LOCUS       NM_022836               3755 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DNA cross-link repair 1B (DCLRE1B), transcript variant
            1, mRNA.
ACCESSION   NM_022836
VERSION     NM_022836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Sonmez,C., Toia,B., Eickhoff,P., Matei,A.M., El Beyrouthy,M.,
            Wallner,B., Douglas,M.E., de Lange,T. and Lottersberger,F.
  TITLE     DNA-PK controls Apollo's access to leading-end telomeres
  JOURNAL   Nucleic Acids Res 52 (8), 4313-4327 (2024)
   PUBMED   38407308
  REMARK    GeneRIF: DNA-PK controls Apollo's access to leading-end telomeres.
REFERENCE   2  (bases 1 to 3755)
  AUTHORS   Bories,C., Lejour,T., Adolphe,F., Kermasson,L., Couve,S.,
            Tanguy,L., Luszczewska,G., Watzky,M., Poillerat,V., Garnier,P.,
            Groisman,R., Ferlicot,S., Richard,S., Saparbaev,M., Revy,P., Gad,S.
            and Renaud,F.
  TITLE     DCLRE1B/Apollo germline mutations associated with renal cell
            carcinoma impair telomere protection
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167107 (2024)
   PUBMED   38430974
  REMARK    GeneRIF: DCLRE1B/Apollo germline mutations associated with renal
            cell carcinoma impair telomere protection.
REFERENCE   3  (bases 1 to 3755)
  AUTHORS   Li,L., Wang,F., Deng,Z., Zhang,G., Zhu,L., Zhao,Z. and Liu,R.
  TITLE     DCLRE1B promotes tumor progression and predicts immunotherapy
            response through METTL3-mediated m6A modification in pancreatic
            cancer
  JOURNAL   BMC Cancer 23 (1), 1073 (2023)
   PUBMED   37936074
  REMARK    GeneRIF: DCLRE1B promotes tumor progression and predicts
            immunotherapy response through METTL3-mediated m6A modification in
            pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3755)
  AUTHORS   Yosaatmadja,Y., Baddock,H.T., Newman,J.A., Bielinski,M.,
            Gavard,A.E., Mukhopadhyay,S.M.M., Dannerfjord,A.A., Schofield,C.J.,
            McHugh,P.J. and Gileadi,O.
  TITLE     Structural and mechanistic insights into the Artemis endonuclease
            and strategies for its inhibition
  JOURNAL   Nucleic Acids Res 49 (16), 9310-9326 (2021)
   PUBMED   34387696
  REMARK    GeneRIF: Structural and mechanistic insights into the Artemis
            endonuclease and strategies for its inhibition.
REFERENCE   5  (bases 1 to 3755)
  AUTHORS   Baddock,H.T., Newman,J.A., Yosaatmadja,Y., Bielinski,M.,
            Schofield,C.J., Gileadi,O. and McHugh,P.J.
  TITLE     A phosphate binding pocket is a key determinant of exo- versus
            endo-nucleolytic activity in the SNM1 nuclease family
  JOURNAL   Nucleic Acids Res 49 (16), 9294-9309 (2021)
   PUBMED   34387694
  REMARK    GeneRIF: A phosphate binding pocket is a key determinant of exo-
            versus endo-nucleolytic activity in the SNM1 nuclease family.
REFERENCE   6  (bases 1 to 3755)
  AUTHORS   Lenain,C., Bauwens,S., Amiard,S., Brunori,M., Giraud-Panis,M.J. and
            Gilson,E.
  TITLE     The Apollo 5' exonuclease functions together with TRF2 to protect
            telomeres from DNA repair
  JOURNAL   Curr Biol 16 (13), 1303-1310 (2006)
   PUBMED   16730175
  REMARK    GeneRIF: SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease
            activity and functions together with TRF2 to protect telomeres from
            damage and fusion.
REFERENCE   7  (bases 1 to 3755)
  AUTHORS   Freibaum,B.D. and Counter,C.M.
