LOCUS       NM_003737              10713 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens dachsous cadherin-related 1 (DCHS1), mRNA.
ACCESSION   NM_003737
VERSION     NM_003737.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10713)
  AUTHORS   Zhou,N., Zhao,Q., Li,R., Cheng,R., Wu,Q., Cheng,J. and Chen,Y.
  TITLE     Mutation in mitral valve prolapse susceptible gene DCHS1 causes
            familial mitral annular disjunction
  JOURNAL   J Med Genet 61 (2), 125-131 (2024)
   PUBMED   37399314
  REMARK    GeneRIF: Mutation in mitral valve prolapse susceptible gene DCHS1
            causes familial mitral annular disjunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10713)
  AUTHORS   Li,D., Yi,Z., Wu,Q., Huang,Y., Yao,H., Tan,Z., Yang,Y. and Zhang,W.
  TITLE     De novo DCHS1 splicing mutation in a patient with mitral valve
            prolapse
  JOURNAL   QJM 116 (2), 121-122 (2023)
   PUBMED   36053189
  REMARK    GeneRIF: De novo DCHS1 splicing mutation in a patient with mitral
            valve prolapse.
REFERENCE   3  (bases 1 to 10713)
  AUTHORS   Medina,E., Easa,Y., Lester,D.K., Lau,E.K., Sprinzak,D. and
            Luca,V.C.
  TITLE     Structure of the planar cell polarity cadherins Fat4 and Dachsous1
  JOURNAL   Nat Commun 14 (1), 891 (2023)
   PUBMED   36797229
  REMARK    GeneRIF: Structure of the planar cell polarity cadherins Fat4 and
            Dachsous1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10713)
  AUTHORS   Qureshi,A.H., Liang,D., Canas,J., Hooks,J., Arrregui,S.W.,
            Saxena,V., Rooney,R., Nolan,V., Schwaderer,A.L. and Hains,D.S.
  TITLE     DCHS1 DNA copy number loss associated with pediatric urinary tract
            infection risk
  JOURNAL   Innate Immun 26 (6), 473-481 (2020)
   PUBMED   32295462
  REMARK    GeneRIF: DCHS1 DNA copy number loss associated with pediatric
            urinary tract infection risk.
REFERENCE   5  (bases 1 to 10713)
  AUTHORS   Crespo-Enriquez,I., Hodgson,T., Zakaria,S., Cadoni,E., Shah,M.,
            Allen,S., Al-Khishali,A., Mao,Y., Yiu,A., Petzold,J.,
            Villagomez-Olea,G., Pitsillides,A.A., Irvine,K.D. and
            Francis-West,P.
  TITLE     Dchs1-Fat4 regulation of osteogenic differentiation in mouse
  JOURNAL   Development 146 (14) (2019)
   PUBMED   31358536
  REMARK    GeneRIF: Fat4 and Dchs1 mutants mimic the craniofacial phenotype of
            the human Van Maldergem syndrome and Dchs1-Fat4 signalling is
            essential for osteoblast differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10713)
  AUTHORS   Tsukasaki,Y., Miyazaki,N., Matsumoto,A., Nagae,S., Yonemura,S.,
            Tanoue,T., Iwasaki,K. and Takeichi,M.
  TITLE     Giant cadherins Fat and Dachsous self-bend to organize properly
            spaced intercellular junctions
  JOURNAL   Proc Natl Acad Sci U S A 111 (45), 16011-16016 (2014)
   PUBMED   25355906
  REMARK    GeneRIF: These findings suggest that Fat and Dachsous self-bend due
            to the loss of Ca(2+)-binding amino acids from specific EC-EC
            linkers, and can therefore adapt to confined spaces.
REFERENCE   7  (bases 1 to 10713)
  AUTHORS   Cappello,S., Gray,M.J., Badouel,C., Lange,S., Einsiedler,M.,
            Srour,M., Chitayat,D., Hamdan,F.F., Jenkins,Z.A., Morgan,T.,
            Preitner,N., Uster,T., Thomas,J., Shannon,P., Morrison,V., Di
            Donato,N., Van Maldergem,L., Neuhann,T., Newbury-Ecob,R.,
            Swinkells,M., Terhal,P., Wilson,L.C., Zwijnenburg,P.J.,
            Sutherland-Smith,A.J., Black,M.A., Markie,D., Michaud,J.L.,
            Simpson,M.A., Mansour,S., McNeill,H., Gotz,M. and Robertson,S.P.
