LOCUS       NM_006571               1054 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dynactin subunit 6 (DCTN6), mRNA.
ACCESSION   NM_006571
VERSION     NM_006571.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Su,X., Li,H., Chen,S. and Qin,C.
  TITLE     Study on the Prognostic Values of Dynactin Genes in Low-Grade
            Glioma
  JOURNAL   Technol Cancer Res Treat 20, 15330338211010143 (2021)
   PUBMED   33896271
  REMARK    GeneRIF: Study on the Prognostic Values of Dynactin Genes in
            Low-Grade Glioma.
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   4  (bases 1 to 1054)
  AUTHORS   Yeh,T.Y., Kowalska,A.K., Scipioni,B.R., Cheong,F.K., Zheng,M.,
            Derewenda,U., Derewenda,Z.S. and Schroer,T.A.
  TITLE     Dynactin helps target Polo-like kinase 1 to kinetochores via its
            left-handed beta-helical p27 subunit
  JOURNAL   EMBO J 32 (7), 1023-1035 (2013)
   PUBMED   23455152
  REMARK    GeneRIF: Dynactin helps target Polo-like kinase 1 to kinetochores
            via its left-handed beta-helical p27 subunit.
REFERENCE   5  (bases 1 to 1054)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 1054)
  AUTHORS   Parisi,G., Fornasari,M.S. and Echave,J.
  TITLE     Dynactins p25 and p27 are predicted to adopt the LbetaH fold
  JOURNAL   FEBS Lett 562 (1-3), 1-4 (2004)
   PUBMED   15043994
REFERENCE   7  (bases 1 to 1054)
  AUTHORS   Eckley,D.M., Gill,S.R., Melkonian,K.A., Bingham,J.B., Goodson,H.V.,
            Heuser,J.E. and Schroer,T.A.
  TITLE     Analysis of dynactin subcomplexes reveals a novel actin-related
            protein associated with the arp1 minifilament pointed end
  JOURNAL   J Cell Biol 147 (2), 307-320 (1999)
   PUBMED   10525537
REFERENCE   8  (bases 1 to 1054)
  AUTHORS   Murdock,D.G., Boone,B.E., Esposito,L.A. and Wallace,D.C.
  TITLE     Up-regulation of nuclear and mitochondrial genes in the skeletal
            muscle of mice lacking the heart/muscle isoform of the adenine
            nucleotide translocator
  JOURNAL   J Biol Chem 274 (20), 14429-14433 (1999)
   PUBMED   10318868
REFERENCE   9  (bases 1 to 1054)
  AUTHORS   Ichikawa,K., Yamabe,Y., Imamura,O., Kuromitsu,J., Sugawara,K.,
            Suzuki,N., Shimamoto,A., Matsumoto,T., Tokutake,Y., Kitao,S.,
            Kataoka,H., Satoh,M., Sugimoto,M., Goto,M., Sugawara,M. and
            Furuichi,Y.
  TITLE     Cloning and characterization of a novel gene, WS-3, in human
            chromosome 8p11-p12
  JOURNAL   Gene 189 (2), 277-287 (1997)
   PUBMED   9168138
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013175.1 and D79389.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006571.3.
            
            Summary: The protein encoded by this gene contains an RGD
            (Arg-Gly-Asp) motif in the N-terminal region, which confers
            adhesive properties to macromolecular proteins like fibronectin. It
            shares a high degree of sequence similarity with the mouse homolog,
            which has been suggested to play a role in mitochondrial
            biogenesis. The exact biological function of this gene is not
            known. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.517648.1,
                                           SRR3476690.1104743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221114.8/ ENSP00000221114.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-959               BC013175.1         17-975
            960-1054            D79389.1           127-221
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..1054
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /note="dynactin subunit 6"
                     /db_xref="GeneID:10671"
                     /db_xref="HGNC:HGNC:16964"
                     /db_xref="MIM:612963"
     exon            1..38
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..588
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /note="novel RGD-containing protein; protein WS-3;
                     dynactin subunit p27; dynactin 6"
                     /codon_start=1
                     /product="dynactin subunit 6"
                     /protein_id="NP_006562.1"
                     /db_xref="CCDS:CCDS6076.1"
                     /db_xref="GeneID:10671"
                     /db_xref="HGNC:HGNC:16964"
                     /db_xref="MIM:612963"
                     /translation="MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAE
                     AGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMG
                     DNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQ
                     TLQLDFLMKILPNYHHLKKTMKGSSTPVKN"
     exon            39..103
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     exon            104..209
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     exon            210..298
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..346
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..489
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1054
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /note="hexamer: AATAAA"
     polyA_site      953
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /note="major polyA site"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /note="hexamer: ATTAAA"
     polyA_site      1054
                     /gene="DCTN6"
                     /gene_synonym="p27; WS-3; WS3"
                     /note="major polyA site"
ORIGIN      
        1 aattggggcc gtaccatggc ggagaagact caaaagagtg tgaagattgc tcctggagca
       61 gttgtatgtg tagaaagtga aatcagagga gatgtaacta tcggacctcg gacagtgatc
      121 caccctaaag caagaattat tgcggaagcc gggccaatag tgattggcga agggaaccta
      181 atagaagaac aggcccttat cataaatgct tacccagata atatcactcc tgacactgaa
      241 gatccagaac caaaacctat gatcattggc accaataatg tgtttgaagt tggctgttat
      301 tcccaagcca tgaagatggg agataataat gtcattgaat caaaagcata tgtaggcaga
      361 aatgtaatat tgacaagtgg ctgcatcatt ggggcttgtt gcaacctaaa tacatttgaa
      421 gtcatccctg agaatacggt gatctatggt gcagactgcc ttcgtcgggt gcagactgag
      481 cgaccgcagc cccagacact acagctggat ttcttgatga aaatcttgcc aaattaccac
      541 cacctaaaga agactatgaa aggaagctca actccagtaa agaactaaga acagtgtata
      601 acatgaagat aacattttgt ctttgaccac tgtcttttga atgggcccac agtgtttatg
      661 tactcttaac aactcacaga ataatacatg ttcactttat tttgtaaaat tgggttgaga
      721 ggaaactaat ggagtttcat tgtaactgtc ctttgtaatt tatataaatg tattattttc
      781 ctatatcctt ggttcttttc tgataattta cagatttagc ttttcttttg ttatataaac
      841 tgctagccac aaattttagt tatgtaaaag gctacccttg acaagaaaag acatactgtc
      901 atgtatttat attctagcat agactaaact gaataaaaat gctgataaca ggacctttag
      961 taagcatact ttaatcagtt tttctccttg aattaatctt ttctcttaat ttttattatg
     1021 tactagttgt attaaagcta atgtgtttac tttt
//
