LOCUS       NM_001322184            4643 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens dopachrome tautomerase (DCT), transcript variant 5,
            mRNA.
ACCESSION   NM_001322184
VERSION     NM_001322184.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4643)
  AUTHORS   Khong,H.T. and Rosenberg,S.A.
  TITLE     Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new
            TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with
            a dramatic response to immunotherapy
  JOURNAL   J Immunol 168 (2), 951-956 (2002)
   PUBMED   11777994
REFERENCE   2  (bases 1 to 4643)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystal structure of human D-dopachrome tautomerase, a homologue of
            macrophage migration inhibitory factor, at 1.54 A resolution
  JOURNAL   Biochemistry 38 (11), 3268-3279 (1999)
   PUBMED   10079069
REFERENCE   3  (bases 1 to 4643)
  AUTHORS   Nishihira,J., Fujinaga,M., Kuriyama,T., Suzuki,M., Sugimoto,H.,
            Nakagawa,A., Tanaka,I. and Sakai,M.
  TITLE     Molecular cloning of human D-dopachrome tautomerase cDNA:
            N-terminal proline is essential for enzyme activation
  JOURNAL   Biochem Biophys Res Commun 243 (2), 538-544 (1998)
   PUBMED   9480844
REFERENCE   4  (bases 1 to 4643)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystallization and preliminary X-ray analysis of human
            D-dopachrome tautomerase
  JOURNAL   J Struct Biol 120 (1), 105-108 (1997)
   PUBMED   9356298
REFERENCE   5  (bases 1 to 4643)
  AUTHORS   Sturm,R.A., O'Sullivan,B.J., Box,N.F., Smith,A.G., Smit,S.E.,
            Puttick,E.R., Parsons,P.G. and Dunn,I.S.
  TITLE     Chromosomal structure of the human TYRP1 and TYRP2 loci and
            comparison of the tyrosinase-related protein gene family
  JOURNAL   Genomics 29 (1), 24-34 (1995)
   PUBMED   8530077
REFERENCE   6  (bases 1 to 4643)
  AUTHORS   Yokoyama,K., Yasumoto,K., Suzuki,H. and Shibahara,S.
  TITLE     Cloning of the human DOPAchrome tautomerase/tyrosinase-related
            protein 2 gene and identification of two regulatory regions
            required for its pigment cell-specific expression
  JOURNAL   J Biol Chem 269 (43), 27080-27087 (1994)
   PUBMED   7929451
REFERENCE   7  (bases 1 to 4643)
  AUTHORS   Cassady,J.L. and Sturm,R.A.
  TITLE     Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA
  JOURNAL   Gene 143 (2), 295-298 (1994)
   PUBMED   8206391
REFERENCE   8  (bases 1 to 4643)
  AUTHORS   Yokoyama,K., Suzuki,H., Yasumoto,K., Tomita,Y. and Shibahara,S.
  TITLE     Molecular cloning and functional analysis of a cDNA coding for
            human DOPAchrome tautomerase/tyrosinase-related protein-2
  JOURNAL   Biochim Biophys Acta 1217 (3), 317-321 (1994)
   PUBMED   8148378
REFERENCE   9  (bases 1 to 4643)
  AUTHORS   Bouchard,B., Del Marmol,V., Jackson,I.J., Cherif,D. and
            Dubertret,L.
  TITLE     Molecular characterization of a human tyrosinase-related-protein-2
            cDNA. Patterns of expression in melanocytic cells
  JOURNAL   Eur J Biochem 219 (1-2), 127-134 (1994)
   PUBMED   8306979
REFERENCE   10 (bases 1 to 4643)
  AUTHORS   Thomas,M.G., Zippin,J. and Brooks,B.P.
  TITLE     Oculocutaneous Albinism and Ocular Albinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37053367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139318.9.