  TITLE     hSnm1B is a novel telomere-associated protein
  JOURNAL   J Biol Chem 281 (22), 15033-15036 (2006)
   PUBMED   16606622
  REMARK    GeneRIF: the C terminus of Snm1B was shown to interact with the TRF
            homology domain of TRF2 indicating that Snm1B is likely recruited
            to the telomere via interaction with the double-stranded
            telomere-binding protein TRF2
REFERENCE   8  (bases 1 to 3755)
  AUTHORS   Ishiai,M., Kimura,M., Namikoshi,K., Yamazoe,M., Yamamoto,K.,
            Arakawa,H., Agematsu,K., Matsushita,N., Takeda,S., Buerstedde,J.M.
            and Takata,M.
  TITLE     DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear
            focus formation
  JOURNAL   Mol Cell Biol 24 (24), 10733-10741 (2004)
   PUBMED   15572677
REFERENCE   9  (bases 1 to 3755)
  AUTHORS   Demuth,I., Digweed,M. and Concannon,P.
  TITLE     Human SNM1B is required for normal cellular response to both DNA
            interstrand crosslink-inducing agents and ionizing radiation
  JOURNAL   Oncogene 23 (53), 8611-8618 (2004)
   PUBMED   15467758
  REMARK    GeneRIF: siRNA knockdown of hSNM1B rendered cells sensitive to
            ionizing radiation, suggesting the possibility of hSNM1B
            involvement in homologous recombination repair of double-strand
            breaks arising as intermediates of ICL repair
REFERENCE   10 (bases 1 to 3755)
  AUTHORS   Dronkert,M.L., de Wit,J., Boeve,M., Vasconcelos,M.L., van Steeg,H.,
            Tan,T.L., Hoeijmakers,J.H. and Kanaar,R.
  TITLE     Disruption of mouse SNM1 causes increased sensitivity to the DNA
            interstrand cross-linking agent mitomycin C
  JOURNAL   Mol Cell Biol 20 (13), 4553-4561 (2000)
   PUBMED   10848582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR005221.1, BC029687.1 and
            AI669133.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 25, 2018 this sequence version replaced NM_022836.3.
            
            Summary: DNA interstrand cross-links prevent strand separation,
            thereby physically blocking transcription, replication, and
            segregation of DNA. DCLRE1B is one of several evolutionarily
            conserved genes involved in repair of interstrand cross-links
            (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.162258.1,
                                           SRR1803614.276786.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650450.2/ ENSP00000498042.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                DR005221.1         34-123
            91-3741             BC029687.1         1-3651
            3742-3755           AI669133.1         8-21                c
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..3755
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /note="DNA cross-link repair 1B"
                     /db_xref="GeneID:64858"
                     /db_xref="HGNC:HGNC:17641"
                     /db_xref="MIM:609683"
     exon            1..450
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1860
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /EC_number="3.5.2.6"
                     /note="isoform a is encoded by transcript variant 1; DNA
                     cross-link repair 1B (PSO2 homolog, S. cerevisiae); 5'
