LOCUS       NM_053283                519 bp    mRNA    linear   PRI 02-AUG-2023
DEFINITION  Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.
ACCESSION   NM_053283
VERSION     NM_053283.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Lager TW, Conner C, Keating CR, Warshaw JN and Panopoulos AD.
  TITLE     Cell surface GRP78 and Dermcidin cooperate to regulate breast
            cancer cell migration through Wnt signaling
  JOURNAL   Oncogene 40 (23), 4050-4059 (2021)
   PUBMED   33981001
  REMARK    GeneRIF: Cell surface GRP78 and Dermcidin cooperate to regulate
            breast cancer cell migration through Wnt signaling.
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 519)
  AUTHORS   Nunez-Naveira L, Marinas-Pardo LA and Montero-Martinez C.
  TITLE     Mass Spectrometry Analysis of the Exhaled Breath Condensate and
            Proposal of Dermcidin and S100A9 as Possible Markers for Lung
            Cancer Prognosis
  JOURNAL   Lung 197 (4), 523-531 (2019)
   PUBMED   31115649
  REMARK    GeneRIF: Exhaled breath condensate analysis suggests that dermcidin
            and S100A9 may serve as biomarkers for lung cancer diagnosis or
            prognosis.
REFERENCE   4  (bases 1 to 519)
  AUTHORS   Jana P, Khan MM, De SK, Sinha AK, Guha S, Khan GA and Maiti S.
  TITLE     Estriol Inhibits Dermcidin Isoform-2 Induced Inflammatory Cytokine
            Expression Via Nitric Oxide Synthesis in Human Neutrophil
  JOURNAL   Curr Mol Med 18 (10), 672-678 (2018)
   PUBMED   30734678
  REMARK    GeneRIF: the stress-induced DCN-2 production in AIHD propagates the
            inflammatory response. Steroid molecule like estriol plays a
            protective role by reducing DCN-2 responses in the NO synthesis.
REFERENCE   5  (bases 1 to 519)
  AUTHORS   Krukovskaya,L.L., Polev,D.E., Kurbatova,T.V., Karnaukhova,Y.X. and
            Kozlov,A.P.
  TITLE     [Study of tumor-specific expression of some evolutionary new genes]
  JOURNAL   Vopr Onkol 62 (3), 495-500 (2016)
   PUBMED   30463107
  REMARK    GeneRIF: in this paper we have showed that evolutionary new genes
            DCD1(Dermicidin), LINC00309 and CLLU1 have tumor-specific
            expression profile
REFERENCE   6  (bases 1 to 519)
  AUTHORS   Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S,
            Schirle M, Schroeder K, Blin N, Meier F, Rassner G and Garbe C.
  TITLE     Dermcidin: a novel human antibiotic peptide secreted by sweat
            glands
  JOURNAL   Nat Immunol 2 (12), 1133-1137 (2001)
   PUBMED   11694882
  REMARK    GeneRIF: identified as antibiotic peptide secreted by sweat glands
REFERENCE   7  (bases 1 to 519)
  AUTHORS   Cunningham TJ, Jing H, Wang Y and Hodge L.
  TITLE     Calreticulin binding and other biological activities of survival
            peptide Y-P30 including effects of systemic treatment of rats
  JOURNAL   Exp Neurol 163 (2), 457-468 (2000)
   PUBMED   10833321
REFERENCE   8  (bases 1 to 519)
  AUTHORS   Cunningham TJ, Hodge L, Speicher D, Reim D, Tyler-Polsz C, Levitt
            P, Eagleson K, Kennedy S and Wang Y.
  TITLE     Identification of a survival-promoting peptide in medium
            conditioned by oxidatively stressed cell lines of nervous system
            origin
  JOURNAL   J Neurosci 18 (18), 7047-7060 (1998)
   PUBMED   9736629
REFERENCE   9  (bases 1 to 519)
  AUTHORS   Todorov PT, Deacon M and Tisdale MJ.
  TITLE     Structural analysis of a tumor-produced sulfated glycoprotein
            capable of initiating muscle protein degradation
  JOURNAL   J Biol Chem 272 (19), 12279-12288 (1997)
   PUBMED   9139670
REFERENCE   10 (bases 1 to 519)
  AUTHORS   Todorov P, Cariuk P, McDevitt T, Coles B, Fearon K and Tisdale M.
  TITLE     Characterization of a cancer cachectic factor
  JOURNAL   Nature 379 (6567), 739-742 (1996)
   PUBMED   8602222
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EF503687.1 and AC079310.20.
            
            On May 17, 2019 this sequence version replaced NM_053283.3.
            
            Summary: This antimicrobial gene encodes a secreted protein that is
            subsequently processed into mature peptides of distinct biological
            activities. The C-terminal peptide is constitutively expressed in
            sweat and has antibacterial and antifungal activities. The
            N-terminal peptide, also known as diffusible survival evasion
            peptide, promotes neural cell survival under conditions of severe
            oxidative stress. A glycosylated form of the N-terminal peptide may
            be associated with cachexia (muscle wasting) in cancer patients.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            3' coding region, resulting in a frameshift compared to variant 2.
            The encoded isoform (1) has a distinct C-terminus , and is shorter,
            compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL598959.1, CD000439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162895, SAMN02400288
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000293371.11/
                                                  ENSP00000293371.6
            Protein has antimicrobial activity :: PMID: 11694882
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               EF503687.1         129-606
            479-519             AC079310.20        82582-82622         c
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..519
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /note="dermcidin"
                     /db_xref="GeneID:117159"
                     /db_xref="HGNC:HGNC:14669"
                     /db_xref="MIM:606634"
     exon            1..120
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..395
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; survival promoting peptide; diffusible
                     survival/evasion peptide; preproteolysin; proteolysis
                     inducing factor"
                     /codon_start=1
                     /product="dermcidin isoform 1 preproprotein"
                     /protein_id="NP_444513.1"
                     /db_xref="CCDS:CCDS8884.1"
                     /db_xref="GeneID:117159"
                     /db_xref="HGNC:HGNC:14669"
                     /db_xref="MIM:606634"
                     /translation="MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKEN
                     AGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDV
                     KDVLDSVL"
     exon            121..159
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /inference="alignment:Splign:2.1.0"
     exon            160..261
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /inference="alignment:Splign:2.1.0"
     exon            262..351
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /inference="alignment:Splign:2.1.0"
     exon            352..519
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      496..501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /note="hexamer: ATTAAA"
     polyA_site      519
                     /gene="DCD"
                     /gene_synonym="AIDD; DCD-1; DSEP; HCAP; PIF"
                     /note="major polyA site"
ORIGIN      
        1 gacaccctag atcccaagat ctccaaggat ttggtggcat acccactcca gcacacagaa
       61 gcatgaggtt catgactctc ctcttcctga cagctctggc aggagccctg gtctgtgcct
      121 atgatccaga ggccgcctct gccccaggat cggggaaccc ttgccatgaa gcatcagcag
      181 ctcaaaagga aaatgcaggt gaagacccag ggttagccag acaggcacca aagccaagga
      241 agcagagatc cagccttctg gaaaaaggcc tagacggagc aaaaaaagct gtggggggac
      301 tcggaaaact aggaaaagat gcagtcgaag atctagaaag cgtgggtaaa ggagccgtcc
      361 atgacgttaa agacgtcctt gactcagtac tatagctgta aggagaagct gagaaatgat
      421 acccaggagc agcaggcttt acgtcttcag cctaaaacct aaaaaaaaaa aaaaaaaaaa
      481 aaatttaaaa cagctattaa actgaaagca tctgtaata
//
