LOCUS       NM_001322185            4589 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens dopachrome tautomerase (DCT), transcript variant 6,
            mRNA.
ACCESSION   NM_001322185
VERSION     NM_001322185.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4589)
  AUTHORS   Khong,H.T. and Rosenberg,S.A.
  TITLE     Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new
            TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with
            a dramatic response to immunotherapy
  JOURNAL   J Immunol 168 (2), 951-956 (2002)
   PUBMED   11777994
REFERENCE   2  (bases 1 to 4589)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystal structure of human D-dopachrome tautomerase, a homologue of
            macrophage migration inhibitory factor, at 1.54 A resolution
  JOURNAL   Biochemistry 38 (11), 3268-3279 (1999)
   PUBMED   10079069
REFERENCE   3  (bases 1 to 4589)
  AUTHORS   Nishihira,J., Fujinaga,M., Kuriyama,T., Suzuki,M., Sugimoto,H.,
            Nakagawa,A., Tanaka,I. and Sakai,M.
  TITLE     Molecular cloning of human D-dopachrome tautomerase cDNA:
            N-terminal proline is essential for enzyme activation
  JOURNAL   Biochem Biophys Res Commun 243 (2), 538-544 (1998)
   PUBMED   9480844
REFERENCE   4  (bases 1 to 4589)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystallization and preliminary X-ray analysis of human
            D-dopachrome tautomerase
  JOURNAL   J Struct Biol 120 (1), 105-108 (1997)
   PUBMED   9356298
REFERENCE   5  (bases 1 to 4589)
  AUTHORS   Sturm,R.A., O'Sullivan,B.J., Box,N.F., Smith,A.G., Smit,S.E.,
            Puttick,E.R., Parsons,P.G. and Dunn,I.S.
  TITLE     Chromosomal structure of the human TYRP1 and TYRP2 loci and
            comparison of the tyrosinase-related protein gene family
  JOURNAL   Genomics 29 (1), 24-34 (1995)
   PUBMED   8530077
REFERENCE   6  (bases 1 to 4589)
  AUTHORS   Yokoyama,K., Yasumoto,K., Suzuki,H. and Shibahara,S.
  TITLE     Cloning of the human DOPAchrome tautomerase/tyrosinase-related
            protein 2 gene and identification of two regulatory regions
            required for its pigment cell-specific expression
  JOURNAL   J Biol Chem 269 (43), 27080-27087 (1994)
   PUBMED   7929451
REFERENCE   7  (bases 1 to 4589)
  AUTHORS   Cassady,J.L. and Sturm,R.A.
  TITLE     Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA
  JOURNAL   Gene 143 (2), 295-298 (1994)
   PUBMED   8206391
REFERENCE   8  (bases 1 to 4589)
  AUTHORS   Yokoyama,K., Suzuki,H., Yasumoto,K., Tomita,Y. and Shibahara,S.
  TITLE     Molecular cloning and functional analysis of a cDNA coding for
            human DOPAchrome tautomerase/tyrosinase-related protein-2
  JOURNAL   Biochim Biophys Acta 1217 (3), 317-321 (1994)
   PUBMED   8148378
REFERENCE   9  (bases 1 to 4589)
  AUTHORS   Bouchard,B., Del Marmol,V., Jackson,I.J., Cherif,D. and
            Dubertret,L.
  TITLE     Molecular characterization of a human tyrosinase-related-protein-2
            cDNA. Patterns of expression in melanocytic cells
  JOURNAL   Eur J Biochem 219 (1-2), 127-134 (1994)
   PUBMED   8306979
REFERENCE   10 (bases 1 to 4589)
  AUTHORS   Thomas,M.G., Zippin,J. and Brooks,B.P.
  TITLE     Oculocutaneous Albinism and Ocular Albinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37053367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139318.9.
