LOCUS       NM_080927               6128 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens discoidin, CUB and LCCL domain containing 2 (DCBLD2),
            mRNA.
ACCESSION   NM_080927
VERSION     NM_080927.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6128)
  AUTHORS   Chen,J., Xu,Q., Liu,D., Li,X., Guo,M., Chen,X., Liao,J., Lei,R.,
            Li,W., Huang,H., Saw,P.E., Song,E., Yan,X. and Nie,Y.
  TITLE     CD146 promotes malignant progression of breast phyllodes tumor
            through suppressing DCBLD2 degradation and activating the AKT
            pathway
  JOURNAL   Cancer Commun (Lond) 43 (11), 1244-1266 (2023)
   PUBMED   37856423
  REMARK    GeneRIF: CD146 promotes malignant progression of breast phyllodes
            tumor through suppressing DCBLD2 degradation and activating the AKT
            pathway.
REFERENCE   2  (bases 1 to 6128)
  AUTHORS   Ruan,Y., Chen,T., Zheng,L., Cai,J., Zhao,H., Wang,Y., Tao,L.,
            Xu,J., Ji,L. and Cai,X.
  TITLE     cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma
            by sponging miR-345-5p binding to the TOP2A coding sequence
  JOURNAL   Int J Biol Sci 19 (14), 4608-4626 (2023)
   PUBMED   37781045
  REMARK    GeneRIF: cDCBLD2 mediates sorafenib resistance in hepatocellular
            carcinoma by sponging miR-345-5p binding to the TOP2A coding
            sequence.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6128)
  AUTHORS   Tan,J., Li,C., Ren,L., Zhu,X., Hua,F. and Fu,Y.
  TITLE     miR-451a suppresses papillary thyroid cancer cell proliferation and
            invasion and facilitates apoptosis through targeting DCBLD2 and
            AKT1
  JOURNAL   Mol Cell Probes 66, 101863 (2022)
   PUBMED   36252912
  REMARK    GeneRIF: miR-451a suppresses papillary thyroid cancer cell
            proliferation and invasion and facilitates apoptosis through
            targeting DCBLD2 and AKT1.
REFERENCE   4  (bases 1 to 6128)
  AUTHORS   Coppo,R., Orso,F., Virga,F., Dalmasso,A., Baruffaldi,D., Nie,L.,
            Clapero,F., Dettori,D., Quirico,L., Grassi,E., Defilippi,P.,
            Provero,P., Valdembri,D., Serini,G., Sadeghi,M.M., Mazzone,M. and
            Taverna,D.
  TITLE     ESDN inhibits melanoma progression by blocking E-selectin
            expression in endothelial cells via STAT3
  JOURNAL   Cancer Lett 510, 13-23 (2021)
   PUBMED   33862151
  REMARK    GeneRIF: ESDN inhibits melanoma progression by blocking E-selectin
            expression in endothelial cells via STAT3.
REFERENCE   5  (bases 1 to 6128)
  AUTHORS   Alhamoudi,K.M., Barhoumi,T., Al-Eidi,H., Asiri,A., Nashabat,M.,
            Alaamery,M., Alharbi,M., Alhaidan,Y., Tabarki,B., Umair,M. and
            Alfadhel,M.
  TITLE     A homozygous nonsense mutation in DCBLD2 is a candidate cause of
            developmental delay, dysmorphic features and restrictive
            cardiomyopathy
  JOURNAL   Sci Rep 11 (1), 12861 (2021)
   PUBMED   34145321
  REMARK    GeneRIF: A homozygous nonsense mutation in DCBLD2 is a candidate
            cause of developmental delay, dysmorphic features and restrictive
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6128)
  AUTHORS   Chen,Y., Low,T.Y., Choong,L.Y., Ray,R.S., Tan,Y.L., Toy,W., Lin,Q.,
            Ang,B.K., Wong,C.H., Lim,S., Li,B., Hew,C.L., Sze,N.S., Druker,B.J.
            and Lim,Y.P.
