkaria,I.S., Pham,D., Ghossein,R.A., Talbot,S.G., Hezel,M.,
            Dudas,M.E., Ebright,M.I., Chuai,S., Memoli,N., Venkatraman,E.S.,
            Miller,V.A., Kris,M.G., Zakowski,M.F., Rusch,V.W. and Singh,B.
  TITLE     SCCRO expression correlates with invasive progression in
            bronchioloalveolar carcinoma
  JOURNAL   Ann Thorac Surg 78 (5), 1734-1741 (2004)
   PUBMED   15511464
  REMARK    Review article
REFERENCE   7  (bases 1 to 7849)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 7849)
  AUTHORS   Talbot,S.G., O-charoenrat,P., Sarkaria,I.S., Ghossein,R., Reddy,P.,
            Ngai,I., Cordeiro,C.N., Wong,R.J., Kris,M.G., Rusch,V.W. and
            Singh,B.
  TITLE     Squamous cell carcinoma related oncogene regulates angiogenesis
            through vascular endothelial growth factor-A
  JOURNAL   Ann Surg Oncol 11 (5), 530-534 (2004)
   PUBMED   15123463
REFERENCE   9  (bases 1 to 7849)
  AUTHORS   Estilo,C.L., O-Charoenrat,P., Ngai,I., Patel,S.G., Reddy,P.G.,
            Dao,S., Shaha,A.R., Kraus,D.H., Boyle,J.O., Wong,R.J.,
            Pfister,D.G., Huryn,J.M., Zlotolow,I.M., Shah,J.P. and Singh,B.
  TITLE     The role of novel oncogenes squamous cell carcinoma-related
            oncogene and phosphatidylinositol 3-kinase p110alpha in squamous
            cell carcinoma of the oral tongue
  JOURNAL   Clin Cancer Res 9 (6), 2300-2306 (2003)
   PUBMED   12796399
REFERENCE   10 (bases 1 to 7849)
  AUTHORS   Mas,C., Bourgeois,F., Bulfone,A., Levacher,B., Mugnier,C. and
            Simonneau,M.
  TITLE     Cloning and expression analysis of a novel gene, RP42, mapping to
            an autism susceptibility locus on 6q16
  JOURNAL   Genomics 65 (1), 70-74 (2000)
   PUBMED   10777668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK297328.1, BC013163.1, AF292100.2, AK025764.1, AW103206.1,
            AC092953.7 and BU620603.1.
            
            On May 17, 2019 this sequence version replaced NM_020640.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1898845.1,
                                           SRR1803613.132627.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292782.9/ ENSP00000292782.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AK297328.1         1-295
            296-366             BC013163.1         232-302
            367-454             AF292100.2         347-434
            455-1736            BC013163.1         391-1672
            1737-1775           AK025764.1         1363-1401
            1776-1780           AF292100.2         1756-1760
            1781-2808           AK025764.1         1408-2435
            2809-3152           AW103206.1         6-349
            3153-7025           AC092953.7         58677-62549
            7026-7765           BU620603.1         17-756              c
            7766-7849           AC092953.7         63290-63373
FEATURES             Location/Qualifiers
     source          1..7849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..7849
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="defective in cullin neddylation 1 domain containing
                     1"
                     /db_xref="GeneID:54165"
                     /db_xref="HGNC:HGNC:18184"