            
            On May 31, 2019 this sequence version replaced NM_001322185.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.166387.1,
                                           SRR1803616.43740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AL139318.9         122508-122744       c
            238-537             AL139318.9         42084-42383         c
            538-638             AL139318.9         39896-39996         c
            639-805             AL139318.9         38971-39137         c
            806-985             AL139318.9         35348-35527         c
            986-1121            AL139318.9         33429-33564         c
            1122-1323           AL139318.9         16774-16975         c
            1324-4589           AL139318.9         10149-13414         c
FEATURES             Location/Qualifiers
     source          1..4589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..4589
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="dopachrome tautomerase"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
     exon            1..237
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..537
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..638
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..805
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..985
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             876..1502
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /EC_number="5.3.3.12"
                     /note="isoform 3 is encoded by transcript variant 6;
                     dopachrome delta-isomerase; L-dopachrome tautomerase; DT;
                     TRP2; L-dopachrome Delta-isomerase; dopachrome tautomerase
                     (dopachrome delta-isomerase, tyrosine-related protein 2);
                     tyrosinase related protein-2; L-dopachrome isomerase"
                     /codon_start=1
                     /product="L-dopachrome tautomerase isoform 3"
                     /protein_id="NP_001309114.1"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
                     /translation="MGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFD
                     KADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPP
                     ADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPT
                     TLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA"
     exon            986..1121
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1323
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..4589
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      3755
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     polyA_site      4063
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4096
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
     regulatory      4570..4575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4589
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
ORIGIN      
        1 agaggcaccc tcggcgccgg aagacgcgaa cgacccgggc cgcggtggcg agacggggcc
       61 gcgcgccgcc tggggggctg gtgtgagacc cgaggctccg atgggaggag gtctggtctg
      121 tccacggggc cagcaaaaca ccttcatccc aatttcatcg cattccttct aagtatccga
      181 atttgaagaa aaagcaaaac tgttgagtgg tcagatggcc cccacctggc gttgccggaa
      241 actttgccgg ctataattgt ggagactgca agtttggctg gaccggtccc aactgcgagc
      301 ggaagaaacc accagtgatt cggcagaaca tccattcctt gagtcctcag gaaagagagc
      361 agttcttggg cgccttagat ctcgcgaaga agagagtaca ccccgactac gtgatcacca
      421 cacaacactg gctgggcctg cttgggccca atggaaccca gccgcagttt gccaactgca
      481 gtgtttatga tttttttgtg tggctccatt attattctgt tagagataca ttattaggac
      541 caggacgccc ctacagggcc atagatttct cacatcaagg acctgcattt gttacctggc
      601 accggtacca tttgttgtgt ctggaaagag atctccagcg actcattggc aatgagtctt
      661 ttgctttgcc ctactggaac tttgccactg ggaggaacga gtgtgatgtg tgtacagacc
      721 agctgtttgg ggcagcgaga ccagacgatc cgactctgat tagtcggaac tcaagattct
      781 ccagctggga aactgtctgt gatagcttgg atgactacaa ccacctggtc accttgtgca
      841 atggaaccta tgaaggtttg ctgagaagaa atcaaatggg aagaaacagc atgaaattgc
      901 caaccttaaa agacatacga gattgcctgt ctctccagaa gtttgacaat cctcccttct
      961 tccagaactc taccttcagt ttcaggaatg ctttggaagg gtttgataaa gcagatggga
     1021 ctctggattc tcaagtgatg agccttcata atttggttca ttccttcctg aacgggacaa
     1081 acgctttgcc acattcagcc gccaatgatc ccatttttgt ggttcttcat tcctttactg
