LOCUS       NM_152494               2279 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens DC-STAMP domain containing 1 (DCST1), transcript
            variant 1, mRNA.
ACCESSION   NM_152494
VERSION     NM_152494.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2279)
  AUTHORS   Wang,X. and Wang,Y.
  TITLE     LncRNA DCST1-AS1 inhibits PDLCs' proliferation in periodontitis and
            may bind with miR-21 precursor to upregulate PLAP-1
  JOURNAL   J Periodontal Res 56 (2), 256-264 (2021)
   PUBMED   33533513
  REMARK    GeneRIF: LncRNA DCST1-AS1 inhibits PDLCs' proliferation in
            periodontitis and may bind with miR-21 precursor to upregulate
            PLAP-1.
REFERENCE   2  (bases 1 to 2279)
  AUTHORS   Hu,S., Yao,Y., Hu,X. and Zhu,Y.
  TITLE     LncRNA DCST1-AS1 downregulates miR-29b through methylation in
            glioblastoma (GBM) to promote cancer cell proliferation
  JOURNAL   Clin Transl Oncol 22 (12), 2230-2235 (2020)
   PUBMED   32418155
  REMARK    GeneRIF: LncRNA DCST1-AS1 downregulates miR-29b through methylation
            in glioblastoma (GBM) to promote cancer cell proliferation.
REFERENCE   3  (bases 1 to 2279)
  AUTHORS   Guardiola,C.J.A., Clemente-Napimoga,J.T., Martinez,E.F.,
            Abdalla,H.B., Peruzzo,D.C., Joly,J.C. and Napimoga,M.H.
  TITLE     DC-STAMP and TACE Levels are Higher in Patients with Periodontitis
  JOURNAL   Braz Dent J 31 (2), 122-126 (2020)
   PUBMED   32556010
  REMARK    GeneRIF: TACE and DC-STAMP protein levels are elevated in patients
            with periodontitis, favoring progression of bone resorption.
REFERENCE   4  (bases 1 to 2279)
  AUTHORS   Nair,S., Bist,P., Dikshit,N. and Krishnan,M.N.
  TITLE     Global functional profiling of human ubiquitome identifies E3
            ubiquitin ligase DCST1 as a novel negative regulator of Type-I
            interferon signaling
  JOURNAL   Sci Rep 6, 36179 (2016)
   PUBMED   27782195
  REMARK    GeneRIF: DCST1 regulated Type I interferon signaling by interacting
            with and promoting ubiquitination-mediated degradation of STAT2, an
            essential component of antiviral gene induction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2279)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   6  (bases 1 to 2279)
  AUTHORS   Hartgers,F.C., Vissers,J.L., Looman,M.W., van Zoelen,C.,
            Huffine,C., Figdor,C.G. and Adema,G.J.
  TITLE     DC-STAMP, a novel multimembrane-spanning molecule preferentially
            expressed by dendritic cells
  JOURNAL   Eur J Immunol 30 (12), 3585-3590 (2000)
   PUBMED   11169400
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451085.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 27, 2019 this sequence version replaced NM_152494.3.
            
            Summary: This gene encodes a protein with a domain similar to one
            found in dendritic cells (PMID:11169400) which play a key role in
            antigen processing and display for immune responses. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295542.6/ ENSP00000295542.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL451085.20        162262-162292
            32-157              AL451085.20        162410-162535
            158-283             AL451085.20        162873-162998
            284-358             AL451085.20        163091-163165
            359-487             AL451085.20        167841-167969
            488-627             AL451085.20        168923-169062
            628-844             AL451085.20        169835-170051
            845-988             AL451085.20        170152-170295
            989-1110            AL451085.20        171173-171294
            1111-1268           AL451085.20        171790-171947
            1269-1368           AL451085.20        174331-174430
            1369-1464           AL451085.20        174563-174658
            1465-1591           AL451085.20        174798-174924
            1592-1708           AL451085.20        175634-175750
            1709-1851           AL451085.20        176225-176367
            1852-1965           AL451085.20        176495-176608
            1966-2279           AL451085.20        179055-179368
FEATURES             Location/Qualifiers
     source          1..2279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2279
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /note="DC-STAMP domain containing 1"
                     /db_xref="GeneID:149095"
                     /db_xref="HGNC:HGNC:26539"
                     /db_xref="MIM:619860"
     exon            1..31
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            32..157
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2217
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DC-STAMP domain-containing protein 1; RING-type E3
                     ubiquitin transferase; E3 ubiquitin-protein ligase DCST1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DCST1 isoform 1"
                     /protein_id="NP_689707.2"
                     /db_xref="CCDS:CCDS1083.1"
                     /db_xref="GeneID:149095"
                     /db_xref="HGNC:HGNC:26539"
                     /db_xref="MIM:619860"