                     /db_xref="MIM:605905"
     exon            1..52
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..829
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="isoform 1 is encoded by transcript variant 1; RP42
                     homolog; DCN1-like protein 1; squamous cell
                     carcinoma-related oncogene; DCUN1 domain-containing
                     protein 1; defective in cullin neddylation protein 1-like
                     protein 1; DCN1, defective in cullin neddylation 1, domain
                     containing 1"
                     /codon_start=1
                     /product="DCN1-like protein 1 isoform 1"
                     /protein_id="NP_065691.2"
                     /db_xref="CCDS:CCDS3240.1"
                     /db_xref="GeneID:54165"
                     /db_xref="HGNC:HGNC:18184"
                     /db_xref="MIM:605905"
                     /translation="MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNF
                     FQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISV
                     LIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQF
                     TFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLD
                     FSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV"
     exon            53..269
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            270..438
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..569
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..652
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            653..749
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..7849
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3530..3535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="hexamer: AATAAA"
     polyA_site      3562
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="major polyA site"
     regulatory      4465..4470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="hexamer: TATAAA"
     polyA_site      4486
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="major polyA site"
     regulatory      6139..6144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="hexamer: AGTAAA"
     polyA_site      6165
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
     regulatory      7465..7470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="hexamer: AATAAA"
     polyA_site      7495
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
     regulatory      7746..7751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="hexamer: AATAAA"
     regulatory      7764..7769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
                     /note="hexamer: AATATA"
     polyA_site      7765
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
     polyA_site      7782
                     /gene="DCUN1D1"
                     /gene_synonym="DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3"
ORIGIN      
        1 attcgctgcg gagccggagg aggaggggag aggcctggag gacaccaaca tgaacaagtt
       61 gaaatcatcg cagaaggata aagttcgtca gtttatgatc ttcacacaat ctagtgaaaa
      121 aacagcagta agttgtcttt ctcaaaatga ctggaagtta gatgttgcaa cagataattt
      181 tttccaaaat cctgaacttt atatacgaga gagtgtaaaa ggatcattgg acaggaagaa
