LOCUS       NM_144622               2419 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens DC-STAMP domain containing 2 (DCST2), mRNA.
ACCESSION   NM_144622
VERSION     NM_144622.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2419)
  AUTHORS   van der Valk,R.J., Kreiner-Moller,E., Kooijman,M.N., Guxens,M.,
            Stergiakouli,E., Saaf,A., Bradfield,J.P., Geller,F., Hayes,M.G.,
            Cousminer,D.L., Korner,A., Thiering,E., Curtin,J.A., Myhre,R.,
            Huikari,V., Joro,R., Kerkhof,M., Warrington,N.M., Pitkanen,N.,
            Ntalla,I., Horikoshi,M., Veijola,R., Freathy,R.M., Teo,Y.Y.,
            Barton,S.J., Evans,D.M., Kemp,J.P., St Pourcain,B., Ring,S.M.,
            Davey Smith,G., Bergstrom,A., Kull,I., Hakonarson,H., Mentch,F.D.,
            Bisgaard,H., Chawes,B., Stokholm,J., Waage,J., Eriksen,P.,
            Sevelsted,A., Melbye,M., van Duijn,C.M., Medina-Gomez,C.,
            Hofman,A., de Jongste,J.C., Taal,H.R., Uitterlinden,A.G.,
            Armstrong,L.L., Eriksson,J., Palotie,A., Bustamante,M.,
            Estivill,X., Gonzalez,J.R., Llop,S., Kiess,W., Mahajan,A.,
            Flexeder,C., Tiesler,C.M., Murray,C.S., Simpson,A., Magnus,P.,
            Sengpiel,V., Hartikainen,A.L., Keinanen-Kiukaanniemi,S., Lewin,A.,
            Da Silva Couto Alves,A., Blakemore,A.I., Buxton,J.L., Kaakinen,M.,
            Rodriguez,A., Sebert,S., Vaarasmaki,M., Lakka,T., Lindi,V.,
            Gehring,U., Postma,D.S., Ang,W., Newnham,J.P., Lyytikainen,L.P.,
            Pahkala,K., Raitakari,O.T., Panoutsopoulou,K., Zeggini,E.,
            Boomsma,D.I., Groen-Blokhuis,M., Ilonen,J., Franke,L.,
            Hirschhorn,J.N., Pers,T.H., Liang,L., Huang,J., Hocher,B., Knip,M.,
            Saw,S.M., Holloway,J.W., Melen,E., Grant,S.F., Feenstra,B.,
            Lowe,W.L., Widen,E., Sergeyev,E., Grallert,H., Custovic,A.,
            Jacobsson,B., Jarvelin,M.R., Atalay,M., Koppelman,G.H.,
            Pennell,C.E., Niinikoski,H., Dedoussis,G.V., Mccarthy,M.I.,
            Frayling,T.M., Sunyer,J., Timpson,N.J., Rivadeneira,F.,
            Bonnelykke,K. and Jaddoe,V.W.
  CONSRTM   Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium;
            Genetic Investigation of ANthropometric Traits (GIANT) Consortium;
            Early Growth Genetics (EGG) Consortium
  TITLE     A novel common variant in DCST2 is associated with length in early
            life and height in adulthood
  JOURNAL   Hum Mol Genet 24 (4), 1155-1168 (2015)
   PUBMED   25281659
  REMARK    GeneRIF: This study highlights that common variation in DCST2
            influences variation in early growth and adult height.
REFERENCE   2  (bases 1 to 2419)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   3  (bases 1 to 2419)
  AUTHORS   Jansen,B.J., Eleveld-Trancikova,D., Sanecka,A., van Hout-Kuijer,M.,
            Hendriks,I.A., Looman,M.G., Leusen,J.H. and Adema,G.J.
