LOCUS       NM_001033855            5960 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DNA cross-link repair 1C (DCLRE1C), transcript variant
            a, mRNA.
ACCESSION   NM_001033855
VERSION     NM_001033855.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5960)
  AUTHORS   Cowan,M.J., Yu,J., Facchino,J., Fraser-Browne,C., Sanford,U.,
            Kawahara,M., Dara,J., Long-Boyle,J., Oh,J., Chan,W., Chag,S.,
            Broderick,L., Chellapandian,D., Decaluwe,H., Golski,C., Hu,D.,
            Kuo,C.Y., Miller,H.K., Petrovic,A., Currier,R., Hilton,J.F.,
            Punwani,D., Dvorak,C.C., Malech,H.L., McIvor,R.S. and Puck,J.M.
  TITLE     Lentiviral Gene Therapy for Artemis-Deficient SCID
  JOURNAL   N Engl J Med 387 (25), 2344-2355 (2022)
   PUBMED   36546626
  REMARK    GeneRIF: Lentiviral Gene Therapy for Artemis-Deficient SCID.
REFERENCE   2  (bases 1 to 5960)
  AUTHORS   Watanabe,G. and Lieber,M.R.
  TITLE     Dynamics of the Artemis and DNA-PKcs Complex in the Repair of
            Double-Strand Breaks
  JOURNAL   J Mol Biol 434 (23), 167858 (2022)
   PUBMED   36270581
  REMARK    GeneRIF: Dynamics of the Artemis and DNA-PKcs Complex in the Repair
            of Double-Strand Breaks.
            Review article
REFERENCE   3  (bases 1 to 5960)
  AUTHORS   Watanabe,G., Lieber,M.R. and Williams,D.R.
  TITLE     Structural analysis of the basal state of the Artemis:DNA-PKcs
            complex
  JOURNAL   Nucleic Acids Res 50 (13), 7697-7720 (2022)
   PUBMED   35801871
  REMARK    GeneRIF: Structural analysis of the basal state of the
            Artemis:DNA-PKcs complex.
REFERENCE   4  (bases 1 to 5960)
  AUTHORS   Hognon,C. and Monari,A.
  TITLE     Staring at the Naked Goddess: Unraveling the Structure and
            Reactivity of Artemis Endonuclease Interacting with a DNA Double
            Strand
  JOURNAL   Molecules 26 (13), 3986 (2021)
   PUBMED   34210101
  REMARK    GeneRIF: Staring at the Naked Goddess: Unraveling the Structure and
            Reactivity of Artemis Endonuclease Interacting with a DNA Double
            Strand.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5960)
  AUTHORS   Kurosawa,A. and Adachi,N.
  TITLE     Functions and regulation of Artemis: a goddess in the maintenance
            of genome integrity
  JOURNAL   J Radiat Res 51 (5), 503-509 (2010)
   PUBMED   20543526
  REMARK    Review article
REFERENCE   6  (bases 1 to 5960)
  AUTHORS   Li,L., Moshous,D., Zhou,Y., Wang,J., Xie,G., Salido,E., Hu,D., de
            Villartay,J.P. and Cowan,M.J.
  TITLE     A founder mutation in Artemis, an SNM1-like protein, causes SCID in
            Athabascan-speaking Native Americans
  JOURNAL   J Immunol 168 (12), 6323-6329 (2002)
   PUBMED   12055248
  REMARK    GeneRIF: A nonsense founder mutation discovered in exon 8 of
            Artemis results in the truncation of the deduced protein product
            and indicates that the SNM1-like gene (Artemis) is the gene
            responsible for SCID in Athabascan-speaking Native Americans.
REFERENCE   7  (bases 1 to 5960)
  AUTHORS   Ma,Y., Pannicke,U., Schwarz,K. and Lieber,M.R.
  TITLE     Hairpin opening and overhang processing by an Artemis/DNA-dependent
            protein kinase complex in nonhomologous end joining and V(D)J
            recombination
  JOURNAL   Cell 108 (6), 781-794 (2002)
   PUBMED   11955432
  REMARK    GeneRIF: DNA-PKcs regulates Artemis by both phosphorylation and
            complex formation to permit enzymatic activities that are critical
            for the hairpin-opening step of V(D)J recombination and for the 5'
            and 3' overhang processing in nonhomologous DNA end joining.
REFERENCE   8  (bases 1 to 5960)
  AUTHORS   Moshous,D., Callebaut,I., de Chasseval,R., Corneo,B.,
            Cavazzana-Calvo,M., Le Deist,F., Tezcan,I., Sanal,O., Bertrand,Y.,
            Philippe,N., Fischer,A. and de Villartay,J.P.
