LOCUS       NM_001387274            7298 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens doublecortin domain containing 1 (DCDC1), transcript
            variant 6, mRNA.
ACCESSION   NM_001387274 XM_024448470
VERSION     NM_001387274.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7298)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat Genet 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7298)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7298)
  AUTHORS   Kaplan,A. and Reiner,O.
  TITLE     Linking cytoplasmic dynein and transport of Rab8 vesicles to the
            midbody during cytokinesis by the doublecortin domain-containing 5
            protein
  JOURNAL   J Cell Sci 124 (Pt 23), 3989-4000 (2011)
   PUBMED   22159412
  REMARK    GeneRIF: DCDC5 colocalizes with Rab8 and links it to dynein during
            cytokinesis. DCDC5 knockdown increased apoptosis and the number of
            multinucleated cells.
REFERENCE   4  (bases 1 to 7298)
  AUTHORS   Cheng,F., Song,W., Kang,Y., Yu,S. and Yuan,H.
  TITLE     A 556 kb deletion in the downstream region of the PAX6 gene causes
            familial aniridia and other eye anomalies in a Chinese family
  JOURNAL   Mol Vis 17, 448-455 (2011)
   PUBMED   21321669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7298)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   6  (bases 1 to 7298)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7298)
  AUTHORS   Zeng,L., Gu,S., Li,Y., Zhao,E., Xu,J., Ye,X., Wu,Q., Wang,L.,
            Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human doublecortin-domain-containing gene
            (DCDC1) expressed mainly in testis
  JOURNAL   J Hum Genet 48 (7), 393-396 (2003)
   PUBMED   12820024
  REMARK    GeneRIF: DCDC1 was mapped to 11p13; mainly expressed in adult
            testis; and its expression in fetal brain was much higher than in
            adult brain
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137804.7, AL162614.25,
            AL133376.6, AL137160.7 and AL135932.7.
            
            On Sep 28, 2020 this sequence version replaced XM_024448470.1.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene is a hydrophilic, intracellular
            protein. It contains a single doublecortin domain and is unable to
            bind microtubules and to regulate microtubule polymerization. This
            gene is mainly expressed in adult testis. It does not have a mouse
            homolog. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (6).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000684477.1/ ENSP00000507427.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL137804.7         26838-26880
            44-161              AL137804.7         61013-61130
            162-331             AL137804.7         68291-68460
            332-601             AL137804.7         88669-88938
            602-758             AL137804.7         90189-90345
            759-921             AL137804.7         90800-90962
            922-1127            AL137804.7         105725-105930
            1128-1221           AL162614.25        25478-25571
            1222-1388           AL162614.25        49462-49628
            1389-1481           AL133376.6         62194-62286
            1482-1652           AL133376.6         72339-72509
            1653-1754           AL133376.6         89617-89718
            1755-1918           AL133376.6         93018-93181
