LOCUS       NM_001921               1928 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dCMP deaminase (DCTD), transcript variant 2, mRNA.
ACCESSION   NM_001921
VERSION     NM_001921.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1928)
  AUTHORS   Fugger,K., Bajrami,I., Silva Dos Santos,M., Young,S.J.,
            Kunzelmann,S., Kelly,G., Hewitt,G., Patel,H., Goldstone,R.,
            Carell,T., Boulton,S.J., MacRae,J., Taylor,I.A. and West,S.C.
  TITLE     Targeting the nucleotide salvage factor DNPH1 sensitizes
            BRCA-deficient cells to PARP inhibitors
  JOURNAL   Science 372 (6538), 156-165 (2021)
   PUBMED   33833118
REFERENCE   2  (bases 1 to 1928)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1928)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1928)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1928)
  AUTHORS   Xie,G., Roshandel,D., Sherva,R., Monach,P.A., Lu,E.Y., Kung,T.,
            Carrington,K., Zhang,S.S., Pulit,S.L., Ripke,S., Carette,S.,
            Dellaripa,P.F., Edberg,J.C., Hoffman,G.S., Khalidi,N.,
            Langford,C.A., Mahr,A.D., St Clair,E.W., Seo,P., Specks,U.,
            Spiera,R.F., Stone,J.H., Ytterberg,S.R., Raychaudhuri,S., de
            Bakker,P.I., Farrer,L.A., Amos,C.I., Merkel,P.A. and
            Siminovitch,K.A.
  TITLE     Association of granulomatosis with polyangiitis (Wegener's) with
            HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide
            analysis
  JOURNAL   Arthritis Rheum 65 (9), 2457-2468 (2013)
   PUBMED   23740775
REFERENCE   6  (bases 1 to 1928)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   7  (bases 1 to 1928)
  AUTHORS   Weiner,K.X., Ciesla,J., Jaffe,A.B., Ketring,R., Maley,F. and
            Maley,G.F.
  TITLE     Chromosomal location and structural organization of the human
            deoxycytidylate deaminase gene
  JOURNAL   J Biol Chem 270 (32), 18727-18729 (1995)
   PUBMED   7642519
REFERENCE   8  (bases 1 to 1928)
  AUTHORS   Weiner,K.X., Weiner,R.S., Maley,F. and Maley,G.F.
  TITLE     Primary structure of human deoxycytidylate deaminase and
            overexpression of its functional protein in Escherichia coli
  JOURNAL   J Biol Chem 268 (17), 12983-12989 (1993)
   PUBMED   7685356
REFERENCE   9  (bases 1 to 1928)
  AUTHORS   Maley,G.F., Lobo,A.P. and Maley,F.
  TITLE     Properties of an affinity-column-purified human deoxycytidylate
            deaminase
  JOURNAL   Biochim Biophys Acta 1162 (1-2), 161-170 (1993)
   PUBMED   8448179
REFERENCE   10 (bases 1 to 1928)
  AUTHORS   Tyrsted,G., Chao,P.C. and Munch-Petersen,B.
  TITLE     Deoxycytidylate deaminase activity in non-stimulated and
            phytohemagglutinin-stimulated human lymphocytes, and in leukemic
            cells
  JOURNAL   Mol Cell Biochem 76 (1), 27-34 (1987)
   PUBMED   3627112
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ228061.1, BC001286.1,
            BU188090.1 and AC079766.7.
            
            On Aug 13, 2020 this sequence version replaced NM_001921.2.
            
            Summary: The protein encoded by this gene catalyzes the deamination
            of dCMP to dUMP, the nucleotide substrate for thymidylate synthase.
