LOCUS       NM_018403               5926 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens decapping mRNA 1A (DCP1A), transcript variant 1, mRNA.
ACCESSION   NM_018403
VERSION     NM_018403.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5926)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5926)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5926)
  AUTHORS   Wu,H., Zhang,J., Bai,Y., Zhang,S., Zhang,Z., Tong,W., Han,P.,
            Fu,B., Zhang,Y. and Shen,Z.
  TITLE     DCP1A is an unfavorable prognostic-related enhancer RNA in
            hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 13 (19), 23020-23035 (2021)
   PUBMED   34609335
  REMARK    GeneRIF: DCP1A is an unfavorable prognostic-related enhancer RNA in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 5926)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5926)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   6  (bases 1 to 5926)
  AUTHORS   Leonard,D., Ajuh,P., Lamond,A.I. and Legerski,R.J.
  TITLE     hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA
            splicing
  JOURNAL   Biochem Biophys Res Commun 308 (4), 793-801 (2003)
   PUBMED   12927788
REFERENCE   7  (bases 1 to 5926)
  AUTHORS   Ingelfinger,D., Arndt-Jovin,D.J., Luhrmann,R. and Achsel,T.
  TITLE     The human LSm1-7 proteins colocalize with the mRNA-degrading
            enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
  JOURNAL   RNA 8 (12), 1489-1501 (2002)
   PUBMED   12515382
REFERENCE   8  (bases 1 to 5926)
  AUTHORS   Lykke-Andersen,J.
  TITLE     Identification of a human decapping complex associated with hUpf
            proteins in nonsense-mediated decay
  JOURNAL   Mol Cell Biol 22 (23), 8114-8121 (2002)
   PUBMED   12417715
  REMARK    GeneRIF: These data suggest that a human decapping complex
            containing decapping enzymes hDcp1a and hDcp2 may be recruited to
            mRNAs containing premature termination codons by the hUpf proteins.
REFERENCE   9  (bases 1 to 5926)
  AUTHORS   Callebaut,I.
  TITLE     An EVH1/WH1 domain as a key actor in TGFbeta signalling
  JOURNAL   FEBS Lett 519 (1-3), 178-180 (2002)
   PUBMED   12023040
REFERENCE   10 (bases 1 to 5926)
  AUTHORS   Bai,R.Y., Koester,C., Ouyang,T., Hahn,S.A., Hammerschmidt,M.,
            Peschel,C. and Duyster,J.
  TITLE     SMIF, a Smad4-interacting protein that functions as a co-activator
            in TGFbeta signalling
  JOURNAL   Nat Cell Biol 4 (3), 181-190 (2002)
   PUBMED   11836524
  REMARK    GeneRIF: Overexpression of wild-type SMIF enhanced expression of
            TGFbeta/BMP regulated genes, whereas a dominant-negative SMIF
            mutant suppressed expression.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY146651.1, AC112218.2 and
            CD676826.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018403.6.
            
            Summary: Decapping is a key step in general and regulated mRNA
            decay. The protein encoded by this gene is a decapping enzyme. This
            protein and another decapping enzyme form a decapping complex,
            which interacts with the nonsense-mediated decay factor hUpf1 and
            may be recruited to mRNAs containing premature termination codons.