            1919-2044           AL133376.6         96209-96334
            2045-2150           AL133376.6         97696-97801
            2151-2285           AL137160.7         6666-6800
            2286-2404           AL137160.7         9339-9457
            2405-2465           AL137160.7         22925-22985
            2466-2600           AL137160.7         35697-35831
            2601-2758           AL137160.7         36224-36381
            2759-2882           AL135932.7         24832-24955
            2883-3064           AL135932.7         45448-45629
            3065-3164           AL135932.7         51992-52091
            3165-3300           AL135932.7         54762-54897
            3301-3460           AL135932.7         56465-56624
            3461-3619           AL135932.7         60372-60530
            3620-3820           AL135932.7         61689-61889
            3821-3914           AL135932.7         65980-66073
            3915-4085           AL135932.7         68284-68454
            4086-4271           AL135932.7         70675-70860
            4272-4475           AL135932.7         72236-72439
            4476-4677           AL135932.7         73717-73918
            4678-4830           AL135932.7         76902-77054
            4831-4932           AL135932.7         77758-77859
            4933-5069           AL135932.7         83016-83152
            5070-5249           AL135932.7         84403-84582
            5250-5400           AL135932.7         96092-96242
            5401-5568           AL135932.7         98689-98856
            5569-7298           AL135932.7         112068-113797
FEATURES             Location/Qualifiers
     source          1..7298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1-p13"
     gene            1..7298
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /note="doublecortin domain containing 1"
                     /db_xref="GeneID:341019"
                     /db_xref="HGNC:HGNC:20625"
                     /db_xref="MIM:608062"
     exon            1..43
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            44..161
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            162..331
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..5528
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /note="isoform 6 is encoded by transcript variant 6;
                     doublecortin domain-containing protein 1; doublecortin
                     domain-containing protein 5; doublecortin
                     domain-containing 5 protein"
                     /codon_start=1
                     /product="doublecortin domain-containing protein 1 isoform
                     6"
                     /protein_id="NP_001374203.1"
                     /db_xref="CCDS:CCDS91453.1"
                     /db_xref="GeneID:341019"
                     /db_xref="HGNC:HGNC:20625"
                     /db_xref="MIM:608062"
                     /translation="MAKTGAEDHREALSQSSLSLLTEAMEVLQQSSPEGTLDGNTVNP
                     IYKYILNDLPREFMSSQAKAVIKTTDDYLQSQFGPNRLVHSAAVSEGSGLQDCSTHQT
                     ASDHSHDEISDLDSYKSNSKNNSCSISASKRNRPVSAPVGQLRVAEFSSLKFQSARNW
                     QKLSQRHKLQPRVIKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLA
                     DGKEALEPEDIPHEADVYVSTGEPFLNPFKKIKDHLLLIKKVTWTMNGLMLPTDIKRR
                     KTKPVLSIRMKKLTERTSVRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLP
                     ARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSKGEGFSPSGAKMYIQGVLL
                     ALYQRLKSAKKYYKQLNLVMNEQKEKITEKVILSMTAKEHHKEQEEVSRLIDELQTAI
                     KSNIGHLCKLGPQLQAEQEQFSSYVYQHIKSLPANTLVPGGLQLKVFENGKNTGEISV
                     GISKKDLGSDSPIQTDHMMERLLLKIHQRLQGSSINPPGLNYSSMRLFDENGQEIKNP
                     LSLKNEQKIWVSYGRAYRSPLNLALGLTFDRVSAFARGDIMVAYKTFLDPNAVLLPGC
                     GNWEVCEGFPINFNCTSQQIPDQFEKVDLENHFLQNKVDPNIVLHASVSIGKWSFSGS
                     EASSRSQIAPSILWPVASVWLITKTGMILSRAITQGCLAIGHPIRVKAAEGTSLEGYK
                     LILQKRHSGDDSQKWVFGTDGCIYSKAYPQFVLTYLEELNAQVDVTQTEYHIHHGAWT
                     TAHQEHGRNLAEEVLQESASNLGLKQLPEPSDTHLMPEGSLEETGELTVALVRKLEEK
                     HPKASAQRWAIKHEGTSKPGQWKHSRVENPLWNKLTYMWPVLPSGQLNEEFDWPIQGL
                     LVPSSPPMKKPICKTTEPYAPVRLRVLQNGEKNKNRSVTILGPDISPGRKTQCTEILN
                     LPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDLSIAQQKKQIFLRNLESD
                     IAKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAIFGEEKQVTEPEEKQMQEDPL
                     TTENASSEILDSHVRAHLRMKACHTLPRYAWQETSHDFDEDDSLPKKTEKGLFENVEP
                     QKKHSCSPKHSKLHKHCHQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLVEKKS
                     DGSHQRWIHQEDSRTFHLVSNPDLVLAVSMTKTRNEVCGYPVIVQKYKPYNNGAANQK
                     WHYMKNIKALVAFHSTALDKEITSANYAGVCTSSVIKEENIDQPGYCYLSPDGKRKTM
                     LCLACGQSMRTEKGLKQLLPGVPFLCISGTKTQKPFLQGPFKVISVAEVDLSCDKAEK
                     TLSYYQARLLSLRMKTCTQAASHSGMAATHQKAVKIIAYKNGDGYRNGKLIVAGTFPM
                     LLTECTEQLGLARAASKVYTKDGTPIFTLRDLVLWALDESFLQRDSEKQKQDAAPVGK
                     EQIIVESMEENPRMKVKNRLFAKSVTSDSLDGIDKSLLTLILRNPIAIWVSCGEPFLP
                     PNALQKAEKLEKQNWLKKDRILADLDTMRHKMRQLKGRRVAACQPATMVPTKSPVQPV
                     VVEGGWTEQTQQEIKLMELIRHTEAHLSEIQEMESKINFPIATKRIAVKPSNLYKQPN
                     TKRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDI
                     ERDMVICVSMGHGFKTPKELKQLMEIRANYARIRRQQGPQATDIVVSPSTKLLSLAHL
                     HN"
     exon            332..601
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            602..758
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            759..921
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1127
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1221
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1388
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1481
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1652
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1754
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1918
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2044
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2150
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2285
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2404
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2465
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2600
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2758
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2882
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3064
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3164
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3300
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3460
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3619