  TITLE     Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel
            tyrosine phosphorylation targets of EGF signaling and Iressa in
            human cancer cells
  JOURNAL   Proteomics 7 (14), 2384-2397 (2007)
   PUBMED   17570516
  REMARK    GeneRIF: our study is the first to identify and validate Endofin,
            DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine
            signaling network
REFERENCE   7  (bases 1 to 6128)
  AUTHORS   Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
            Lauffenburger,D.A. and White,F.M.
  TITLE     Time-resolved mass spectrometry of tyrosine phosphorylation sites
            in the epidermal growth factor receptor signaling network reveals
            dynamic modules
  JOURNAL   Mol Cell Proteomics 4 (9), 1240-1250 (2005)
   PUBMED   15951569
REFERENCE   8  (bases 1 to 6128)
  AUTHORS   Koshikawa,K., Osada,H., Kozaki,K., Konishi,H., Masuda,A.,
            Tatematsu,Y., Mitsudomi,T., Nakao,A. and Takahashi,T.
  TITLE     Significant up-regulation of a novel gene, CLCP1, in a highly
            metastatic lung cancer subline as well as in lung cancers in vivo
  JOURNAL   Oncogene 21 (18), 2822-2828 (2002)
   PUBMED   11973641
REFERENCE   9  (bases 1 to 6128)
  AUTHORS   Kobuke,K., Furukawa,Y., Sugai,M., Tanigaki,K., Ohashi,N.,
            Matsumori,A., Sasayama,S., Honjo,T. and Tashiro,K.
  TITLE     ESDN, a novel neuropilin-like membrane protein cloned from vascular
            cells with the longest secretory signal sequence among eukaryotes,
            is up-regulated after vascular injury
  JOURNAL   J Biol Chem 276 (36), 34105-34114 (2001)
   PUBMED   11447234
REFERENCE   10 (bases 1 to 6128)
  AUTHORS   Nadadur,S.S., Ehrke,M.J. and Gurtoo,H.L.
  TITLE     A novel TNF-inducible message with putative growth suppressor
            function
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 433-439 (1999)
   PUBMED   10673047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026303.25, AB073146.1, AF387547.1 and AC106728.6.
            
            On Nov 22, 2018 this sequence version replaced NM_080927.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073146.1, SRR1803614.95055.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326840.11/ ENSP00000321573.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC026303.25        27351-27356
            7-430               AB073146.1         1-424
            431-437             AF387547.1         73-79
            438-6099            AB073146.1         432-6093
            6100-6128           AC106728.6         100063-100091
FEATURES             Location/Qualifiers
     source          1..6128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.1"
     gene            1..6128
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="discoidin, CUB and LCCL domain containing 2"
                     /db_xref="GeneID:131566"
                     /db_xref="HGNC:HGNC:24627"
                     /db_xref="MIM:608698"
     exon            1..574
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..2697
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="endothelial and smooth muscle cell-derived
                     neuropilin-like protein; 1700055P21Rik; coagulation factor
                     V/VIII-homology domains protein 1; discoidin, CUB and LCCL
                     domain-containing protein 2; CUB, LCCL and coagulation
                     factor V/VIII-homology domains protein 1"
                     /codon_start=1
                     /product="discoidin, CUB and LCCL domain-containing
                     protein 2 precursor"
                     /protein_id="NP_563615.3"