  TITLE     Artemis, a novel DNA double-strand break repair/V(D)J recombination
            protein, is mutated in human severe combined immune deficiency
  JOURNAL   Cell 105 (2), 177-186 (2001)
   PUBMED   11336668
REFERENCE   9  (bases 1 to 5960)
  AUTHORS   Li,L., Drayna,D., Hu,D., Hayward,A., Gahagan,S., Pabst,H. and
            Cowan,M.J.
  TITLE     The gene for severe combined immunodeficiency disease in
            Athabascan-speaking Native Americans is located on chromosome 10p
  JOURNAL   Am J Hum Genet 62 (1), 136-144 (1998)
   PUBMED   9443881
REFERENCE   10 (bases 1 to 5960)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ932042.1, AJ296101.1,
            AW954867.1 and AL360083.27.
            
            On Nov 23, 2018 this sequence version replaced NM_001033855.2.
            
            Summary: This gene encodes a nuclear protein that is involved in
            V(D)J recombination and DNA repair. The encoded protein has
            single-strand-specific 5'-3' exonuclease activity; it also exhibits
            endonuclease activity on 5' and 3' overhangs and hairpins. The
            protein also functions in the regulation of the cell cycle in
            response to DNA damage. Mutations in this gene can cause
            Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn
            syndrome. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.206455.1, AK290598.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378278.7/ ENSP00000367527.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BQ932042.1         337-384
            49-726              AJ296101.1         1-678
            727-733             AW954867.1         521-527
            734-1762            AJ296101.1         686-1714
            1763-5960           AL360083.27        4985-9182           c
FEATURES             Location/Qualifiers
     source          1..5960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..5960
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /note="DNA cross-link repair 1C"
                     /db_xref="GeneID:64421"
                     /db_xref="HGNC:HGNC:17642"
                     /db_xref="MIM:605988"
     exon            1..195
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2165
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /note="isoform a is encoded by transcript variant a; DNA
                     cross-link repair 1C (PSO2 homolog, S. cerevisiae); severe
                     combined immunodeficiency, type a (Athabascan); protein
                     artemis; SNM1 homolog C; SNM1-like protein"
                     /codon_start=1
                     /product="protein artemis isoform a"
                     /protein_id="NP_001029027.1"
                     /db_xref="CCDS:CCDS31149.1"
                     /db_xref="GeneID:64421"
                     /db_xref="HGNC:HGNC:17642"
                     /db_xref="MIM:605988"
                     /translation="MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRA
                     PTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGE
                     KEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQ
                     SVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTN
                     LSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITS
                     RNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCP
                     VNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYL
                     FDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFV
                     DCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFP
                     SSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERN
                     SGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTL
                     SSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAV
                     KKRKCSLLDT"
     exon            196..247
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            248..332
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            333..392
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            393..448
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            449..550
