LOCUS       NM_005215              10181 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens DCC netrin 1 receptor (DCC), mRNA.
ACCESSION   NM_005215
VERSION     NM_005215.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10181)
  AUTHORS   Badary,D.M., Elsaied,H., Abdel-Fadeil,M.R., Ali,M.K., Abou-Taleb,H.
            and Iraqy,H.M.
  TITLE     Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular
            Endothelial Growth Factor Signaling Pathway in the Pathogenesis of
            Placenta Accreta Spectrum: A Case-control Study
  JOURNAL   Int J Gynecol Pathol 43 (6), 565-572 (2024)
   PUBMED   38289148
  REMARK    GeneRIF: Possible Role of Netrin-1/Deleted in Colorectal
            Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the
            Pathogenesis of Placenta Accreta Spectrum: A Case-control Study.
REFERENCE   2  (bases 1 to 10181)
  AUTHORS   Marquez-Gonzalez,R.M., Saucedo-Sarinana,A.M., de Jesus
            Tovar-Jacome,C., Barros-Nunez,P., Gallegos-Arreola,M.P.,
            Orozco-Gutierrez,M.H., Mariscal-Ramirez,I., Pineda-Razo,T.D.,
            Alcaraz-Wong,A.A., Marin-Contreras,M.E. and Rosales-Reynoso,M.A.
  TITLE     NME1 and DCC variants are associated with susceptibility and tumor
            characteristics in Mexican patients with colorectal cancer
  JOURNAL   J Egypt Natl Canc Inst 36 (1), 10 (2024)
   PUBMED   38556604
  REMARK    GeneRIF: NME1 and DCC variants are associated with susceptibility
            and tumor characteristics in Mexican patients with colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10181)
  AUTHORS   Serwer,T., Wahid,M., Imtiaz,F. and Memon,A.S.
  TITLE     Identification of specific codon 201 mutation of the DCC Gene in
            the colonoscopic specimen of colorectal cancer
  JOURNAL   J Pak Med Assoc 74 (2), 287-293 (2024)
   PUBMED   38419228
  REMARK    GeneRIF: Identification of specific codon 201 mutation of the DCC
            Gene in the colonoscopic specimen of colorectal cancer.
REFERENCE   4  (bases 1 to 10181)
  AUTHORS   Li,W., Lee,J., Vikis,H.G., Lee,S.H., Liu,G., Aurandt,J., Shen,T.L.,
            Fearon,E.R., Guan,J.L., Han,M., Rao,Y., Hong,K. and Guan,K.L.
  TITLE     Activation of FAK and Src are receptor-proximal events required for
            netrin signaling
  JOURNAL   Nat Neurosci 7 (11), 1213-1221 (2004)
   PUBMED   15494734
REFERENCE   5  (bases 1 to 10181)
  AUTHORS   Keino-Masu,K., Masu,M., Hinck,L., Leonardo,E.D., Chan,S.S.,
            Culotti,J.G. and Tessier-Lavigne,M.
  TITLE     Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
  JOURNAL   Cell 87 (2), 175-185 (1996)
   PUBMED   8861902
REFERENCE   6  (bases 1 to 10181)
  AUTHORS   Cho,K.R., Oliner,J.D., Simons,J.W., Hedrick,L., Fearon,E.R.,
            Preisinger,A.C., Hedge,P., Silverman,G.A. and Vogelstein,B.
  TITLE     The DCC gene: structural analysis and mutations in colorectal
            carcinomas
  JOURNAL   Genomics 19 (3), 525-531 (1994)
   PUBMED   8188295
REFERENCE   7  (bases 1 to 10181)
  AUTHORS   Fearon,E.R., Ekstrand,B.C., Hu,G., Pierceall,W.E., Reale,M.A. and
            Bigner,S.H.