  TITLE     Mutations in genes encoding the cadherin receptor-ligand pair DCHS1
            and FAT4 disrupt cerebral cortical development
  JOURNAL   Nat Genet 45 (11), 1300-1308 (2013)
   PUBMED   24056717
  REMARK    GeneRIF: findings show that mutations in genes encoding the
            receptor-ligand cadherin pair DCHS1 and FAT4 lead to a recessive
            syndrome in humans that includes periventricular neuronal
            heterotopia
REFERENCE   8  (bases 1 to 10713)
  AUTHORS   Freed,L.A., Acierno,J.S. Jr., Dai,D., Leyne,M., Marshall,J.E.,
            Nesta,F., Levine,R.A. and Slaugenhaupt,S.A.
  TITLE     A locus for autosomal dominant mitral valve prolapse on chromosome
            11p15.4
  JOURNAL   Am J Hum Genet 72 (6), 1551-1559 (2003)
   PUBMED   12707861
  REMARK    GeneRIF: MMVP2 was found on chromosome 11.
REFERENCE   9  (bases 1 to 10713)
  AUTHORS   Nakajima,D., Nakayama,M., Kikuno,R., Hirosawa,M., Nagase,T. and
            Ohara,O.
  TITLE     Identification of three novel non-classical cadherin genes through
            comprehensive analysis of large cDNAs
  JOURNAL   Brain Res Mol Brain Res 94 (1-2), 85-95 (2001)
   PUBMED   11597768
REFERENCE   10 (bases 1 to 10713)
  AUTHORS   Matsuyoshi,N. and Imamura,S.
  TITLE     Multiple cadherins are expressed in human fibroblasts
  JOURNAL   Biochem Biophys Res Commun 235 (2), 355-358 (1997)
   PUBMED   9199196
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB053446.1 and AC091564.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003737.3.
            
            Summary: This gene is a member of the cadherin superfamily whose
            members encode calcium-dependent cell-cell adhesion molecules. The
            encoded protein has a signal peptide, 27 cadherin repeat domains
            and a unique cytoplasmic region. This particular cadherin family
            member is expressed in fibroblasts but not in melanocytes or
            keratinocytes. The cell-cell adhesion of fibroblasts is thought to
            be necessary for wound healing. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB053446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299441.5/ ENSP00000299441.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AB053446.1         44-199
            157-157             AC091564.12        53151-53151         c
            158-2268            AB053446.1         201-2311
            2269-2269           AC091564.12        31700-31700         c
            2270-4062           AB053446.1         2313-4105
            4063-4063           AC091564.12        28885-28885         c
            4064-4581           AB053446.1         4107-4624
            4582-4582           AC091564.12        28077-28077         c
            4583-10713          AB053446.1         4626-10756
FEATURES             Location/Qualifiers
     source          1..10713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..10713
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /note="dachsous cadherin-related 1"
                     /db_xref="GeneID:8642"
                     /db_xref="HGNC:HGNC:13681"
                     /db_xref="MIM:603057"
     exon            1..247
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..2164
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..10264
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /note="cadherin-related family member 6; fibroblast
                     cadherin FIB1; fibroblast cadherin 1; protocadherin-16;
                     cadherin-19; cadherin-25; protein dachsous homolog 1;
                     myxomatous mitral valve prolapse 2"
                     /codon_start=1
                     /product="protocadherin-16 precursor"
                     /protein_id="NP_003728.1"
                     /db_xref="CCDS:CCDS7771.1"
                     /db_xref="GeneID:8642"
                     /db_xref="HGNC:HGNC:13681"
