LOCUS       NM_001922               5074 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens dopachrome tautomerase (DCT), transcript variant 1,
            mRNA.
ACCESSION   NM_001922
VERSION     NM_001922.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5074)
  AUTHORS   Khong,H.T. and Rosenberg,S.A.
  TITLE     Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new
            TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with
            a dramatic response to immunotherapy
  JOURNAL   J Immunol 168 (2), 951-956 (2002)
   PUBMED   11777994
REFERENCE   2  (bases 1 to 5074)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystal structure of human D-dopachrome tautomerase, a homologue of
            macrophage migration inhibitory factor, at 1.54 A resolution
  JOURNAL   Biochemistry 38 (11), 3268-3279 (1999)
   PUBMED   10079069
REFERENCE   3  (bases 1 to 5074)
  AUTHORS   Nishihira,J., Fujinaga,M., Kuriyama,T., Suzuki,M., Sugimoto,H.,
            Nakagawa,A., Tanaka,I. and Sakai,M.
  TITLE     Molecular cloning of human D-dopachrome tautomerase cDNA:
            N-terminal proline is essential for enzyme activation
  JOURNAL   Biochem Biophys Res Commun 243 (2), 538-544 (1998)
   PUBMED   9480844
REFERENCE   4  (bases 1 to 5074)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystallization and preliminary X-ray analysis of human
            D-dopachrome tautomerase
  JOURNAL   J Struct Biol 120 (1), 105-108 (1997)
   PUBMED   9356298
REFERENCE   5  (bases 1 to 5074)
  AUTHORS   Sturm,R.A., O'Sullivan,B.J., Box,N.F., Smith,A.G., Smit,S.E.,
            Puttick,E.R., Parsons,P.G. and Dunn,I.S.
  TITLE     Chromosomal structure of the human TYRP1 and TYRP2 loci and
            comparison of the tyrosinase-related protein gene family
  JOURNAL   Genomics 29 (1), 24-34 (1995)
   PUBMED   8530077
REFERENCE   6  (bases 1 to 5074)
  AUTHORS   Yokoyama,K., Yasumoto,K., Suzuki,H. and Shibahara,S.
  TITLE     Cloning of the human DOPAchrome tautomerase/tyrosinase-related
            protein 2 gene and identification of two regulatory regions
            required for its pigment cell-specific expression
  JOURNAL   J Biol Chem 269 (43), 27080-27087 (1994)
   PUBMED   7929451
REFERENCE   7  (bases 1 to 5074)
  AUTHORS   Cassady,J.L. and Sturm,R.A.
  TITLE     Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA
  JOURNAL   Gene 143 (2), 295-298 (1994)
   PUBMED   8206391
REFERENCE   8  (bases 1 to 5074)
  AUTHORS   Yokoyama,K., Suzuki,H., Yasumoto,K., Tomita,Y. and Shibahara,S.
  TITLE     Molecular cloning and functional analysis of a cDNA coding for
            human DOPAchrome tautomerase/tyrosinase-related protein-2
  JOURNAL   Biochim Biophys Acta 1217 (3), 317-321 (1994)
   PUBMED   8148378
REFERENCE   9  (bases 1 to 5074)
  AUTHORS   Bouchard,B., Del Marmol,V., Jackson,I.J., Cherif,D. and
            Dubertret,L.
  TITLE     Molecular characterization of a human tyrosinase-related-protein-2
            cDNA. Patterns of expression in melanocytic cells
  JOURNAL   Eur J Biochem 219 (1-2), 127-134 (1994)
   PUBMED   8306979
REFERENCE   10 (bases 1 to 5074)
  AUTHORS   Thomas,M.G., Zippin,J. and Brooks,B.P.
  TITLE     Oculocutaneous Albinism and Ocular Albinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37053367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139318.9.
            
            On Nov 22, 2018 this sequence version replaced NM_001922.4.