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            551..623
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            624..764
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            765..866
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1003
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1058
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1147
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1242
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..5960
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /note="hexamer: AATAAA"
     polyA_site      3702
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /note="major polyA site"
     regulatory      5940..5945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /note="hexamer: AATAAA"
     polyA_site      5960
                     /gene="DCLRE1C"
                     /gene_synonym="A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C"
                     /note="major polyA site"
ORIGIN      
        1 ggcttcccgg aagtggcggc gcggtcaggg ctggccttgg cttcagctgc ggttttgggg
       61 tcccggactc tgggatcggc ggcgctatga gttctttcga ggggcagatg gccgagtatc
      121 caactatctc catagaccgc ttcgataggg agaacctgag ggcccgcgcc tacttcctgt
      181 cccactgcca caaagatcac atgaaaggat taagagcccc taccttgaaa agaaggttgg
      241 agtgcagctt gaaggtttat ctatactgtt cacctgtgac taaggagttg ttgttaacga
      301 gcccgaaata cagattttgg aagaaacgaa ttatatctat tgaaatcgag actcctaccc
      361 agatatcttt agtggatgaa gcatcaggag agaaggaaga gattgttgtg actctcttac
      421 cagctggtca ctgtccggga tcagttatgt ttttatttca gggcaataat ggaactgtcc
      481 tgtacacagg agacttcaga ttggcgcaag gagaagctgc tagaatggag cttctgcact
      541 ccgggggcag agtcaaagac atccaaagtg tatatttgga tactacgttc tgtgatccaa
      601 gattttacca aattccaagt cgggaggagt gtttaagtgg agtcttagag ctggtccgaa
      661 gctggatcac tcggagcccg taccatgttg tgtggctgaa ctgcaaagcg gcttatggct
      721 atgaatatct gttcaccaac cttagtgaag aattaggagt ccaggttcat gtgaataagc
      781 tagacatgtt taggaacatg cctgagatcc ttcatcatct cacaacagac cgcaacactc
      841 agatccatgc atgccggcat cccaaggcag aggaatattt tcagtggagc aaattaccct
      901 gtggaattac ttccagaaat agaattccac tccacataat cagcattaag ccatccacca
      961 tgtggtttgg agaaaggagc agaaaaacaa atgtaattgt gaggactgga gagagttcat
     1021 acagagcttg tttttctttt cactcctcct acagtgagat taaagatttc ttgagctacc
     1081 tctgtcctgt gaacgcatat ccaaatgtca ttccagttgg cacaactatg gataaagttg
     1141 tcgaaatctt aaagccttta tgccggtctt cccaaagtac ggagccaaag tataaaccac
     1201 tgggaaaact gaagagagct agaacagttc accgagactc agaggaggaa gatgactatc
     1261 tctttgatga tcctctgcca atacctttaa ggcacaaagt tccatacccg gaaacttttc
     1321 accctgaggt attttcaatg actgcagtat cagaaaagca gcctgaaaaa ctgagacaaa
     1381 ccccaggatg ctgcagagca gagtgtatgc agagctctcg tttcacaaac tttgtagatt
     1441 gtgaagaatc caacagtgaa agtgaagaag aagtaggaat cccagcttca ctgcaaggag
     1501 atctgggctc tgtacttcac ctgcaaaagg ctgatgggga tgtaccccag tgggaagtat
     1561 tctttaaaag aaatgatgaa atcacagatg agagtttgga aaacttccct tcctccacag
     1621 tggcaggggg atctcagtca ccaaagcttt tcagtgactc tgatggagaa tcaactcaca
     1681 tctcctccca gaattcttcc cagtcaacac acataacaga acaaggaagt caaggctggg
     1741 acagccaatc tgatactgtt ttgttatctt cccaagagag aaacagtggg gatattactt
     1801 ccttggacaa agctgactac agaccaacaa tcaaagagaa tattcctgcc tctctcatgg
     1861 aacaaaatgt aatttgccca aaggatactt actctgattt gaaaagcaga gataaagatg
     1921 tgacaatagt tcctagtact ggagaaccaa ctactctaag cagtgagaca catatacccg
     1981 aggaaaaaag tttgctaaat cttagcacaa atgcagattc ccagagctct tctgattttg
     2041 aagttccctc aactccagaa gctgagttac ctaaacgaga gcatttacaa tatttatatg
     2101 agaagctggc aactggtgag agtatagcag tcaaaaaaag aaaatgctca ctcttagata
     2161 cctaagaatt caaagcgttt caacctagag caaccactaa aaaacctgca cagagatgac
     2221 agtcaatatt acaatagaga aaatacagta cttaaaaatg ttcaaataac ctggttgggt
     2281 gtggtggctc acacttgtaa tcccagcact ttgaggtggg caatggcttg agcccaggag
     2341 ttcgacacca gcctggccaa cacagtgaaa tgtgtctcta cttacaaaaa aaaaaaaaaa
     2401 aaaaaaagcc aggcatggtg gtgggctact ctggaggccc ttgaggatca cttgagccca
     2461 ggagattgag gctgcagtga gccatgactg tgccactgca cctctagtct gggtgacaga
     2521 gcaagaccct gtttaaaaaa gaaaaaggcc aggcacggtg gctcatgcct gtaatcccag