                     /db_xref="MIM:603057"
                     /translation="MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQA
                     GSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVR
                     TARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT
                     RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR
                     SHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQ
                     VFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQA
                     RDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSD
                     PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSP
                     PLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQV
                     TYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSV
                     ALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS
                     GSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNP
                     PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSG
                     LLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFS
                     VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDREL
                     LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIY
                     TLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARD
                     GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG
                     PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGT
                     ATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQ
                     LSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDL
                     NDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE
                     LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEP
                     PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT
                     FALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAF
                     ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGA
                     LSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV
                     RLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDRE
                     QRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSL
                     LTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDR
                     GSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQ
                     LQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLT
                     VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG
                     AFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAP
                     TFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSY
                     TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSE
                     ATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGL
                     DFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPL
                     LQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLM
                     ATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSG
                     PVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV
                     LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGF
                     SVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAP
                     SFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLA
                     EAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN
                     DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDE
                     SSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLS
                     TSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRAR
                     VPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARR
                     GHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGG
                     GGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAAS
                     LGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSEHL
                     YHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSL
                     AARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATA
                     FLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPL
                     ASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPAS
                     HRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPD
                     DTELHI"
     exon            2165..2353
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2585
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2822
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..3848
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4042
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4139
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4297
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..5162
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5402
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5403..5528
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5738
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5739..6617
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6618..6731
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6732..6943
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6944..7098
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7099..7229
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7230..7513
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7514..7652
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7653..10713
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10696..10701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /note="hexamer: AATAAA"
     polyA_site      10713
                     /gene="DCHS1"
                     /gene_synonym="CDH19; CDH25; CDHR6; FIB1; MMVP2; MVP2;
                     PCDH16; VMLDS1"
                     /note="major polyA site"
ORIGIN      
        1 agcggagctc gcatcctcgg cggggcggct gtgcaggagg cggcgcccgg gcgtcagcgg
       61 acggaccgat cgacggccaa gggcgcgcgg accgacggcg gctgcccgga ggggatcgcg
      121 ggcctcggag acagcgactg cggacgatgc gcggcctcag gccccgcgcg agcgggcgct
      181 gcccgggggg ctgaccgcgg ccggacggcg ccccagcacc gggcgaggga gcccgcgtcg
      241 cgcggaggtc agggagcctg agctggagcc agggccccag tgggacctga cccaaagtct
      301 gaggtcaagc tgggcccaga gcctggcctg gagctggagc ccaaggcaca gctggactac
      361 ccttgtcatg cagaaggagc tgggcattgt gccttcctgc cctggcatga agagccccag
      421 gccccacctc ctgctaccat tgctgctgct gctgctgctg ctgctggggg ctggggtgcc
      481 aggtgcctgg ggtcaggctg ggagcctgga cttgcagatt gatgaggagc agccagcggg
      541 tacactgatt ggcgacatca gtgcggggct tccggcaggc acggcagctc ctctcatgta
      601 cttcatctct gcccaagagg gcagcggcgt gggcacagac ctggccattg acgaacacag
      661 tggggtcgtc cgtacagccc gtgtcttgga ccgtgagcag cgggaccgct accgcttcac
      721 tgcagtcact cctgatggtg ccaccgtaga agttacagtg cgagtggctg acatcaacga
      781 ccatgctcca gccttcccac aggctcgggc tgccctgcag gtacctgagc atacagcttt
      841 tggcacccgc tacccactgg agcctgctcg tgatgcagat gctgggcgtc tgggaaccca
      901 gggctatgcg ctatctggtg atggggctgg agagaccttc cggctggaga cacgccccgg
      961 tccagatggg actccagtac ctgagctggt agttactggg gaactggacc gagagaaccg
     1021 ctcacactat atgctacagc tggaggccta tgatggtggt tcaccccccc ggagggccca
     1081 ggccctgctg gacgtgacac tgctggacat caatgaccat gccccggctt tcaatcagag
     1141 ccgctaccat gctgtggtgt ctgagagcct ggcccctggc agtcctgtct tgcaggtgtt
     1201 cgcatctgat gccgatgctg gtgtcaatgg ggctgtgact tacgagatca accggaggca
     1261 gagcgagggt gatggaccct tctccatcga cgcacacacg gggctgctgc agttagagcg
     1321 gccactggac tttgagcagc ggcgggtcca tgaactggtg gtgcaagcac gagatggtgg
     1381 ggctcaccct gagctgggct cggcctttgt gactgtgcat gtgcgagatg ccaatgacaa
