LOCUS       NM_152640               2033 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens decapping mRNA 1B (DCP1B), transcript variant 1, mRNA.
ACCESSION   NM_152640
VERSION     NM_152640.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Ziemniak,M., Mugridge,J.S., Kowalska,J., Rhoads,R.E., Gross,J.D.
            and Jemielity,J.
  TITLE     Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2
            RNA decapping complex
  JOURNAL   RNA 22 (4), 518-529 (2016)
   PUBMED   26826132
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Tritschler,F., Braun,J.E., Motz,C., Igreja,C., Haas,G.,
            Truffault,V., Izaurralde,E. and Weichenrieder,O.
  TITLE     DCP1 forms asymmetric trimers to assemble into active mRNA
            decapping complexes in metazoa
  JOURNAL   Proc Natl Acad Sci U S A 106 (51), 21591-21596 (2009)
   PUBMED   19966221
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Fenger-Gron,M., Fillman,C., Norrild,B. and Lykke-Andersen,J.
  TITLE     Multiple processing body factors and the ARE binding protein TTP
            activate mRNA decapping
  JOURNAL   Mol Cell 20 (6), 905-915 (2005)
   PUBMED   16364915
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 2033)
  AUTHORS   Cougot,N., Babajko,S. and Seraphin,B.
  TITLE     Cytoplasmic foci are sites of mRNA decay in human cells
  JOURNAL   J Cell Biol 165 (1), 31-40 (2004)
   PUBMED   15067023
REFERENCE   10 (bases 1 to 2033)
  AUTHORS   Lykke-Andersen,J.
  TITLE     Identification of a human decapping complex associated with hUpf
            proteins in nonsense-mediated decay
  JOURNAL   Mol Cell Biol 22 (23), 8114-8121 (2002)
   PUBMED   12417715
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY146652.1, AK299203.1,
            BC015368.3 and AW204088.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152640.4.
            
            Summary: This gene encodes a member of a family of proteins that
            function in removing the 5' cap from mRNAs, which is a step in
            regulated mRNA decay. This protein localizes to cytoplasmic foci
            which are the site of mRNA breakdown and turnover. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056200.1, SRR1660805.203232.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280665.11/ ENSP00000280665.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-790               AY146652.1         55-844
            791-808             AK299203.1         930-947
            809-2025            BC015368.3         372-1588
            2026-2033           AW204088.1         21-28               c
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..2033
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /note="decapping mRNA 1B"
                     /db_xref="GeneID:196513"
                     /db_xref="HGNC:HGNC:24451"
                     /db_xref="MIM:609843"
     exon            1..176
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1880
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /EC_number="3.6.1.62"
                     /note="isoform 1 is encoded by transcript variant 1;
                     decapping enzyme hDcp1b; mRNA-decapping enzyme 1B; DCP1
                     decapping enzyme homolog B"
                     /codon_start=1
                     /product="mRNA-decapping enzyme 1B isoform 1"
                     /protein_id="NP_689853.3"
                     /db_xref="CCDS:CCDS31727.1"
                     /db_xref="GeneID:196513"
                     /db_xref="HGNC:HGNC:24451"
                     /db_xref="MIM:609843"
                     /translation="MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFG
                     HRANEWEKTDVEGTLFVYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLY
                     RNARLSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVD
                     ILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQT
                     LDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSY
                     EEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQP
                     GSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVT
                     PVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQ
                     ELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQ
                     VISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQS
                     PEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM"
     exon            177..217
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..345
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..412
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..548
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..677
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1550
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1799
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2033
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /note="hexamer: AGTAAA"
     polyA_site      2006
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /note="major polyA site"
     polyA_site      2033
                     /gene="DCP1B"
                     /gene_synonym="DCP1"
                     /note="major polyA site"
ORIGIN      
        1 gtgcctatgt ctgggaggga gggaagatgg cagccgtggc ggcaggcggc ctggtgggaa
       61 aggggcgcga catcagccta gcggccctgc agcgccacga cccctatatc aaccgcatcg
      121 tggacgtggc cagccaggtg gctctgtaca ccttcggcca tcgggccaac gagtgggaga
      181 aaactgatgt ggaaggaacc ttatttgttt atacaaggtc tgcttctcca aagcatggat
      241 tcaccattat gaataggctg agcatggaaa ataggacaga acctattact aaagacttgg
      301 atttccaact ccaggaccct ttccttctct acagaaatgc cagattgtcc atctatggaa
      361 tttggtttta tgataaggaa gaatgccaaa gaattgcaga gcttatgaaa aacctaactc
      421 agtatgaaca gttgaaagcc catcagggaa ctggagcagg aatttcccca gtgatcctca
      481 attcaggaga gggcaaagaa gtagacattt tacgaatgct catcaaggcc aaagacgaat
      541 acacaaagtg taaaacctgt tctgagccaa aaaagataac cagttcctct gccatctatg
      601 acaatccaaa tctcatcaaa ccaattccag tgaaacccag tgaaaaccag caacagcgta
      661 tacctcagcc caaccagacc ttagaccctg aaccccaaca cttatccttg acagctctgt
      721 ttgggaagca ggacaaagct acatgtcagg aaactgtgga gcctccgcag actctccacc
      781 agcagcagca gcagcagcag cagcagcaag agaagcttcc aattaggcag ggggttgtac
      841 gctccctgtc ctatgaggaa cccagaagac actcaccccc cattgagaag cagctctgtc
      901 cagccattca gaaactcatg gtcaggagcg cagacctcca cccattgtca gagctgcctg
      961 aaaaccggcc ttgtgaaaat ggcagtaccc attctgcggg agaatttttt acaggacctg
     1021 tccagccagg gtctcctcac aacattggaa cttctcgtgg tgtacaaaat gcttccagaa
     1081 ctcagaacct gttcgagaaa cttcagagta ccccaggggc agcaaacaag tgtgacccta
     1141 gtacaccagc acctgccagc tcagctgccc tgaaccgcag cagagctccc acttctgtca
     1201 cccctgtggc tccaggaaag ggtctggctc agccaccaca ggcctatttc aatggctccc
     1261 ttccacctca gacagtagga catcaggctc atggaagaga acagtccaca ctcccaagac
     1321 aaacactccc catctctggt agtcagactg gcagctctgg agtgatctcc cctcaagagt
     1381 tactgaagaa gcttcagatt gtacagcagg agcagcagct gcatgcctct aaccggccag
     1441 ccttggccgc taagtttcct gtgctcgctc agagctctgg aacagggaaa cccttggaat
     1501 cctggatcaa caagacaccc aacacagaac agcagactcc tcttttccag gtcatctcac
     1561 ctcagcgcat ccctgctaca gcagctccgt ctctgcttat gtcccccatg gtgttcgcac
     1621 aacccacctc cgtcccgcca aaggaaaggg agagcggcct cttgcctgtg ggaggccagg
     1681 agccacctgc tgctgccacc agcctcctcc tgcccataca gagcccggag ccctccgtga
     1741 tcaccagcag cccactcacc aagctccagc tccaggaggc actgctgtac ctcattcaga
     1801 atgatgacaa cttcttaaat ataatctatg aagcctatct cttcagcatg actcaagcag
     1861 ccatgaaaaa gactatgtga cagcaaggcc ttttaaaact gattttcaag gtccttctag
     1921 aactccggca caaggttctt tcatgttgag tgttgtttcc ttcaatgttt ctgccttttt
     1981 taaaaaaaaa gtatgtgtaa tatgaagtaa aatgtttcag actttttttt ata
//