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3820
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3914
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4085
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4271
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4475
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4677
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            4678..4830
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..4932
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            4933..5069
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            5070..5249
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5400
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5568
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            5569..7298
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7274..7279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /note="hexamer: AATAAA"
     polyA_site      7298
                     /gene="DCDC1"
                     /gene_synonym="DCDC5"
                     /note="major polyA site"
ORIGIN      
        1 atggtaaccg gtcaccgctt ctatggagtg gcgtttacta ccaattgcaa ataagaaaat
       61 tccagattcc attccaagat ggccaaatag gaacagctcc agcctgcagc tcccagcgtg
      121 attaatgtag aagatgggtg atttctgcat ttccaactaa gctgaaaatg gcaaaaacag
      181 gagcagaaga tcacagagaa gcactatctc agtcttcctt atccctcttg actgaagcaa
      241 tggaagtatt acagcaaagt agccctgaag gcactttgga tgggaatact gtaaacccaa
      301 tttacaaata tattttgaat gatttaccaa gagagtttat gtcatcccag gcaaaagcag
      361 ttattaaaac tactgatgat tatttgcagt ctcagtttgg ccccaacaga ctcgtgcatt
      421 cagcagcagt atcagaaggg tcaggacttc aagattgctc cacacatcaa acagcatcag
      481 atcacagcca tgatgaaata tcagacctag atagctacaa atcaaacagt aaaaacaatt
      541 cttgttctat atcagcatcc aagagaaaca gacctgtcag tgctccagtg ggtcaactga
      601 gggttgcaga gttctcttct ttaaaatttc agtcagcccg gaattggcag aaattgtctc
      661 aaagacacaa acttcaacca agagtgatta aagtaacagc ttacaaaaat ggatctagaa
      721 cagtctttgc cagagttact gtaccaacca tcaccttgct gctggaggag tgcacagaaa
      781 agctgaatct gaacatggcc gcaagacgag tgttcttggc agacggcaag gaagccctcg
      841 aacctgaaga tataccccat gaagccgatg tttatgtttc aacgggagag ccctttttaa
      901 atccattcaa aaaaattaaa gaccatctgt tgttaattaa gaaagtaact tggacaatga
      961 atgggttgat gcttcctact gatatcaaaa gacggaaaac caagcctgtt ctttctatta
     1021 gaatgaagaa acttactgag aggacctcag tccgaattct gttctttaag aatggcatgg
     1081 ggcaggatgg gcatgagatt acagtgggaa aagaaacaat gaaaaaggtt ttagatactt
     1141 gtacaataag aatgaatcta aatttaccag ccagatattt ttatgatttg tatggcagaa
     1201 aaattgaaga tatttcaaaa gttcctctgc ttgaaaaatg cctgcaaaat tccatcacac
     1261 ctttgcgagg actactttgg gtctctaagg gagaaggttt cagcccctca ggagctaaga
     1321 tgtacatcca aggagttctt ttggccctgt accaacgatt aaagtctgca aaaaaatatt
     1381 ataaacagtt gaacctggtc atgaatgaac agaaggagaa aattacagaa aaagtcattc
     1441 tttcaatgac ggcaaaggaa caccataagg aacaggaaga agtgagcagg ctgattgatg
     1501 aattgcagac agctatcaaa agtaacatag gtcatctctg taaacttggc ccccaattac
     1561 aggctgagca ggagcaattc tcctcttatg tctaccaaca cattaaaagc cttccagcaa
     1621 acacgcttgt cccaggaggc ctgcagctta aggtatttga aaatggtaaa aacactggag
     1681 agatctctgt tggtatcagt aaaaaagatt tgggatcgga tagcccaatt caaactgacc
     1741 atatgatgga aagattactt ctcaagattc atcaaaggct tcaaggttct tccatcaacc
     1801 caccaggcct caattattct tcaatgcggc tttttgatga gaatggccaa gaaattaaga