     1441 tcagccctcc atgactgtca tctttctcag tgcagatggc tccccccaag tgtctgaggc
     1501 cgccccacct ggacagctcg ttgctcgcat ctctgtgtca gacccagatg atggtgactt
     1561 tgcccatgtc aatgtgtccc tggaaggtgg agagggccac tttgccctaa gcacccaaga
     1621 cagcgtcatc tatctggtgt gtgtggctcg gcggctggat cgagaggaga gggatgccta
     1681 taacttgagg gttacagcca cagactcagg ctcacctcca ctgcgggctg aggctgcctt
     1741 tgtgctgcac gtcactgatg tcaacgacaa tgcacctgcc tttgaccgcc agctctaccg
     1801 acctgagccc ctgcctgagg ttgcgctgcc tggcagcttt gtagtgcggg tgactgctcg
     1861 ggatcctgac caaggcacca atggtcaggt cacttatagc ctagcccctg gcgcccacac
     1921 ccactggttc tccattgacc ccacctcagg cattatcact acggctgcct cactggacta
     1981 tgagttggaa cctcagccac agctgattgt ggtggccaca gatggtggcc tgccccctct
     2041 agcctcctct gccacagtta gcgtggccct gcaagatgtg aatgataatg agccccaatt
     2101 ccagaggact ttctacaatg cctcactgcc tgagggcacc cagcctggaa cttgcttcct
     2161 gcaggtgaca gccacagacg cggatagtgg cccatttggc ctcctctcct attccttggg
     2221 tgctggactt gggtcctccg gatctccccc attccgcatt gatgcccaca gcggtgatgt
     2281 gtgcacaacc cggaccctgg accgtgacca ggggccctca agctttgact tcacagtgac
     2341 agctgtggat gggggaggcc tcaagtccat ggtatatgtg aaggtgtttc tgtcagacga
     2401 gaatgacaac cctcctcagt tttatccacg ggagtatgct gccagtataa gtgcccagag
     2461 tccaccaggc acagctgtgc tgaggttgcg tgcccatgac cctgaccagg gatcccatgg
     2521 gcgactctcc taccatatcc tggctggcaa cagcccccca ctttttacct tggatgagca
     2581 atcagggctg ttgacagtag cctggccctt ggccagacgg gccaattctg tggtgcagct
     2641 ggagatcggg gctgaggacg gaggtggcct acaggcagaa cccagtgccc gagtggacat
     2701 cagcattgtg cctggaaccc ccacaccacc catatttgag caactacagt atgttttttc
     2761 tgtgccagag gatgtggcac caggcaccag tgtgggcata gtccaggcac acaacccacc
     2821 aggtcgcttg gcacctgtga ccctttccct atcaggtggg gatccccgag gactcttctc
     2881 cctagatgcg gtatcaggac tgttgcaaac acttcgccct ctggaccggg agctactggg
     2941 accagtgttg gagctggagg tgcgagcagg cagtggagtg cccccagctt tcgctgtagc
     3001 tcgggtgcgt gtgctgctgg atgatgtgaa tgacaactcc cctgcctttc ctgcacctga
     3061 agacacggta ttgctaccac caaacactgc cccagggact cccatctata cactgcgggc
     3121 tcttgacccc gactcaggtg ttaacagtcg agtcaccttt accctgcttg ctgggggtgg
     3181 tggagccttc accgtggacc ccaccacagg ccatgtacgg cttatgaggc ctctggggcc
     3241 ctcaggaggg ccagcccatg agctggagct ggaggcccgg gatgggggct ccccaccacg
     3301 caccagccac tttcgactac gggtggtggt acaggatgtg ggaacccgtg ggctggctcc
     3361 ccgattcaac agccctacct accgtgtgga cctgccctca ggcaccactg ctggaactca
     3421 ggtcctgcaa gtgcaggccc aagcaccaga tgggggccct atcacctatc accttgcagc
     3481 agagggagca agtagcccct ttggcctgga gccacagagt gggtggctat gggtgcgggc
     3541 agcactagac cgtgaggccc aggaattgta catactgaag gtaatggcag tgtctgggtc
     3601 caaagctgag ttggggcagc agacaggcac agccaccgtg agggtcagca tcctcaacca
     3661 gaatgaacac agtccccgct tgtctgagga tcccaccttc ctggctgtgg ctgagaacca
     3721 gcccccaggg accagcgtgg gccgagtctt tgccactgac cgagactcag gacccaatgg
     3781 acgtctgacc tacagcctgc aacagctgtc tgaagacagc aaggccttcc gcatccaccc
     3841 ccagactgga gaagtgacca cactccaaac cctggaccgt gagcagcaga gcagctatca
     3901 gctcctggtg caggtgcagg atggagggag cccaccccgc agcaccacag gcactgtgca
     3961 tgttgcagtg cttgacctca acgacaacag ccccacgttc ctgcaggctt caggagctgc
     4021 tggtgggggc ctccctatac aggtaccaga ccgcgtgcct ccgggaacac tggtgacgac
     4081 tctgcaggcg aaggatccag atgaggggga gaatgggacc atcttgtaca cgctaactgg
     4141 tcctggctca gagcttttct ctctgcaccc tcactcaggg gagctgctca ctgcagctcc
     4201 cctgatccga gcagagcggc cccactatgt gctgacactg agtgctcatg accaaggcag
     4261 ccctcctcga agtgccagcc tccagctgct ggtgcaggtg cttccctcag ctcgcttggc
     4321 cgagccgccc ccagatctcg cagagcggga cccagcggca ccagtgcctg tcgtgctgac
     4381 ggtgacagca gctgagggac tgcggcccgg ctctctgttg ggctcggtgg cagcgccaga
     4441 gcccgcgggt gtgggtgcac tcacctacac actggtgggc ggtgccgatc ccgagggcac