            
            On May 31, 2019 this sequence version replaced NM_001322184.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.226184.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AL139318.9         122508-122744       c
            238-291             AL139318.9         62715-62768         c
            292-591             AL139318.9         42084-42383         c
            592-692             AL139318.9         39896-39996         c
            693-859             AL139318.9         38971-39137         c
            860-1039            AL139318.9         35348-35527         c
            1040-1175           AL139318.9         33429-33564         c
            1176-1377           AL139318.9         16774-16975         c
            1378-4643           AL139318.9         10149-13414         c
FEATURES             Location/Qualifiers
     source          1..4643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..4643
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="dopachrome tautomerase"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
     exon            1..237
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..291
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..591
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..692
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..859
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1039
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             930..1556
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /EC_number="5.3.3.12"
                     /note="isoform 3 is encoded by transcript variant 5;
                     dopachrome delta-isomerase; L-dopachrome tautomerase; DT;
                     TRP2; L-dopachrome Delta-isomerase; dopachrome tautomerase
                     (dopachrome delta-isomerase, tyrosine-related protein 2);
                     tyrosinase related protein-2; L-dopachrome isomerase"
                     /codon_start=1
                     /product="L-dopachrome tautomerase isoform 3"
                     /protein_id="NP_001309113.1"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
                     /translation="MGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFD
                     KADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPP
                     ADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPT
                     TLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA"
     exon            1040..1175
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1377
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..4643
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3785..3790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      3809
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     polyA_site      4117
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4150
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
     regulatory      4624..4629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4643
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
ORIGIN      
        1 agaggcaccc tcggcgccgg aagacgcgaa cgacccgggc cgcggtggcg agacggggcc
       61 gcgcgccgcc tggggggctg gtgtgagacc cgaggctccg atgggaggag gtctggtctg
      121 tccacggggc cagcaaaaca ccttcatccc aatttcatcg cattccttct aagtatccga
      181 atttgaagaa aaagcaaaac tgttgagtgg tcagatggcc cccacctggc gttgccgatg
      241 aggaatctga ggctgagaga gaataaccac ttgtccaggg tcatagaact ggaaactttg
      301 ccggctataa ttgtggagac tgcaagtttg gctggaccgg tcccaactgc gagcggaaga
      361 aaccaccagt gattcggcag aacatccatt ccttgagtcc tcaggaaaga gagcagttct
      421 tgggcgcctt agatctcgcg aagaagagag tacaccccga ctacgtgatc accacacaac
      481 actggctggg cctgcttggg cccaatggaa cccagccgca gtttgccaac tgcagtgttt
      541 atgatttttt tgtgtggctc cattattatt ctgttagaga tacattatta ggaccaggac
      601 gcccctacag ggccatagat ttctcacatc aaggacctgc atttgttacc tggcaccggt
      661 accatttgtt gtgtctggaa agagatctcc agcgactcat tggcaatgag tcttttgctt
      721 tgccctactg gaactttgcc actgggagga acgagtgtga tgtgtgtaca gaccagctgt
      781 ttggggcagc gagaccagac gatccgactc tgattagtcg gaactcaaga ttctccagct
      841 gggaaactgt ctgtgatagc ttggatgact acaaccacct ggtcaccttg tgcaatggaa
      901 cctatgaagg tttgctgaga agaaatcaaa tgggaagaaa cagcatgaaa ttgccaacct
      961 taaaagacat acgagattgc ctgtctctcc agaagtttga caatcctccc ttcttccaga
     1021 actctacctt cagtttcagg aatgctttgg aagggtttga taaagcagat gggactctgg