                     /db_xref="CCDS:CCDS46878.1"
                     /db_xref="GeneID:131566"
                     /db_xref="HGNC:HGNC:24627"
                     /db_xref="MIM:608698"
                     /translation="MASRAVVRARRCPQCPQVRAAAAAPAWAALPLSRSLPPCSNSSS
                     FSMPLFLLLLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWE
                     IRVKMGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIES
                     KGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLP
                     FAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISVVISKGIPYYESSLANNVTSV
                     VGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLK
                     KPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKW
                     TVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQ
                     FIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQT
                     TASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILILVCAWHWRNRKKKTEGTYD
                     LPYWDRAGWWKGMKQFLPAKAVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQP
                     LVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYHAYAEPLPITGPEYATPII
                     MDMSGHPTTSVGQPSTSTFKATGNQPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKP
                     GLPAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL"
     exon            575..802
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            803..940
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            941..992
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1065
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1199
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1240
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1456
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1581
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1732
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1819
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1945
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2039
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2089
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2227
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..6128
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4270..4275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="hexamer: AATAAA"
     polyA_site      4286
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="major polyA site"
     regulatory      5879..5884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="hexamer: AATAAA"
     polyA_site      5900
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="major polyA site"
     regulatory      6058..6063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="hexamer: AATAAA"
     regulatory      6096..6101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="hexamer: TATAAA"
     polyA_site      6102
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
                     /note="major polyA site"
     polyA_site      6128
                     /gene="DCBLD2"
                     /gene_synonym="CLCP1; ESDN"
ORIGIN      
        1 gggcctgcct gccagctagc cggagccgcg ggtgagcgcg gcgagcggcg accctggtga
       61 ggagcgcggc gcgggaggca cgttccttag ctccgccgcg gccgtcctcc gcggctcgag
      121 gactccgctt ccttccctcc cctcccctgc gctccggcct ggggtctcgg cgcggggagc
      181 ggagggaagg gacgaaggag gagtaggtga aagcggggtg aggggcggaa gggtcccggc
      241 gcggggtgag gcgagggctg cctcttgttc tcccgccgct gccgccgtct cctggtcggg
      301 tgccgcggcc agaggcgcgc ggggctgccg aggcacccgc actatgcagg cagactgccg