     4501 cttcgcgctg gatgcggcct cagggcgctt gtacctggcg cggcccctgg acttcgaagc
     4561 tggcccgccg tggcgcgcgc ttacggtacg cgctgagggg ccgggaggcg cgggcgcgcg
     4621 gctgctgcga gtgcaggtgc aagtgcagga cgagaatgag catgcgcccg cctttgcgcg
     4681 cgacccgctg gcgctggcgc tgccagagaa cccggagccc ggcgcagcgc tgtacacttt
     4741 ccgcgcgtcg gacgccgacg gccccggccc caatagcgac gtgcgctacc gcctgctgcg
     4801 ccaggagccg cccgtgccgg cgcttcgcct ggacgcgcgc accggggcgc tcagcgctcc
     4861 gcgcggcctg gaccgagaga ccactcccgc gctgctgctg ctggtggaag ccaccgaccg
     4921 gcccgccaac gccagccgcc gtcgtgcagc gcgcgtttca gcgcgcgtct tcgtcacgga
     4981 tgagaatgac aacgcgcctg tcttcgcctc gccgtcacgc gtgcgcctcc cagaggacca
     5041 gccgcctggg cccgcggccc tgcacgtggt agcccgggac ccggatctgg gcgaggctgc
     5101 acgcgtgtcc tatcggctgg catctggcgg ggacggccac ttccggctgc actcaagcac
     5161 tggagcgctg tccgtggtgc ggccgttgga ccgcgaacaa cgagctgagc acgtactgac
     5221 agtggtggcc tcagaccacg gctccccgcc gcgctcggcc acgcaggtcc tgaccgtcag
     5281 tgtcgctgac gtcaacgacg aggcgcctac tttccagcag caggagtaca gcgtcctctt
     5341 gcgtgagaac aaccctcctg gcacatctct gctcaccctg cgagcaaccg accccgacgt
     5401 gggggccaac gggcaagtga cttatggagg cgtctctagc gaaagctttt ctctggatcc
     5461 tgacactggt gttctcacga ctcttcgggc cctggatcga gaggaacagg aggagatcaa
     5521 cctgacagtg tatgcccagg acaggggctc acctcctcag ttaacgcatg tcactgttcg
     5581 agtggctgtg gaggatgaga atgaccatgc accaaccttt gggagtgccc atctctctct
     5641 ggaggtgcct gagggccagg acccccagac ccttaccatg cttcgggcct ctgatccaga
     5701 tgtgggagcc aatgggcagt tgcagtaccg catcctagat ggggacccat caggagcctt
     5761 tgtcctagac cttgcttctg gagagtttgg caccatgcgg ccactagaca gagaagtgga
     5821 gccagctttc cagctgagga tagaggcccg ggatggaggc cagccagctc tcagtgccac
     5881 gctgcttttg acagtgacag tgctggatgc caatgaccat gctccagcct ttcctgtgcc
     5941 tgcctactcg gtggaggtgc cggaggatgt gcctgcaggg accctgctgc tgcagctaca
     6001 ggctcatgac cctgatgctg gagctaatgg ccatgtgacc tactacctgg gcgccggtac
     6061 agcaggagcc ttcctgctgg agcccagctc tggagaactg cgcacagctg cagccttgga
     6121 cagagaacag tgtcccagct acaccttttc tgtgagtgca gtggatggtg cagctgctgg
     6181 gcccctaagc accacagtgt ctgtcaccat cacggtgcgc gatgtcaatg accatgcacc
     6241 caccttcccc accagtcctc tgcgcctacg tctgccccgc ccaggcccca gcttcagtac
     6301 cccaaccctg gctctggcca cactgagagc tgaagatcgt gatgctggtg ccaatgcttc
     6361 cattctgtac cggctggcag gcacaccacc tcctggcact actgtggact cttacactgg
     6421 tgaaatccgc gtggcccgct ctcctgtagc tctaggcccc cgagatcgtg tcctcttcat
     6481 tgtggccact gatcttggcc gtccagctcg ctctgccact ggtgtgatca ttgttggact
     6541 gcagggggaa gctgagcgtg gaccccgctt tccccgggct agcagtgagg ctacgattcg
     6601 tgagaatgcg cccccaggga ctcctattgt ctcccccagg gccgtccatg caggaggcac
     6661 aaatggaccc atcacctaca gcattctcag tgggaatgag aaagggacat tctccatcca
     6721 gcctagtaca ggtgccatca cagttcgctc agcagagggg ctagacttcg aggtgagtcc
     6781 acggctgcga ctggtgctgc aggcagagag tggaggagcc tttgccttca ctgtgctgac
     6841 cctgaccctg caagatgcca acgacaatgc tccccgtttc ctgcggcccc attatgtggc
     6901 cttccttcct gagtcccggc ccttggaggg gcccctgctg caggtggagg cggatgacct
     6961 ggatcaaggc tctggaggac agatttccta cagtctggct gcatcccagc cggcacgtgg
     7021 attgttccac gtagacccaa ccacaggcac tatcactacc acagccatcc tggaccgtga
     7081 gatctgggct gaaacacggt tggtgctgat ggccacagac agagggagcc cagccctggt
     7141 gggctcagct accttgacgg tgatggtcat cgacaccaat gacaatcgcc ccaccatccc
     7201 ccaaccctgg gagctccgag tgtcagaaga tgcgttattg ggctcagaga ttgcacaggt
     7261 aacagggaat gatgtggact caggacccgt gctgtggtat gtgctaagcc catctgggcc
     7321 ccaggatccc ttcagtgttg gccgctatgg aggccgtgtc tccctcacgg ggcccctgga
     7381 ctttgagcag tgtgaccgct accagctgca gctgctggca catgatgggc ctcatgaggg
     7441 ccgtgccaac ctcacagtgc ttgtggagga tgtcaatgac aatgcacctg ccttctcaca
     7501 gagcctctac caggtaatgc tgcttgagca cacaccccca ggcagtgcca ttctctccgt
     7561 ctctgccact gatcgggact caggtgccaa cggtcacatt tcctaccacc tggcttcccc