  TITLE     Studies of the deleted in colorectal cancer gene in normal and
            neoplastic tissues
  JOURNAL   Cold Spring Harb Symp Quant Biol 59, 637-643 (1994)
   PUBMED   7587124
REFERENCE   8  (bases 1 to 10181)
  AUTHORS   Meneret,A., Trouillard,O., Dunoyer,M., Depienne,C. and Roze,E.
  TITLE     Congenital Mirror Movements
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25763452
REFERENCE   9  (bases 1 to 10181)
  AUTHORS   Nigro,J.M., Cho,K.R., Fearon,E.R., Kern,S.E., Ruppert,J.M.,
            Oliner,J.D., Kinzler,K.W. and Vogelstein,B.
  TITLE     Scrambled exons
  JOURNAL   Cell 64 (3), 607-613 (1991)
   PUBMED   1991322
REFERENCE   10 (bases 1 to 10181)
  AUTHORS   Fearon,E.R., Cho,K.R., Nigro,J.M., Kern,S.E., Simons,J.W.,
            Ruppert,J.M., Hamilton,S.R., Preisinger,A.C., Thomas,G.,
            Kinzler,K.W. et al.
  TITLE     Identification of a chromosome 18q gene that is altered in
            colorectal cancers
  JOURNAL   Science 247 (4938), 49-56 (1990)
   PUBMED   2294591
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011155.13, X76132.1,
            BC036524.1 and AC103949.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005215.3.
            
            Summary: This gene encodes a netrin 1 receptor. The transmembrane
            protein is a member of the immunoglobulin superfamily of cell
            adhesion molecules, and mediates axon guidance of neuronal growth
            cones towards sources of netrin 1 ligand. The cytoplasmic tail
            interacts with the tyrosine kinases Src and focal adhesion kinase
            (FAK, also known as PTK2) to mediate axon attraction. The protein
            partially localizes to lipid rafts, and induces apoptosis in the
            absence of ligand. The protein functions as a tumor suppressor, and
            is frequently mutated or downregulated in colorectal cancer and
            esophageal carcinoma. [provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267772, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442544.7/ ENSP00000389140.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               AC011155.13        118274-118931       c
            659-1853            X76132.1           68-1262
            1854-3046           BC036524.1         1065-2257
            3047-3443           X76132.1           2456-2852
            3444-3754           BC036524.1         2422-2732
            3755-5193           X76132.1           3164-4602
            5194-10181          AC103949.6         130365-135352
FEATURES             Location/Qualifiers
     source          1..10181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..10181
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /note="DCC netrin 1 receptor"
                     /db_xref="GeneID:1630"
                     /db_xref="HGNC:HGNC:2701"
                     /db_xref="MIM:120470"
     exon            1..682
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..4935
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /note="colorectal cancer suppressor; tumor suppressor
                     protein DCC; immunoglobulin superfamily DCC subclass
                     member 1; deleted in colorectal carcinoma; putative
                     colorectal tumor suppressor"
                     /codon_start=1
                     /product="netrin receptor DCC"
                     /protein_id="NP_005206.2"
