LOCUS       NM_024096               1181 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1,
            mRNA.
ACCESSION   NM_024096
VERSION     NM_024096.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1181)
  AUTHORS   Wang,Y., Chen,X., Chen,Q., Liu,T., Wu,Y., Huang,L. and Chen,Y.
  TITLE     Expression of human dCTP pyrophosphatase 1 (DCTPP1) and its
            association with cisplatin resistance characteristics in ovarian
            cancer
  JOURNAL   J Cell Mol Med 28 (9), e18371 (2024)
   PUBMED   38686496
  REMARK    GeneRIF: Expression of human dCTP pyrophosphatase 1 (DCTPP1) and
            its association with cisplatin resistance characteristics in
            ovarian cancer.
REFERENCE   2  (bases 1 to 1181)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1181)
  AUTHORS   Yue,Z., Shusheng,J., Hongtao,S., Shu,Z., Lan,H., Qingyuan,Z.,
            Shaoqiang,C. and Yuanxi,H.
  TITLE     Silencing DSCAM-AS1 suppresses the growth and invasion of
            ER-positive breast cancer cells by downregulating both DCTPP1 and
            QPRT
  JOURNAL   Aging (Albany NY) 12 (14), 14754-14774 (2020)
   PUBMED   32716908
  REMARK    GeneRIF: Silencing DSCAM-AS1 suppresses the growth and invasion of
            ER-positive breast cancer cells by downregulating both DCTPP1 and
            QPRT.
            Erratum:[Aging (Albany NY). 2022 Jan 15;14(1):528-529. doi:
            10.18632/aging.203837.. PMID: 35050859]
REFERENCE   4  (bases 1 to 1181)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1181)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1181)
  AUTHORS   Song,F.F., Xia,L.L., Ji,P., Tang,Y.B., Huang,Z.M., Zhu,L.,
            Zhang,J., Wang,J.Q., Zhao,G.P., Ge,H.L., Zhang,Y. and Wang,Y.
  TITLE     Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and
            stemness through the modulation on 5-methyl-dCTP metabolism and
            global hypomethylation
  JOURNAL   Oncogenesis 4 (6), e159 (2015)
   PUBMED   26075750
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1181)
  AUTHORS   Requena,C.E., Perez-Moreno,G., Ruiz-Perez,L.M., Vidal,A.E. and
            Gonzalez-Pacanowska,D.
  TITLE     The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and
            cleansing of the dNTP pool in human cells
  JOURNAL   Biochem J 459 (1), 171-180 (2014)
   PUBMED   24467396
  REMARK    GeneRIF: DCTPP1 has a central role in the balance of dCTP and the
            metabolism of deoxycytidine analogues.
REFERENCE   8  (bases 1 to 1181)
  AUTHORS   Zhang,Y., Ye,W.Y., Wang,J.Q., Wang,S.J., Ji,P., Zhou,G.Y.,
            Zhao,G.P., Ge,H.L. and Wang,Y.
  TITLE     dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple
            carcinomas
  JOURNAL   Eur J Histochem 57 (3), e29 (2013)
   PUBMED   24085278
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1181)
  AUTHORS   Corson,T.W., Cavga,H., Aberle,N. and Crews,C.M.
  TITLE     Triptolide directly inhibits dCTP pyrophosphatase
  JOURNAL   Chembiochem 12 (11), 1767-1773 (2011)
   PUBMED   21671327
  REMARK    GeneRIF: Human dCTP pyrophosphatase 1 binds and is inhibited by the
            small molecule triptolide in vitro.
REFERENCE   10 (bases 1 to 1181)
  AUTHORS   Moroz,O.V., Murzin,A.G., Makarova,K.S., Koonin,E.V., Wilson,K.S.
            and Galperin,M.Y.
  TITLE     Dimeric dUTPases, HisE, and MazG belong to a new superfamily of
            all-alpha NTP pyrophosphohydrolases with potential 'house-cleaning'
            functions
  JOURNAL   J Mol Biol 347 (2), 243-255 (2005)
   PUBMED   15740738
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001344.1 and AC116348.3.
            
            On May 17, 2019 this sequence version replaced NM_024096.1.
