LOCUS       NM_030788               1953 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens dendrocyte expressed seven transmembrane protein
            (DCSTAMP), transcript variant 1, mRNA.
ACCESSION   NM_030788
VERSION     NM_030788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1953)
  AUTHORS   Lee,J.J., Hsu,Y.C., Huang,W.C. and Cheng,S.P.
  TITLE     Upregulation of dendrocyte-expressed seven transmembrane protein is
            associated with unfavorable outcomes in differentiated thyroid
            cancer
  JOURNAL   Endocrine 81 (3), 513-520 (2023)
   PUBMED   37058220
  REMARK    GeneRIF: Upregulation of dendrocyte-expressed seven transmembrane
            protein is associated with unfavorable outcomes in differentiated
            thyroid cancer.
REFERENCE   2  (bases 1 to 1953)
  AUTHORS   Mullin,B.H., Zhu,K., Brown,S.J., Mullin,S., Tickner,J.,
            Pavlos,N.J., Dudbridge,F., Xu,J., Walsh,J.P. and Wilson,S.G.
  TITLE     Genetic regulatory mechanisms in human osteoclasts suggest a role
            for the STMP1 and DCSTAMP genes in Paget's disease of bone
  JOURNAL   Sci Rep 9 (1), 1052 (2019)
   PUBMED   30705363
  REMARK    GeneRIF: Genetic regulatory mechanisms in human osteoclasts suggest
            a role for the STMP1 and DCSTAMP genes in Paget's disease of bone.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1953)
  AUTHORS   Laurier,E., Amiable,N., Gagnon,E., Brown,J.P. and Michou,L.
  TITLE     Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of
            patients with Paget's disease of bone
  JOURNAL   BMC Med Genet 18 (1), 133 (2017)
   PUBMED   29145829
  REMARK    GeneRIF: Our results suggest that the rare genetic variant of
            TM7SF4 gene, found in our French-Canadian cohort of patients with
            Paget's disease of bone and which encodes the DC-STAMP protein,
            increase the number of nuclei per multinucleated cells and affect
            DC-STAMP expression during osteoclastogenesis in Paget's disease of
            bone.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1953)
  AUTHORS   Yang,X., Song,X., Wang,X., Liu,X. and Peng,Z.
  TITLE     Downregulation of TM7SF4 inhibits cell proliferation and metastasis
            of A549 cells through regulating the PI3K/AKT/mTOR signaling
            pathway
  JOURNAL   Mol Med Rep 16 (5), 6122-6127 (2017)
   PUBMED   28849122
  REMARK    GeneRIF: TM7SF4 may be involved in the progression of lung cancer.
REFERENCE   5  (bases 1 to 1953)
  AUTHORS   Zeng,X.X., Chu,T.J., Yuan,J.Y., Zhang,W., Du,Y.M., Ban,Z.Y.,
            Lei,D.M., Cao,J. and Zhang,Z.
  TITLE     Transmembrane 7 superfamily member 4 regulates cell cycle
            progression in breast cancer cells
  JOURNAL   Eur Rev Med Pharmacol Sci 19 (22), 4353-4361 (2015)
   PUBMED   26636523
  REMARK    GeneRIF: TM7SF4 plays an essential role in regulating cell cycle
            progression in breast cancer.
REFERENCE   6  (bases 1 to 1953)
  AUTHORS   Jansen,B.J., Eleveld-Trancikova,D., Sanecka,A., van Hout-Kuijer,M.,
            Hendriks,I.A., Looman,M.G., Leusen,J.H. and Adema,G.J.
  TITLE     OS9 interacts with DC-STAMP and modulates its intracellular
            localization in response to TLR ligation
  JOURNAL   Mol Immunol 46 (4), 505-515 (2009)
   PUBMED   18952287
  REMARK    GeneRIF: An interaction between OS9 and DC-STAMP was confirmed by
            yeast-2-hybrid analysis and cellular colocalization.ER-to-Golgi
            translocation of DC-STAMP following TLR stimulation in CHO cells
            was demonstrated, involving the DC-STAMP/OS9 interaction. The data
            indicate that OS9 is critically involved in ER-to-Golgi transport
            of DC-STAMP, and may be important in both myeloid differentiation
            and cell fusion.
