LOCUS       NM_001394672            5651 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens doublecortin like kinase 3 (DCLK3), transcript variant
            1, mRNA.
ACCESSION   NM_001394672 XM_011534167
VERSION     NM_001394672.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5651)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   2  (bases 1 to 5651)
  AUTHORS   Wierinckx,A., Auger,C., Devauchelle,P., Reynaud,A., Chevallier,P.,
            Jan,M., Perrin,G., Fevre-Montange,M., Rey,C., Figarella-Branger,D.,
            Raverot,G., Belin,M.F., Lachuer,J. and Trouillas,J.
  TITLE     A diagnostic marker set for invasion, proliferation, and
            aggressiveness of prolactin pituitary tumors
  JOURNAL   Endocr Relat Cancer 14 (3), 887-900 (2007)
   PUBMED   17914117
REFERENCE   3  (bases 1 to 5651)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5651)
  AUTHORS   Ohmae,S., Takemoto-Kimura,S., Okamura,M., Adachi-Morishima,A.,
            Nonaka,M., Fuse,T., Kida,S., Tanji,M., Furuyashiki,T., Arakawa,Y.,
            Narumiya,S., Okuno,H. and Bito,H.
  TITLE     Molecular identification and characterization of a family of
            kinases with homology to Ca2+/calmodulin-dependent protein kinases
            I/IV
  JOURNAL   J Biol Chem 281 (29), 20427-20439 (2006)
   PUBMED   16684769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105749.2.
            
            On Apr 30, 2021 this sequence version replaced NM_001394672.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.198514.1,
                                           SRR14038192.510246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636136.2/ ENSP00000489900.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               AC105749.2         128274-128645       c
            373-2249            AC105749.2         101300-103176       c
            2250-2382           AC105749.2         85619-85751         c
            2383-2550           AC105749.2         82102-82269         c
            2551-5651           AC105749.2         76513-79613         c
FEATURES             Location/Qualifiers
     source          1..5651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..5651
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /note="doublecortin like kinase 3"
                     /db_xref="GeneID:85443"
                     /db_xref="HGNC:HGNC:19005"
                     /db_xref="MIM:613167"
     exon            1..372
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..2744
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     doublecortin and CaM kinase-like 3;
                     serine/threonine-protein kinase DCLK3; CLICK-I,II-related;
                     doublecortin-like and CAM kinase-like 3; doublecortin
                     domain-containing protein 3C"
                     /codon_start=1
                     /product="serine/threonine-protein kinase DCLK3 isoform 1"
                     /protein_id="NP_001381601.1"
                     /db_xref="CCDS:CCDS93239.1"
                     /db_xref="GeneID:85443"
                     /db_xref="HGNC:HGNC:19005"
                     /db_xref="MIM:613167"
                     /translation="MPAATPAPQPPPPPARPAPACPARPAPGQQGLCDHSLKYLSSRI
                     TERKLQGSWLPASRGNLEKPFLGPRGPVVPLFCPRNGLHSAHPENSPLKPRVVTVVKL
                     GGQRPRKITLLLNRRSVQTFEQLLADISEALGSPRWKNDRVRKLFNLKGREIRSVSDF
                     FREGDAFIAMGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALK
                     GDHRCGETETPKSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSK
                     PPREATLEERHARGEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELD
                     MGKGPMYDVEKLVRTRSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDK
                     KEDRGPEDQESHAQGAAKAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQ
                     AGFEKLRRTRGEEKEAEKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSG
                     RKPRPMGIIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKED
                     MVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAA
                     LMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTV
                     CGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGH
                     FEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQVS
                     PSSEGHFRSQHKRVVEQVS"
     exon            373..2249
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2382
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2550
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..5651
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3123..3128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /note="hexamer: AATAAA"
     polyA_site      3148
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /note="major polyA site"
     regulatory      5631..5636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
                     /note="hexamer: AATAAA"
     polyA_site      5651
                     /gene="DCLK3"
                     /gene_synonym="CLR; DCAMKL3; DCDC3C; DCK3"
ORIGIN      
        1 gggccaggag cggcgcgcat ggcgggaccg gcgcagagag ggcggctgca gctggtgcgc
       61 ggttgctaag tcccgcgccc ccggagacgt tcccggtggc tgtcgccggg cgctgcgcgg
      121 cgcggggctg gcaggcgggc ggcgggcggc gggagggaga gaagagggag agtcggcgcg
      181 ggctcgtggc tgctcgtctc gccccgcctt cccgcgcctg ctcgaccgtc gagccgcgtc
      241 cccgcgctgc cacctctgct ccaggctctc cccgagcccg ccgccgcgcc atgcccgccg
      301 ccactccagc cccgcagccg ccgccgcccc cggcccggcc agccccagcc tgcccggcgc
      361 ggcctgcccc gggacagcaa ggcctatgtg accattctct aaaatattta agctcgagaa
      421 tcacagagcg gaagctgcaa ggctcctggc tgcctgccag ccgagggaat ctggagaaac
      481 cattcctggg gccgcgtggc cccgtcgtgc ccttgttctg ccctcggaat ggccttcact
      541 cagcacatcc tgagaacagc cctctgaagc ccagggtcgt gaccgtagtg aagctgggtg
      601 ggcagcgccc ccgaaagatc actctgctcc tcaacaggcg atcagtgcag acgttcgagc
      661 agctcttagc tgacatctca gaagccttgg gctctcccag atggaagaat gaccgtgtga
      721 ggaaactgtt taacctcaag ggcagggaaa tcaggagcgt ctctgatttc ttcagggaag
      781 gggatgcttt catagctatg ggcaaagaac cactgacact gaagagcatt caggtggctg
      841 tagaagaact gtaccccaac aaagcccggg ccctgacact ggcccagcac agccgtgccc
      901 cttctccaag gctgaggagc aggctgttta gcaaggctct gaaaggagac caccgctgtg
      961 gggagaccga gacccccaag agctgcagcg aagttgcagg atgcaaggca gccatgaggc
     1021 accaggggaa gatccccgag gagctttcac tagatgacag agcgaggacc cagaagaagt
     1081 gggggagggg gaaatgggag ccagaaccca gtagcaagcc ccccagggaa gccactctgg
     1141 aagagaggca cgcaagggga gagaagcatc ttggggtgga gattgaaaag acctcgggtg
     1201 aaattatcag atgcgagaag tgcaagagag agagggagct ccagcagagc ctggagcgtg
     1261 agaggctttc tctggggacc agtgagctgg atatggggaa gggcccaatg tatgatgtgg
     1321 agaagctggt gaggaccaga agctgcagga ggtctcccga ggcaaatcct gcaagtgggg
     1381 aggaagggtg gaagggtgac agccacagga gcagccccag gaatcccact caagagctga
     1441 ggagacccag caagagcatg gacaagaaag aggacagagg cccagaggat caagaaagcc
     1501 atgctcaggg agcagccaag gccaagaagg accttgtgga agttcttcct gtcacagagg
     1561 aggggctgag ggaggtgaag aaggacacca ggcccatgag caggagcaaa catggtggct
     1621 ggctcctgag agagcaccag gcgggctttg agaagctccg caggacccga ggagaagaga
     1681 aggaggcaga gaaggagaaa aagccatgta tgtctggagg cagaaggatg actctcagag
     1741 atgaccaacc tgcaaagcta gaaaaggagc ccaagacgag gccagaagag aacaagccag
     1801 agcggcccag cggtcggaag ccacggccca tgggcatcat tgccgccaat gtggaaaagc
     1861 attatgagac tggccgggtc attggggatg ggaactttgc tgtcgtgaag gagtgcagac
     1921 accgcgagac caggcaggcc tatgcgatga agatcattga caagtccaga ctcaagggca
     1981 aggaggacat ggtggacagt gagatcttga tcatccagag cctctctcac cccaacatcg
     2041 tgaaattgca tgaagtctac gaaacagaca tggaaatcta cctgatcctg gagtacgtgc
     2101 agggaggaga cctttttgac gccatcatag aaagtgtgaa gttcccggag cccgatgctg
     2161 ccctcatgat catggactta tgcaaagccc tcgtccacat gcacgacaag agcattgtcc
     2221 accgggacct caagccggaa aaccttttgg ttcagcgaaa tgaggacaaa tctactacct
     2281 tgaaattggc tgattttgga cttgcaaagc atgtggtgag acctatattt actgtgtgtg
     2341 ggaccccaac ttacgtagct cccgaaattc tttctgagaa aggttatgga ctggaggtgg