            
            Summary: The protein encoded by this gene is dCTP pyrophosphatase,
            which converts dCTP to dCMP and inorganic pyrophosphate. The
            encoded protein also displays weak activity against dTTP and dATP,
            but none against dGTP. This protein may be responsible for
            eliminating excess dCTP after DNA synthesis and may prevent
            overmethylation of CpG islands. Three transcript variants, one
            protein-coding and the other two non-protein coding, have been
            found for this gene. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) is the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.623808.1,
                                           SRR7410570.623803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319285.5/ ENSP00000322524.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1098              BC001344.1         23-1120
            1099-1181           AC116348.3         97765-97847
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1181
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /note="dCTP pyrophosphatase 1"
                     /db_xref="GeneID:79077"
                     /db_xref="HGNC:HGNC:28777"
                     /db_xref="MIM:615840"
     exon            1..151
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..563
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /EC_number="3.6.1.12"
                     /note="XTP3-transactivated protein A; dCTPase 1;
                     deoxycytidine-triphosphatase 1; XTP3-transactivated gene A
                     protein"
                     /codon_start=1
                     /product="dCTP pyrophosphatase 1"
                     /protein_id="NP_077001.1"
                     /db_xref="CCDS:CCDS10680.1"
                     /db_xref="GeneID:79077"
                     /db_xref="HGNC:HGNC:28777"
                     /db_xref="MIM:615840"
                     /translation="MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAE
                     RDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIY
                     LVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADI
                     PCDSTGQTST"
     exon            152..262
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /inference="alignment:Splign:2.1.0"
     exon            263..1181
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1074..1079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /note="hexamer: AATAAA"
     polyA_site      1098
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /note="major polyA site"
     regulatory      1155..1160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
                     /note="hexamer: AGTAAA"
     polyA_site      1181
                     /gene="DCTPP1"
                     /gene_synonym="CDA03; RS21C6; XTP3TPA"
ORIGIN      
        1 gagcgtggct cgtgggtttt ccgtgaagtc gcggtgcagc ggtgggcggc atgtctgtgg
       61 ccggtgggga gattcgtggg gacacggggg gagaggacac tgctgctccc ggccggttca
      121 gcttcagccc ggagcccacg ctcgaggaca tccgccgcct ccatgctgag tttgctgcgg
      181 aacgagactg ggaacagttc catcagcctc ggaatctcct cctggccttg gttggggaag
      241 tgggggagct ggcagaactc tttcagtgga aaaccgatgg ggaacctggc ccccaaggct
      301 ggtcccccag ggaacgggca gcccttcaag aggagcttag tgacgtcctc atctacctgg
      361 tggcattagc agcccgctgc cgtgtggatc tgccgctagc agtgctctcc aaaatggaca
      421 tcaaccggcg acgctaccca gcccatctgg cccgcagctc ttcccgcaag tatacagaat
      481 tgccccatgg ggccatctct gaagaccagg ctgtggggcc tgcggacatt ccctgtgact
      541 ccacaggcca gacctcaacc tagaaagatg gccacaggac ttgcaactca gggtggtgtc
      601 tgaagagcag agagtggcct ggccctggag cctttttcta gtcttttcag aatagatcat
      661 gggcctgagg cctccacttc ttgaggtctg aggcccagca gcctctagaa ggtagcctcc
      721 tggtgtttgt tctcccagta aaatggtttt gggcgataac ttctagatta ttcctggatg
      781 gccagggagg ctctctgtct cagcaggtga tgacgggggt accaggggtg cctctgagac
      841 ccattctcgt gtttccctgt tgtacctttt gcctgcaggg cagagagatc tggtttctag
      901 caaattccca gtaggatgtc atgtaagttc cttccccctc ttagagattg aaggctgtaa
      961 gagtccagat ggtggagcca ggctgtctgg gttcaaatgc catctttgac acttgcaagc
     1021 taaatgacat tactcaaatt aatcgttctg cacttcagct tccttgtcta tcaaataaaa
     1081 agaatagtac ctgcccaata gggtcgtgag gtttcaatga gttatgtgaa tgctcagggc
     1141 ggggcctggc acatagtaaa gtacacttgg taagttttgc a
//
