LOCUS       NM_016221               4116 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dynactin subunit 4 (DCTN4), transcript variant 2,
            mRNA.
ACCESSION   NM_016221
VERSION     NM_016221.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Su,X., Li,H., Chen,S. and Qin,C.
  TITLE     Study on the Prognostic Values of Dynactin Genes in Low-Grade
            Glioma
  JOURNAL   Technol Cancer Res Treat 20, 15330338211010143 (2021)
   PUBMED   33896271
  REMARK    GeneRIF: Study on the Prognostic Values of Dynactin Genes in
            Low-Grade Glioma.
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 4116)
  AUTHORS   Ayalon,G., Davis,J.Q., Scotland,P.B. and Bennett,V.
  TITLE     An ankyrin-based mechanism for functional organization of
            dystrophin and dystroglycan
  JOURNAL   Cell 135 (7), 1189-1200 (2008)
   PUBMED   19109891
REFERENCE   7  (bases 1 to 4116)
  AUTHORS   Lim,C.M., Cater,M.A., Mercer,J.F. and La Fontaine,S.
  TITLE     Copper-dependent interaction of dynactin subunit p62 with the N
            terminus of ATP7B but not ATP7A
  JOURNAL   J Biol Chem 281 (20), 14006-14014 (2006)
   PUBMED   16554302
  REMARK    GeneRIF: ATP7B interaction with p62 is a key component of the
            copper-induced trafficking pathway that delivers ATP7B to subapical
            vesicles of hepatocytes for the removal of excess copper into bile
REFERENCE   8  (bases 1 to 4116)
  AUTHORS   Boultwood,J., Fidler,C., Strickson,A.J., Watkins,F., Kostrzewa,M.,
            Jaju,R.J., Muller,U. and Wainscoat,J.S.
  TITLE     Transcription mapping of the 5q- syndrome critical region: cloning
            of two novel genes and sequencing, expression, and mapping of a
            further six novel cDNAs
  JOURNAL   Genomics 66 (1), 26-34 (2000)
   PUBMED   10843801
REFERENCE   9  (bases 1 to 4116)
  AUTHORS   Karki,S., Tokito,M.K. and Holzbaur,E.L.
  TITLE     A dynactin subunit with a highly conserved cysteine-rich motif
            interacts directly with Arp1
  JOURNAL   J Biol Chem 275 (7), 4834-4839 (2000)
   PUBMED   10671518
REFERENCE   10 (bases 1 to 4116)
  AUTHORS   Bingham,J.B. and Schroer,T.A.
  TITLE     Self-regulated polymerization of the actin-related protein Arp1
  JOURNAL   Curr Biol 9 (4), 223-226 (1999)
   PUBMED   10074429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC321382.1, AK000299.1, AL162085.1 and AC008453.6.
            
            On Feb 27, 2020 this sequence version replaced NM_016221.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026323.1, AK000299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447998.7/ ENSP00000416968.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DC321382.1         79-81
            4-1627              AK000299.1         1-1624
            1628-3809           AL162085.1         656-2837
            3810-4116           AC008453.6         12110-12416
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..4116
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /note="dynactin subunit 4"
                     /db_xref="GeneID:51164"
                     /db_xref="HGNC:HGNC:15518"
                     /db_xref="MIM:614758"
     exon            1..159
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1407
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /note="isoform b is encoded by transcript variant 2;
                     dynactin p62 subunit; dynactin subunit p62; dynactin 4
                     (p62)"
                     /codon_start=1
                     /product="dynactin subunit 4 isoform b"
                     /protein_id="NP_057305.1"
                     /db_xref="CCDS:CCDS4310.1"