                     exonuclease Apollo; SNM1 homolog B; beta-lactamase
                     DCLRE1B"
                     /codon_start=1
                     /product="5' exonuclease Apollo isoform a"
                     /protein_id="NP_073747.1"
                     /db_xref="CCDS:CCDS866.1"
                     /db_xref="GeneID:64858"
                     /db_xref="HGNC:HGNC:17641"
                     /db_xref="MIM:609683"
                     /translation="MNGVLIPHTPIAVDFWSLRRAGTARLFFLSHMHSDHTVGLSSTW
                     ARPLYCSPITAHLLHRHLQVSKQWIQALEVGESHVLPLDEIGQETMTVTLLDANHCPG
                     SVMFLFEGYFGTILYTGDFRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQE
                     AAHQIVQLIRKHPQHNIKIGLYSLGKESLLEQLALEFQTWVVLSPRRLELVQLLGLAD
                     VFTVEEKAGRIHAVDHMEICHSNMLRWNQTHPTIAILPTSRKIHSSHPDIHVIPYSDH
                     SSYSELRAFVAALKPCQVVPIVSRRPCGGFQDSLSPRISVPLIPDSVQQYMSSSSRKP
                     SLLWLLERRLKRPRTQGVVFESPEESADQSQADRDSKKAKKEKLSPWPADLEKQPSHH
                     PLRIKKQLFPDLYSKEWNKAVPFCESQKRVTMLTAPLGFSVHLRSTDEEFISQKTREE
                     IGLGSPLVPMGDDDGGPEATGNQSAWMGHGSPLSHSSKGTPLLATEFRGLALKYLLTP
                     VNFFQAGYSSRRFDQQVEKYHKPC"
     exon            451..616
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     exon            617..799
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     exon            800..3755
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /note="hexamer: ATTAAA"
     polyA_site      2139
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /note="major polyA site"
     regulatory      3736..3741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
                     /note="hexamer: AATGAA"
     polyA_site      3749
                     /gene="DCLRE1B"
                     /gene_synonym="APOLLO; DKCB8; SNM1B; SNMIB"
ORIGIN      
        1 gctttgagtg cccggctcgg cctccgctcc cgcgcggttg ggagtgtcca gcgccctccg
       61 cgatttgggc tccagcgggc agggtgactt cctttttctg cccactctgg taacttattg
      121 ctctgctggg ctctttccct tagggtctct ggccctgttc ttgccccagc atgactttta
      181 tcgggacgcc gttgtggaag cctcacgcag gagccctgcc cccgtggaga agatcccact
      241 ggtgactcca accctaccac catgaatggg gtcctgatcc cccatacgcc catcgcagtg
      301 gacttctgga gcctgcgccg ggctggcacc gcacgtctct tcttcttgtc tcacatgcac
      361 tcggaccaca ccgtgggcct gtctagcacc tgggcccggc ccctctactg ctccccaatt
      421 acagcccacc tcttgcatcg tcacctacag gtatctaagc aatggatcca agccctggag
      481 gttggtgaga gccatgtatt acccctagat gaaattggac aagagaccat gaccgtaacc
      541 ctcctcgatg ccaatcactg tcctggttct gtcatgtttc tctttgaagg atattttgga
      601 accatcctct acacaggtga ttttcgatac acaccatcca tgctaaagga gccagccctg
      661 acactgggga aacagatcca tactttatac ctagacaaca ccaattgcaa tccagccctg
      721 gttcttcctt cccgacaaga agctgcccac cagattgtcc agctcattcg aaaacaccca
      781 caacataaca taaagattgg actctacagc ctgggaaagg aatcactgct ggagcagctg
      841 gccctggagt ttcagacctg ggtggtattg agtcctcggc gcctggagtt ggtacagcta
      901 ctgggcctgg cagatgtgtt cacagtggag gagaaggctg gccgcatcca tgcagtagac
      961 catatggaga tctgccattc caacatgctg cgttggaacc agacccaccc tacgattgct
     1021 atccttccca caagccgaaa aatccacagc tcccaccctg atatccacgt catcccttac
     1081 tctgaccatt cctcttactc cgagcttcgt gcctttgtcg cagcactgaa gccttgccag