            This protein also participates in the TGF-beta signaling pathway.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB075507.1, SRR1803612.205466.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610213.6/ ENSP00000476386.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1985              AY146651.1         1-1985
            1986-5459           AC112218.2         13309-16782         c
            5460-5926           CD676826.1         1-467
FEATURES             Location/Qualifiers
     source          1..5926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..5926
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /note="decapping mRNA 1A"
                     /db_xref="GeneID:55802"
                     /db_xref="HGNC:HGNC:18714"
                     /db_xref="MIM:607010"
     exon            1..161
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1775
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /EC_number="3.6.1.62"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription factor SMIF; Smad4-interacting
                     transcriptional co-activator; mRNA-decapping enzyme 1A;
                     decapping enzyme hDcp1a; putative protein product of
                     Nbla00360; DCP1 decapping enzyme homolog A; DCP1 decapping
                     enzyme-like protein A"
                     /codon_start=1
                     /product="mRNA-decapping enzyme 1A isoform a"
                     /protein_id="NP_060873.4"
                     /db_xref="CCDS:CCDS46847.2"
                     /db_xref="GeneID:55802"
                     /db_xref="HGNC:HGNC:18714"
                     /db_xref="MIM:607010"
                     /translation="MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQ
                     WEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASL
                     SIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEM
                     LSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLT
                     VEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGV
                     PSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPS
                     LPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSV
                     DLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASA
                     SLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIPVAGAPLVTATTTAVSSVLLAPSVFQ
                     QTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLH
                     EVYLQVLTKNKDNHNL"
     exon            162..202
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            203..330
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            331..397
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            398..536
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            537..650
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            651..1409
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1475
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1694
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..5926
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5895..5900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /note="hexamer: AATAAA"
     polyA_site      5926
                     /gene="DCP1A"
                     /gene_synonym="HSA275986; Nbla00360; SMAD4IP1; SMIF"
                     /note="major polyA site"
ORIGIN      
        1 agaggggcta ggctctggga ttcaagatgg aggcgctgag tcgagctggg caggagatga
       61 gcctagcggc cctgaagcaa cacgacccct atatcaccag catcgcagac ctcacgggcc
      121 aggtcgctct gtacaccttc tgccccaagg ccaaccagtg ggagaagact gatatagaag