            
            Transcript Variant: This variant (1) represents the more abundant
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17547.1, L18967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377028.10/ ENSP00000366227.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-722               AL139318.9         52299-53020         c
            723-1022            AL139318.9         42084-42383         c
            1023-1123           AL139318.9         39896-39996         c
            1124-1290           AL139318.9         38971-39137         c
            1291-1470           AL139318.9         35348-35527         c
            1471-1606           AL139318.9         33429-33564         c
            1607-1808           AL139318.9         16774-16975         c
            1809-5074           AL139318.9         10149-13414         c
FEATURES             Location/Qualifiers
     source          1..5074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..5074
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="dopachrome tautomerase"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
     exon            1..722
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..1987
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /EC_number="5.3.3.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; dopachrome delta-isomerase; L-dopachrome
                     tautomerase; DT; TRP2; L-dopachrome Delta-isomerase;
                     dopachrome tautomerase (dopachrome delta-isomerase,
                     tyrosine-related protein 2); tyrosinase related protein-2;
                     L-dopachrome isomerase"
                     /codon_start=1
                     /product="L-dopachrome tautomerase isoform 1 precursor"
                     /protein_id="NP_001913.2"
                     /db_xref="CCDS:CCDS9470.1"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
                     /translation="MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRL
                     GAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFA
                     GYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITT
                     QHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVT
                     WHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRN
                     SRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKF
                     DNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIF
                     VVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQ
                     LGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMET
                     HLSSKRYTEEA"
     exon            723..1022
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1123
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1290
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1470
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1606
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1808
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..5074
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4216..4221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4240
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     polyA_site      4548
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     regulatory      4559..4564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4581
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
     regulatory      5055..5060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      5074
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
ORIGIN      
        1 aactgagttc aaggcaatta aagtcaagag ctaaggaggg agggagaggg tttagaaata
       61 ccagcataat aagtagtatg actgggtgct ctgtaaatta actcaattag acaaagcctg
      121 acttaacggg ggaagatggt gagaagcgct accctcatta aatttggttg ttagaggcgc
      181 ttctaaggaa attaagtctg ttagttgttt gaatcacata aaattgtgtg tgcacgttca
      241 tgtacacatg tgcacacatg taacctctgt gattcttgtg ggtatttttt taagaagaaa
      301 ggaatagaaa gcaaagaaaa ataaaaaata ctgaaaagaa aagactgaaa gagtagaaga
      361 taaggagaaa agtacgacag agacaaggaa agtaagagag agagagagct ctcccaatta
      421 taaagccatg agcccccttt ggtgggggtt tctgctcagt tgcttgggct gcaaaatcct
      481 gccaggagcc cagggtcagt tcccccgagt ctgcatgacg gtggacagcc tagtgaacaa
      541 ggagtgctgc ccacgcctgg gtgcagagtc ggccaatgtc tgtggctctc agcaaggccg
      601 ggggcagtgc acagaggtgc gagccgacac aaggccctgg agtggtccct acatcctacg
      661 aaaccaggat gaccgtgagc tgtggccaag aaaattcttc caccggacct gcaagtgcac
      721 aggaaacttt gccggctata attgtggaga ctgcaagttt ggctggaccg gtcccaactg
      781 cgagcggaag aaaccaccag tgattcggca gaacatccat tccttgagtc ctcaggaaag
      841 agagcagttc ttgggcgcct tagatctcgc gaagaagaga gtacaccccg actacgtgat
      901 caccacacaa cactggctgg gcctgcttgg gcccaatgga acccagccgc agtttgccaa
      961 ctgcagtgtt tatgattttt ttgtgtggct ccattattat tctgttagag atacattatt
     1021 aggaccagga cgcccctaca gggccataga tttctcacat caaggacctg catttgttac
     1081 ctggcaccgg taccatttgt tgtgtctgga aagagatctc cagcgactca ttggcaatga
