LOCUS       NM_001129889            5173 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens dopachrome tautomerase (DCT), transcript variant 2,
            mRNA.
ACCESSION   NM_001129889
VERSION     NM_001129889.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5173)
  AUTHORS   Khong,H.T. and Rosenberg,S.A.
  TITLE     Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new
            TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with
            a dramatic response to immunotherapy
  JOURNAL   J Immunol 168 (2), 951-956 (2002)
   PUBMED   11777994
REFERENCE   2  (bases 1 to 5173)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystal structure of human D-dopachrome tautomerase, a homologue of
            macrophage migration inhibitory factor, at 1.54 A resolution
  JOURNAL   Biochemistry 38 (11), 3268-3279 (1999)
   PUBMED   10079069
REFERENCE   3  (bases 1 to 5173)
  AUTHORS   Nishihira,J., Fujinaga,M., Kuriyama,T., Suzuki,M., Sugimoto,H.,
            Nakagawa,A., Tanaka,I. and Sakai,M.
  TITLE     Molecular cloning of human D-dopachrome tautomerase cDNA:
            N-terminal proline is essential for enzyme activation
  JOURNAL   Biochem Biophys Res Commun 243 (2), 538-544 (1998)
   PUBMED   9480844
REFERENCE   4  (bases 1 to 5173)
  AUTHORS   Sugimoto,H., Taniguchi,M., Nakagawa,A., Tanaka,I., Suzuki,M. and
            Nishihira,J.
  TITLE     Crystallization and preliminary X-ray analysis of human
            D-dopachrome tautomerase
  JOURNAL   J Struct Biol 120 (1), 105-108 (1997)
   PUBMED   9356298
REFERENCE   5  (bases 1 to 5173)
  AUTHORS   Sturm,R.A., O'Sullivan,B.J., Box,N.F., Smith,A.G., Smit,S.E.,
            Puttick,E.R., Parsons,P.G. and Dunn,I.S.
  TITLE     Chromosomal structure of the human TYRP1 and TYRP2 loci and
            comparison of the tyrosinase-related protein gene family
  JOURNAL   Genomics 29 (1), 24-34 (1995)
   PUBMED   8530077
REFERENCE   6  (bases 1 to 5173)
  AUTHORS   Yokoyama,K., Yasumoto,K., Suzuki,H. and Shibahara,S.
  TITLE     Cloning of the human DOPAchrome tautomerase/tyrosinase-related
            protein 2 gene and identification of two regulatory regions
            required for its pigment cell-specific expression
  JOURNAL   J Biol Chem 269 (43), 27080-27087 (1994)
   PUBMED   7929451
REFERENCE   7  (bases 1 to 5173)
  AUTHORS   Cassady,J.L. and Sturm,R.A.
  TITLE     Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA
  JOURNAL   Gene 143 (2), 295-298 (1994)
   PUBMED   8206391
REFERENCE   8  (bases 1 to 5173)
  AUTHORS   Yokoyama,K., Suzuki,H., Yasumoto,K., Tomita,Y. and Shibahara,S.
  TITLE     Molecular cloning and functional analysis of a cDNA coding for
            human DOPAchrome tautomerase/tyrosinase-related protein-2
  JOURNAL   Biochim Biophys Acta 1217 (3), 317-321 (1994)
   PUBMED   8148378
REFERENCE   9  (bases 1 to 5173)
  AUTHORS   Bouchard,B., Del Marmol,V., Jackson,I.J., Cherif,D. and
            Dubertret,L.
  TITLE     Molecular characterization of a human tyrosinase-related-protein-2
            cDNA. Patterns of expression in melanocytic cells
  JOURNAL   Eur J Biochem 219 (1-2), 127-134 (1994)
   PUBMED   8306979
REFERENCE   10 (bases 1 to 5173)
  AUTHORS   Thomas,M.G., Zippin,J. and Brooks,B.P.
  TITLE     Oculocutaneous Albinism and Ocular Albinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37053367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139318.9.