      181 ggaccttatt cgtatatcga aggtcagctt ccccttacca tggttttacc attgtgaatc
      241 gactaaatat gcacaatcta gttgaaccag tgaataaaga tttggaattt cagctccatg
      301 aaccatttct tctgtataga aatgcaagct tgtcgatata tagtatctgg ttttatgaca
      361 agaatgactg tcaccgcata gcaaaactca tggctgatgt ggtagaagag gagacacggc
      421 gatcccagca agctgctcgg gacaaacaga gtcccagcca ggccaatggc tgcagcgacc
      481 acaggcccat cgacatcctg gagatgctga gcagagccaa ggatgagtat gagaggaatc
      541 agatgggtga ctcaaatatc tccagccctg ggttacagcc aagcactcag ctctccaatc
      601 tgggaagcac cgagactcta gaagaaatgc cctccgggtc acaggataag tctgctccat
      661 ctggacacaa gcatctgacg gtagaagagt tatttggaac ctctttgcca aaggaacaac
      721 cagcagttgt gggtctggat tcagaagaaa tggagaggtt gccaggagat gcctcccaga
      781 aagagcccaa ttcattccta ccatttccct ttgagcagtt aggaggagcc cctcaatcag
      841 aaaccctggg tgtcccttct gctgcccacc attcagtcca gcctgaaatc accaccccgg
      901 tgctaatcac tccagcctcc atcacacagt ccaatgaaaa gcatgctcca acctacacaa
      961 tcccgttgag ccctgttctc agtcccactc tgccagctga agctcctact gcacaggttc
     1021 cccccagctt acctcgaaac agcaccatga tgcaggcagt gaagaccacg cctagacaga
     1081 ggtctccact cctgaaccag ccagtccctg agctaagcca tgccagtctg attgccaacc
     1141 agagcccctt cagggcccca ttgaacgtga cgaacacagc tggcacatcc ctcccaagcg
     1201 ttgatcttct ccagaaactc aggttgaccc cacagcatga ccaaatacag acacaaccac
     1261 ttgggaaagg tgcaatggta gccagctttt ctccggcagc tggtcagcta gccacacctg
     1321 agagcttcat agagcctccc tctaagacag cagcagcaag agtggcggcc tcagcctccc
     1381 tgagcaacat ggtgcttgct ccccttcagt ctatgcagca gaaccaggat cctgaagtat
     1441 ttgtgcagcc taaggtgtta tccagtgcca tcccggttgc aggcgcccca ctggttactg
     1501 caacgaccac tgcagtgtct tcagtcctgc tggccccaag tgttttccag cagacagtta
     1561 caagatcttc ggaccttgag aggaaagcca gctccccttc tcctctaact attggaacgc
     1621 cagaaagtca gagaaagcct tccattattc tcagcaagtc tcagctccag gatacattaa
     1681 tacatctaat aaagaatgat tccagcttcc tcagtacact tcatgaagtc tacttgcagg
     1741 ttctgaccaa gaacaaagac aaccacaacc tatgactgga gcagaataag tctaaaggca
     1801 gagccccagc ctcagagaca aataggcttc atcatggaaa cttctgagca gaacattgag
     1861 tttgagaatc ctgaaattga gcctatgaga aagagactca tttcttaaga atgttttcca
     1921 agtgacattc tcagtgataa tggaggtttc actgtgaagc atcaccagca gatccttgtt
     1981 ttgacaaaaa aaaaaaaaaa aaaaaaaaaa aagagagcga tcattgtgtt aagttatgtg
     2041 ggtgttttca tcagctagga gcaaggctgt ggaataagga gtcagattct cagcttgctt
     2101 tcactttcaa ggacttacag aggagtagtc accagcctca cagcagaagt tcagcccggc
     2161 ccccaccgct tcccccagcc taccccatag aaacgggctt tgggctgaca agtcaagttt
     2221 tgaacagagt agaaggcagc tctgcaaagt agcttctagt ttttaggacc agaatttaag
     2281 ccggcaaatt aggaattatt tcctcaagtg aagtatattt tatatgaatg ccccatttgg
     2341 gccttaaaag ttgtgaaatt tcttaatagc attttgtttt taagtgcccc agtcctgccc
     2401 tgcagcaggc ccccagtgca gcattaccat ttgaataggg cactgtcagg ctctggtggt
     2461 gtggacacag gcatgtcata cctttgaagg aaaggctggg gctgggaatg cccacatcct
     2521 atcaaatctt cattttaggt taaactctcc attggttctg aaaatgctaa gtttgtgtgt
     2581 gaagcacagc cttattttcc ttttctgtca ttgttgattg ttttccttaa cactttgaca
     2641 aaaggaccag tggaccaatc tgacaaagcc attctggttc ctttccttga gtgtactgag
     2701 aatagtttta aagctatgca gaaaagggag ctgttattca cactgccctt attttgttgt
     2761 agaattatgg agttaaaaga aaatgtgatt ccgaactcta ccaatgtatt cctaggctgt
     2821 gagtactttc ccggcccaaa gtgtgaaaat atgtaaagaa gctttgttat gctgctattg
     2881 atctgccatg atttctattt attcttttat ggcatgtaat ggtgtttagt aatattttaa
     2941 tgtagatttt gatttatttc agcaatagta attttaagat attctttgaa tgaaagtgtc
     3001 ttcgtttcta tgatacaggt cattttgtag tatttaacca attaagatgc actgcttact