     1141 gtcttttgct ttgccctact ggaactttgc cactgggagg aacgagtgtg atgtgtgtac
     1201 agaccagctg tttggggcag cgagaccaga cgatccgact ctgattagtc ggaactcaag
     1261 attctccagc tgggaaactg tctgtgatag cttggatgac tacaaccacc tggtcacctt
     1321 gtgcaatgga acctatgaag gtttgctgag aagaaatcaa atgggaagaa acagcatgaa
     1381 attgccaacc ttaaaagaca tacgagattg cctgtctctc cagaagtttg acaatcctcc
     1441 cttcttccag aactctacct tcagtttcag gaatgctttg gaagggtttg ataaagcaga
     1501 tgggactctg gattctcaag tgatgagcct tcataatttg gttcattcct tcctgaacgg
     1561 gacaaacgct ttgccacatt cagccgccaa tgatcccatt tttgtggttc ttcattcctt
     1621 tactgatgcc atctttgatg agtggatgaa aagatttaat cctcctgcag atgcctggcc
     1681 tcaggagctg gcccctattg gtcacaatcg gatgtacaac atggttcctt tcttccctcc
     1741 agtgactaat gaagaactct ttttaacctc agaccaactt ggctacagct atgccatcga
     1801 tctgccagtt tcagttgaag aaactccagg ttggcccaca actctcttag tagtcatggg
     1861 aacactggtg gctttggttg gtctttttgt gctgttggct tttcttcaat atagaagact
     1921 tcgaaaagga tatacacccc taatggagac acatttaagc agcaagagat acacagaaga
     1981 agcctagggt gctcatgcct tacctaagag aagaggctgg ccaagccaca gttctgacgc
     2041 tgacaataaa ggaactaatc ctcactgttc cttcttgagt tgaagatctt tgacataggt
     2101 tcttctatag tgatgatgat ctcattcaga agatgcttag ctgtagtttc cgctttgctt
     2161 gcttgtttaa caaacccaac taaagtgctt gaggctacct ctaccttcaa ataaagatag
     2221 acctgacaat ttgtgatatc taataataac ccccccccca atattgatta agcctcctcc
     2281 ttttctgaaa gcatttaaaa aaaaacaaaa aaaatcccaa aacattgatc caggggagtc
     2341 atttaaattt gcaggtcagt gcaatgtgag acctggccaa gaccatacat caatctttct
     2401 tagccccagt gtctttattg gtaatgccat ggaggtggga gttggtaggt gctagatgag
     2461 tctccaagat cccttttagc tataaacatc tctgcttcta ggcaccctcc tgattatctt
     2521 ccttgggctt ctttttcttc ttttctctat atttttcctc tccagcttag aagatgagaa
     2581 taagccttgt tttctttaca ggatggaaaa tgactaaatg aaggatcaat tccactctat
     2641 tgtgtaaact agattttacg gattttactt aaaatctgca gttttaaaca gtagacctat
     2701 attacaggat tcaatagctg gatacacatt gattctatag tgataaatag agaagataat
     2761 aaaattatag agtttcctgg ttagttgata tgctactgta aacctattaa caaatacaga
     2821 attactcttt ccaaggaagg ctgactgaag gctggtgagg ctgtaaacct gaacatgaga
     2881 caatttgact tgagtcccat tactctgagg tctctttggc tgatcctcta ccaatttctt
     2941 tactaggtag cctcagatga aaaattattc ccacataatg cactgggctt atttttaagc
     3001 attgatgtta gattgattaa tgttgccgaa tactcacagt tacttatgaa tgctgatcaa
     3061 ttaagtctta tcatttgaaa gcaaaccatc tgtacaaaac atgacaattc agaattaagt
     3121 ggttatattc tgctatgcaa tcatcagatc atgaggaata agaatgagac aatctttact
     3181 acgatgttca gacttatcat gatggacccc acttcagaga agttaatggc tcttgagatt
     3241 tccaggcaaa tttcatctgc tcatatctgg tttctgtgca tcaggagtga gactgaagtt
     3301 ctagggcgtg gcttgtctgt cgaggcccct ctctactgga atgaatgaat gtaaagaatg
     3361 ggtgttaaga ggtccctgga gctgccttca acataagggg tcctagaggg tgcaagactc
     3421 atcaagaacc agtttacccc atgcaaaagg actgctaaag ccagagaaat ggacaaagcc
     3481 cagttggaac tgaatttgaa tctcataaag ctacaggtgc atctgagagc aggctcagtg
     3541 gtgaagatca agatagcccg gtaaagccct gcttgggctt tttagcctca gccacatgga
     3601 tacctctcag ttcctgccat taacaatatt catggaaaat acagcactgt gtctttcaca
     3661 tgctccactc tggaaggttt atgctctgag ctcaggatag ttggggaaca catttttaaa
     3721 tcttggtttt aaacaaaaag agaaatttat taaaatggag atataattgt gcatggtaca
     3781 tatatttctg aaaagttatg tataaatcaa ttatgttaaa agcgccagaa gttacttttt
     3841 ataagtgaac tattacgaat aatttcataa agcaaataac cacctctagc ttatctgtca
     3901 ggtatatcag aattctcata tatcatagtc tcataagact tggttaaagc agatctatct
     3961 taggtaggaa aaaatagtaa tcgattatac ttagctgctt ttatctgtag tgtgggtgac
     4021 tttttataac tattatgttt tataatgtct tcctgagaga atttcctaat tttgtagttc
     4081 atataagaga aatacaattt tctagcattt tctgacctta caataaatca attatgaatg
     4141 cattttaaca aatattaagg taggataaac caacagaata aaaagttggt atttacttac
     4201 attgaatatc atgcaaataa actcagaaaa tgtcaccaaa tactgtgggc tatatttctc
     4261 aatgataggg ggaagaattc aaccttggag aaaatgacca gatcacttta ctgcttatat
     4321 cttcagtatt agaaaaactg catgtatgat tttaatagaa atgcttttta taaagctaac
     4381 attcagaaat gggataaaat gcaataacat ctttcctttg tgcattaaat tcccttctaa
     4441 ttctaaaatt gacatttgta tcttgcttag gatttaacat tgttaattat aatactttta
     4501 atgactagtt ttaatctcat tattaagaag tagaaaactt actaaaaagg aaactaaaaa
     4561 taaatgttgt tttgcagatt attgtttgtc ttttgaggat tattgttttt taagtagtgt
     4621 gcatcaattc ccatcttttg ggcactcagc atgtatattg aaatatatat acatgtaaaa
     4681 tatataataa caacctcagt ctgaaaaata atctcttaaa ctgatatgct attttctggt
     4741 gagtttccaa acaattgcta ttttctgaat ctgtttgaac aggtaggaaa aggagagcca
     4801 gcctttcctc aggtgaagtt acttttgata ttccccacag tttagtgact aatcctgggg
     4861 tggaagcagg tggctgcttc aagtgactga ccagggaaga gaggtcctgc agtagctaac
     4921 ttggtgatct cccagataag ccttcaagat gggtcaattt gttggagact ctaaggttga
     4981 agctcttcct atttctatag tgccttactt atcctgagta ttttataaat attctttgaa
     5041 tgaataagtg aatgaataaa ctaatttcaa agta
//
