LOCUS       NM_001920               6850 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens decorin (DCN), transcript variant A1, mRNA.
ACCESSION   NM_001920
VERSION     NM_001920.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6850)
  AUTHORS   Cui,J., Zhang,S., Acharya,K., Xu,Y., Guo,H., Li,T., Fu,D., Yang,Z.,
            Hou,L., Xing,X. and Hu,X.
  TITLE     Decorin attenuates hypertrophic scar fibrosis via TGFbeta/Smad
            signalling
  JOURNAL   Exp Dermatol 33 (7), e15133 (2024)
   PUBMED   39045898
  REMARK    GeneRIF: Decorin attenuates hypertrophic scar fibrosis via
            TGFbeta/Smad signalling.
REFERENCE   2  (bases 1 to 6850)
  AUTHORS   Eremenko,E.E., Kwan,P.O., Ding,J., Ghosh,S. and Tredget,E.E.
  TITLE     The effects of TGF-beta1 and IFN-alpha2b on decorin, decorin
            isoforms and type I collagen in hypertrophic scar dermal
            fibroblasts
  JOURNAL   Wound Repair Regen 32 (2), 135-145 (2024)
   PUBMED   38243615
  REMARK    GeneRIF: The effects of TGF-beta1 and IFN-alpha2b on decorin,
            decorin isoforms and type I collagen in hypertrophic scar dermal
            fibroblasts.
REFERENCE   3  (bases 1 to 6850)
  AUTHORS   Li,Y., Gan,L., Lu,M., Zhang,X., Tong,X., Qi,D., Zhao,Y. and Ye,X.
  TITLE     HBx downregulated decorin and decorin-derived peptides inhibit the
            proliferation and tumorigenicity of hepatocellular carcinoma cells
  JOURNAL   FASEB J 37 (4), e22871 (2023)
   PUBMED   36929160
  REMARK    GeneRIF: HBx downregulated decorin and decorin-derived peptides
            inhibit the proliferation and tumorigenicity of hepatocellular
            carcinoma cells.
REFERENCE   4  (bases 1 to 6850)
  AUTHORS   Neill,T., Schaefer,L. and Iozzo,R.V.
  TITLE     Decorin: a guardian from the matrix
  JOURNAL   Am J Pathol 181 (2), 380-387 (2012)
   PUBMED   22735579
  REMARK    Review article
REFERENCE   5  (bases 1 to 6850)
  AUTHORS   Danielson,K.G., Fazzio,A., Cohen,I., Cannizzaro,L.A.,
            Eichstetter,I. and Iozzo,R.V.
  TITLE     The human decorin gene: intron-exon organization, discovery of two
            alternatively spliced exons in the 5' untranslated region, and
            mapping of the gene to chromosome 12q23
  JOURNAL   Genomics 15 (1), 146-160 (1993)
   PUBMED   8432526
REFERENCE   6  (bases 1 to 6850)
  AUTHORS   Rodahl,E., Knappskog,P.M., Bredrup,C. and Boman,H.
  TITLE     Congenital Stromal Corneal Dystrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301741
REFERENCE   7  (bases 1 to 6850)
  AUTHORS   Krumdieck,R., Hook,M., Rosenberg,L.C. and Volanakis,J.E.
  TITLE     The proteoglycan decorin binds C1q and inhibits the activity of the
            C1 complex
  JOURNAL   J Immunol 149 (11), 3695-3701 (1992)
   PUBMED   1431141
REFERENCE   8  (bases 1 to 6850)
  AUTHORS   Winnemoller,M., Schon,P., Vischer,P. and Kresse,H.
  TITLE     Interactions between thrombospondin and the small proteoglycan
            decorin: interference with cell attachment
  JOURNAL   Eur J Cell Biol 59 (1), 47-55 (1992)
   PUBMED   1468447
REFERENCE   9  (bases 1 to 6850)
  AUTHORS   Murphy-Ullrich,J.E., Schultz-Cherry,S. and Hook,M.
