LOCUS       NM_014881               4450 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens DNA cross-link repair 1A (DCLRE1A), transcript variant
            2, mRNA.
ACCESSION   NM_014881 XM_378170
VERSION     NM_014881.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4450)
  AUTHORS   Swift,L.P., Lagerholm,B.C., Henderson,L.R., Ratnaweera,M.,
            Baddock,H.T., Sengerova,B., Lee,S., Cruz-Migoni,A., Waithe,D.,
            Renz,C., Ulrich,H.D., Newman,J.A., Schofield,C.J. and McHugh,P.J.
  TITLE     SNM1A is crucial for efficient repair of complex DNA breaks in
            human cells
  JOURNAL   Nat Commun 15 (1), 5392 (2024)
   PUBMED   38918391
  REMARK    GeneRIF: SNM1A is crucial for efficient repair of complex DNA
            breaks in human cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4450)
  AUTHORS   Yosaatmadja,Y., Baddock,H.T., Newman,J.A., Bielinski,M.,
            Gavard,A.E., Mukhopadhyay,S.M.M., Dannerfjord,A.A., Schofield,C.J.,
            McHugh,P.J. and Gileadi,O.
  TITLE     Structural and mechanistic insights into the Artemis endonuclease
            and strategies for its inhibition
  JOURNAL   Nucleic Acids Res 49 (16), 9310-9326 (2021)
   PUBMED   34387696
  REMARK    GeneRIF: Structural and mechanistic insights into the Artemis
            endonuclease and strategies for its inhibition.
REFERENCE   3  (bases 1 to 4450)
  AUTHORS   Baddock,H.T., Yosaatmadja,Y., Newman,J.A., Schofield,C.J.,
            Gileadi,O. and McHugh,P.J.
  TITLE     The SNM1A DNA repair nuclease
  JOURNAL   DNA Repair (Amst) 95, 102941 (2020)
   PUBMED   32866775
  REMARK    GeneRIF: The SNM1A DNA repair nuclease.
            Review article
REFERENCE   4  (bases 1 to 4450)
  AUTHORS   Diene,S.M., Pinault,L., Keshri,V., Armstrong,N., Khelaifia,S.,
            Chabriere,E., Caetano-Anolles,G., Colson,P., La Scola,B.,
            Rolain,J.M., Pontarotti,P. and Raoult,D.
  TITLE     Human metallo-beta-lactamase enzymes degrade penicillin
  JOURNAL   Sci Rep 9 (1), 12173 (2019)
   PUBMED   31434986
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4450)
  AUTHORS   Ishiai,M., Kimura,M., Namikoshi,K., Yamazoe,M., Yamamoto,K.,
            Arakawa,H., Agematsu,K., Matsushita,N., Takeda,S., Buerstedde,J.M.
            and Takata,M.
  TITLE     DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear
            focus formation
  JOURNAL   Mol Cell Biol 24 (24), 10733-10741 (2004)
   PUBMED   15572677
REFERENCE   6  (bases 1 to 4450)
  AUTHORS   Akhter,S., Richie,C.T., Deng,J.M., Brey,E., Zhang,X., Patrick,C.
            Jr., Behringer,R.R. and Legerski,R.J.
  TITLE     Deficiency in SNM1 abolishes an early mitotic checkpoint induced by
            spindle stress
  JOURNAL   Mol Cell Biol 24 (23), 10448-10455 (2004)
   PUBMED   15542852
  REMARK    GeneRIF: Snm1 and 53BP1 are components of a mitotic stress
            checkpoint that negatively targets the APC prior to chromosome
            condensation
REFERENCE   7  (bases 1 to 4450)
  AUTHORS   Richie,C.T., Peterson,C., Lu,T., Hittelman,W.N., Carpenter,P.B. and
            Legerski,R.J.
  TITLE     hSnm1 colocalizes and physically associates with 53BP1 before and
            after DNA damage
  JOURNAL   Mol Cell Biol 22 (24), 8635-8647 (2002)
   PUBMED   12446782
  REMARK    GeneRIF: Results suggest that 53BP1 and Snm1 may cooperate in the
            cellular response to genotoxic damage.
REFERENCE   8  (bases 1 to 4450)
  AUTHORS   Zhang,X., Richie,C. and Legerski,R.J.