     1081 attctcaagt gatgagcctt cataatttgg ttcattcctt cctgaacggg acaaacgctt
     1141 tgccacattc agccgccaat gatcccattt ttgtggttct tcattccttt actgatgcca
     1201 tctttgatga gtggatgaaa agatttaatc ctcctgcaga tgcctggcct caggagctgg
     1261 cccctattgg tcacaatcgg atgtacaaca tggttccttt cttccctcca gtgactaatg
     1321 aagaactctt tttaacctca gaccaacttg gctacagcta tgccatcgat ctgccagttt
     1381 cagttgaaga aactccaggt tggcccacaa ctctcttagt agtcatggga acactggtgg
     1441 ctttggttgg tctttttgtg ctgttggctt ttcttcaata tagaagactt cgaaaaggat
     1501 atacacccct aatggagaca catttaagca gcaagagata cacagaagaa gcctagggtg
     1561 ctcatgcctt acctaagaga agaggctggc caagccacag ttctgacgct gacaataaag
     1621 gaactaatcc tcactgttcc ttcttgagtt gaagatcttt gacataggtt cttctatagt
     1681 gatgatgatc tcattcagaa gatgcttagc tgtagtttcc gctttgcttg cttgtttaac
     1741 aaacccaact aaagtgcttg aggctacctc taccttcaaa taaagataga cctgacaatt
     1801 tgtgatatct aataataacc ccccccccaa tattgattaa gcctcctcct tttctgaaag
     1861 catttaaaaa aaaacaaaaa aaatcccaaa acattgatcc aggggagtca tttaaatttg
     1921 caggtcagtg caatgtgaga cctggccaag accatacatc aatctttctt agccccagtg
     1981 tctttattgg taatgccatg gaggtgggag ttggtaggtg ctagatgagt ctccaagatc
     2041 ccttttagct ataaacatct ctgcttctag gcaccctcct gattatcttc cttgggcttc
     2101 tttttcttct tttctctata tttttcctct ccagcttaga agatgagaat aagccttgtt
     2161 ttctttacag gatggaaaat gactaaatga aggatcaatt ccactctatt gtgtaaacta
     2221 gattttacgg attttactta aaatctgcag ttttaaacag tagacctata ttacaggatt
     2281 caatagctgg atacacattg attctatagt gataaataga gaagataata aaattataga
     2341 gtttcctggt tagttgatat gctactgtaa acctattaac aaatacagaa ttactctttc
     2401 caaggaaggc tgactgaagg ctggtgaggc tgtaaacctg aacatgagac aatttgactt
     2461 gagtcccatt actctgaggt ctctttggct gatcctctac caatttcttt actaggtagc
     2521 ctcagatgaa aaattattcc cacataatgc actgggctta tttttaagca ttgatgttag
     2581 attgattaat gttgccgaat actcacagtt acttatgaat gctgatcaat taagtcttat
     2641 catttgaaag caaaccatct gtacaaaaca tgacaattca gaattaagtg gttatattct
     2701 gctatgcaat catcagatca tgaggaataa gaatgagaca atctttacta cgatgttcag
     2761 acttatcatg atggacccca cttcagagaa gttaatggct cttgagattt ccaggcaaat
     2821 ttcatctgct catatctggt ttctgtgcat caggagtgag actgaagttc tagggcgtgg
     2881 cttgtctgtc gaggcccctc tctactggaa tgaatgaatg taaagaatgg gtgttaagag
     2941 gtccctggag ctgccttcaa cataaggggt cctagagggt gcaagactca tcaagaacca
     3001 gtttacccca tgcaaaagga ctgctaaagc cagagaaatg gacaaagccc agttggaact
     3061 gaatttgaat ctcataaagc tacaggtgca tctgagagca ggctcagtgg tgaagatcaa
     3121 gatagcccgg taaagccctg cttgggcttt ttagcctcag ccacatggat acctctcagt
     3181 tcctgccatt aacaatattc atggaaaata cagcactgtg tctttcacat gctccactct
     3241 ggaaggttta tgctctgagc tcaggatagt tggggaacac atttttaaat cttggtttta
     3301 aacaaaaaga gaaatttatt aaaatggaga tataattgtg catggtacat atatttctga
     3361 aaagttatgt ataaatcaat tatgttaaaa gcgccagaag ttacttttta taagtgaact
     3421 attacgaata atttcataaa gcaaataacc acctctagct tatctgtcag gtatatcaga
     3481 attctcatat atcatagtct cataagactt ggttaaagca gatctatctt aggtaggaaa
     3541 aaatagtaat cgattatact tagctgcttt tatctgtagt gtgggtgact ttttataact
     3601 attatgtttt ataatgtctt cctgagagaa tttcctaatt ttgtagttca tataagagaa
     3661 atacaatttt ctagcatttt ctgaccttac aataaatcaa ttatgaatgc attttaacaa
     3721 atattaaggt aggataaacc aacagaataa aaagttggta tttacttaca ttgaatatca
     3781 tgcaaataaa ctcagaaaat gtcaccaaat actgtgggct atatttctca atgatagggg
     3841 gaagaattca accttggaga aaatgaccag atcactttac tgcttatatc ttcagtatta
     3901 gaaaaactgc atgtatgatt ttaatagaaa tgctttttat aaagctaaca ttcagaaatg
     3961 ggataaaatg caataacatc tttcctttgt gcattaaatt cccttctaat tctaaaattg
     4021 acatttgtat cttgcttagg atttaacatt gttaattata atacttttaa tgactagttt
     4081 taatctcatt attaagaagt agaaaactta ctaaaaagga aactaaaaat aaatgttgtt
     4141 ttgcagatta ttgtttgtct tttgaggatt attgtttttt aagtagtgtg catcaattcc
     4201 catcttttgg gcactcagca tgtatattga aatatatata catgtaaaat atataataac
     4261 aacctcagtc tgaaaaataa tctcttaaac tgatatgcta ttttctggtg agtttccaaa
     4321 caattgctat tttctgaatc tgtttgaaca ggtaggaaaa ggagagccag cctttcctca
     4381 ggtgaagtta cttttgatat tccccacagt ttagtgacta atcctggggt ggaagcaggt
     4441 ggctgcttca agtgactgac cagggaagag aggtcctgca gtagctaact tggtgatctc
     4501 ccagataagc cttcaagatg ggtcaatttg ttggagactc taaggttgaa gctcttccta
     4561 tttctatagt gccttactta tcctgagtat tttataaata ttctttgaat gaataagtga
     4621 atgaataaac taatttcaaa gta
//