                     /db_xref="CCDS:CCDS11952.1"
                     /db_xref="GeneID:1630"
                     /db_xref="HGNC:HGNC:2701"
                     /db_xref="MIM:120470"
                     /translation="MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLS
                     EPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNI
                     LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK
                     CEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPA
                     SSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRG
                     EEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL
                     NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVK
                     SDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWR
                     PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEW
                     GPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCT
                     EVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSA
                     PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL
                     FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNC
                     IIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKA
                     FNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT
                     HDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT
                     MYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLE
                     ANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGV
                     GPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHG
                     SVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQK
                     DLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTS
                     HSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYP
                     GILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH
                     SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTH
                     VKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLM
                     KQLNAITGSAF"
     exon            683..1003
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1288
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1439
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1576
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1731
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1852
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2009
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2164
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2313
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2452
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2502
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2644
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2755
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2950
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3046
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3279
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3418
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3526
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3721
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3754
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3820
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3983
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            3984..4210
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4327
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4489
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4702
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            4703..4845
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..10181
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10163..10168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /note="hexamer: AATAAA"
     polyA_site      10181
                     /gene="DCC"
                     /gene_synonym="CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1;
                     NTN1R1"
                     /note="major polyA site"
ORIGIN      
        1 gcacaccgct ggcggacacc ccagtaacaa gtgagagcgc tccaccccgc agtccccccc
       61 gcctctcctc cctgggtccc ctcggctctc ggaagaaaaa ccaacagcat ctccagctct
      121 cgcgcggaat tgtctcttca actttaccca accgacgaca aggaaccagc ctcaaccttt
      181 taatgcacag cccggccaca ggattgcctt ccatctcctc ttggtccctc ctggatgtgg
      241 tttattgatg acttgcgagc ccctcagaga gctgtcttcc ctcctctggc tccctccgtt
      301 tccttgagtt agttttctaa ggttttaccg gggctcggga tctcttggac cgaatggaac
      361 tttttgctgc ctgcttttgc tgctgattct gtcagtggac aaggaaaaag gcttcgaagg
      421 cagcagaggc gcaggggagg tggagaaaga ggtggaggaa gaggacgagg aggaggagga
      481 agccgaaggg gctcggcgcg tgtgtgtgca tgtgtgcatg cgtgtgtgag tgcatgtgtg
      541 tgagtgctgc cgctgcccgc gacccctggc cccgaaggtg ttggctgaaa tatggagaat
      601 agtcttagat gtgtttgggt acccaagctg gcttttgtac tcttcggagc ttccttgttc
      661 agcgcgcatc ttcaagtaac cggttttcaa attaaagctt tcacagcact gcgcttcctc
      721 tcagaacctt ctgatgccgt cacaatgcgg ggaggaaatg tcctcctcga ctgctccgcg
      781 gagtccgacc gaggagttcc agtgatcaag tggaagaaag atggcattca tctggccttg
      841 ggaatggatg aaaggaagca gcaactttca aatgggtctc tgctgataca aaacatactt
      901 cattccagac accacaagcc agatgaggga ctttaccaat gtgaggcatc tttaggagat
      961 tctggctcaa ttattagtcg gacagcaaaa gttgcagtag caggaccact gaggttcctt
     1021 tcacagacag aatctgtcac agccttcatg ggagacacag tgctactcaa gtgtgaagtc
     1081 attggggagc ccatgccaac aatccactgg cagaagaacc aacaagacct gactccaatc
     1141 ccaggtgact cccgagtggt ggtcttgccc tctggagcat tgcagatcag ccgactccaa
     1201 ccgggggaca ttggaattta ccgatgctca gctcgaaatc cagccagctc aagaacagga
     1261 aatgaagcag aagtcagaat tttatcagat ccaggactgc atagacagct gtattttctg
     1321 caaagaccat ccaatgtagt agccattgaa ggaaaagatg ctgtcctgga atgttgtgtt
     1381 tctggctatc ctccaccaag ttttacctgg ttacgaggcg aggaagtcat ccaactcagg
     1441 tctaaaaagt attctttatt gggtggaagc aacttgctta tctccaatgt gacagatgat
     1501 gacagtggaa tgtatacctg tgttgtcaca tataaaaatg agaatattag tgcctctgca
     1561 gagctcacag tcttggttcc gccatggttt ttaaatcatc cttccaacct gtatgcctat
     1621 gaaagcatgg atattgagtt tgaatgtaca gtctctggaa agcctgtgcc cactgtgaat
     1681 tggatgaaga atggagatgt ggtcattcct agtgattatt ttcagatagt gggaggaagc
     1741 aacttacgga tacttggggt ggtgaagtca gatgaaggct tttatcaatg tgtggctgaa
     1801 aatgaggctg gaaatgccca gaccagtgca cagctcattg tccctaagcc tgctatccca
     1861 agctccagtg tcctcccttc ggctcccaga gatgtggtcc ctgtcttggt ttccagccga
     1921 tttgtccgtc tcagctggcg cccacctgca gaagcgaaag ggaacattca aactttcacg
     1981 gtctttttct ccagagaagg tgacaacagg gaacgagcat tgaatacaac acagcctggg
     2041 tcccttcagc tcactgtggg aaacctgaag ccagaagcca tgtacacctt tcgagttgtg