     7621 tgccgatggc ttcagtgttg accccaacaa tgggaccctg ttcacaatag tgggaacagt
     7681 ggccttgggc catgacgggt caggagcagt ggatgtggtg ctggaagcac gagaccacgg
     7741 ggctccaggc cgggcagcac gagccacagt gcacgtgcag ctgcaggacc agaacgacca
     7801 cgccccgagc ttcacattgt cacactaccg tgtggctgtg actgaagacc tgccccctgg
     7861 ctccactctg ctcaccctgg aggctacaga tgctgatgga agccgcagcc atgccgctgt
     7921 ggactacagc atcatcagtg gcaactgggg ccgagtcttc cagctggaac ccaggctggc
     7981 tgaggctggg gagagtgctg gaccaggccc ccgggcactg ggctgcctgg tgttgcttga
     8041 acctctagac tttgaaagcc tgacacagta caatctaaca gtggctgcag ctgaccgtgg
     8101 gcagccaccc caaagctcag tcgtgccagt cactgtcact gtactagatg tcaatgacaa
     8161 cccacctgtc tttacccgag catcctaccg tgtgacagta cctgaggaca cacctgttgg
     8221 agctgagctg ctgcatgtag aggcctctga cgctgaccct ggccctcatg gcctcgtgcg
     8281 tttcactgtc agctcaggcg acccatcagg gctctttgag ctggatgaga gctcaggcac
     8341 cttgcgactg gcccatgccc tggactgtga gacccaggct cgacatcagc ttgtagtaca
     8401 ggctgctgac cctgctggtg cacactttgc tttggcacca gtgacaattg aggtccagga
     8461 tgtgaatgat catggcccag ccttcccact gaacttactc agcaccagcg tggccgagaa
     8521 tcagcctcca ggcactctcg tgaccactct gcatgcaatc gacggggatg ctggggcttt
     8581 tgggaggctc cgttacagcc tgttggaggc tgggccagga cctgagggcc gtgaggcatt
     8641 tgcactgaac agctcaacag gggagttgcg tgcgcgagtg ccctttgact atgagcacac
     8701 agaaagcttc cggctgctgg tgggtgctgc tgatgctggg aatctctcag cctctgtcac
     8761 tgtgtcggtg ctagtgactg gagaggatga gtatgaccct gtatttctgg caccagcttt
     8821 ccacttccaa gtgcccgaag gtgcccggcg tggccacagc ttgggtcacg tgcaggccac
     8881 agatgaggat gggggtgccg atggcctggt tctgtattcc cttgccacct cttcccccta
     8941 ttttggtatt aaccagacta caggagccct gtacctgcgg gtggacagtc gggcaccagg
     9001 cagcggaaca gccacctctg ggggtggggg ccggacccgg cgggaagcac cacgggagct
     9061 gaggctggag gtgatagcac gggggcctct gcctggttcc cggagtgcca cagtgcctgt
     9121 gaccgtggat atcacccaca ccgcactggg cctggcacct gacctcaacc tgctattagt
     9181 aggggccgtg gcagcctcct tgggagttgt ggtggtgctt gcactggcag ccctggtcct
     9241 aggacttgtt cgggcccgta gccgcaaggc tgaggcagcc cctggcccaa tgtcacaggc
     9301 agcaccccta gccagtgact cactgcagaa actgggccgg gagccaccta gtccaccacc
     9361 ctctgagcac ctctatcacc agactcttcc cagctatggt gggccaggag ctggaggacc
     9421 ctacccccgt ggtggctcct tggacccttc acattcaagt ggccgaggat cagcagaggc
     9481 tgcagaggat gatgagatcc gcatgatcaa tgagttcccc cgtgtggcca gtgtggcctc
     9541 ctctctggct gcccgtggcc ctgactcagg catccagcag gatgcagatg gtctgagtga
     9601 cacatcctgc gaaccacctg cccctgacac ctggtataag ggccgaaagg cagggctgct
     9661 gctgccaggt gcaggagcca ctctctacag agaggagggg cccccagcca ctgccacagc
     9721 cttcctgggg ggctgtggcc tgagccctgc acccactggg gactatggct tcccagcaga
     9781 tggcaagcca tgtgtggcag gtgcgctgac agccattgtg gccggcgagg aggagctccg
     9841 tggcagctat aactgggact acctgctgag ctggtgccct cagttccaac cactggccag
     9901 tgtcttcaca gagatcgctc ggctcaagga tgaagctcgg ccatgtcccc cagctccccg
     9961 tatcgaccca ccacccctca tcactgccgt ggcccaccca ggagccaagt ctgtgccccc
    10021 caagccagca aacacagctg cagcccgggc catcttccca ccagcttctc accgctcccc
    10081 catcagccat gaaggctccc tgtcctcagc tgccatgtcc cccagcttct caccctctct
    10141 gtctcctctg gctgctcgct cacccgttgt ctcaccattt ggggtggccc agggtccctc
    10201 agcctcagca ctcagcgcag agtctggcct ggagccacct gatgacacgg agctgcacat
    10261 ctagctgtgg cccaggctgg gccccgacct gggatgcgca cagtgtcccc aacgcaggcc
    10321 ccactctgag cctgccctgg gcagcctcgg actatgactg gctacgggga ggccaccacc
    10381 aggccccagc tctccaccct gaactcccca gccccctcag agtactagga ccacagaagc
    10441 cctgttgctc actgacctgt gaccaggtcc aatgtgggga gaaatatgaa ggaggtagca
    10501 gccctgggtt ctcctcagtg agggatccct gccctgcacc agcaccctga gatggagctg
    10561 agactttatt tattgggggt agggggatgg aggaggtccc tccaacatgt ttggacccag
    10621 ctcctttggg ttccactgac acccctgccc ctgcccctgc ccagaaccaa gtgccatttc
    10681 tcactctgga gccttaataa actgcaattt gta
//