      361 gccgccgcga tggcgagccg ggcggtggtg agagccaggc gctgcccgca gtgtccccaa
      421 gtccgggccg cggccgccgc ccccgcctgg gccgcgctcc ccctctcccg ctccctccct
      481 ccctgctcca actcctcctc cttctccatg cctctgttcc tcctgctctt acttgtcctg
      541 ctcctgctgc tcgaggacgc tggagcccag caaggtgatg gatgtggaca cactgtacta
      601 ggccctgaga gtggaaccct tacatccata aactacccac agacctatcc caacagcact
      661 gtttgtgaat gggagatccg tgtaaagatg ggagagagag ttcgcatcaa atttggtgac
      721 tttgacattg aagattctga ttcttgtcac tttaattact tgagaattta taatggaatt
      781 ggagtcagca gaactgaaat aggcaaatac tgtggtctgg ggttgcaaat gaaccattca
      841 attgaatcaa aaggcaatga aatcacattg ctgttcatga gtggaatcca tgtttctgga
      901 cgcggatttt tggcctcata ctctgttata gataaacaag atctaattac ttgtttggac
      961 actgcatcca attttttgga acctgagttc agtaagtact gcccagctgg ttgtctgctt
     1021 ccttttgctg agatatctgg aacaattcct catggatata gagattcctc gccattgtgc
     1081 atggctggtg tgcatgcagg agtagtgtca aacacgttgg gcggccaaat cagtgttgta
     1141 attagtaaag gtatccccta ttatgaaagt tctttggcta acaacgtcac atctgtggtg
     1201 ggacacttat ctacaagtct ttttacattt aagacaagtg gatgttatgg aacactgggg
     1261 atggagtctg gtgtgatcgc ggatcctcaa ataacagcat catctgtgct ggagtggact
     1321 gaccacacag ggcaagagaa cagttggaaa cccaaaaaag ccaggctgaa aaaacctgga
     1381 ccgccttggg ctgcttttgc cactgatgaa taccagtggt tacaaataga tttgaataag
     1441 gaaaagaaaa taacaggcat tataaccact ggatccacca tggtggagca caattactat
     1501 gtgtctgcct acagaatcct gtacagtgat gatgggcaga aatggactgt gtacagagag
     1561 cctggtgtgg agcaagataa gatatttcaa ggaaacaaag attatcacca ggatgtgcgt
     1621 aataactttt tgccaccaat tattgcacgt tttattagag tgaatcctac ccaatggcag
     1681 cagaaaattg ccatgaaaat ggagctgctc ggatgtcagt ttattcctaa aggtcgtcct
     1741 ccaaaactta ctcaacctcc acctcctcgg aacagcaatg acctcaaaaa cactacagcc
     1801 cctccaaaaa tagccaaagg tcgtgcccca aaatttacgc aaccactaca acctcgcagt
     1861 agcaatgaat ttcctgcaca gacagaacaa acaactgcca gtcctgatat cagaaatact
     1921 accgtaactc caaatgtaac caaagatgta gcgctggctg cagttcttgt ccctgtgctg
     1981 gtcatggtcc tcactactct cattctcata ttagtgtgtg cttggcactg gagaaacaga
     2041 aagaaaaaaa ctgaaggcac ctatgactta ccttactggg accgggcagg ttggtggaaa
     2101 ggaatgaagc agtttcttcc tgcaaaagca gtggaccatg aggaaacccc agttcgctat
     2161 agcagcagcg aagttaatca cctgagtcca agagaagtca ccacagtgct gcaggctgac
     2221 tctgcagagt atgctcagcc actggtagga ggaattgttg gtacacttca tcaaagatct
     2281 acctttaaac cagaagaagg aaaagaagca ggctatgcag acctagatcc ttacaactca
     2341 ccagggcagg aagtttatca tgcctatgct gaaccactcc caattacggg gcctgagtat
     2401 gcaaccccaa tcatcatgga catgtcaggg caccccacaa cttcagttgg tcagccctcc
     2461 acatccactt tcaaggctac ggggaaccaa cctcccccac tagtgggaac ttacaataca
     2521 cttctctcca ggactgacag ctgctcctca gcccaggccc agtatgatac cccgaaagct
     2581 gggaagccag gtctacctgc cccagacgaa ttggtgtacc aggtgccaca gagcacacaa
     2641 gaagtatcag gagcaggaag ggatggggaa tgtgatgttt ttaaagaaat cctttgaaga
     2701 tgatgctgct ttttacaaag catcgtttta aagcacatgg cctttttttt ttaattatta
     2761 gtggtagtaa tatatagaat gtattacata actgtcactg aagtggttgg ggaaaatgtg
     2821 gtgactgagg tacaggaaac tactaatctt gccatcttgc tttaaggtgt tatggtggca
     2881 cagttactgc tcgcctgtta aatttcaaat gtcctgtttg atactactgt agaacactat
     2941 ttttaataca gaaaaagctc cctataatgc acttcagaga aattaaaaat cacagagtat
     3001 ttattaccaa tgctgcaggt acattaatga actcgagatg gctctgtaag cctgactggc
     3061 aataacgcac ggtactgttc ttgaaatacc taatggcttg aaattctagt ctgtttgtga
     3121 aagatgggta ctatcatgat ttcctcttct attcctatat tcttttctgg atttttttta
     3181 ataattagtg atataagcat tgtttttatt gcagccatat ccacttatcc atcttaagat