REFERENCE   7  (bases 1 to 1953)
  AUTHORS   Eleveld-Trancikova,D., Triantis,V., Moulin,V., Looman,M.W.,
            Wijers,M., Fransen,J.A., Lemckert,A.A., Havenga,M.J., Figdor,C.G.,
            Janssen,R.A. and Adema,G.J.
  TITLE     The dendritic cell-derived protein DC-STAMP is highly conserved and
            localizes to the endoplasmic reticulum
  JOURNAL   J Leukoc Biol 77 (3), 337-343 (2005)
   PUBMED   15601667
  REMARK    GeneRIF: The dendritic cell-specific transmembrane protein is a
            multimembrane-spanning protein preferentially expressed by human DC
            (hDC).
REFERENCE   8  (bases 1 to 1953)
  AUTHORS   Hartgers,F.C., Looman,M.W., van der Woning,B., Merkx,G.F.,
            Figdor,C.G. and Adema,G.J.
  TITLE     Genomic organization, chromosomal localization, and 5' upstream
            region of the human DC-STAMP gene
  JOURNAL   Immunogenetics 53 (2), 145-149 (2001)
   PUBMED   11345591
REFERENCE   9  (bases 1 to 1953)
  AUTHORS   Staege,H., Brauchlin,A., Schoedon,G. and Schaffner,A.
  TITLE     Two novel genes FIND and LIND differentially expressed in
            deactivated and Listeria-infected human macrophages
  JOURNAL   Immunogenetics 53 (2), 105-113 (2001)
   PUBMED   11345586
REFERENCE   10 (bases 1 to 1953)
  AUTHORS   Hartgers,F.C., Vissers,J.L., Looman,M.W., van Zoelen,C.,
            Huffine,C., Figdor,C.G. and Adema,G.J.
  TITLE     DC-STAMP, a novel multimembrane-spanning molecule preferentially
            expressed by dendritic cells
  JOURNAL   Eur J Immunol 30 (12), 3585-3590 (2000)
   PUBMED   11169400
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069349.1, AP003471.2 and
            AF277290.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030788.3.
            
            Summary: This gene encodes a seven-pass transmembrane protein that
            is primarily expressed in dendritic cells. The encoded protein is
            involved in a range of immunological functions carried out by
            dendritic cells. This protein plays a role in osteoclastogenesis
            and myeloid differentiation. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF277290.1, AF305068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297581.2/ ENSP00000297581.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1443              BC069349.1         1-1443
            1444-1444           AP003471.2         81029-81029
            1445-1953           AF277290.1         1453-1961
FEATURES             Location/Qualifiers
     source          1..1953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..1953
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /note="dendrocyte expressed seven transmembrane protein"
                     /db_xref="GeneID:81501"
                     /db_xref="HGNC:HGNC:18549"
                     /db_xref="MIM:605933"
     exon            1..37
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            38..1078
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1462
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     IL-Four (IL-4) induced; DC-specific transmembrane protein;
                     IL-Four INDuced; Dendritic cells (DC)-specific
                     transmembrane protein; IL-4-induced protein; dendritic
                     cell-specific transmembrane protein; transmembrane 7
                     superfamily member 4; IL-four-induced protein"
                     /codon_start=1
                     /product="dendritic cell-specific transmembrane protein
                     isoform 1"
                     /protein_id="NP_110415.1"
                     /db_xref="CCDS:CCDS6301.1"