     1141 gtggtgccca ttgtaagtcg gcggccctgt ggaggctttc aggacagtct gagccccagg
     1201 atctccgtgc ccctgattcc ggactctgta cagcaataca tgagttcttc ctctagaaaa
     1261 ccaagccttc tctggctgtt agaaaggagg ctaaagaggc cgagaaccca aggtgttgtg
     1321 tttgaatccc ctgaggaaag tgctgatcaa tctcaagctg acagagactc aaagaaggcc
     1381 aagaaagaga aactttctcc ctggcctgcg gaccttgaaa agcagccttc ccaccatcct
     1441 ttgcggatca agaagcagtt gttcccagat ctctatagca aagaatggaa caaggcagtg
     1501 cctttctgtg agtctcaaaa gagggtgact atgttgacgg ccccactggg attttcagtg
     1561 cacttaaggt ctacagatga ggagtttatt tctcaaaaaa ccagggagga aattggttta
     1621 gggtccccct tggtacccat gggagatgat gatggaggtc cagaagccac agggaatcag
     1681 agtgcctgga tgggccatgg ttctcccctg tcccacagca gcaagggcac ccctcttcta
     1741 gctactgaat tcaggggtct agcactcaaa tatcttctga ctccagtgaa ctttttccag
     1801 gcagggtatt cttccaggag atttgaccag caagtggaaa aataccataa accctgctga
     1861 agacaggaga gtacagaatg acaacattga gcccacactg cagttttgaa gatagtaact
     1921 gatggctggt gggaaagagt ttgtttttgg ggcctacttt tctatcttta caagactctt
     1981 atgggcccac cgtggagcag cacttcccaa aacttgttca ctggggtcct cgtgcctatg
     2041 gaatccttct ttttataact aagtttaaga aatacttttt ttataaaatc tttggagtat
     2101 gcgtgagcaa attaaaagtt ctttgaagtc ctacagtaac ttaatctgtt taaccttgtt
     2161 taacccagta tttctcaaac ttttgtgaac atgcaatcat cttatgtggg tacagaaaga
     2221 ggtaaagagt ctgaatcaaa aaggaccagg ttattgctgt tgctgttttg tggtgtcatg
     2281 agccattctc catgtcccct tctccctctt ctcagatcaa aatccctagg gagttctatt
     2341 tttaaaatta tgaactatgg cgctgcatgc ttcaatcctg aacgtcactg acttgctgtg
     2401 accatccaaa taattttcct gtctctgcct ctgggaggga acaggaagcg atgaagaggt
     2461 cttggaacag tagtgaaaat tctacctcta tgtccttcat gaggatgtgc agtatcccag
     2521 tatcactggg atccatgtgg aacagagcca gctggggggt tgggcagctc tctccaaggc
     2581 agtacctaga gcccagctga acaacaaggc tttgggtgtg aagggactcc ccagcctgga
     2641 gaccctattt ggctgaaaca gttacaaaat atcaaatgtg ttgtcagata ttcctccaat
     2701 tgttcacata gctgggatat ttgttgctcc cctcacccct tggattatgt agggagccag
     2761 tgcacacagc ctgtttgttt tagtatccaa ggaagagacc aaggagccag ctggcgggaa
     2821 ggggtggggg tgtgcagtct gccctgtcct tctgctcata acctgacaaa atgccaaact
     2881 agtaagcagg atagctgata ccacggctat gagggagtag gctctgagag ggcacagact
     2941 tgtggagctg ggcgtctgga tcaaaactgc tttgggatgg aacctcgagc cctagcagtg
     3001 aagaagattc catttcttgt ccaggggatt taaaagagtt ttctgctttg agagagaaat
     3061 agagagttta gaaagcaatt gctcttggga aagctataca cagctctgtt ttgtcaatga
     3121 cctttgttgt aagtctccca acgtcctatt aggagccaca gcaggtgagg catttggtgc
     3181 agcaggaaac atggggactg cctaggctcg aatctgtggc accctgagca attacttaaa
     3241 ttgtggagcc tagttcctca tctgtaagat ggacttgaga ttcctacctc tcatgattac
     3301 tatggagatt gaataattgg taaaattctc ctagctcagt gactgccaca ggatgggtct
     3361 ttcagatttt ggttctcttt agcttctggt tcttgaaaga aattaatctg tatataacat
     3421 aagaaacttt gaaagtcaaa aaaacaaaaa attttaattc ctcgtagatt aattgatttg
     3481 ctatctttta gttttttttt ctatgcatgt agatgtatta aatatgtaaa tgtttttcaa
     3541 agttgaggta atattgtata gaattttata gcctacattt taatttcttg atatcttaag
     3601 catttcactt attagatatt gttcaaaaat gccattttta atatttgtat aataccctat
     3661 catgtgagta taccttaact aagccattcc catattcaac attttgtgta ctgtttttct
     3721 aattacatat attacaatga acaaccttat gcata
//