                     /db_xref="GeneID:51164"
                     /db_xref="HGNC:HGNC:15518"
                     /db_xref="MIM:614758"
                     /translation="MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSH
                     EVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTT
                     MKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKV
                     ERDRKKLARRRNYMPLAFSDKYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEP
                     AQAVDEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLR
                     CRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVE
                     NLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDELAEPQDFQDDPDII
                     AFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQH
                     VELSLGPLLP"
     exon            160..230
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            231..409
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            410..453
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            454..561
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            562..635
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            636..748
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            749..858
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            859..932
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            933..987
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1095
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1193
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..4116
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /note="hexamer: AATAAA"
     polyA_site      3809
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /note="major polyA site"
     regulatory      4028..4033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
                     /note="hexamer: TATAAA"
     polyA_site      4049
                     /gene="DCTN4"
                     /gene_synonym="DYN4; P62"
ORIGIN      
        1 gtcatcgcct cctccctccc caagatggcg tccttgctgc agtcggaccg ggttctctat
       61 ctagtccagg gagaaaagaa ggttcgggcc ccgctctcgc aactctactt ctgccgctat
      121 tgtagcgaac tgcggtcgct ggaatgtgtg tctcacgagg tggactccca ttattgtccc
      181 agttgtttag aaaatatgcc atcggctgaa gccaaactaa aaaagaatag atgtgccaat
      241 tgttttgact gtcctggctg catgcacacc ctctctactc gggccacgag catctccaca
      301 cagcttccag atgacccagc caagaccacc atgaagaaag cctattacct ggcatgtgga
      361 ttttgtcgct ggacgtctag agatgtgggc atggcagaca aatctgtagc tagtggcggt
      421 tggcaggaac ctgaaaatcc tcacacacaa cggatgaaca aattgattga atattaccag
      481 cagcttgctc agaaagagaa ggttgagcga gatcgcaaga aactggcacg acgtagaaac
      541 tatatgcctc tggctttttc ggacaaatat ggtcttggaa ccaggcttca gcgaccacga
      601 gctggtgcat ccatcagtac ccttgccgga ctttccctta aagaaggaga ggatcagaaa
      661 gagataaaga ttgagccagc tcaggctgtg gatgaagtgg aacctctacc tgaagactat
      721 tatacaagac cagtaaattt aacagaggta acaacccttc agcagcgtct gttacagcct
      781 gacttccagc cagtctgtgc ttcacagctc tatcctcgcc acaaacatct tctgatcaaa
      841 cggtccctgc gctgccgtaa atgtgaacat aatttgagca agccagaatt taacccaacg
      901 tcaatcaaat tcaaaatcca gctggtcgct gtcaattata ttccagaagt gagaatcatg
      961 tcaattccca accttcgcta catgaaggag agccaggtcc tcctgactct tacaaatcca
     1021 gttgagaacc tcacccatgt gactctcttc gagtgtgagg agggggaccc tgatgatatc
     1081 aacagcactg ctaaggtggt ggtgcctccc aaagagctcg ttttagctgg caaggatgca
     1141 gcagcagagt acgatgagtt ggcagaacct caagactttc aggacgatcc tgacattata
     1201 gccttcagaa aggccaacaa agtgggtatt ttcatcaaag ttacaccaca gcgtgaggag