     3241 ctgtagctgg gattttctga cttgtaatga gcagggggat tgctttttca ctttgtgaca
     3301 ctctttagag ctttaatgct tcacagtata tggcctggtc tcatccttgc gtgttccact
     3361 tgaggccctt tggtgtcttg ccccattctt gtgtttataa aatgtttgag tatttctgat
     3421 gagtgatgct tgccttagtc tcatgaattc agatcccttc atgtccttta agtatgctcc
     3481 tcaatgtgta aacaggaaca actttatgat ttgaaagctt taaaggagat tcttctccca
     3541 cccccaactt tatttgcaat gggatttttc ctaggagagt tatgaaaagt tgaaggcttc
     3601 taagggaata ctgtaaacat gacccactta tatttatcac agtgaaaggc aaaattattc
     3661 actcagaagt aatataaatt acctctttaa aaagtaacca gaatttgtcc tttttggttt
     3721 tatacattca caaacatata catttttctt gagtctcaag gtattttata tttttagtca
     3781 gaaaaaataa tttttcattt cagttttcca taaactgtta cacaaaatat aaacctaacg
     3841 tgtatttttc aggactgcgt gatcgtgcac tttgtgtggt aagaggtttg agtagtccta
     3901 tatgtcacct agggaacaga cattatagct tactagcaaa tgaatattca tgccttgttt
     3961 ttgatacctc ctggcagctt ccatgtcacc acttgttcat acctgcccag agctagtttt
     4021 agacatggca aaatagaaat catctgtaat ttattagcta acaatgtaaa accatctttt
     4081 aaagccttca gactgtcaag acgacatgag cagctcacca tatgataaaa atacataaat
     4141 ttgacattcc ctcttccata aacctttgtt tgtagattta atgttgaaca gtacttttcc
     4201 ataaagttct agtcacttct gttggcctga gccaccagat tatgatgttg ccagaattca
     4261 ctcaatttga ataaagatga acagtatttg ttttcttgtt tccatgaatt atatcagtat
     4321 tctaaaacat cgcttcagaa agagaactgt ttatttctgc aggcttcctg tccttttgtg
     4381 gtatggtttt ttggccttat tttcactggc ttttccttct ccaaactttg aggcgtgatt
     4441 tcattcattg aagaatcaat acatattttg tttcaaaatg tttgaaacaa aagacataga
     4501 tggtagactt ttattaaaac atatatggat gtggaaagca catatattaa tgcagtcatc
     4561 ccttttcagg tgggaagaga gcaaaccagt tgatttttta attcatcctt agtacacaga
     4621 gaatatactt ttcctcaagt aatatacctg tttgaagctt taagagagat gtttttggta
     4681 actatttcat tttcccaaag aagtttgcta ttcttgtgtt aattgtgtat acctgattgt
     4741 tttttcctgg aggtttttgt tgttgttgtt tagttttggg tttttttttt tttaagaggg
     4801 gcaagtgttt tctgaaatga tgcatatttt aagactcgat tcatattgcc actgtgctat
     4861 ccttgaacta ccaataattt ttataaaata tctagttttt actactttta tataaacttt
     4921 actttccaga tgaagagctg agcctgattc aaatggtttt tctgctttat acttcttttt
     4981 agttcattgg tttttatagt agaggttttc tatttttttt tttttttttt ttactacatt
     5041 tatatgtctg atacatatac ggctttggag acaatcaagt aacaactgaa aatgtgaaag
     5101 taaccatatc tgacaaaatt cccttgaatt tttatccttt gcttgcaaca tttaagactc
     5161 aaagtcactg gtatattgga ttaagttttt tcctgttaat gcaattatag aaatacatcg
     5221 gagacacaac aaatgtggcc attacaggtt tcataaaatt acactgactt ggctgttact
     5281 tgatcttagg aaacagcaca gtttaagata ttgtgaattc tgacttatac tttattaaat
     5341 gctgtaaatc taaatagatc ctgttggatg tgatgggtct agtccagttt atttaagttc
     5401 atgtttcact gtttgcactt tgcattgaac aatgggttta ttcgctgatg taaacggttc
     5461 gagtgaagaa ttaatgcagt aagtatgaca acacatacac acttgcctct ccccatctcc
     5521 agaagagggg agcagagtcc gagcttatct aaatatgaat gtggccacaa agctgtggaa
     5581 ggtgacaaag cttaaacacc tttgccctgg ctctgcattg tcacctagag agcaagaggt
     5641 ctatagaaac atcatgtcac atgaaacgat tctctgcttt ttggttctga acttgaagtc
     5701 cctaaactgc aaaatctaag agttgggtgg ttattaaaat gcttttaaag tcaactgtgg
     5761 caccaattct aatgtaatcc aacttgtgac tgtttttttt tgttttgttt tgtttttgtg
     5821 tgtgtgtgtg tggcactggg aaaagtggaa acaaacatgt attgaaatac atattggaaa
     5881 taaaaatggt ttgagcgtca gtgatattct cccagaatgt acttatctta cctcggcatg
     5941 tactgtagtc actcagtatt tgtatatgtt gctagaattt agattgtaaa atagtgaaat
     6001 tttaatgtgt tcatttgttt ttaatgtata tatgtcttgc tcagattatt tggtttaaat
     6061 aaaacaacct tgaggtttgt agcttttcct tatactataa aatgccagat tcttctattt
     6121 taacctca
//