  TITLE     Transforming growth factor-beta complexes with thrombospondin
  JOURNAL   Mol Biol Cell 3 (2), 181-188 (1992)
   PUBMED   1550960
REFERENCE   10 (bases 1 to 6850)
  AUTHORS   Fisher,L.W., Hawkins,G.R., Tuross,N. and Termine,J.D.
  TITLE     Purification and partial characterization of small proteoglycans I
            and II, bone sialoproteins I and II, and osteonectin from the
            mineral compartment of developing human bone
  JOURNAL   J Biol Chem 262 (20), 9702-9708 (1987)
   PUBMED   3597437
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD689331.1, BX571756.1,
            BM672011.1, AC007115.1, BX094949.1 and AW444736.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001920.4.
            
            Summary: This gene encodes a member of the small leucine-rich
            proteoglycan family of proteins. Alternative splicing results in
            multiple transcript variants, at least one of which encodes a
            preproprotein that is proteolytically processed to generate the
            mature protein. This protein plays a role in collagen fibril
            assembly. Binding of this protein to multiple cell surface
            receptors mediates its role in tumor suppression, including a
            stimulatory effect on autophagy and inflammation and an inhibitory
            effect on angiogenesis and tumorigenesis. This gene and the related
            gene biglycan are thought to be the result of a gene duplication.
            Mutations in this gene are associated with congenital stromal
            corneal dystrophy in human patients. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (A1) represents the longest
            transcript and encodes the longest isoform. Both variants A1 and A2
            encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.52260.1,
                                           SRR5189664.108798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000052754.10/ ENSP00000052754.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               CD689331.1         319-481
            164-1808            BX571756.1         185-1829
            1809-2076           BM672011.1         18-285              c
            2077-3144           AC007115.1         51139-52206
            3145-3656           BX094949.1         20-531
            3657-4057           AW444736.1         16-416              c
            4058-6850           AC007115.1         53120-55912
FEATURES             Location/Qualifiers
     source          1..6850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..6850
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="decorin"
                     /db_xref="GeneID:1634"
                     /db_xref="HGNC:HGNC:2705"
                     /db_xref="MIM:125255"
     exon            1..163
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            164..407
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1276
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="isoform a preproprotein is encoded by transcript
                     variant A1; small leucine-rich protein 1B; dermatan
                     sulphate proteoglycans II; bone proteoglycan II;
                     proteoglycan core protein"
                     /codon_start=1
                     /product="decorin isoform a preproprotein"
                     /protein_id="NP_001911.1"
                     /db_xref="CCDS:CCDS9039.1"
                     /db_xref="GeneID:1634"
                     /db_xref="HGNC:HGNC:2705"
                     /db_xref="MIM:125255"