  TITLE     OS9 interacts with DC-STAMP and modulates its intracellular
            localization in response to TLR ligation
  JOURNAL   Mol Immunol 46 (4), 505-515 (2009)
   PUBMED   18952287
  REMARK    GeneRIF: OS9 is critically involved in the modulation of
            ER-to-Golgi transport of DC-STAMP in response to TLR triggering,
            suggesting a novel role for OS9 in myeloid differentiation and cell
            fusion.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB025590.1, BC111794.1 and AA401747.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144622.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111794.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368424.4/ ENSP00000357409.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB025590.1         1-21
            22-2311             BC111794.1         1-2290
            2312-2419           AA401747.1         3-110               c
FEATURES             Location/Qualifiers
     source          1..2419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2419
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /note="DC-STAMP domain containing 2"
                     /db_xref="GeneID:127579"
                     /db_xref="HGNC:HGNC:26562"
                     /db_xref="MIM:619861"
     exon            1..348
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2402
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /codon_start=1
                     /product="DC-STAMP domain-containing protein 2"
                     /protein_id="NP_653223.2"
                     /db_xref="CCDS:CCDS1082.2"
                     /db_xref="GeneID:127579"
                     /db_xref="HGNC:HGNC:26562"
                     /db_xref="MIM:619861"
                     /translation="MPKVMKDVVHPLGGEEPSMARAVVRSVGGFTLGLSLATAYGLLE
                     LLVEGHSPWGCLVGTLTLAAFLSLGMGFSRQVRATVLLLLPQAFSRQGRTLLLVAAFG
                     LVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLQRAKQPLVSALNKIKAIARKTK
                     EVADRVRKFFRSIMDGVKHIARALRNVWQWLLHIGDVCNSELGNPYLKCARVFDDAKD
                     SCMMVIPQAYHLCYVLMPFKLALCGLASLVQVFCVIPKYIQPFLRQTIGTPVIQLLNR
                     VRQEFEFNMTATHHFSVDLNASRSLSQVAMDLHEAVSMKLHRVREALALMGFTTPLLL
                     VLLYLQALFYRYCYLNWDHYDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPP
                     GSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVLDLARHQLQGEIVARSPV
                     LVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYG
                     LCFFITLFGSYVSRLRRVICASYYPSREQERISYLYNVLLSRRTNLLAALHRSVRRRA
                     ADQGHRSAFLVLASRCPCLGPFVSHFWLHQAYCLGCGQPQDEGDMENTVSCSTPGCQG
                     LYCLTCFRLLDNTCSVCASPLSYQGDLDLELDSSDEEGPQLWLAAAQRKDPEQAWLLQ
                     QQLQEVLGRSLSMESTSESSDLDEEKGPQQRKHGQQPLPEAHQPVSILTSPEPHRPPE
                     TSSATKGAPTPASEPSVPLSPPSLPDPSHPPPK"
     exon            349..519
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            520..621
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            622..819
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            820..885
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1099
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1257
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1422
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1590
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1691
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1822