     2101 gcttacaatg aatggggacc gggagagagt tctcaaccca tcaaggtggc cacacagcct
     2161 gagttgcaag ttccagggcc agtagaaaac ctgcaagctg tatctacctc acctacctca
     2221 attcttatta cctgggaacc ccctgcctat gcaaacggtc cagtccaagg ttacagattg
     2281 ttctgcactg aggtgtccac aggaaaagaa cagaatatag aggttgatgg actatcttat
     2341 aaactggaag gcctgaaaaa attcaccgaa tatagtcttc gattcttagc ttataatcgc
     2401 tatggtccgg gcgtctctac tgatgatata acagtggtta cactttctga cgtgccaagt
     2461 gccccgcctc agaacgtctc cctggaagtg gtcaattcaa gaagtatcaa agttagctgg
     2521 ctgcctcctc catcaggaac acaaaatgga tttattaccg gctataaaat tcgacacaga
     2581 aagacgaccc gcaggggtga gatggaaaca ctggagccaa acaacctctg gtacctattc
     2641 acaggactgg agaaaggaag tcagtacagt ttccaggtgt cagccatgac agtcaatggt
     2701 actggaccac cttccaactg gtatactgca gagactccag agaatgatct agatgaatct
     2761 caagttcctg atcaaccaag ctctcttcat gtgaggcccc agactaactg catcatcatg
     2821 agttggactc ctcccttgaa cccaaacatc gtggtgcgag gttatattat cggttatggc
     2881 gttgggagcc cttacgctga gacagtgcgt gtggacagca agcagcgata ttattccatt
     2941 gagaggttag agtcaagttc ccattatgta atctccctaa aagcttttaa caatgccgga
     3001 gaaggagttc ctctttatga aagtgccacc accaggtcta taaccgatcc cactgaccca
     3061 gttgattatt atcctttgct tgatgatttc cccacctcgg tcccagatct ctccaccccc
     3121 atgctcccac cagtaggtgt acaggctgtg gctcttaccc atgatgctgt gagggtcagc
     3181 tgggcagaca actctgtccc taagaaccaa aagacgtctg aggtgcgact ttacaccgtc
     3241 cggtggagaa ccagcttttc tgcaagtgca aaatacaagt cagaagacac aacatctcta
     3301 agttacacag caacaggcct caaaccaaac acaatgtatg aattctcggt catggtaaca
     3361 aaaaacagaa ggtccagtac ttggagcatg actgcacatg ccaccacgta tgaagcagcc
     3421 cccacctctg ctcccaagga cttgacagtc attactaggg aagggaagcc tcgtgccgtc
     3481 attgtgagtt ggcagcctcc cttggaagcc aatgggaaaa ttactgctta catcttattt
     3541 tataccttgg acaagaacat cccaattgat gactggatta tggaaacaat cagtggtgat
     3601 aggcttactc atcaaatcat ggatctcaac cttgatacta tgtattactt tcgaattcaa
     3661 gcacgaaatt caaaaggagt ggggccactc tctgatccta tcctcttcag gactctgaaa
     3721 gtggaacacc ctgacaaaat ggctaatgac caaggtcgtc atggagatgg aggttattgg
     3781 ccagttgata ctaatttgat tgatagaagc accctaaatg agccgccaat tggacaaatg
     3841 caccccccgc atggcagtgt cactcctcag aagaacagca acctgcttgt gatcattgtg
     3901 gtcaccgttg gtgtcatcac agtgctggta gtggtcatcg tggctgtgat ttgcacccga
     3961 cgctcttcag cccagcagag aaagaaacgg gccacccaca gtgctggcaa aaggaagggc
     4021 agccagaagg acctccgacc ccctgatctt tggatccatc atgaagaaat ggagatgaaa
     4081 aatattgaaa agccatctgg cactgaccct gcaggaaggg actctcccat ccaaagttgc
     4141 caagacctca caccagtcag ccacagccag tcagaaaccc aactgggaag caaaagcacc
     4201 tctcattcag gtcaagacac tgaggaagca gggagctcta tgtccactct ggagaggtcg
     4261 ctggctgcac gccgagcccc ccgggccaag ctcatgattc ccatggatgc ccagtccaac
     4321 aatcctgctg tcgtgagcgc catcccggtg ccaacgctag aaagtgccca gtacccagga
     4381 atcctcccgt ctcccacctg tggatatccc cacccgcagt tcactctccg gcctgtgcca
     4441 ttcccaacac tctcagtgga ccgaggtttc ggagcaggaa gaagtcagtc agtgagtgaa
     4501 ggaccaacta cccaacaacc acctatgctg cccccatctc agcctgagca ttctagcagc
     4561 gaggaggcac caagcagaac catccccaca gcttgtgttc gaccaactca cccactccgc
     4621 agctttgcta atcctttgct acctccacca atgagtgcaa tagaaccgaa agtcccttac
     4681 acaccacttt tgtctcagcc agggcccact cttcctaaga cccatgtgaa aacagcctcc
     4741 cttgggttgg ctggaaaagc aagatcccct ttgcttcctg tgtctgtgcc aacagcccct