                     /translation="MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDR
                     DFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFK
                     NLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHEN
                     EITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQG
                     LPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHL
                     DNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPV
                     QYWEIQPSTFRCVYVRSAIQLGNYK"
     exon            408..520
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            521..734
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            735..848
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            849..942
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1081
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..6850
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AATAAA"
     polyA_site      1464
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="major polyA site"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
     polyA_site      1808
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="major polyA site"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AATAAA"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: ATTAAA"
     polyA_site      2076
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
     polyA_site      2086
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
     regulatory      2234..2239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AGTAAA"
     polyA_site      2255
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AATAAG"
     polyA_site      2295
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AATAAA"
     polyA_site      4059
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
     regulatory      6822..6827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
                     /note="hexamer: AATAAA"
     polyA_site      6850
                     /gene="DCN"
                     /gene_synonym="CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B"
ORIGIN      
        1 aactgtgcta tggagtagaa gcaggaggtt ttcaacctag tcacagagca gcacctaccc
       61 cctcctcctt tccacacctg caaactcttt tacttgggct gaatatttag tgtaattaca
      121 tctcagcttt gagggctcct gtggcaaatt cccggattaa aaggttccct ggttgtgaaa
      181 atacatgaga taaatcatga aggccactat catcctcctt ctgcttgcac aagtttcctg
      241 ggctggaccg tttcaacaga gaggcttatt tgactttatg ctagaagatg aggcttctgg
      301 gataggccca gaagttcctg atgaccgcga cttcgagccc tccctaggcc cagtgtgccc
      361 cttccgctgt caatgccatc ttcgagtggt ccagtgttct gatttgggtc tggacaaagt
      421 gccaaaggat cttccccctg acacaactct gctagacctg caaaacaaca aaataaccga
      481 aatcaaagat ggagacttta agaacctgaa gaaccttcac gcattgattc ttgtcaacaa
      541 taaaattagc aaagttagtc ctggagcatt tacacctttg gtgaagttgg aacgacttta
      601 tctgtccaag aatcagctga aggaattgcc agaaaaaatg cccaaaactc ttcaggagct
      661 gcgtgcccat gagaatgaga tcaccaaagt gcgaaaagtt actttcaatg gactgaacca
      721 gatgattgtc atagaactgg gcaccaatcc gctgaagagc tcaggaattg aaaatggggc
      781 tttccaggga atgaagaagc tctcctacat ccgcattgct gataccaata tcaccagcat
      841 tcctcaaggt cttcctcctt cccttacgga attacatctt gatggcaaca aaatcagcag
      901 agttgatgca gctagcctga aaggactgaa taatttggct aagttgggat tgagtttcaa
      961 cagcatctct gctgttgaca atggctctct ggccaacacg cctcatctga gggagcttca
     1021 cttggacaac aacaagctta ccagagtacc tggtgggctg gcagagcata agtacatcca
     1081 ggttgtctac cttcataaca acaatatctc tgtagttgga tcaagtgact tctgcccacc