                     /translation="MDIKHHQNGTRGQRRKQPHTTVQRLLTWGLPVSCSWFLWRQPGE
                     FPVTALLLGAGAGGLLAIGLFQLLVNPMNIYEEQKIMFLYSLVGLGAMGWGTSPHIRC
                     ASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNTRA
                     AWRISTAPLRAMFKDLLSSKELLRAETRNISATFEDLDAQVNSETGYTPEDTMDSGET
                     AQGREARQAPASRLHLSTQKMYELKTKLRCSYVVNQAILSCRRWFDRKHEQCMKHIWV
                     PLLTHLLCLPMKFKFFCGIAKVMEVWCRNRIPVEGNFGQTYDSLNQSIRGLDGEFSAN
                     IDFKEEKQAGVLGLNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHAS
                     FSYMDSYNHDIRFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQA
                     SEMSNVVRELLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVG
                     GDSMLARLLRKTIGALNTSSETVMESNNMPCLPQPVGLDARAYWRAAVPIGLLVCLCL
                     LQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLKKRAAFTKLRRAAILRRERQQKAPR
                     HPLADILHRGCPLLRRWLCRRCVVCQAPETPESYVCRTLDCEAVYCWSCWDDMRQRCP
                     VCTPREELSSSAFSDSNDDTAYAG"
     exon            158..283
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            284..358
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            359..487
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            488..627
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            628..844
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            845..988
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1110
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1268
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1368
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1464
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1591
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1708
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1851
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1965
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2279
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2259..2264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /note="hexamer: AATAAA"
     polyA_site      2279
                     /gene="DCST1"
                     /gene_synonym="SNKY; SPE49"
                     /note="major polyA site"
ORIGIN      
        1 gacccagttc cgaggactgg agaggggata gaaccttgtg tccaaggagg tccttcagga
       61 gacctgggat gagtggtgct tccccaaaac agactcatgg acattaaaca tcatcagaat
      121 ggcacaagag ggcaaagaag aaaacagcct cataccacgg tgcagaggct cctgacctgg
      181 gggctgccag tctcctgtag ctggttcctg tggcgccagc cgggcgagtt tcctgtcact
      241 gctctcctgc tgggggcagg cgctgggggg ctcctggcca taggtctctt tcagctcctg
      301 gtgaacccca tgaacatcta cgaagaacag aagattatgt tcttgtacag cttggtgggc
      361 ttgggggcca tgggctgggg gacctcccct cacatccgct gtgccagcct cctactagta
      421 cccaagatgc tgggcaagga aggcaggctc tttgtcctgg gatacgcctt ggctgccatc
      481 tatgtggggc cagtagccaa tctgcgacac aatctcaaca acgtgatcgc atcgctgggc
      541 tgcaccgtgg agctgcagat caacaacacc cgcgcagctt ggcgcatctc cacagccccc
      601 ttacgggcca tgttcaagga cctgctgagt agcaaagaat tgctgagagc agagactcgg
      661 aacatctccg ccacttttga ggacctggat gcccaggtga atagtgagac gggctacacg
      721 cctgaggata ccatggactc aggggagaca gcccagggca gggaggcccg ccaagcccca
      781 gcctccagac tccacctgtc gacacagaag atgtatgagc tgaagaccaa gctgcgttgc
      841 tcctatgtgg tgaaccaggc catactcagc tgccgtcgtt ggtttgaccg caagcatgaa
      901 cagtgcatga agcacatctg ggtcccactc ctcacccacc tgctctgcct gcctatgaag
      961 ttcaagttct tctgtggcat tgccaaggtg atggaggttt ggtgccgcaa tcgcatccca
     1021 gtggaaggca actttgggca gacctacgac tccctcaacc agtctattcg tggcctggat
     1081 ggggaatttt cagccaatat tgacttcaag gaagagaagc aggctggggt gctggggctc
     1141 aacacaagct gggagcgcgt gagcaccgag gtgcgggact acgtgtaccg ccaggaggcc
     1201 cggctggagt gggccctggg gctgctgcac gtgctgctct cctgcacttt cctgctggtc
     1261 ctgcatgcgt ctttctccta catggacagc tataaccatg acattcgttt tgacaacatc
     1321 tacatcagta cctacttctg ccagatcgat gaccgcagga agaagctggg caaacggact
     1381 ctgctgccac tccgcaaagc tgaggagaaa accgtcatct tcccttgcaa gcccaccatc
     1441 caggcctcag aaatgagcaa tgtggtgagg gagctcctgg agacactgcc cattctgctg
     1501 ctgctggtgg tgctgtgtgg cttggactgg gctctctact ccatcttcga caccatccgc
     1561 caccactcct tcctgcagta ctccttccgc agcagtcata aactggaggt gaaggtcggg
     1621 ggagactcca tgctagcccg gcttcttcga aaaaccattg gggccctgaa cacctcctca
     1681 gagacagtga tggaatcaaa caacatgccc tgcctgcccc agcctgtggg cctggatgcc
     1741 agggcctact ggagagctgc agtaccgatt ggcctgttag tgtgtctctg cctgttacag
     1801 gcttttggct accgactccg gagggtcatc gcagccttct acttccccaa gcgagagaag
     1861 aagcggatcc tgttcctcta caatgaccta ttgaagaaaa gagcagcctt caccaaactc
     1921 aggagggccg ctatcctgag gcgggagcga cagcagaagg ctccgcgcca cccgctggcg
     1981 gatatcctgc accgcggctg cccgctcctg cgccgctggc tgtgccggcg ctgcgtggtg
     2041 tgccaggcac ccgagacgcc cgagtcctac gtgtgccgga cgctggactg cgaggccgtg
     2101 tactgctggt cgtgctggga cgacatgcgg cagcggtgcc cggtctgcac gccccgcgaa
     2161 gagctctctt cctccgcctt tagtgacagc aacgacgaca ctgcctacgc ggggtgaaga
     2221 ggcgtcctgc tcgctcttcc gcaccgtcct tcccggttaa taaaatgccc tgtacgctt
//