     3061 tttctgagca ctatttaatg atggggtaaa aacccaattg gctcaaccag ctagcataag
     3121 gattagctgt gaataatgct gacagatatg atggttcctt aggaacaatc atttaagctt
     3181 taatggtaac tcaatcataa gtccatagat tatttttttc tagctaaaat tttagaaaat
     3241 tacttgtgaa ttacatactt gttttagttt ggtcttagtt tttagcataa agaatgattg
     3301 gcttttgttg atctaaacat gcttcctgga cagggtttct gcttctcatt ttagtgtctt
     3361 ctattgctgt ctacctaatt atgtgtgaat tgtgcagaat tcagggaagc ttataagttt
     3421 tcatgctcaa ttgtgaatag tttgttttca cagatagtat gtaaattaag caaccaaaaa
     3481 tgaattcctt atgcatcatc tgggaacgag aaagctatag tgggatacag agtgttgctg
     3541 acaccgggag atggtgtcca gggagccacg tgacttccat aaagtggacg caccagtagg
     3601 tgtgattgca cctcaagtgt agtctcagtg ggcttcggtg aacagacgaa tcaagggatt
     3661 cttgaatcga aattatgctt ttgagtatgt aatattatga gagagttaag agagaatatc
     3721 ctaaagagag tctgtgatca tactaatttt cacctttaat gctaggaatg gatatgatag
     3781 acagtaaaga gcatctatga taaggcttcc ttagtgtgaa agtaaactta agtgcccaag
     3841 tcatggagac ttgaaaaggg taaacctgtt tcacctccca aatttatata ttcaaagtat
     3901 ttacttaaaa ttcagaagcc agaagttcat gtcatgatta ccaggaagtt caggccagaa
     3961 tgaatcccta gagaagccag gccaagcctg gataattgca gctggatgac cctggcccga
     4021 aagtcacagt tcagttgcct tattcctagt tcaggcttac tatctagaac ctcatgctag
     4081 cttaggttgc atgtttacat tgctgcagtg tctttactgg aagcttagtt ggatcgaaat
     4141 ggacaccgag atggagatgc ttctggctag atttcgcaga accccaggag acctgcattt
     4201 agaccactct gtccatttgt gtgcccaccc ccacccccag ggtctaagtg tagactccaa
     4261 gaggagcagc ccagagcttg gaggagaggt gtgtctgggg caccactggt gggtggtgct
     4321 gctcttcttt ttgttgtagt taatgcggtg tcttttaatg gactctcagg cctcccagac
     4381 agccttgttc ctttaaggca gaagctcttc ttcattgtgt acctcctggg attcatgagg
     4441 tgtgagattt ggcctgcttg actttgaatt caagtttttc aagtgactct cagtgtcaga
     4501 agaagcattt catgctgtcc acatgtggta tgtccacagc tcaccttcaa aggcttagat
     4561 gtagccatca cagagagtgg tattttatta agaacccaag tcccagcctg accaacatgg
     4621 tgaaacccca tctctactaa aaatacaaaa attagccggg cgtggtggca cgcgcctata
     4681 ctcccagcta cttaggaggc tgaggcagga gaatcacttg aacccgggag gcagaggttg
     4741 cagtgagcca agatcacacc actgcactct agcctgggcg acagtgagac tccacctcaa
     4801 aaaaaaaaaa aaaaaaaaaa aaaaaaaagt cacgctgggc ccctctctac agggggacac
     4861 acaggcttag tttagtatat gtctaaccag attttgcatg tcaagcattt gtccttttcc
     4921 tggcttatgt tttcttgtag aaattatata aaccctatca aatccactac taggtaaatt
     4981 tttaaaccat gcagctttat tactctcctc ccccaaagaa tgtagtttga aattttctca
     5041 tttccatagt agaggcccta actgccattg tattactaat aatgcaacat gaaattgaag
     5101 gtgcctaact gctcaaaaaa caaaatcagc catcatactg taactctgag aggaatgaga
     5161 ggtggcacag gcacgagtgg gctcagcccg tgtgagtgag gagaactgag gaatcctagg
     5221 gtgcgcatcc tgcatcctgg ctgcacgttt gctgcagagt atgtttttct ttcttgcctc
     5281 ccttcagttt tcttcagttg cgttcagtgt atcttctgga accaatagtg ccctgtgttc
     5341 tcaagtctct aaaatgctaa gatctgagca aagtcaagca gcttacacta ggctttttta
     5401 cagctgtgct tgagaacatt tccgagtgga ccagggcctt gaggagcctg tttttcagca
     5461 aattcaacag atgtgtgcag tgattccctc cgttttgtat ttgacacctt catttaaaat
     5521 gctaagatgc aatatcattc acttcaaagt ggggaaaatg cagaattgtg tttccttttt
     5581 atctgtgtga ttccttaaga aacatgtttt taaaatatgt gttctaaatg gttttttatt
     5641 ctgtattact gctttggcca tgtggctctc atgactttca ttgtaccaga ttctcagctc
     5701 cctgaaacat ggggacgaga agctctggaa ttacagcaag atttttgttc catgagcgca
     5761 atactgtatc attaacattt ttaatggtat ggattttata gcatctgtgt atgtttgcaa
     5821 atattaagtt attacatgtt ttaaaatgag cgtttttcat cttaaatttt atatgtttgc
     5881 aaatatattt ttttaataaa atttcaaaac caagttttag caccta
//