     1141 tggacacaac accaaaaagg cttcttattc gggtgtgagt cttttcagca acccggtcca
     1201 gtactgggag atacagccat ccaccttcag atgtgtctac gtgcgctctg ccattcaact
     1261 cggaaactat aagtaattct caagaaagcc ctcattttta taacctggca aaatcttgtt
     1321 aatgtcattg ctaaaaaata aataaaagct agatactgga aacctaactg caatgtggat
     1381 gttttaccca catgacttat tatgcataaa gccaaatttc cagtttaagt aattgcctac
     1441 aataaaaaga aattttgcct gccattttca gaatcatctt ttgaagcttt ctgttgatgt
     1501 taactgagct actagagata ttcttatttc actaaatgta aaatttggag taaatatata
     1561 tgtcaatatt tagtaaagct tttctttttt aatttccagg aaaaaataaa aagagtatga
     1621 gtcttctgta attcattgag cagttagctc atttgagata aagtcaaatg ccaaacacta
     1681 gctctgtatt aatccccatc attactggta aagcctcatt tgaatgtgtg aattcaatac
     1741 aggctatgta aaatttttac taatgtcatt attttgaaaa aataaattta aaaatacatt
     1801 caaaattact attgtataca agcttaattg ttaatattcc ctaaacacaa ttttatgaag
     1861 ggagaagaca ttggtttgtt gacaataaca gtacatcttt tcaagttctc agctatttct
     1921 tctacctctc cctatcttac atttgagtat ggtaacttat gtcatctatg ttgaatgtaa
     1981 gcttataaag cacaaagcat acatttcctg actggtctag agaactgatg tttcaattta
     2041 cccctctgct aaataaatat taaaactatc atgtgacttc atgtaatcag gctgaacatt
     2101 tctacaatta ctagatgtat tagacgtaag tattttcttt agttaaacca cccatgttag
     2161 aaatgttttc tgtagaattt ataaacaact atcaatgcag acaatttaat aagcctgggg
     2221 atgatttact tacagtaaac atttatcaaa ttgtacattt gtgctatcaa caattaataa
     2281 gcaaatatgt gaaaatagtt tctgtcttct atgaagttag atatttgatg gttaaaaccc
     2341 ctataaatca tagtttcata tgggaaaaaa taattgaaat acagtgtaaa tttaaataat
     2401 ttattaagta tagcaaataa ttgaaatatg gtggactaaa ttttgtcata gaaatatgtg
     2461 caagttatag tagtggctca catgagaggt aatcaattct gctaatagta gcagaatgag
     2521 tgcagtggaa catgaaaaac ttgaggagat aacagttgag gtgggtttcc atagatgcat
     2581 aatagttcaa gagcaagatt tggtggggag gcactattca agacagggac taagttcaaa
     2641 atccaagacg tatgctggga cacacctctg acaggttggc ataaaggagg cttaatcaaa
     2701 ctatttttct tcttctgaaa cagaagcaat aattttcatt tacatttgac atatcccgag
     2761 gtaatattaa cattagggaa agttactctt ttccatcttt ccacattctt gcaggaccat
     2821 aaaatctgaa ttttccagta tttttaataa gagggaagaa acctctcttt ttcttctctt
     2881 tttcatctcc caagagatcc tcctctcatg actacagttg aataggtggt ttctattgga
     2941 agacattcag gaattcaagg tgcatgtcca taaatggact ttttttgttg ttgttcagag
     3001 ctggaccttg aatgatgcat ccttctctct gttgtaacca tgaataatgc acccttcatg
     3061 ctatagcctt taacgattca cccttcttat tgtaaccttg aatgattcac cctttatggt
     3121 gtagccttga gtgacgcacc cttcatgttg tagccttcaa tgatgcacac tccatgttat
     3181 agccttgaat gatataccct ttatgctgca gcctttctct tatggggaaa agcctgcaga
     3241 tatcctgctg cttaactgac aagtgtggtg agaaataagt agaaatctaa agaggggaag
     3301 accattttgg acacttatct gcaaggcaga tccaacacac ttttccagta gtcaagctac
     3361 ttctaatttt gttcagtatc aaaatgagaa acaggcctga ttctccagca ctcttgtcaa
     3421 cacaacttcc ccccatattt atatatatac acacacatat atatctttat atatatacac
     3481 acatatatat ctttatatat atatatttat atatatatct ttttgcatat atacatatat
     3541 atgtatcttt atttcctttg aaataaagat aaatatagct gatttctttg gcttcgacac
     3601 ttactatttg catgactaag ggaagctagt taacctttct gtgactcatt tccttgtcca
     3661 taaaatggga atattaattg tacatgtctt atggattggt gtgtgaattc agttagcgag
     3721 tgtagaatat aacttataga tcaaagtaga gtaaatggaa agggctcaac tatggtgttg
     3781 ctactgccat tgttattaca ggcacacagt tcgagctata atcatttcaa gggaaattct
     3841 tatgtgtcag ttctggatcg aggtctgaga ttctgcattt caaacaaact tccaggaatg
     3901 ctgctgcttc ttggtccaca cttggagaaa taagtcagca gagagtcctc tcgtttccta
     3961 ttgtaccatg tctgtctttt gtctcctgct tattggcctc tgtaaggaac tcacagctgc