     2581 ctacgcagga ggccaaggca ggagaatcac ttgaacctgg gaggtggtgg ttgcagtgag
     2641 ctgagattgt gtcattgcac tccagcctgg gcaacaagag caaaactctg tctcaaaaaa
     2701 aaaaaaaaaa aaaaagaaaa aaaaatggta gaactaaacc catacgtatc aatgattaca
     2761 ttaaatgtaa atggtctaag tgcatcaatg acaagagaca cggaaaaaac caacataacc
     2821 cagtgatctg ctgtctataa agaaagtcaa ttcaagtgat tgataggtta aaaggatgga
     2881 aaaaccatgt aaacaattaa aaatggagtg gttatatgga cagtttccta atgataaaag
     2941 gtctagttca ccaagaagac aaaataatcc taaacgtata tgcacctaac agctccaaaa
     3001 atttatgaag ctagaacagc tgaaaagaga caaactaatg cacaattaca gctagggatt
     3061 aatttaacat ccctccttag taacagaact agtatataca cattaatcag taagaatata
     3121 gaactgaaaa tcataagccg actggattaa attgacattt atagaacaca ccaccccaaa
     3181 ctagcagaat gtatctcctg aagtacacat ggaacattca gcatgatcat atctttgctc
     3241 ataaacacac ctgatttaaa ttgacaaact tggatctagt atgataaact gatggctata
     3301 gacaaaatca gcaccttatt tatccccaaa gatgttaagt cacttaacct tgatgtgaat
     3361 acggtggcca aattagaagc ggacaattag aatataaaag aaaatgctca agaattaaat
     3421 ggtggccagg cacagtaact cctgcctgca atcccagtac tttgggaggc tcgcttgagc
     3481 tcagggtttt gagtccagcc tgggcaacac acagggagac cctgtctcca caaaatgtta
     3541 gccagacatg gtggtgtgca cctgtagtcc tcgctacttg gaaggcttag gtggcaggat
     3601 ggattgagcc caggaggttg aaactgcagt gagctgattg tgcccagcct gggcaacaaa
     3661 gcaagacccc atctcaagaa aaataaatta aaaaaaacta aagtatatgt gttattctgt
     3721 gagtcattca acattcttga agtccatcaa tgtgttaggc ttttgtgtta tgtatgagga
     3781 tttttaacaa gttttaacag atattcagga acacttagtt attgtgacat ttcatagatt
     3841 atggaagcaa aagcagagac accacttaaa acaatttgca gatcagttaa actaacactt
     3901 gatatgcatt atcatgatgc tgcatggcaa tccgaccaaa aagtattgga tccaccagac
     3961 taaccagggt aacaagactc agagttagta tacacataac tatacacatt tgtatatatt
     4021 cactgttaac taaaacttag ttttaacagt gtaccttatg atcgaaagtg gttgttcaaa
     4081 aaatgcctgt aaacattcct ctgaatatat tcctgttatt ttataatcac attaatatta
     4141 catactgtta cgtttgtttt atatgtgagt ctggcattat aaatgctggc tgaatgaatt
     4201 gggctaagac aactacaaca gatgtgatca agaaaccgat agtgattacc agaaattata
     4261 tttggtgctt actctgatga tgctcttaag ttttttacag actatatgaa ctcctttaat
     4321 tttcacaacc accctttgag gtagatacat ttctaatccc catgtacaaa tgagacaaag
     4381 gcacagaggt tagttcacat agctatgagg cacaggcaga attcaaacac aggcagtttg
     4441 gcttcagaga ccatgatctt aactgctatg ctctgatgtc tctccaaaaa agtataaaca
     4501 tgagcagggt taattgtagc agctacttgg tttttacgtc aagaatcata aaccacaaga
     4561 ggaaacatga agtttttgtt ttttactttt caagatggag tctcgctctg tcactcaggc
     4621 tggaatgcag tggccctatc tcagctcact gcaacctcag cctccagggt tcaagtgatt
     4681 ttcctgcctc agcctcccaa gtagctggga ttacaggtgt gtgccacacc tggctaattt
     4741 ttgtattttt agtagagaca gggtttcacc atattggtca gactggtctt gaactcctga
     4801 cctctggtga tccactcgcc tcggcctccc aaagtgctgg gattacaggc gtcagctacc
     4861 gtgtccagcc gaaacatgaa gtttcaaaat gccaagatgt atcacagaag acactcagca
     4921 gtcagccaca tttatcttgg agaagagttc caggacttaa atgtttgaat agtataaact
     4981 agttttttaa aaagtctgcc tgaagccgaa gattaaatac tttaaaaagt tcactgggtg
     5041 atcttggcat gttgacatta tcttaacagt ctaagcttgt taccttacac caacctgaca
     5101 ggttcattag aagcacatga atacatataa aaggcataaa agactgggtc aatgaatatg
     5161 agctctgaat tctaaaattc ctttgcattt ctaggcagta cttaccatag tatgtttacg
     5221 tacctggtga gtgacaatgc tcaaaaattt ctgaagtatt catccacatt atgctagcga
     5281 aatgtcaaat tgtcctttaa tattcaaatg catgaaccat cactccttgg ccttttggcc
     5341 aagatcaagt gtagtatcaa atgcatgaac catgaaagct atcttaaaag gaaagtaaca
     5401 tttaaaggaa ttgaatataa accttcggtt aatcttgcta gcacgtagtc aatacatcag
     5461 tatttttctg ccccttttat agtcttactg gaaatgactg taaaacagaa acaaagctaa
     5521 gccatggtaa atagaacatt aaatgcccaa cctaatttat tttgctaaga gaaactgatg
     5581 aactaaaaga gaaacaacta ttgtctacat tttagatatg ggggaaaaaa ccctgagatt
     5641 actaattatg tatcaccatc ctcttaatgt agatcctgaa aatgatggta tcaatataat
     5701 acatacagtg gattcacctt ttaaactgga tctattacct ttgatatttg tcttacactg
     5761 aaaaattctg acatcttcag gaaaccaata tgatggataa gctaaatgtt gacttaaaat
     5821 agttaaaccc cttaataaca tcctttagtt tctattattt cactgcttaa gttcagcatc
     5881 tgaataacaa aggtaacata agtagtactt aagatcccaa aggcccatta cattctatca
     5941 ataaagacaa aacaaaacta
//