                     /db_xref="GeneID:81501"
                     /db_xref="HGNC:HGNC:18549"
                     /db_xref="MIM:605933"
                     /translation="MGIWTSGTDIFLSLWEIYVSPRSPGWMDFIQHLGVCCLVALISV
                     GLLSVAACWFLPSIIAAAASWIITCVLLCCSKHARCFILLVFLSCGLREGRNALIAAG
                     TGIVILGHVENIFHNFKGLLDGMTCNLRAKSFSIHFPLLKKYIEAIQWIYGLATPLSV
                     FDDLVSWNQTLAVSLFSPSHVLEAQLNDSKGEVLSVLYQMATTTEVLSSLGQKLLAFA
                     GLSLVLLGTGLFMKRFLGPCGWKYENIYITRQFVQFDERERHQQRPCVLPLNKEERRK
                     YVIIPTFWPTPKERKNLGLFFLPILIHLCIWVLFAAVDYLLYRLIFSVSKQFQSLPGF
                     EVHLKLHGEKQGTQDIIHDSSFNISVFEPNCIPKPKFLLSETWVPLSVILLILVMLGL
                     LSSILMQLKILVSASFYPSVERKRIQYLHAKLLKKRSKQPLGEVKRRLSLYLTKIHFW
                     LPVLKMIRKKQMDMASADKS"
     exon            1079..1387
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1953
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /note="hexamer: ATTAAA"
     polyA_site      1953
                     /gene="DCSTAMP"
                     /gene_synonym="FIND; hDC-STAMP; TM7SF4"
                     /note="major polyA site"
ORIGIN      
        1 gcatttctgc attcgaagaa gaatctgaga gaaacctgac gcagggagca tgggtatctg
       61 gacctcaggc actgatatct tcctaagtct ttgggagatt tacgtgtctc caagaagccc
      121 cggatggatg gactttatcc agcatttggg agtttgctgt ttggttgctc ttatttcagt
      181 gggcctcctg tctgtggccg cctgctggtt tctgccatca atcatagcgg ccgctgcctc
      241 ctggattatc acgtgtgttc tgctgtgttg ctccaagcat gcacgatgtt ttattcttct
      301 tgtctttctc tcttgtggcc tgcgtgaagg caggaatgct ttgattgcag ctggcacagg
      361 gatcgtcatc ttgggacacg tagaaaatat ttttcacaac tttaaaggtc tcctagatgg
      421 tatgacttgc aacctaaggg caaagagctt ttccatacat tttccacttt tgaaaaaata
      481 tattgaggca attcagtgga tttatggcct tgccactcca ctaagtgtat ttgatgacct
      541 tgtttcttgg aaccagaccc tggcagtctc tcttttcagt cccagccatg tcctggaggc
      601 acagctaaat gacagcaaag gggaagtcct gagcgtcttg taccagatgg caacaaccac
      661 agaggtgttg tcctccctgg gtcagaagct acttgccttt gcagggcttt cgctcgtcct
      721 gcttggcact ggcctcttca tgaagcgatt tttgggccct tgtggttgga agtatgaaaa
      781 catctacatc accagacaat ttgttcagtt tgatgaaagg gagagacatc aacagaggcc
      841 ctgtgtgctc ccgctgaata aggaggaaag gaggaagtat gtcatcatcc cgactttctg
      901 gccgactcct aaagaaagga aaaacctggg gctgtttttc ctccccatac ttatccatct
      961 ctgcatctgg gtgctgtttg cagctgtaga ttatctgctg tatcggctca ttttctcagt
     1021 gagcaagcag tttcaaagct tgccagggtt tgaggttcac ttgaaactgc acggagagaa
     1081 acaaggaact caagatatta tccatgattc ttcctttaat atatctgtgt ttgaacccaa
     1141 ctgtatccca aaaccaaaat tccttctatc tgagacctgg gttcctctca gtgttattct
     1201 tttgatatta gtgatgctgg gactgttgtc ctctatcctt atgcaactta aaatcctggt
     1261 gtcagcatct ttctacccca gcgtggagag gaagcgcatc caatatctgc atgcaaagct
     1321 gcttaaaaaa agatcaaagc agccgctggg agaagtcaaa agacggctga gtctctatct
     1381 tacaaagatt catttctggc ttccagtcct gaaaatgatt aggaagaagc aaatggacat
     1441 ggcaagtgca gacaagtcat gagagacccc gactactcct cagccacatc gcaccaacaa
     1501 ttctcttcag gtctaggatg gcagtcacta ttcatgccgg ataatagaga actatgtgac
     1561 gcagtcctct caggagtctg agtttacaga gccaacttgc agcacctggt tatgcctcct
     1621 ttcatctcaa agccaaagag ctgccaggta aatggttatg tggtctatgt tccaaacaaa
     1681 ccacatgatc ttgcctgtgt cacaatgtaa caagactcta gctgggtccc ctggtgatga
     1741 gtttcagcat agaataatgt tcaaggaaaa gaaaacgaaa acagtttaaa tctctaccac
     1801 agcctcacaa gcaaatgcta aggggaacat acatgtaaaa agccagcaaa ctatcttcaa
     1861 actcttccgt ccttaatgtc ttccatggct attgccccca caatggtctc ttttctccct
     1921 gctcccttat taaagaactc tttctgaaac cca
//