            The encoded protein is allosterically activated by dCTP and
            inhibited by dTTP, and is found as a homohexamer. This protein uses
            zinc as a cofactor for its activity. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            compared to variant 1. The resulting isoform (b) is shorter at the
            N-terminus compared to isoform a. Variants 2 through 9 encode the
            same isoform (9).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001286.1, SRR11853561.22784.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438320.7/ ENSP00000398194.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BQ228061.1         208-241
            35-366              BC001286.1         1-332
            367-820             BU188090.1         287-740
            821-1928            AC079766.7         38872-39979         c
FEATURES             Location/Qualifiers
     source          1..1928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..1928
                     /gene="DCTD"
                     /note="dCMP deaminase"
                     /db_xref="GeneID:1635"
                     /db_xref="HGNC:HGNC:2710"
                     /db_xref="MIM:607638"
     exon            1..76
                     /gene="DCTD"
                     /inference="alignment:Splign:2.1.0"
     exon            77..191
                     /gene="DCTD"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..620
                     /gene="DCTD"
                     /EC_number="3.5.4.12"
                     /note="isoform b is encoded by transcript variant 2;
                     deoxycytidylate deaminase"
                     /codon_start=1
                     /product="deoxycytidylate deaminase isoform b"
                     /protein_id="NP_001912.2"
                     /db_xref="CCDS:CCDS3831.1"
                     /db_xref="GeneID:1635"
                     /db_xref="HGNC:HGNC:2710"
                     /db_xref="MIM:607638"
                     /translation="MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNS
                     ENKIVGIGYNGMPNGCSDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCS
                     MYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCS
                     KIVIDFDSINSRPSQKLQ"
     exon            192..327
                     /gene="DCTD"
                     /inference="alignment:Splign:2.1.0"
     exon            328..444
                     /gene="DCTD"
                     /inference="alignment:Splign:2.1.0"
     exon            445..541
                     /gene="DCTD"
                     /inference="alignment:Splign:2.1.0"
     exon            542..1928
                     /gene="DCTD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      747..752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTD"
                     /note="hexamer: TATAAA"
     polyA_site      765
                     /gene="DCTD"
                     /note="major polyA site"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTD"
                     /note="hexamer: ATTAAA"
     regulatory      1905..1910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCTD"
                     /note="hexamer: ATTAAA"
     polyA_site      1920
                     /gene="DCTD"
                     /note="major polyA site"
     polyA_site      1928
                     /gene="DCTD"
                     /note="major polyA site"
ORIGIN      
        1 ctcccccgac ttccttccct gagcacggcg gcggcgggga cgagcaccgg cctgcgcgcg
       61 gagccggcac cggatgaccc aacatgagtg aagtttcctg caagaaacgg gacgactatt
      121 tggaatggcc agagtatttt atggctgtgg ccttcttatc agcacagaga agcaaagatc
      181 caaattccca ggtcggcgcc tgcatcgtga attcagaaaa caagattgtc gggattgggt
      241 acaatgggat gccaaatggg tgcagtgatg acgtgttgcc ttggagaagg acagcagaga
      301 ataagctgga caccaaatac ccgtacgtgt gccatgcgga gctgaatgcc atcatgaaca
      361 aaaattcgac cgatgtgaaa ggctgtagta tgtatgttgc cttgttccct tgtaatgaat
      421 gcgctaagct catcatccag gcaggtataa aagaagtgat tttcatgtct gataaatacc
      481 atgatagtga cgaggcaact gctgcgaggc tcctgtttaa tatggccggg gtgacattcc
      541 ggaaattcat accgaagtgc agcaagattg tcattgactt tgattcaatt aacagcagac
      601 cgagtcaaaa gcttcagtga gttacatctc attcaatctc cagaagattg ggattatcgt
      661 cttctaagag gttgctaatg cctttcatct tgaagttaca cataacttct tactagccag
      721 tatggcaaaa gtaggcatct aaagaatata aagcctcaaa tcttccttac tgtctctctt
      781 gtcacatgga atctacatgt gtttgaacta ttgctttagg gtttaaaata ggggagcctg
      841 tggtggcctg gtgcacaggg ctagaacgag agtgcctccc cttcttgtgt cctggctggc
      901 tgggatgctg gtggctcttc agaggagcat cagctgtctg tcatctgctg cgatccggca
      961 gcctctcttc actgctacat gtgctggaag gacaaataaa taattgtggt tgtgttctta
     1021 atggggacga gcagacacac tgatctgaac atctggccca agtgaagcat ggcatatagt
     1081 gcccttggaa gaaaattagg cctcaaatga cagtagcatt gaagtgtttg ctgcagagtt
     1141 gagggaaacc cccagccacc ctcccggaat ccgagatagg gtggcacatc tgtcctgaca
     1201 gacgaggagt gtaactgaac caggaatatt tcctccattc ctgctctccc actgcacaca
     1261 gggtggtggc acattatccc tctggggggt ggggacgcct gttgttttgg ctcaatttgg
     1321 gtttgttggt cacatggagc tcttccattt cgtttagctg aataatgagt tgttcctaga
     1381 ggagacagcc tgtctctcct tgttgccccc aaagcccatg ccctgccgtg gtggcagctg
     1441 gggctgtgga tgggaggggt ccccaacatg gatgtgttgc ccctcctccg catgccaacg
     1501 cagttcatgt acaaggcccc tctgcaactg gagagaaaat taattcctat cccgtgagtg
     1561 gattgtgaga aattccaccc acgtggagac agcttactgc agcactgttg gtgttcggag
     1621 ctcttctgtg ccctggctcc atgctttcac ctacacaagc atcaccttcc taatcaccgc
     1681 ggggcgggga gcgtgtggct gtgccccttc tctttaatct catttaattt ttattaaaca
     1741 tgctcagtac ctgtgttgag aaaaggcttt ctttatccta aagattatta cctttttaaa
     1801 gtgctcttat attttcatga gtttttattt tgtctctgag attttgtatt ccacattcta
     1861 gggtattctg taatttggct ccttaccaat attattaaaa tcttattaaa atctacccta
     1921 ccaaagca
//