     1261 ggtgaagtga ccgtgtgctt caagatgaag catgatttta aaaacctggc agcccccatt
     1321 cgccccattg aagaaagtga ccagggaaca gaagtcatct ggctcaccca gcatgtggaa
     1381 cttagcttgg gcccacttct tccttaaaag gttccactgg agggcagatc ccaaaggaca
     1441 gtatcaccgt aaacctgcgt taaaatgtgg aagctgctgc ttcattaggc cttgtttata
     1501 acgatgtacc catgcactac ggaattctat tgctaagaaa gtgggagcat aggcaaggca
     1561 ttgggaacac agggtagctg ctgttgctct tgctctcacc cctgttgaca ccagtaagtc
     1621 tgtgtctccc tcactgaacc ctgcacgttg agtaacagca gcataattcc atcctaggaa
     1681 aggggatggg tgttccttgg aatggcattg tatttaccac ctgagaaact ctgtactgtc
     1741 tcttgatctg atctcactaa ggatcacaat gtcacagatg aaacttaaat gataacccaa
     1801 aggtagacct gctgttaatg atccagcatt ggtcacaatg taccaactgc tttctgcatt
     1861 ccgttaaata tcatctaaca gtctaaaaca tatcccttca ttgccataat ggctgccatt
     1921 ttgccataga tttccatata actgaaaaac tgaattgtca ctttatcttt agtatcatga
     1981 tgattggaaa aacctgtgaa gttgttaagg cactctcatt tgccctcttt ttctaagtga
     2041 atacaggaca cgtattagtt gttcttaatt tttttcccag taaaatatgg atcttttaag
     2101 aagaatttga gaagcaaaca attacatgtc atgtcaaggg ggtagcagat tccattcgtt
     2161 ttcaatattg ccacaatacc cagggattaa tgctgccaca ggggggcaat ctttatttgt
     2221 cttacttcct accccttccc tgttctgcct ctttaactca gttaagttgt tctgtttggg
     2281 acctggaaaa gaacccaaag aaaacctgag tggacaggtt catttctgga atgcagaaaa
     2341 cattttaaag gctagatttt tagaatattc tcaactagca ttctttccat tgatttgaag
     2401 gggaaattaa ctattataat ctcttgaatc caaaactgga tattaagaac tttccccctt
     2461 actaagttta agacttttgt catgtggtga gtcaaataag accattttga ttgtaaacca
     2521 taaaatagtt cagcaagtag cccacagttc tggcctaaca gcagacttgc tgttttcact
     2581 tggtatcctg gagttgggtt gctaacctta atttctatga tgttttctaa aatgaaactt
     2641 gataaagtag accaccagct gcaccgtgtt ttctgtaaaa gtattgttag taagtggcca
     2701 agagacttga ggaaaataca gattttttgt ttaccttggt cttgttttaa gtcttaaaaa
     2761 attaaagata acattataat gtagaataca gatgggacat agtccttgta agcttccctt
     2821 gaaaatgttt taaatattta ggaagctttt aaaagacact aaattgtact ctaaaagaca
     2881 ctaaattgta ctaattgtac aaaggtcaag ccaattttat gaaacagtcc tacagagtaa
     2941 tatatgtgat gcagtgtaag aaggaaaata ctcatctcta acattatggt aataacattt
     3001 agcctcttag gagttggagc agggggatgg gtaattacag atttgcagac tatagaaaga
     3061 gtttcatttt tttgtgaccc cacagagtct caaattttta tttcactacc tgctagagcc
     3121 tactgtgaaa tcactgctcc atatttgcca gtggaggaaa tgggcataga gtagagaata
     3181 gcttcatatg tttacacgtt tgcatagact acacacatgt catgcgttta tggcaggtag
     3241 ctggtattta ttccccaaag taataatgtt gaagtatggg tctcatcatt cccatacaca
     3301 gaaacacaaa acactttgat cataaacttt tttcttcaga agccaaacta acttgcagaa
     3361 taatagagcc actggtttaa tgtttcctca agataggttt tagtgtaagc tagtattctg
     3421 tgtgttcgta gaaatgattc aatacctgca gctggtgaat taggaattgt atttgttgcc
     3481 ttttttatat tagatgaggt gcaaaaattt taatgctagt cagtatgcac caccacagga
     3541 aagttagatc ccattagcac ttgaaactac agctttggaa acttaggcta agttaatttg
     3601 gatttgttac ttgattcacc tactgacctt ttcttttgtt tgaagtgctt atcagcataa
     3661 tgagctaagt gtcatgcata tttgtgaaga aacacccttt ttggtccctt ttgggacaga
     3721 gaggtactcc ttgatcttta tgaatgacag gttactgttt tgccttattg cttaacttaa
     3781 tgtagtgaaa taaagcagac aaagcttgag cgtgtctttt gtttgctctc atgtagatac
     3841 taagtagcat ggctcagagc caaaagacaa gcgtgaagtt aagagagttg gctaagagag
     3901 ttggtggggc atgctccctt ccattcctta aatgaagtaa tctaaaatct cttagcaggt
     3961 tagttcacca taatatataa gtagatgttg ctttgagctt cttatataca tattcacaga
     4021 accattatat aaatgttgtt agacctctac cagtttttat cctgggtcat tgcttctaaa
     4081 gatatccttt acaatataca cagtggtctg actcca
//