      241 gttagaacag ctgtacaata gatacaaaga ccctcaagat gagaataaaa ttggaataga
      301 tggcatacag cagttctgtg atgacctggc actcgatcca gccagcatta gtgtgttgat
      361 tattgcgtgg aagttcagag cagcaacaca gtgcgagttc tccaaacagg agttcatgga
      421 tggcatgaca gaattaggat gtgacagcat agaaaaacta aaggcccaga tacccaagat
      481 ggaacaagaa ttgaaagaac caggacgatt taaggatttt taccagttta cttttaattt
      541 tgcaaagaat ccaggacaaa aaggattaga tctagaaatg gccattgcct actggaactt
      601 agtgcttaat ggaagattta aattcttaga cttatggaat aaatttttgt tggaacatca
      661 taaacgatca ataccaaaag acacttggaa tcttctttta gacttcagta cgatgattgc
      721 agatgacatg tctaattatg atgaagaagg agcatggcct gttcttattg atgactttgt
      781 ggaatttgca cgccctcaaa ttgctgggac aaaaagtaca acagtgtagc actaaaggaa
      841 ccttctagaa tgtacatagt ctgtacaata aatacaacag aaaattgcac agtcaatttc
      901 tgctggctgg actgaactga agatcaatcc tcacaattca gactgagggt tgagacaaaa
      961 ctttaaggat acatcttgga ccatatcgta tttcattctt ctaatggtgg tttgggcttg
     1021 tcttctagtc tgggccgctc taaacattta taattccaac attgtggatt tcatcttata
     1081 tctgtggacc atcctagttt attctcccat aagtcttaga agctttatgg tgattatttt
     1141 gaggttttca ttctcgcata aagcacaatg ctgtcttcat cagaaaacag ttggcataag
     1201 aattaaacat atgaacatca caaaacaatt tataaaaact tcttaaatat acgctttggg
     1261 ctagttgcaa agactatgct aatagcactt ccagtgagag tgatatattt aagtgtactg
     1321 gatctggaat ggtgttttgg tttgggggga attttttttt tttcctggca aatcacatgt
     1381 gttgttgatg tgagtatctg atgaaaaaac aatgtcagaa taaccgacat gaaaattttt
     1441 taggataact tggtgcctac ctgaaaaatg tattgtgttt tagactcttg atttcaaaag
     1501 gttccacaga actagtctgc gcttacctta cccatgttta tatatagctg tcctacaggg
     1561 agcttttatt tagaaaatgt ctgcataatg ttagattctt ctcctgtcta cattatgcac
     1621 tacataattg gacttcatta tgcttttgaa atgcttatct gcctgtcaca taagttaaac
     1681 tatttaattt gttttgaatg ttttggattg ctacacaata caatattcta aatttaggca
     1741 tgagggtttt tttgttttgt ttttactttt tttttgtcat cgcactatgg aacacaaatg
     1801 gaattctctt aatttataag aagatagttg cagttaaatt ttgaaaatgg ttgtaatgag
     1861 ccatgaagtt caatctttat aatataggta ctgctctttc agacaaatag tccattttcg
     1921 atgacttatt attttgttga aattgcttta actgctaatc actgtggttg ccaaatattt
     1981 acttcaggag caaagatttt caaacaagca tacacgatgc aaaataccaa tctggcttct
     2041 agtctcttta ctgttttcgt ttcactcaga ttagctcagt tttctcatca aagcagaatg
     2101 ctatcttgta tgtatttttt tcattacaag ccccatgagc tgcttttatg ctgaaaatgg
     2161 tcatttccct gttcacttac tgacatgtga agaagggttt cttgctttct taaacatttc
     2221 cgtaaggcag gctagaaatg taatacttca aatgtttgat gattatggtc ttttgatagg
     2281 aatagattct gcttgggata tatatccagg cactctctaa ggtctagggt tgatattaac
     2341 aaaggaatgt acttagaata gcagtacatt ttatgcaaat atggaaatta ttttaagaaa
     2401 caatgacata tcaaaactgc tttttacatg attttgaaat agactagaaa gctttcccta
     2461 tagacatatt aatattccaa tcataacttt aattcaagaa tgcagtttta ccaaaagaaa
     2521 aatttgaaaa tttctattca ggctactgga attggttatt aaaagaaaaa ggaaaaagaa
     2581 gaatcttgct gctttcagta tttcctgatt tttttgtaaa tataaagagg aacttcaatt
     2641 atgaaaaatt tttaaaagat atatatatct atatatctat atatatgtac tgttttgttt
     2701 cctgtcttga agattttgag ttatggttat tggtttcaga ttgattaatt cacatatgct