            
            On Aug 14, 2020 this sequence version replaced NM_001129889.2.
            
            Transcript Variant: This variant (2) includes two alternate
            in-frame exons and is predicted to encode a slightly longer protein
            isoform (2) compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3725742.1, DQ902581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-722               AL139318.9         52299-53020         c
            723-1022            AL139318.9         42084-42383         c
            1023-1123           AL139318.9         39896-39996         c
            1124-1290           AL139318.9         38971-39137         c
            1291-1470           AL139318.9         35348-35527         c
            1471-1606           AL139318.9         33429-33564         c
            1607-1662           AL139318.9         25945-26000         c
            1663-1705           AL139318.9         19057-19099         c
            1706-1907           AL139318.9         16774-16975         c
            1908-5173           AL139318.9         10149-13414         c
FEATURES             Location/Qualifiers
     source          1..5173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..5173
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="dopachrome tautomerase"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
     exon            1..722
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..2086
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /EC_number="5.3.3.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; dopachrome delta-isomerase; L-dopachrome
                     tautomerase; DT; TRP2; L-dopachrome Delta-isomerase;
                     dopachrome tautomerase (dopachrome delta-isomerase,
                     tyrosine-related protein 2); tyrosinase related protein-2;
                     L-dopachrome isomerase"
                     /codon_start=1
                     /product="L-dopachrome tautomerase isoform 2 precursor"
                     /protein_id="NP_001123361.1"
                     /db_xref="CCDS:CCDS45060.1"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
                     /translation="MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRL
                     GAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFA
                     GYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITT
                     QHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVT
                     WHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRN
                     SRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKF
                     DNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIF
                     VVISNRLLYNATTNILEHVRKEKATKELPSLHVLVLHSFTDAIFDEWMKRFNPPADAW
                     PQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLV
                     VMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA"
     exon            723..1022
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1123
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1290
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1470
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1606
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1662
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1705
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1907
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..5173