     4021 tataataaag taccaaaaac tgggtggctt aaaacaacag aaacttactt tctcacaatt
     4081 ctggaggcta aaaattcaaa atcaaggtgt cagcagggtc agattccttc caaagccttt
     4141 aggagaggac ctttccttgc tcctcctagg tttctggtta aatctaggtg ttctttgcct
     4201 tatggcagcg tgactctaat ttatgcctcc atcttcaccc tcacatggcc ttctctctca
     4261 tgtgtttgtg tcttttctct tcttcttcta tgaacatgag ttatattgga ttaaggctca
     4321 ccctaattta gtatgaaccc atcttaactt gattatatct gcaaagactc tatttccaaa
     4381 tgaagtcaga ctcacaggta ttgggggttt gatattgaac atatcttctg ggaggagaca
     4441 caacttaatc attaatatcc actttctttt ttccttatta aatgtttaat ttttttgttt
     4501 tcattaaaac tgttgttcga ttatgggtgc ttcacataaa aggttggaaa cttaaaaatt
     4561 tgtctctgac ccctcctggt tggaaaggcc tctgttgtac atttatgcta gcctaggcca
     4621 taccactttc tgtcttcagt acagccatct tagtttattc aagtgacaca gattttccag
     4681 aacacagtat tcatgatctt ttaaagcatt tttcttcaaa gactttgatc tggcaataaa
     4741 tgttactatg taattctcat gacataaatt aggcataact tggatctcct cttcttctgc
     4801 tcattcattt gtctgaatca tcactattat cttttttata ttcctttacc gttctccata
     4861 atgcttttcc aagaaactgg tttattccac aattttattg cagaggcagc tgcaggatat
     4921 cataatctta tctttatacg aaggaagaat tgcctaatcc ctcaagtaaa ctaaaaatgt
     4981 tttatacagt catttctcat tcatccaatg ttccaggcag tcccagtcca agactgcccc
     5041 ttcacacaca caacaactct tcacaagact tcactgtcct tcagactctc ctgcagcaca
     5101 gacattcgag gttgctgagt cgacattgca gttatttcac tcttgatttt gctgctcaat
     5161 tttaagtttc cacacttatt gctaaaacat tccttctagt ggatctgttt atgtattcaa
     5221 gcacaccatc tgtcacaatt atttcaaatc acaggtctgt gacagactgt caatttcaca
     5281 ccacaaagta taatagtgga aaacaaagta aaatcaagaa agggagaaca ctaaacttat
     5341 taaaaccata tacaagcata cgcattcagg aaactaaaac aaccttcaaa gaagttgaac
     5401 aattttgagc caaaagaaag ggcatatgca caccctaccc cagtataaga taaccagaaa
     5461 aggactgggt gagttgcctc ctgagtatta tgactgccat caatcactta ggcattggag
     5521 atcaggagac tcttcccagg ccacacattc tgcagtgact gtgagggctg aatgaatgct
     5581 tccaggccat caggaacaag catagaaaca caaatcaatt ttaaaataca ctcaaaaatg
     5641 tcaaaataat ccaacttttt tgtcttgatc agatatatct actagcacat attacttcat
     5701 tttttcagcc aatatttatt aataacctac tgtgtgcttg acagtgttct agtggcagag
     5761 acacagcagt gcataatgcc ttgccctctg aagcagatgt tgcagcagga ggagacattc
     5821 caggacatga caattaaagt ggaggaatgt caagcagaac tggggaataa gggatgtgaa
     5881 gggggtgaga cttgctattt tatataggat ggtcggaaaa aggacttatc aggagtgaca
     5941 tttgagcagg gagatgaaga actgaaggga gcaagccaag aaaagaggcc ctgaatttgg
     6001 aaaatacatg gcacgttcca acaagagcag agaggacaaa cgtgagcaga gtaaagtgag
     6061 caagaagaga taatatatga tacaaggtca gaaaggtaat gacaatcgca tcctgtagga
     6121 ctttttaggc cattgtaaag atgagctttt actctgagta agacagagag ctattagagg
     6181 ggtctcggta gaggagtgac ttgattcaac tgtctttgag aggatccctt tgcgtgtata
     6241 gactgtaagg taacaggaat aggccaagag agaatatttc ggatgctagt gcaataatca
     6301 ggtgagagat gatgaagact ttgacctgga taatagtaga aaaattgttg agaagggatc
     6361 aaaatatggg gtttgttttg atggtagaga ggccagggat ggctgaatga tcagatgggg
     6421 catgagagag aaagaaaaga aacagagatg acttcaggaa ttttggcctg ggccactgga
     6481 aggatgaagt caccatttac tgagatggta atgactggga ggttgagctg gaagaactga
     6541 gaatcaaata tctggttttg aatctgttct ttttgagatg catattcaac ttccatatgg
     6601 aggtgtcaag gaggatttag atctagaatt ttggagctca agggaaaggg ttgagctgta
     6661 gacataaatt ctagagatgc cggaatatag attgtgatcc ttctttatca gcacagaaat
     6721 gacttgactt tgtccaaact aagcaatcat actgtacatg ttagcaacac attttacagg
     6781 gccaatttgg ccttttgcaa tgttctgtgg tttctaagat aaataaacat attatatgtt
     6841 tccctctgga
//