     2401 acatgtgggc tgctggcgtg atcctctata tcctgctgtg tggctttccc ccattccgca
     2461 gccctgagag ggaccaggac gagctcttta acatcatcca gctgggccac tttgagttcc
     2521 tcccccctta ctgggacaat atctctgatg ctgctaaaga tctggtgagc cggttgctgg
     2581 tggtagaccc caaaaagcgc tacacagctc atcaggttct tcagcacccc tggatcgaaa
     2641 cagctggcaa gaccaataca gtgaaacgac agaagcaggt gtcccccagc agcgagggtc
     2701 acttccggag ccagcacaag agggttgtgg agcaggtatc atagtcacca ccttgggaat
     2761 ctgtccagcc cccagttctg ctcaaggaca gagaaaagga tagaagtttg agagaaaaac
     2821 aatgaaagag gcttcttcac ataattggtg aatcagaggg agagacactg agtatatttt
     2881 aaagcatatt aaaaaaatta agtcaatgtt aaatgtcaca acatattttt agatttgtat
     2941 atttaaagcc tttaatacat ttttgggggg taagcattgt catcagtgag gaattttggt
     3001 aataatgatg tgttttgctt cccctttgta accaagttta ttctgtacta caggagtggt
     3061 gcttaccagg gtctaaactc cccctgtgag attaataagg tgcattgtgg tctttctgtg
     3121 ttaataaaat gtgctctgaa taacagaagt gggcctgtat tctgattact tctttgtgct
     3181 ggtgatgaca gcacaaaaat tcaaaaatga attatagttc aggcatatct cctgaagctg
     3241 atatgactac atatagatgt gaaggacact tgattagttg acaagacctg tttatttagg
     3301 atgcactaat cttggtctct tgcatttcag tcttaccaaa aatcagtttt ggtgcagtct
     3361 gagacatgga aagaaaaaaa acaaaccatt gaatcattct tgctcctgca ataccgttat
     3421 actgcttttc agccccaatt atccctgagc ctgagtcatt tctatgtgaa gtcaggcgct
     3481 caggctgtga ccgtgttaac attttcagat cacgagggag ccatttagta cattaatatg
     3541 tcagaaatgc agtaaatgga ttacactggg gctcgaagga gctcagagtt caagcacatt
     3601 cctacctgca gggcatacac ccaggacaca ttccagattt ctgtgctgaa atattggtct
     3661 ttgcagatga ttctgggagt ctgtgtgagc tgacagcaag acatatccta atatttccca
     3721 aattgacctt cctagattat gaatgacctg gttagtaggc cacaaaatct agtcaagagt
     3781 gtggcttttt cacgtctacc ttccctaaca gttttggagc catctgggcg gaggcgtgtg
     3841 ttagttagga aaaccggaat agtactagag aattcaacat aaggaattgc ttaatcaggt
     3901 tttggaaaat ggaagaagca caaaggaggc tctggtataa tttagagata gtaactgcag
     3961 gaagtggctc ctgttctttg gagaaccaag ggaagaagtt ggggttatta gaacctattg
     4021 aaggagaaat ttcttgtagt ggacactgta gtatgccact caggtcctcc aagactgaag
     4081 ggaataagct ccttggggtg ctgctggatg atggctctca gctttcagcc ctctacagga
     4141 attaccctcc actggaagag acacctttca gctccctcct gaagcaggct atatcaaatg
     4201 actagtccct gtagggtatg gtggctcagc tcctttgtcc caaacaggga caatactgaa
     4261 gggccatcca actacggacc tgcccatggg ggttggctga actgttggtt gagactgcat
     4321 catagcccac tttctccctt gcccaatcct gcttctttcc tttcccttcc agaggtaatg
     4381 atcctgagac cactccctaa taagcctttt ggatgctaat ctggatttta gagttggctt
     4441 ctcgggaaac caaaccgttg acacccccta gaaacttgaa accacatcaa agaagtacca
     4501 gctggtgctt taacctcaga agcttggaga aggggccctg tggagcaggg actcagaccc
     4561 ctgaggagtg ggtgctgccc agcaggcagt gtaatgggac tcattctgaa cacgtgaaag
     4621 aggctggaag ctggattcag ttgctactag aacatatttt gataaagaca ccagtaacct
     4681 tcatttcact aaatccaaaa gagaattttc aatcctcaaa ttagcatcac ttgaccctat
     4741 tgaccacttt ctctttgaat aatttctcct gttgactacc atgatgtcac atttttctgg
     4801 tttttttttc tcctatacct ttggatctct tgtatagatt cagtcttctt ccagttgcta
     4861 aaagctgtag ttgcatcctt agtggctagg gaaatgcaaa ttaaaatcac aatgaaatat
     4921 cactatacac ccattagaat agctaaaatt aaatggctaa aatgagaaga ctgaccttac
     4981 caactactag cgaggatgca gagtgactgg aacttcccgt acattgctgc tgggagtata
     5041 aaatgggact tctcctttgg agaatggttt ggtagttcct ttaaaagtta aacatgtacc
     5101 taccatatga tattccactt ctagatgttt acccagcaga aattcaagca tatgtcctat
     5161 gaagacttca caatatttat aggtgcttta tttgtagtag ccccaaagtg gaaacatctt
     5221 gaatgggcat gatttggtgc atggataaac agattgtata tccacacaat gaataacagc
     5281 cacaaaaaag ggatgaacta ttcatacacg aacaacatgg atggactgcc aaagaattag
     5341 gctgaatgaa agaagaaaaa aaagactaca ttttgattat ttcatttaca tactattcca
     5401 gaaaatacaa gtgaatctat agtgacagaa agtgatcagg gggtttgctg gagatggaaa
     5461 tggggagagg agggacagaa ggattgcaag ggaacacttg gtaactttgg ggaagaggga
     5521 cgtgttcatt ttcttgaatg taataatgga tttatggggg tatatatgtc aaaacttacc
     5581 aaattgtaca cttttgttat gtgcagttta ttgtgtgtca attatacctc aataaagttg
     5641 ttaaaaatat a
//