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4315..4320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4339
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     polyA_site      4647
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="major polyA site"
     regulatory      4658..4663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      4680
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /note="hexamer: AATAAA"
     polyA_site      5173
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
ORIGIN      
        1 aactgagttc aaggcaatta aagtcaagag ctaaggaggg agggagaggg tttagaaata
       61 ccagcataat aagtagtatg actgggtgct ctgtaaatta actcaattag acaaagcctg
      121 acttaacggg ggaagatggt gagaagcgct accctcatta aatttggttg ttagaggcgc
      181 ttctaaggaa attaagtctg ttagttgttt gaatcacata aaattgtgtg tgcacgttca
      241 tgtacacatg tgcacacatg taacctctgt gattcttgtg ggtatttttt taagaagaaa
      301 ggaatagaaa gcaaagaaaa ataaaaaata ctgaaaagaa aagactgaaa gagtagaaga
      361 taaggagaaa agtacgacag agacaaggaa agtaagagag agagagagct ctcccaatta
      421 taaagccatg agcccccttt ggtgggggtt tctgctcagt tgcttgggct gcaaaatcct
      481 gccaggagcc cagggtcagt tcccccgagt ctgcatgacg gtggacagcc tagtgaacaa
      541 ggagtgctgc ccacgcctgg gtgcagagtc ggccaatgtc tgtggctctc agcaaggccg
      601 ggggcagtgc acagaggtgc gagccgacac aaggccctgg agtggtccct acatcctacg
      661 aaaccaggat gaccgtgagc tgtggccaag aaaattcttc caccggacct gcaagtgcac
      721 aggaaacttt gccggctata attgtggaga ctgcaagttt ggctggaccg gtcccaactg
      781 cgagcggaag aaaccaccag tgattcggca gaacatccat tccttgagtc ctcaggaaag
      841 agagcagttc ttgggcgcct tagatctcgc gaagaagaga gtacaccccg actacgtgat
      901 caccacacaa cactggctgg gcctgcttgg gcccaatgga acccagccgc agtttgccaa
      961 ctgcagtgtt tatgattttt ttgtgtggct ccattattat tctgttagag atacattatt
     1021 aggaccagga cgcccctaca gggccataga tttctcacat caaggacctg catttgttac
     1081 ctggcaccgg taccatttgt tgtgtctgga aagagatctc cagcgactca ttggcaatga
     1141 gtcttttgct ttgccctact ggaactttgc cactgggagg aacgagtgtg atgtgtgtac
     1201 agaccagctg tttggggcag cgagaccaga cgatccgact ctgattagtc ggaactcaag
     1261 attctccagc tgggaaactg tctgtgatag cttggatgac tacaaccacc tggtcacctt
     1321 gtgcaatgga acctatgaag gtttgctgag aagaaatcaa atgggaagaa acagcatgaa
     1381 attgccaacc ttaaaagaca tacgagattg cctgtctctc cagaagtttg acaatcctcc
     1441 cttcttccag aactctacct tcagtttcag gaatgctttg gaagggtttg ataaagcaga
     1501 tgggactctg gattctcaag tgatgagcct tcataatttg gttcattcct tcctgaacgg
     1561 gacaaacgct ttgccacatt cagccgccaa tgatcccatt tttgtggtga tttctaatcg
     1621 tttgctttac aatgctacaa caaacatcct tgaacatgta agaaaagaga aagcgaccaa
     1681 ggaactccct tccctgcatg tgctggttct tcattccttt actgatgcca tctttgatga
     1741 gtggatgaaa agatttaatc ctcctgcaga tgcctggcct caggagctgg cccctattgg
     1801 tcacaatcgg atgtacaaca tggttccttt cttccctcca gtgactaatg aagaactctt
     1861 tttaacctca gaccaacttg gctacagcta tgccatcgat ctgccagttt cagttgaaga
     1921 aactccaggt tggcccacaa ctctcttagt agtcatggga acactggtgg ctttggttgg
     1981 tctttttgtg ctgttggctt ttcttcaata tagaagactt cgaaaaggat atacacccct
     2041 aatggagaca catttaagca gcaagagata cacagaagaa gcctagggtg ctcatgcctt
     2101 acctaagaga agaggctggc caagccacag ttctgacgct gacaataaag gaactaatcc
     2161 tcactgttcc ttcttgagtt gaagatcttt gacataggtt cttctatagt gatgatgatc
     2221 tcattcagaa gatgcttagc tgtagtttcc gctttgcttg cttgtttaac aaacccaact
     2281 aaagtgcttg aggctacctc taccttcaaa taaagataga cctgacaatt tgtgatatct
     2341 aataataacc ccccccccaa tattgattaa gcctcctcct tttctgaaag catttaaaaa