     1141 atgccatctt tgatgagtgg atgaaaagat ttaatcctcc tgcagatgcc tggcctcagg
     1201 agctggcccc tattggtcac aatcggatgt acaacatggt tcctttcttc cctccagtga
     1261 ctaatgaaga actcttttta acctcagacc aacttggcta cagctatgcc atcgatctgc
     1321 cagtttcagt tgaagaaact ccaggttggc ccacaactct cttagtagtc atgggaacac
     1381 tggtggcttt ggttggtctt tttgtgctgt tggcttttct tcaatataga agacttcgaa
     1441 aaggatatac acccctaatg gagacacatt taagcagcaa gagatacaca gaagaagcct
     1501 agggtgctca tgccttacct aagagaagag gctggccaag ccacagttct gacgctgaca
     1561 ataaaggaac taatcctcac tgttccttct tgagttgaag atctttgaca taggttcttc
     1621 tatagtgatg atgatctcat tcagaagatg cttagctgta gtttccgctt tgcttgcttg
     1681 tttaacaaac ccaactaaag tgcttgaggc tacctctacc ttcaaataaa gatagacctg
     1741 acaatttgtg atatctaata ataacccccc ccccaatatt gattaagcct cctccttttc
     1801 tgaaagcatt taaaaaaaaa caaaaaaaat cccaaaacat tgatccaggg gagtcattta
     1861 aatttgcagg tcagtgcaat gtgagacctg gccaagacca tacatcaatc tttcttagcc
     1921 ccagtgtctt tattggtaat gccatggagg tgggagttgg taggtgctag atgagtctcc
     1981 aagatccctt ttagctataa acatctctgc ttctaggcac cctcctgatt atcttccttg
     2041 ggcttctttt tcttcttttc tctatatttt tcctctccag cttagaagat gagaataagc
     2101 cttgttttct ttacaggatg gaaaatgact aaatgaagga tcaattccac tctattgtgt
     2161 aaactagatt ttacggattt tacttaaaat ctgcagtttt aaacagtaga cctatattac
     2221 aggattcaat agctggatac acattgattc tatagtgata aatagagaag ataataaaat
     2281 tatagagttt cctggttagt tgatatgcta ctgtaaacct attaacaaat acagaattac
     2341 tctttccaag gaaggctgac tgaaggctgg tgaggctgta aacctgaaca tgagacaatt
     2401 tgacttgagt cccattactc tgaggtctct ttggctgatc ctctaccaat ttctttacta
     2461 ggtagcctca gatgaaaaat tattcccaca taatgcactg ggcttatttt taagcattga
     2521 tgttagattg attaatgttg ccgaatactc acagttactt atgaatgctg atcaattaag
     2581 tcttatcatt tgaaagcaaa ccatctgtac aaaacatgac aattcagaat taagtggtta
     2641 tattctgcta tgcaatcatc agatcatgag gaataagaat gagacaatct ttactacgat
     2701 gttcagactt atcatgatgg accccacttc agagaagtta atggctcttg agatttccag
     2761 gcaaatttca tctgctcata tctggtttct gtgcatcagg agtgagactg aagttctagg
     2821 gcgtggcttg tctgtcgagg cccctctcta ctggaatgaa tgaatgtaaa gaatgggtgt
     2881 taagaggtcc ctggagctgc cttcaacata aggggtccta gagggtgcaa gactcatcaa
     2941 gaaccagttt accccatgca aaaggactgc taaagccaga gaaatggaca aagcccagtt
     3001 ggaactgaat ttgaatctca taaagctaca ggtgcatctg agagcaggct cagtggtgaa
     3061 gatcaagata gcccggtaaa gccctgcttg ggctttttag cctcagccac atggatacct
     3121 ctcagttcct gccattaaca atattcatgg aaaatacagc actgtgtctt tcacatgctc
     3181 cactctggaa ggtttatgct ctgagctcag gatagttggg gaacacattt ttaaatcttg
     3241 gttttaaaca aaaagagaaa tttattaaaa tggagatata attgtgcatg gtacatatat
     3301 ttctgaaaag ttatgtataa atcaattatg ttaaaagcgc cagaagttac tttttataag
     3361 tgaactatta cgaataattt cataaagcaa ataaccacct ctagcttatc tgtcaggtat
     3421 atcagaattc tcatatatca tagtctcata agacttggtt aaagcagatc tatcttaggt
     3481 aggaaaaaat agtaatcgat tatacttagc tgcttttatc tgtagtgtgg gtgacttttt
     3541 ataactatta tgttttataa tgtcttcctg agagaatttc ctaattttgt agttcatata
     3601 agagaaatac aattttctag cattttctga ccttacaata aatcaattat gaatgcattt
     3661 taacaaatat taaggtagga taaaccaaca gaataaaaag ttggtattta cttacattga
     3721 atatcatgca aataaactca gaaaatgtca ccaaatactg tgggctatat ttctcaatga
     3781 tagggggaag aattcaacct tggagaaaat gaccagatca ctttactgct tatatcttca
     3841 gtattagaaa aactgcatgt atgattttaa tagaaatgct ttttataaag ctaacattca
     3901 gaaatgggat aaaatgcaat aacatctttc ctttgtgcat taaattccct tctaattcta
     3961 aaattgacat ttgtatcttg cttaggattt aacattgtta attataatac ttttaatgac
     4021 tagttttaat ctcattatta agaagtagaa aacttactaa aaaggaaact aaaaataaat
     4081 gttgttttgc agattattgt ttgtcttttg aggattattg ttttttaagt agtgtgcatc
     4141 aattcccatc ttttgggcac tcagcatgta tattgaaata tatatacatg taaaatatat
     4201 aataacaacc tcagtctgaa aaataatctc ttaaactgat atgctatttt ctggtgagtt
     4261 tccaaacaat tgctattttc tgaatctgtt tgaacaggta ggaaaaggag agccagcctt
     4321 tcctcaggtg aagttacttt tgatattccc cacagtttag tgactaatcc tggggtggaa
     4381 gcaggtggct gcttcaagtg actgaccagg gaagagaggt cctgcagtag ctaacttggt
     4441 gatctcccag ataagccttc aagatgggtc aatttgttgg agactctaag gttgaagctc
     4501 ttcctatttc tatagtgcct tacttatcct gagtatttta taaatattct ttgaatgaat
     4561 aagtgaatga ataaactaat ttcaaagta
//