     4801 gaagtgtctg aggagagcca caaaccaaca gaggattcag ccaatgtgta tgaacaggat
     4861 gatctgagtg aacaaatggc aagtttggaa ggactcatga agcagcttaa tgccatcaca
     4921 ggctcagcct tttaacatgt atttctgaat ggatgaggtg aattttccgg gaactttgca
     4981 gcataccaat tacccataaa cagcacacct gtgtccaaga actctaacca gtgtacaggt
     5041 cacccatcag gaccactcag ttaaggaaga tcctgaagca gttcagaagg aataagcatt
     5101 ccttctttca caggcatcag gaattgtcaa atgatgatta tgagttccct aaacaaaagc
     5161 aaagatgcat tttcactgca atgtcaaagt ttaagctgct agaatagtca tgggcctttg
     5221 tcactgcagt gaccacactg tcataactaa tacctatgtt ttcctttgtc aaggcctgtt
     5281 gtttaatgtg taggtctagt cttacaaaat gcaagtgcat tatttaagcc tgtaccatgc
     5341 catggcaaac cagtgcaagc tcactatttt gttttcaact taaacataca aagcacccat
     5401 gggaatctct catgccatag caccaaagga ttggatgttt tccttacagc acaaaaagta
     5461 aatagtaaac aaacaaaagg cagagaatgc ttatgtttgt aactcagtca ttcatcttgc
     5521 acaagtggtg gatattagtg agtggctaaa aattcaccta ttttggcaag tatttgtaaa
     5581 tccacccttg gttaatatgt atgtctggag tccaggaata taaaaatctg caactagtgg
     5641 cattctgcca gcagcagtac atttctggaa agaggatata atatgcaatc ttctcagaca
     5701 catggtaatt atatgcttaa gcttgtaata ggacagtttt caatttgggt ggcttttgtg
     5761 ccataccaca ctgtgataca atttcaaagc ttcactaagg ccatcttcct taggagtttg
     5821 gccagaagaa tgcccccacc ccttcacccc atccctccct gagttctcct tggcaactag
     5881 cgttgggtga aatggccagc tccacatgtc atatggtgca ctggccaatg tcgcctgtct
     5941 tctaatcccg tagaaatggc agactccctg agagcaggaa gagaaggaaa ataaaaggta
     6001 gcttctaaca gtaccttctc ttaaagaatg ccaactctgc ctacagggtc agtgttggca
     6061 agcattggcc accagaccct tttgttaagg gaaactttta cactacacct gtgtcagagt
     6121 cagggggaag cagaggggca ggtgccacct gacacttccg acatgtaaat ccagcagata
     6181 cttttcaaag cagcatctta aactgtggac tacagtttta aacttctatt gccatgttta
     6241 tctacagctt ggaactagct aaaattaaga acattttgta tgcagcattt tagtttctga
     6301 attttcagct gcatttggag ttaatccctg tttatgcagc tgaatcgcca aaagggagct
     6361 agtttgcata tttatcagtt aggtgacttg aaaacccaat gagagagttt cagctgaatt
     6421 attcctttca gctctgcctt tgatttcaag cttgagtagg tcataatttt aaaagagcat
     6481 ggaagggata ggatctttac aacctaatag ctccttttat taggtgggta attatatatg
     6541 aatccctgaa taaaatattt tgagcaaaat ggcactgtaa cagaagtaat aattcagttt
     6601 atttttttac agttttatgt cgggaaggaa atctgatgtc aaagagaggg ctgttcaaat
     6661 ggttcattag aaagtccggt ccatttgcga atttgttcct tcaacaagag tgctcattca
     6721 agttactcag attttctgga agtcttttct gaagagctat gtgatgttgt tctatgggac
     6781 agactactct tatttaacat ctgggcactt aggtagacaa ccttctactg acctggaata
     6841 aagtgtttcc taacataata ttgaattatt cagaaataat ccattacttc aaaaaagaaa
     6901 atattcattg ggctagccca accttctcta ggccctaaga attattacct cccctttcta
     6961 attctagcaa acatggaaca ttctccttag gcacttgaca cccacgaggg taatcctgag
     7021 tgctcagttt ggaataggtt gcaaatctca gattttaggg attgagtcac accttcaatc
     7081 tatagaatga agttgaccaa ttaaaaaaaa aaaaaaaacc tatcattttc acaaatttct
     7141 agatccttct agtcaaaaat aattatttag gaaataaaat ttttaaaaat ccatttaaat
     7201 acatgttatt tgtcttcagt ggaagttata tttctgctgc atgcttttga aactttcttc
     7261 attaaataga atggtttgtc ttagtaactg gcaatgccag tattagcacc atgcatttaa
     7321 tctataatac aatcaattta aacatcctca aaaaactcta gtatcattta cctggtagta
     7381 ttaatataca atgatgtcac cacaactttt gtataactct gttcccttta ccctcaaatg
     7441 attcatatat gtatataatt gcctgcccaa gttttcaggt aacttattaa tttcccagtc