     2401 aaaacaaaaa aaatcccaaa acattgatcc aggggagtca tttaaatttg caggtcagtg
     2461 caatgtgaga cctggccaag accatacatc aatctttctt agccccagtg tctttattgg
     2521 taatgccatg gaggtgggag ttggtaggtg ctagatgagt ctccaagatc ccttttagct
     2581 ataaacatct ctgcttctag gcaccctcct gattatcttc cttgggcttc tttttcttct
     2641 tttctctata tttttcctct ccagcttaga agatgagaat aagccttgtt ttctttacag
     2701 gatggaaaat gactaaatga aggatcaatt ccactctatt gtgtaaacta gattttacgg
     2761 attttactta aaatctgcag ttttaaacag tagacctata ttacaggatt caatagctgg
     2821 atacacattg attctatagt gataaataga gaagataata aaattataga gtttcctggt
     2881 tagttgatat gctactgtaa acctattaac aaatacagaa ttactctttc caaggaaggc
     2941 tgactgaagg ctggtgaggc tgtaaacctg aacatgagac aatttgactt gagtcccatt
     3001 actctgaggt ctctttggct gatcctctac caatttcttt actaggtagc ctcagatgaa
     3061 aaattattcc cacataatgc actgggctta tttttaagca ttgatgttag attgattaat
     3121 gttgccgaat actcacagtt acttatgaat gctgatcaat taagtcttat catttgaaag
     3181 caaaccatct gtacaaaaca tgacaattca gaattaagtg gttatattct gctatgcaat
     3241 catcagatca tgaggaataa gaatgagaca atctttacta cgatgttcag acttatcatg
     3301 atggacccca cttcagagaa gttaatggct cttgagattt ccaggcaaat ttcatctgct
     3361 catatctggt ttctgtgcat caggagtgag actgaagttc tagggcgtgg cttgtctgtc
     3421 gaggcccctc tctactggaa tgaatgaatg taaagaatgg gtgttaagag gtccctggag
     3481 ctgccttcaa cataaggggt cctagagggt gcaagactca tcaagaacca gtttacccca
     3541 tgcaaaagga ctgctaaagc cagagaaatg gacaaagccc agttggaact gaatttgaat
     3601 ctcataaagc tacaggtgca tctgagagca ggctcagtgg tgaagatcaa gatagcccgg
     3661 taaagccctg cttgggcttt ttagcctcag ccacatggat acctctcagt tcctgccatt
     3721 aacaatattc atggaaaata cagcactgtg tctttcacat gctccactct ggaaggttta
     3781 tgctctgagc tcaggatagt tggggaacac atttttaaat cttggtttta aacaaaaaga
     3841 gaaatttatt aaaatggaga tataattgtg catggtacat atatttctga aaagttatgt
     3901 ataaatcaat tatgttaaaa gcgccagaag ttacttttta taagtgaact attacgaata
     3961 atttcataaa gcaaataacc acctctagct tatctgtcag gtatatcaga attctcatat
     4021 atcatagtct cataagactt ggttaaagca gatctatctt aggtaggaaa aaatagtaat
     4081 cgattatact tagctgcttt tatctgtagt gtgggtgact ttttataact attatgtttt
     4141 ataatgtctt cctgagagaa tttcctaatt ttgtagttca tataagagaa atacaatttt
     4201 ctagcatttt ctgaccttac aataaatcaa ttatgaatgc attttaacaa atattaaggt
     4261 aggataaacc aacagaataa aaagttggta tttacttaca ttgaatatca tgcaaataaa
     4321 ctcagaaaat gtcaccaaat actgtgggct atatttctca atgatagggg gaagaattca
     4381 accttggaga aaatgaccag atcactttac tgcttatatc ttcagtatta gaaaaactgc
     4441 atgtatgatt ttaatagaaa tgctttttat aaagctaaca ttcagaaatg ggataaaatg
     4501 caataacatc tttcctttgt gcattaaatt cccttctaat tctaaaattg acatttgtat
     4561 cttgcttagg atttaacatt gttaattata atacttttaa tgactagttt taatctcatt
     4621 attaagaagt agaaaactta ctaaaaagga aactaaaaat aaatgttgtt ttgcagatta
     4681 ttgtttgtct tttgaggatt attgtttttt aagtagtgtg catcaattcc catcttttgg
     4741 gcactcagca tgtatattga aatatatata catgtaaaat atataataac aacctcagtc
     4801 tgaaaaataa tctcttaaac tgatatgcta ttttctggtg agtttccaaa caattgctat
     4861 tttctgaatc tgtttgaaca ggtaggaaaa ggagagccag cctttcctca ggtgaagtta
     4921 cttttgatat tccccacagt ttagtgacta atcctggggt ggaagcaggt ggctgcttca
     4981 agtgactgac cagggaagag aggtcctgca gtagctaact tggtgatctc ccagataagc
     5041 cttcaagatg ggtcaatttg ttggagactc taaggttgaa gctcttccta tttctatagt
     5101 gccttactta tcctgagtat tttataaata ttctttgaat gaataagtga atgaataaac
     5161 taatttcaaa gta
//