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1950
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2044
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2185
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2419
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /note="hexamer: AATAAA"
     polyA_site      2419
                     /gene="DCST2"
                     /gene_synonym="SPE42"
                     /note="major polyA site"
ORIGIN      
        1 agaatacggt gagaaattcc aggagcacag aagtcagcgg gcatctcctg gagacaggca
       61 gacatttggt ctcagcagcc atgcccaaag tcatgaagga tgttgtgcac cccttggggg
      121 gagaggagcc tagcatggcg agagctgtgg ttcgcagcgt gggaggtttt accctgggct
      181 tgtctttagc cacggcctac gggcttctgg agctactggt ggaaggccac agcccctggg
      241 gttgcctggt gggcaccctc actttggctg ccttccttag cctgggcatg ggattctctc
      301 gccaggtccg agccactgtc ctcctgctgc tgcctcaggc cttctccagg cagggccgga
      361 cactactgtt ggtggctgct tttgggttgg tgcttcaagg gccttgtgcc aacactctac
      421 gcaacttcac ccgggccagc gaggctgtag cctgtggggc agagctggcc ctgaaccaga
      481 ccgccgaagt gctacagagg gccaagcaac ctcttgtcag tgccctgaac aagattaaag
      541 ctattgcccg gaagaccaaa gaggtggctg accgggtccg caagttcttt cggtcaatca
      601 tggatggtgt gaaacacata gccagggctc tccggaatgt gtggcagtgg ctcctgcaca
      661 tcggcgatgt gtgcaactcg gaactgggca acccttacct gaagtgtgca cgggttttcg
      721 atgatgccaa ggacagctgc atgatggtca taccacaagc ctaccacctg tgttacgtgc
      781 tcatgccctt caaactggcg ctctgtggac ttgccagcct ggtccaggtg ttctgcgtca
      841 tccctaagta cattcaaccc ttcttgcgcc agaccatcgg cacccccgtg attcagttgc
      901 tcaaccgggt gcgtcaggag tttgagttca acatgacagc cacccaccac ttctctgtgg
      961 atctcaatgc ctctcggagc ctgtcccagg tagccatgga cctccacgag gctgtcagca
     1021 tgaagctgca ccgtgtccga gaggccctgg ctctgatggg cttcaccacg cctctgctgc
     1081 ttgtgcttct ctacctccaa gccctatttt accggtattg ttacctgaac tgggaccatt
     1141 atgacaatat ctacatcact agccgattcc tgcgcatgga ggctgtgcgc tccacggcag
     1201 ggctgcccac agtgctaccg ctcagtgctc acgaggccag gcgctacatc ccaccgggct
     1261 ccatcttctt gtcccaatgg gagaagtttt tttacattct ggagaccttc aaccttatcc
     1321 gacacctcct cctcgtgctg ttcctagtct tcctagacta tgctgtcttc tgggtgcttg
     1381 acctggcccg gcaccagctg cagggggaga ttgtggcccg cagtcctgtg ttggtgtctc
     1441 taaccgtgga aggtactggc tacgctggga atatttatcg tgacctggtg tcagcatttg
     1501 atgtcctgca gcaaggcaac atcagtattt tgtcccggcg ttgtctcctt cgtccctcgg
     1561 agcctgacag cactggctac atagtcattg gcgtcatgta tggcctatgc ttcttcatca
     1621 ccctgtttgg cagctatgtc agccggctgc ggcgagtcat ctgtgcctcc tactacccat
     1681 cccgggagca ggagaggatc tcctacctgt acaatgtact tctgagccgc cgaaccaatc
     1741 tgttggctgc cctgcaccga tcagtgaggc ggcgggcggc tgaccagggc cacagaagtg
     1801 ccttcctagt gctggccagt cggtgcccct gcctaggtcc atttgtcagc cacttttggc
     1861 tgcatcaggc ctactgcctg ggctgtgggc agccccagga tgagggagac atggagaaca
     1921 ctgtgtcctg cagtaccccc ggctgccaag gtctctactg cctcacttgc ttccgcctcc
     1981 tggacaatac ctgctccgtg tgtgcatctc ccctctccta ccagggggac ctggacctgg
     2041 agctggactc cagcgatgag gagggccctc agctatggct ggctgcagct caaaggaagg
     2101 accctgagca ggcatggtta ttgcagcaac agctccaaga agtgctcggc aggagcctct
     2161 caatggagtc cacttccgag tccagtgacc tggatgagga gaaggggcct cagcagagga
     2221 agcacgggca gcagccctta cctgaagccc atcagcctgt cagcattctc accagccctg
     2281 agccccacag accacctgag acatcctccg ccactaaagg agcccccact ccagcttcag
     2341 aaccctcagt ccctctctca cctccctctc ttcctgatcc ttcccaccca ccccccaaat
     2401 aaaccaaaag tggacacaa
//