  TITLE     Translation of hSNM1 is mediated by an internal ribosome entry site
            that upregulates expression during mitosis
  JOURNAL   DNA Repair (Amst) 1 (5), 379-390 (2002)
   PUBMED   12509242
REFERENCE   9  (bases 1 to 4450)
  AUTHORS   Dronkert,M.L., de Wit,J., Boeve,M., Vasconcelos,M.L., van Steeg,H.,
            Tan,T.L., Hoeijmakers,J.H. and Kanaar,R.
  TITLE     Disruption of mouse SNM1 causes increased sensitivity to the DNA
            interstrand cross-linking agent mitomycin C
  JOURNAL   Mol Cell Biol 20 (13), 4553-4561 (2000)
   PUBMED   10848582
REFERENCE   10 (bases 1 to 4450)
  AUTHORS   Demuth,I. and Digweed,M.
  TITLE     Genomic organization of a potential human DNA-crosslink repair
            gene, KIAA0086
  JOURNAL   Mutat Res 409 (1), 11-16 (1998)
   PUBMED   9806498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D42045.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014881.4.
            
            Summary: This gene encodes a conserved protein that is involved in
            the repair of DNA interstrand cross-links. DNA cross-links suppress
            transcription, replication, and DNA segregation. The encoded
            protein is a regulator of the mitotic cell cycle checkpoint.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D42045.1, SRR1803615.122951.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361384.7/ ENSP00000355185.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4450              D42045.1           19-4468
FEATURES             Location/Qualifiers
     source          1..4450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..4450
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /note="DNA cross-link repair 1A"
                     /db_xref="GeneID:9937"
                     /db_xref="HGNC:HGNC:17660"
                     /db_xref="MIM:609682"
     exon            1..1360
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             901..4023
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /EC_number="3.5.2.6"
                     /note="DNA-crosslink repair gene SNM1; SNM1 homolog A;
                     beta-lactamase DCLRE1A"
                     /codon_start=1
                     /product="DNA cross-link repair 1A protein"
                     /protein_id="NP_055696.3"
                     /db_xref="CCDS:CCDS7584.1"
                     /db_xref="GeneID:9937"
                     /db_xref="HGNC:HGNC:17660"
                     /db_xref="MIM:609682"
                     /translation="MLEDISEEDIWEYKSKRKPKRVDPNNGSKNILKSVEKATDGKYQ
                     SKRSRNRKRAAEAKEVKDHEVPLGNAGCQTSVASSQNSSCGDGIQQTQDKETTPGKLC
                     RTQKSQHVSPKIRPVYDGYCPNCQMPFSSLIGQTPRWHVFECLDSPPRSETECPDGLL
                     CTSTIPFHYKRYTHFLLAQSRAGDHPFSSPSPASGGSFSETKSGVLCSLEERWSSYQN
                     QTDNSVSNDPLLMTQYFKKSPSLTEASEKISTHIQTSQQALQFTDFVENDKLVGVALR
                     LANNSEHINLPLPENDFSDCEISYSPLQSDEDTHDIDEKPDDSQEQLFFTESSKDGSL
                     EEDDDSCGFFKKRHGPLLKDQDESCPKVNSFLTRDKYDEGLYRFNSLNDLSQPISQNN
                     ESTLPYDLACTGGDFVLFPPALAGKLAASVHQATKAKPDEPEFHSAQSNKQKQVIEES
                     SVYNQVSLPLVKSLMLKPFESQVEGYLSSQPTQNTIRKLSSENLNAKNNTNSACFCRK
                     ALEGVPVGKATILNTENLSSTPAPKYLKILPSGLKYNARHPSTKVMKQMDIGVYFGLP
                     PKRKEEKLLGESALEGINLNPVPSPNQKRSSQCKRKAEKSLSDLEFDASTLHESQLSV
                     ELSSERSQRQKKRCRKSNSLQEGACQKRSDHLINTESEAVNLSKVKVFTKSAHGGLQR
                     GNKKIPESSNVGGSRKKTCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAG
                     LSKHFTFPVYCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAV
                     MILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFPSQQEVIR
                     FAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIP
                     EINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKCGGKYNQILAFRPTGWTHSNKFTR
                     IADVIPQTKGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGTWKSRSTMEKY
                     FREWKLEAGY"
     exon            1361..3025
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3159
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3278
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3419
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3565
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3720
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3862
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..4450
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4429..4434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /note="hexamer: AATAAA"
     polyA_site      4450
                     /gene="DCLRE1A"
                     /gene_synonym="PSO2; SNM1; SNM1A"
                     /note="major polyA site"
ORIGIN      
        1 ggagctcgct atgcttaacc tggagatgat taaggccccg cttcctggcc tcccagcctc
       61 taatgccaaa agataaggga gaggctggcg tgtgaccccg ttttgagtca ggtggacaga
      121 gggctggcca ccttcggaac catgggtgca atacggagtc agacctcaat acaagcccac
      181 tctttcacat atttgaactt ttttcacata tcaacttttt ttgttcactg tgcagggatt
      241 gttcattgct gctggaggaa gatcatggac tgtcgcggga aactgaagtg gttgagtatc
      301 cactagtcgt ggatgagggc agtgacttcg cagttttttg cgaattacac atctctttga
      361 ttatgttgtg actagttttg ttagatagtc atttagtgtt tgggatacct gttaagccct
      421 ttgtccaggg actgtggttg gatttatgaa ttatttggac ggttgtccac ttgaaagaac
      481 tgacagtagc ttcataacaa tgttacaaat ctcgttctaa gattaagctg ttgaacctat
      541 atttgccatt agcgcttaat ttttgaagta ttatttttat gaatcaagcc ctggaaaagg
      601 acaagatatt tgaatgaaat agcacccata atggagaact tcacagttgc tactcctgtg
      661 ataggtttat cttagtttca ttgtggtata aatggaatag caggtgttgt caggtacaag
      721 gtttgtagct tgccaatatg ttcattacca acactgcaga ttcccattga gttggtgggg
      781 gttttgttac ctttgttttt tttctcagca aaataattct ataacttttt gtttgtgaca
      841 agaaatggac tttcagttta cttaagatta atacttcttg aatgataaaa tcattttgcc
      901 atgttagaag acatttccga agaagacatt tgggaataca aatctaaaag aaaaccaaaa
      961 cgagttgatc caaataatgg ctctaaaaat attctaaaat ctgttgaaaa agcaacagat
     1021 ggaaaatacc agtcaaaacg gagtagaaac agaaaaagag ccgcagaagc taaagaggtg
     1081 aaggaccatg aagtgcccct tggaaatgca ggttgtcaga cttctgttgc ttctagtcag
     1141 aattcaagtt gtggagatgg tattcagcag acccaagaca aggaaactac tccaggaaaa
     1201 ctctgtagaa ctcaaaaaag ccaacacgtg tccccaaaga tacgtccagt ttatgatgga
     1261 tactgtccaa attgccagat gcctttttcc tcattgatag ggcagacacc tcgatggcat
     1321 gtttttgaat gtttggattc tccaccacgc tctgaaacag agtgtcctga tggtcttctg
     1381 tgtacctcaa ccattccttt tcattacaag agatacactc acttcctgct agctcaaagc
     1441 agggctggtg atcatccttt tagcagccca tcacctgcgt caggtggcag tttcagtgag
     1501 actaagtcag gcgtcctttg tagccttgag gaaagatggt cttcgtatca gaaccaaact
     1561 gataactcgg tttcaaatga tcccttattg atgacacagt attttaaaaa gtctccgtct
     1621 ctgactgaag ccagtgaaaa gatttctact catatccaaa catcccaaca agctctacaa
     1681 tttacagatt ttgttgagaa tgacaaacta gtgggagttg ctttgcgtct tgcaaacaac