     7501 tcctgatctc ttgacaagaa gaaacctgtg aatactgcaa actagcctct gacttcctcc
     7561 tactgagtct agttcatggt atccaggact ctttatgctc ataactctct ctgattccca
     7621 ttgggtgata cctgacagcc aaccagccgc tctgccacca gaactcattt ctccctgaaa
     7681 aagaagaaaa tcatatttgg cagagcattc tctggtctgc cctgtaatgt gcttaaatgt
     7741 caggcaacat cctctttttt ttaaaaaaaa tggtattttt ctttaaattt caccctaata
     7801 agaaagctat tttctctcct ctgcagaaat ttctgcattt gtgaaactta taaaaattta
     7861 gatagttcaa atgtataaag aatatttgga tgatgctcta gccaaaagtt aaatatttcg
     7921 tagtgaatca tagccaataa gaaaccagtc atacttgcct ctttgaataa cagagatata
     7981 agcttctaga atatttaaat aatgaagttt tacatttggg tattataaaa tgcatactca
     8041 attgaatgag ctgaaaaaaa taccaagcca gtgatataag tggagattta ttaaggattc
     8101 ctgttgagta tattcttagt ttcctcaaaa tagggattat tcaaaattag gtgtatgttc
     8161 aatctcctgc tttggttcca gctacacaag gagagccatc ctgtgctagt gtgatgtttc
     8221 agacaacatt ctgaaactaa aatgtttggc acttattggc ttttccaata aagaatctct
     8281 taagtacagg tatttctgga agctgttggt gtctgtgctt gaagatgatt gctgatactt
     8341 atccaccctt tgggtacttc tgttgacttt gtttaaataa tcatcttatg gttgtcccca
     8401 aatgtaatat ggtatctcag atatagcagc tggactgtaa ttacaacaaa aggttacctc
     8461 taaagataac atcttaccat tttagataaa attgtgtccc agaattctta tggtttcgga
     8521 atgtacattt ctagtcaatg aaagaaagaa aaatggaaaa attgtctagt ttcaggcatg
     8581 tttaaagaaa acaaagtcat ctgaacttta aaatagatgc agagcagggt tactttccct
     8641 ttcactcagt tcccttcatg caaccacagg cagtcctgca ggccagaggt tactatccta
     8701 acctgctcat aaccatatac tatacagagc ccacaacttt ctggagatgc agaagcagcc
     8761 atacactcaa gtctctgttt ttgtaaatca cattcaaagc aacattttac tcataatttg
     8821 catttctctg gtgactttca gaaatcactt tagtattgta cagaaaagct ttttatttga
     8881 gtctagtgtt taaaattaaa ttggatactt gggaaaatca tagataggtg ttttgtatga
     8941 tattccattc caatgcaaaa tatatgtacc catgcctcaa tgtatcttgc tatctaaata
     9001 cctgttgcca aaaagtattg atttgggaaa aaaaatgcca atttcctggt cagtgaggtt
     9061 atgtaaaaga caaaatacca cacccatatc agcaaatgaa tattactact catctggact
     9121 cttcgttgcc actattgcat aacgttcacg tggcagactt ccagttgcac tctctgaagg
     9181 acttttttct cttactctca atagagagcc tttgtacatt gtcatcctat gattgttgtt
     9241 ggtagaagag caagagcaaa actctgcaag atttaataaa cacaggggca tgggccaagg
     9301 gatctcactg tgtgctgaac atgtattttc agatgcaaga aaggaatgat ggagaggagg
     9361 agaaatgctg ttttttatta ttgtagggta aatctgacaa ttctgaactt tgtgaattgt
     9421 cagcttgttt gggggaaggg tgggcgggta tggggtgtac tttttataag taatatttaa
     9481 tttattattt agagtggctt ctttttggat aatttatgat aaaaagggag atctggttgg
     9541 gatctagata cggctgttaa agctgcagtg ttccatacct cagagggacc actttggaaa
     9601 tgaattgtcc attgctgagt atgaagagat gtccagtcca ggcaaagcct tcactgaagt
     9661 tccatcatcg ccacttctcc ctttttaggg tcattcaaag aagataacac caaacctaaa
     9721 taattctgaa agcattttgc agatcagtgc tactcattca aagggctttg caactcaaac
     9781 agattgttag tgtgctagtg ataagtttat ttggtagaaa tgggtatact acagctttaa
     9841 ctagccttag tgagaaaaga aattttttgt tgttacaaaa cacctttttt aacaaaaagg
     9901 tattttgagc ctacaaaaag tttctttaaa ctgtcagatt ctagcattgt taaccaaatt
     9961 agactagtga ttgcaatatt taagtgtaaa tcttgttcta caagaaagga aacttgctta
    10021 cagtttaaaa caatgactgt ttctacacat gatcttgtat actactacac aaggaaaagg
    10081 gggttttgta aacactgtag aacagtctca tattcatttt tttatagaaa tgttattcca
    10141 atggtgcatt ttttgtttaa taaataaagt tttgatacaa a
//
