LOCUS       NM_001099434            1350 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens doublecortin domain containing 2B (DCDC2B), mRNA.
ACCESSION   NM_001099434 XM_926306 XM_940631
VERSION     NM_001099434.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049795.21, BC128073.1 and
            BM980133.1.
            
            On Sep 17, 2020 this sequence version replaced NM_001099434.1.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two doublecortin domains. The
            doublecortin domain has been demonstrated to bind tubulin and
            enhance microtubule polymerization. [provided by RefSeq, Sep 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128073.1, DRR138524.809426.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409358.2/ ENSP00000386870.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL049795.21        98417-98421
            6-1055              BC128073.1         1-1050
            1056-1350           BM980133.1         23-317              c
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..1350
                     /gene="DCDC2B"
                     /note="doublecortin domain containing 2B"
                     /db_xref="GeneID:149069"
                     /db_xref="HGNC:HGNC:32576"
     exon            1..271
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1055
                     /gene="DCDC2B"
                     /codon_start=1
                     /product="doublecortin domain-containing protein 2B"
                     /protein_id="NP_001092904.1"
                     /db_xref="CCDS:CCDS44100.1"
                     /db_xref="GeneID:149069"
                     /db_xref="HGNC:HGNC:32576"
                     /translation="MAGGSPAAKRVVVYRNGDPFFPGSQLVVTQRRFPTMEAFLCEVT
                     SAVQAPLAVRALYTPCHGHPVTNLADLKNRGQYVAAGFERFHKLHYLPHRGKDPGGKS
                     CRLQGPPVTRHLCDGAIGRQLPAGAPSYIHVFRNGDLVSPPFSLKLSQAASQDWETVL
                     KLLTEKVKLQSGAVCKLCTLEGLPLSAGKELVTGHYYVAVGEDEFKDLPYLELLVPSP
                     SLPRGCWQPPGSKSRPHRQGAQGHRAQVTQPSPKEPDRIKPSAFYARPQQTIQPRSKL
                     PTLSFPSGVIGVYGAPHRRKETAGALEVADDEDTQTEEPLDQRAAQIVEEALSLENQP
                     GAGAAISASAPALPS"
     exon            272..323
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            324..400
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            401..532
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            533..679
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            680..719
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            720..855
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            856..959
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1350
                     /gene="DCDC2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCDC2B"
                     /note="hexamer: AATAAA"
     polyA_site      1350
                     /gene="DCDC2B"
                     /note="major polyA site"
ORIGIN      
        1 acactatggc aggtggcagt ccagcagcca agagggtagt ggtgtaccgg aatggggacc
       61 cattcttccc aggctcccag ctggtggtga ctcaacgccg cttccccacc atggaggcct
      121 tcctctgcga ggtgacatca gctgtgcagg ccccactggc tgtgcgtgcc ctctacacac
      181 cttgtcatgg ccaccctgtc accaacctgg cagacttgaa gaacagaggg cagtatgtgg
      241 ccgctggatt tgaacgattc cacaagctcc actatttacc ccatagaggg aaggacccag
      301 gtgggaagag ctgcagacta caaggtcctc ccgtgactcg ccacttgtgt gatggggcca
      361 ttggacggca gctgcctgca ggtgctccca gctatatcca tgtgttcagg aatggggacc
      421 tggtaagtcc cccatttagt ctgaagctgt cccaggctgc cagccaggac tgggaaactg
      481 tgttgaagct cctgactgag aaggtcaagt tgcagagtgg ggctgtgtgc aaactctgca
      541 ccctagaggg gctcccactg tcagcaggga aggagctggt aactggccat tactatgtgg
      601 ctgtcggaga ggatgagttc aaggaccttc cctatctgga gctgctggtg cccagcccct
      661 ccctgcccag gggctgctgg caacctccag gctcgaagtc taggccccac aggcaggggg
      721 cccaaggcca cagggcccag gtaacccagc cctctccaaa ggaaccagac cgaattaagc
      781 catctgcttt ctatgccaga ccccagcaga ccattcagcc aagaagcaag ctccccacac
      841 tctcattccc atcaggagtt ataggagtat atggagctcc ccaccgaagg aaggagacag
      901 cgggggccct ggaagtagca gatgatgaag acactcagac agaggagccc ttggatcaga
      961 gggcagcaca gatagtggaa gaggccttgt ccctggaaaa ccagcctggg gctggggctg
     1021 ctatctcagc ctcagcccca gctctgccat cttgagagcc agcagctcca gagggcaact
     1081 ggggaccact actctggcca ccttttgtcc ttagcctcca gcagcttgtt cctcaggagc
     1141 cagcacctcc gctgggctca cagggtacac tgcggcctcc tcagccctcc ccgttctcct
     1201 gctcctaaac ccacagccca gccttccctt cctctgagca gagcagccct ggctgtgggg
     1261 gctatttcct tatgggattc tctggccaga gaaaggagta gctgactaag cctgggagag
     1321 ggtttgtcac aataaaagaa tacttactaa
//