     1741 tcagaacaca taaatttgcc attgccagaa aatgacttca gtgactgtga aatctcctat
     1801 tctccacttc aaagtgatga agacactcat gatatcgatg aaaaaccgga tgattcacaa
     1861 gaacaactgt tttttaccga aagctcaaaa gatggcagcc tcgaagaaga tgatgacagc
     1921 tgtggttttt ttaaaaaacg acatggtccc ttactgaagg accaggatga gagctgcccc
     1981 aaagtgaaca gcttcttaac tcgggataag tatgatgaag gattgtatag attcaatagt
     2041 ctaaatgatt tgtctcaacc tatttctcaa aataatgaga gtactttgcc ttatgatctg
     2101 gcatgtactg gtggtgattt tgtgttgttt ccacctgcat tggcagggaa gcttgctgct
     2161 tctgttcatc aggcaactaa agcaaaacct gatgagccag aatttcactc agctcaatca
     2221 aataaacaga aacaggtaat tgaagaatca tctgtttaca atcaagtttc tcttccgtta
     2281 gttaagagtt taatgttgaa accttttgaa agtcaggtag aagggtatct ttcttcccaa
     2341 ccaacccaaa atacaattag aaaattatca agtgagaact tgaatgctaa gaataatact
     2401 aactcagcat gtttctgcag aaaggcatta gagggtgtgc cagttggtaa agctacaatt
     2461 ttaaatacag aaaacttgtc tagtacacct gctccgaagt atttgaaaat attgccttct
     2521 ggtcttaagt ataatgcaag acatccttct accaaggtaa tgaagcaaat ggatataggt
     2581 gtgtattttg gactacctcc caaaagaaag gaagagaaat tgctagggga aagtgcatta
     2641 gaagggataa acttaaatcc agttccaagt cctaatcaaa agaggtcctc gcagtgcaag
     2701 aggaaagcag aaaaatcttt aagtgattta gaatttgatg caagtacttt acatgagagt
     2761 cagctttctg tggaactttc tagtgagagg tcacagcgtc aaaaaaagag atgtagaaag
     2821 tcaaattcac tgcaggaagg agcgtgtcag aagagatcag atcaccttat taatacagaa
     2881 tctgaagcag tcaatttaag taaagtcaaa gtcttcacaa aatcagctca tggtgggctg
     2941 caaaggggca acaagaaaat cccagagtca tctaatgtag gaggatcaag aaaaaagaca
     3001 tgtccattct ataagaaaat acctggaacc ggctttacag ttgatgcctt tcagtatggc
     3061 gtggttgaag gttgcacagc ctattttctc acacattttc attctgatca ttatgctgga
     3121 ttgtctaaac acttcacatt tccagtttat tgtagtgaga taactggcaa tttgttgaag
     3181 aacaagcttc atgtgcaaga acaatatatt cacccattgc cactggacac tgaatgtatt
     3241 gtgaatggtg tcaaagttgt tttgcttgat gccaatcact gtccaggtgc tgtcatgatc
     3301 ctcttttatc ttcctaatgg tactgtcata ttacacacgg gagacttcag agcagatccc
     3361 agcatggaac gttctcttct tgcggaccag aaagtccata tgctgtactt agataccaca
     3421 tattgtagcc cagaatacac ctttccatct cagcaagagg ttatccggtt tgccatcaac
     3481 actgcctttg aggctgtaac tctaaaccca catgctcttg ttgtctgtgg cacttactct
     3541 attggaaaag agaaagtctt cctagccatt gctgatgttt taggttcaaa agtgggcatg
     3601 tcccaggaaa aatataaaac tctacagtgc ctcaatatac cagaaattaa ttcactcatc
     3661 actaccgaca tgtgcagttc attggttcac cttctcccaa tgatgcaaat taattttaag
     3721 ggcttacaga gtcatttgaa gaagtgtggt gggaaataca atcagatttt ggcatttcga
     3781 cctacaggat ggacacactc taacaagttc actagaatag cagatgttat tccccagacc
     3841 aaaggaaaca tttcaatata tggaattcct tacagtgaac acagcagcta cctagaaatg
     3901 aagcgctttg tccagtggct gaagccccag aaaatcatac ctactgtaaa tgtgggcacc
     3961 tggaaatcta ggagcacaat ggagaaatat tttagagagt ggaaattgga agctggatat
     4021 tgatgatacc tccgaggatt cagtagtagt taagttcctt ggatgtagct tgttagtagt
     4081 taaatctata gaaatgtgaa atacactttg tgtggaaaaa cctcatgaag attgttcaga
     4141 tactttattt tctcatttat gtttgaacaa catgttcgtg gtgctgaatg cctctcagca
     4201 tcatcaagga taactgaaac tgggtctccc tgggaccctt aatttcttgt cccctgccct
     4261 ccatgggcag ttatattctg catcaagcct tagaagagga agcaaaggca gattcaggga
     4321 ccaaaaggat taatgataat taataaagta gtttgaagca ttatatatat aagtaattat
     4381 gtgtctttaa aattatgaga tgaaactttt atatgacgtg tatacttaaa taaaattaat
     4441 ataaaatttg
//