     1861 atccactttc gctgaagaat gagcaaaaaa tttgggtctc ttatggtaga gcatacagat
     1921 ctccactaaa tcttgctttg ggtttgacct ttgaccgagt gagtgcattt gccagaggtg
     1981 atatcatggt tgcatataag acctttttgg atcctaatgc tgttctgcta cctggatgtg
     2041 gcaattggga agtttgtgag ggatttccaa ttaatttcaa ctgtaccagt caacagatac
     2101 ctgaccagtt tgaaaaggtg gacttggaga accattttct acagaacaag gtagatccca
     2161 atattgtcct tcatgcctct gtttccattg gaaagtggag tttctcaggc agtgaagcaa
     2221 gcagcaggag tcaaatagcg ccatcgatcc tgtggcctgt agccagtgtg tggctgatca
     2281 ccaagactgg aatgatcctg agccgagcga taactcaggg ctgcctggct attggtcatc
     2341 ctatcagagt caaggctgct gagggaacat cactagaagg atataaatta atcttacaga
     2401 aaagacatag tggagatgac tctcagaagt gggtgtttgg aactgatggt tgcatttatt
     2461 caaaggctta tcctcagttt gttctgacct acctagagga gctaaatgca caagtagatg
     2521 tgacccagac agagtatcac attcaccatg gtgcctggac cacagctcat caggaacatg
     2581 gcagaaactt agcagaagag gttctgcaag aaagtgccag caaccttggt ctgaagcaac
     2641 tgccagaacc ctcagacacc catttaatgc cagaaggttc tcttgaggag acgggggagc
     2701 tgacagtagc actggtgagg aaactggaag agaaacatcc taaggcttct gctcagaggt
     2761 gggccataaa acatgaagga accagtaagc caggccagtg gaaacattct agagttgaaa
     2821 atcctctatg gaacaagctt acctacatgt ggcctgtcct tcccagtggc caacttaatg
     2881 aggagtttga ttggccaata caaggactgc ttgttccgag cagtcctccc atgaagaaac
     2941 ccatctgtaa gacaacagag ccatatgccc ctgtgcgact cagagttttg cagaatggag
     3001 agaagaataa aaacagatcc gttactatcc ttggtccaga tatctcacct ggacggaaaa
     3061 cgcagtgcac tgagatttta aatttacctt ctgcagctcg gagattgtac aatgaaaagg
     3121 ggaaggaaat atttgcctta aaagacctgc aaagagatga actggtgtat gtttcatgtg
     3181 gagaactctg gatcaatcct gacctgtcca ttgctcagca aaagaaacaa atattcctga
     3241 ggaacctaga atcagacatt gccaaaattc aaatcttctg cagcacacat aaaatagaag
     3301 ctcttgtttt agaagtccaa agtgacattg tatctggaag caagcttgct gtgcataaac
     3361 ctgtagcaat ttttggagaa gagaagcaag ttacagaacc ggaagaaaag caaatgcaag
     3421 aagatcctct aacaacggaa aatgcttcca gtgaaattct agattcacac gtaagagctc
     3481 atcttcgaat gaaggcttgt cacacacttc ccaggtatgc ctggcaggaa acttcacatg
     3541 actttgatga ggatgacagt cttccaaaga aaacggaaaa agggctcttt gaaaatgtgg
     3601 aaccacagaa gaaacacagc tgttcaccaa agcatagtaa attgcacaag cattgtcatc
     3661 agcagttcga atacagagat gggcagatta taagccatgc tgctcctcag ctagtcttgg
     3721 gggttcaagg tcccaatctc cgatcaggca tggaggtggt tttggtggag aagaaatctg
     3781 atggtagtca tcagcgctgg atacaccagg aagacagcag gacctttcac cttgtgagta
     3841 accctgacct tgtgctggca gtgtctatga ccaagactag aaatgaagtt tgtggctatc
     3901 cagttattgt tcagaaatat aagccgtaca acaatggagc tgccaatcaa aagtggcatt
     3961 acatgaaaaa tataaaagca cttgtggcct ttcatagcac tgccttggat aaggaaatta
     4021 catcagcaaa ttatgctggt gtctgtacat catctgtgat taaagaagaa aacattgatc
     4081 aaccaggata ctgttatctc tcacctgatg gaaagagaaa aactatgctc tgcttggctt
     4141 gtggacaatc catgagaaca gagaaaggac tgaaacaatt gcttccaggg gttccattcc
     4201 tctgtatttc aggcaccaag actcagaagc ccttcttaca agggcccttc aaggtcatca
     4261 gtgtggctga ggttgatttg tcgtgtgaca aggctgaaaa aactctaagt tactaccaag
     4321 cacgtctatt gtctttacgg atgaagacct gcacgcaagc tgcatctcac agtggcatgg
     4381 cagccacaca ccagaaggca gtgaaaataa ttgcatacaa aaatggggat gggtatcgta
     4441 atgggaagtt aattgtggct ggaacattcc ccatgcttct tacagaatgc acggaacaac
     4501 ttgggcttgc cagagcagcc tccaaagtat ataccaaaga tggaacccca atctttacct