     2761 gtgttttgaa atgagatccc attagctttt tttttttttt ttttttttca atataaagtg
     2821 ttttctttaa aagtcatatt ggttcgtggc ctagtgcctt ggattttaca tatttttctt
     2881 tttaaatgca aaaccttttc aacaaaatag tgtttgtcat caggttggta ctaaacattt
     2941 ataattactg tgtaattata aacaaaaata cataaagctt tgaatataat tatgtagcat
     3001 aaaagttaag gttgttcact atgatggcat cttagaatta aacaaaactt ttactagggc
     3061 tgaaaagaga agactgattt aatgtggtgt gattattctg aagataaatg tctggctaca
     3121 gggaatattt tgtactaaaa aatgattaca catatggctg tgtgtgtttg agtctgtgtc
     3181 tgtgagagag ccagagagag tgagagagat tgacagagaa agggagagac acacacacgc
     3241 cccttgaatt gctttaactc ctaagtgttt cagtcctcat tccggtaaac tccccatgct
     3301 gattctttgt tttaaactga accataggta cagtttcctt tttgccaaat gtcaaaacag
     3361 gtacaaattt taaaatgtaa tgctttttaa atagaaaaat gtataaaatt agaagtgccc
     3421 acatataaaa aatacttgag atgaagatta tctttagtga atatcatctg catatctctg
     3481 taagttcaat tgtgtttctt acagtccctg tcatattacc aacagaggca ataaaagctg
     3541 cagtgaaatt gccatgacta aatcttttca catatttcag tgtatttttt ttatagattt
     3601 aaaatatacc tgaaaacttt tctaggaaga ataattattc atggaaagag cattgtaatg
     3661 gcatgttttg gggagaaaag acatgccaag tcttgtttac tacatttaag atgtttacaa
     3721 ctatactggg ctgctttatt aacaatactg tacttgcata atatggcatt ataagtacat
     3781 gtccttcctt agacttttaa aaagttttaa tgagagaaag taaatttact caacaaaata
     3841 acatgagaaa tcctttacgt aatatcttta ctggggaatt cttatttaag caaggtacac
     3901 tattttttcc tcagacttaa atgaatgaag tgttcattta ttttttattt gatgataatc
     3961 aagaagtgag tagtagtagc taacttaatg tacactttgc ttaggttttt aaacatgtta
     4021 ctattaagac tacgtattgt aaaccttctg taattttcac atatgaatga caggagaaag
     4081 ttaaacctaa tcgaaggagt tttggaataa aaaagtggtg ctggggaaat tcaccatggt
     4141 tcacaaagta tgcctttgta aaactgaatc aacttttagc aagaattaat ttatgtagtt
     4201 ttaaatgtta aattgtgtat atttaacaga aaatacttat ctggcacctc agcagtttta
     4261 atgttacctt atacttttaa cagtatgatt tatattgaat acttagatgt tttcataaga
     4321 ttttatcaaa tttgataatg taatgataaa atgttttttt aaatgtgaac tatttaacat
     4381 ataaatgggg acacaaaacc tgaattgtga tttctacata atgtgataat tagggttcaa
     4441 attatgactc atcatttaat tgattataaa tgagtatatt tctgaactct ttattgcctc
     4501 catttttaca atcataatat agcaataatt tctattttta tttcatagga ctgtggtgaa
     4561 gttatttatc atgacacctt tatctttgat ttctgaggga aaggggtgta tattttgtag
     4621 ttaagataaa tgagaaagtt cctaatagta caaatgccct tttccaggtt tatctttgct
     4681 atttgttgcc atttttctta aatatttgct ttatttgtac ccgatttctg gaggcaaata
     4741 gtgctgtttt ttcaaactca taatatagtt acataaatga ttttatcaga gcattcttgc
     4801 tatcttattt tctttcctac ctgttgagta agtagcattt cttgctcacc aactcattta
     4861 tttgactagg ttcagtgttt cctattaatg tgttttttta ttttcctttg gttgattttg
     4921 aaaaatctgt cacaaataag gaagttatgg taaaagatgc acagcctttg tagttagtgg
     4981 aattctcaat aagtaatgtc tttatggagt tttaaaggga aattatttaa agggaatcat
     5041 gttatagttg tccatttttt aaattgagat tttaaaagtg tttttaagta tagcccaatt
     5101 ttctatttac ttacaagtgc ttcatgattg ttttcttttt tattttttgc catcatgctg
     5161 tgcagaaatc ataatgtagc ttgtaatact tcagagcatt ggtcttgaag ctgtaacttg
     5221 gggctgctgt ccttcatgag gtagggccat agcaggcagg ccctttccca cttcctttat