     4561 tgcgtgattt ggttttatgg gctctagatg aatcctttct ccagagagac tctgagaaac
     4621 aaaagcaaga tgcagctcct gttggaaaag aacagataat tgttgaaagt atggaagaaa
     4681 atccaagaat gaaagtgaaa aacagattat ttgcaaaatc tgtgacatcc gatagtttgg
     4741 atggtataga caagtctttg cttaccctca tcctcagaaa tcctattgcc atctgggtgt
     4801 cttgtggtga accatttcta cctccaaatg ctttgcagaa agcagaaaaa ttagagaaac
     4861 agaactggct aaaaaaggac agaattttgg ctgatctaga taccatgaga cacaaaatga
     4921 gacagttaaa agggcggcga gtagcggcat gtcagccagc caccatggtt cctaccaaga
     4981 gccctgtgca gcccgtggtg gttgaaggag gctggaccga acagactcaa caggaaatta
     5041 aactcatgga acttataaga catacagagg cacacctttc tgaaatccaa gaaatggaat
     5101 ccaaaataaa ttttccaatt gcaaccaaac gtatagcagt caagccgagc aacctgtata
     5161 agcagcccaa cacaaaacga gtgtggattt atctaaatgg aggcagacct gaagatggca
     5221 cttatgcctg gggcaaaact atttcagagc tgctgcaaga ctgctcctct cgtctcaaaa
     5281 tgacccaccc agctagagca ctgtacaccc ccagtggaga gccaattcag tcctgggacg
     5341 acatagagcg agatatggtc atctgtgtgt ctatgggaca tggtttcaaa accccaaaag
     5401 agttaaaaca actgatggag atcagagcaa attatgccag aatccgaagg cagcagggcc
     5461 ctcaagccac agacattgtg gtgtcaccat ccacgaagct gctgtctctg gcacatctcc
     5521 acaattaact cctatcagaa ccatcggatt ttctgctgta tttttctgga aagaaaactt
     5581 tctttaccca cttataaaca gaagactgtg acaagaaggc caattatttc catcgctgaa
     5641 gactctaaat ttggcaaatc ttctaaataa caatcctgca tagtttatta aaaaaaatta
     5701 gtcgtaaaat ttatccttca aaaatctgca ttttaaataa accctgacag tgatttctca
     5761 agactgtaaa gatattagtc tgagaatgca actctaacag actgctctgg gcatcttttc
     5821 tctttgcctt ggccaggcct ctcagaattg agtgagcgtg tgactccatt tgcacagtgg
     5881 gacagatgag tacaactgaa ataaaaagtg gaggcctctg caaaaaataa aaaataaaaa
     5941 ataaatttat ccttcaaaat aactcagttt tttcaatggg cctattttga agaatgaaca
     6001 ttgaaaaatg agacaatata tccataaatt catagtatga cataccataa tcgagagcat
     6061 tgttagccat agacattttg tatgccagtg aaatctgtat acattctcta aatttttcca
     6121 gtttatcgtg tggcttattg gaaaaaaaaa agcatataca ctgactgcat gttttgtctc
     6181 cccaactaaa tgataagtgc ctagagggca ggaacaccct tggttttatt tacttgggac
     6241 agagctctac ccacaagggc tcactgataa aactcatcag tcccacccca cagcaacatg
     6301 atggggacat gaggttcagt tcttctactc ttggcctgag ccgcaaacca aaattacaac
     6361 agtacaatgg gaatagagga tctgctttat agaatttcct ttcagtcagc tgctcagaaa
     6421 ctacaatcct cagagtgaaa ttaaatggag ttatactggg atagtcctct ctgcttttca
     6481 gaggaaagaa acacttctcg aaattgtgca aatgaaagaa atgtcatggt ataaactaga
     6541 catcttatat ccttaaaata tatctttgat gattatacat attggtttca aatcccaagt
     6601 ttgaagaaac atccaaaagt tatgtgaaat tacttataga tgaattgaca acatttgaga
     6661 cttcgacagg caatcatgaa gcagttctca agttgatttg gtttatatag ctctttaaga
     6721 atcttttgga aagccataat ctcacaaaat acagatatgc aatttttttt ttttgagatg
     6781 gagtctcact ctgttgccca gtctggagtt cagtggcgcg atctcagctc actacaagct
     6841 ccccttccca ggttcaagca attctcctgt ctcagcctcc tgagtagctg ggactacagg
     6901 cgcctgccac cacacccagc taacttttgt atttttagta gagatggggt ttcaccttgt
     6961 tggtcaagct ggtctcaaac tcctgacctc aggtgatcca ctcgcctctg cctcccaaag
     7021 tgctgggatt acaggcgtaa gccaccacac ccagcccaaa aaatgtttgt gcacagaact
     7081 gtggatgttt gtcacagaac tttccaaata aagaagttct gataaaagag aagatatttc
     7141 tcatttccat aatctttaag gtgtggggga tacgtaatct ggacttctca aatggatgat
     7201 ttctaaatac gcgtcagatg aagtgattct aactttctct gtagtaatat cttattttgt
     7261 tttattcaaa aacaataaac catgtagatt tattagca
//