     5281 ggcattctac ttttatctgt tgtaggctgt tagtgtttca tattcgattt ggtttgggga
     5341 aaaatactca gttaaaaaaa ttttttttaa tgattggctt tagagggact gttacctctt
     5401 tggcatatct gtcagcggaa tggaaagaaa tggagtcaga ctgaaattca tgccagctta
     5461 atcactgaag gcagcactgc tttgaaaaga agaattttca acccacatcg taaaaacaaa
     5521 gcctgattgg aaacaatgaa gtgtttgaaa cttaggggca gcatgtaagt ggcttaatga
     5581 gcaaacaaac ggaacatact cattttatat ttaaaaagta catatatatt caaatgcatg
     5641 ttcatatgaa tattataatt ttatttcagg ttatgaaata ttctgagaaa accttatatc
     5701 tgatggaaaa cttgggcaat acccaatacg aagcaagaga tttttacaaa aagaaatact
     5761 atagggcata aggttggggg aagaccaatt aatgaaatgg ctaagggaca atgctaatta
     5821 aatcgttaac agtgattttg tcacataatt acatgactta tagctaaaag agcaatattt
     5881 aatcagtaag atttagagat gggtgtactt ggaatccttt gaaagcagcg tgtttagttt
     5941 tcaagcaaat gctaatgttc ttaatcctaa tagtatatta gacttcgttg tgttgaatat
     6001 atcaaatgaa cgaactatga accagagctt taaaatagtg atttgtaaga ctttgttaca
     6061 atggtactta aaaaattgct ttgtataatt tacacactgt aaaattcacc cattgtacat
     6121 gtacaattaa ttgtttttag taaacttaag agttgtgcag tccaatttta gaacatgtcc
     6181 atcagccccc aaaatttact cctgctgctc tgcggttaat ttgctcctgc ctccagcccc
     6241 acgcagccac actgatctgc tttctgtaca gatttaccct ttctagaaat ttcacagagg
     6301 tagaatcatg cagttagtct tttatatctg gcatctttca cttagcatgt ttttgaggtt
     6361 catccatgtt gcagcttata cctgcgtgta gttcctttag ttgctgactt agtgttcact
     6421 gtttggatat accacatttt gtttatccat tcaccagttg atagacattt ggctggccta
     6481 caattagttt ttttaaattg cgaataataa tgctatgaac attcataaat gtctttgtgt
     6541 ggacatgttt tcatctcaga ttcctagttg tggaattgtc aggttgtgtg gtaaatttat
     6601 acctaacgtt tttaaaaaaa ctgctgaact ttttccaaag tggctgtact tctagaacta
     6661 ttcctgccac agtgcatgcg gactgccgtg tctgcacatc cttgccaata cttgtctttt
     6721 ttattgcagc catcctggcg ggtatttact ttatgtgtgt gagttatacc taggcatccc
     6781 aactcgtgta tcgattggat gtgcagtttg agtgagtttc aagtggcctc agcgattgct
     6841 gtaaaattag ttactctagt agacatgtac tctcttggag gtagtatttt ctgtagtcag
     6901 tgagggtaat aataatactt ccagtggggg ttccagtccc tcagtgatct ctggtgagaa
     6961 gaaatgtgtc agcgaagagt ggtgctgatg gctggtgctt tggctctgtt attgtttgta
     7021 ccaaggttga tacagctact cgactagcct atgactgact ggtggtggta attaaacttt
     7081 gtacagatta ctgtgtgcag atagttactg tcttaatatt aagtttccca gagattttac
     7141 ttttgagata gctgagaatt aacgactctt ggaatttata aaaatttagt tgataccatt
     7201 tagttgctgc cagctgcctg tgttcttata cataggagac atcggagtga gtgcttttta
     7261 aaaaattaat ggcgtatgtc aggtatatgt aaaaggacaa ttgcataatg aactcatgtt
     7321 aacatgatca atccatggcc aatcttgatt tatctaaatg ccattcatct ttgaacccct
     7381 atttattttg aagcaaatcc cagatagcaa atcatttcat ttgtaaatat ttcaatatgt
     7441 atgtctaaaa gataaggact gttaaataaa accacaattc tgttgttaga cttaactgtt
     7501 aacagtttgt tagtgttaat aactacccag cagtgttcaa gttgtgcctt tttttttttt
     7561 tttccaattc aagtcaggat tcaaataaga ttcctacatt gcatacatct caaatgtcct
     7621 acccagtgga tccccacact ctccactctt tggcttcaaa ttcatttttt tgaaaaaaca
     7681 atgattgctt tagcacttta aatttctatg caatttcaaa tgtaaggtga aattttgatg
     7741 tacttaataa aaaaattcta acgaatatat ttttcaagtt aatgtagtat ataagaagct
     7801 attatatcaa cagattttcc tttaacttaa aaatacatcg tgacttgta
//
